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| 1 | Honeysuckle-encoded atypical microRNA2911 directly Largets influenza A viruses显示文摘 | Zhen Zhou Xihan Li Jinxiong Liu Lei Dong Qun Chen Jialing Liu Huihui Kongt Qianyi Zhang Xian Qi Dongxia Hou Lin Zhang Guoquan Zhang Yuchen Liu Yujing Zhang Jing Li Jin Wang Xi Chen Hua Wang Junfeng Zhang Hualan Chen Ke Zen Chen-Yu Zhang | 2015 | Cell Research2015，25，1： | 104 |
| 2 | ZIF-8/LiFePO4 derived Fe-N-P Co-doped carbon nanotube encapsulated Fe2P nanoparticles for efficient oxygen reduction and Zn-air batteries显示文摘Iron-based oxygen reduction reaction(ORR)catalysts have been the focus of research,and iron sources play an important role for the preparation of efficient ORR catalysts.Here,we successfully use LiFePO4 as ideal sources of Fe and P to construct the heteroatom doped Fe-based carbon materials.The obtained Fe-N-P co-doped coral-like carbon nanotube arrays encapsulated Fe2P catalyst(C-ZIF/LFP)shows very high half-wave potential of 0.88 V in alkaline electrolytes toward ORR,superior to Pt/C(0.85 V),and also presents a high half-wave potential of 0.74 V in acidic electrolytes,comparable to Pt/C(0.8 V).When further applied into a home-made Zn-air battery as cathode,a peak power density of 140 mW·cm^-2 is reached,exceeds commercial Pt/C(110 mW·cm^-2).Besides,it also presents exceptional durability and methanol resistance compared with Pt/C.Noticeably,the preparation method of such a high-performance catalyst is simple and easy to optimize,suitable for the large-scale production.What’s more,it opens up a more sustainable development scenario to reduce the hazardous wastes such as LiFePO4 by directly using them for preparing high-performance ORR catalysts. | Huihui Jin Huang Zhou Pengxia Ji Chengtian Zhang Jiahuan Luo Weihao Zeng Chenxi Hu Daping He Shichun Mu | 2020 | Nano Research2020，13，3： | 8 |
| 3 | Doxorubicin-conjugated pH-responsive gold nanorods for combined photothermal therapy and chemotherapy of cancer显示文摘Cancer chemotherapy can be hindered by drug resistance which leads to lower drug efficiency.Here,we have developed a drug delivery system that tethers doxorubicin to the surface of gold nanorods via a pHsensitive linkage(AuNRs@DOX),for a combined photothermal and chemical therapy for cancer.First,AuNRs@DOX is ingested by HepG2 liver cancer cells.After endocytosis,the acidic pH triggers the release of doxorubicin,which leads to chemotherapeutic effects.The gold nanorods are not only carriers of DOX,but also photothermal conversion agents.In the presence of an 808 nm near-infrared laser,AuNRs@DOX significantly enhance the cytotoxicity of doxorubicin via the photothermal effect,which induces elevated apoptosis of hepG2 cancer cells,leading to better therapeutic effects in vitro and in vivo. | Jin Chen Xiao Li Xinlian Zhao QianQian Wu Huihui Zhu Zhengwei Mao Changyou Gao | 2018 | Bioactive Materials2018，3，3： | 5 |
| 4 | Design Engineering,Synthesis Protocols,and Energy Applications of MOF-Derived Electrocatalysts显示文摘The core reactions for fuel cells,rechargeable metal-air batteries,and hydrogen fuel production are the oxygen reduction reaction(ORR),oxygen evolution reaction(OER),and hydrogen evolution reaction(HER),which are heavily dependent on the efficiency of electrocatalysts.Enormous attempts have previously been devoted in non-noble electrocatalysts born out of metal-organic frameworks(MOFs)for ORR,OER,and HER applications,due to the following advantageous reasons:(i)The significant porosity eases the electrolyte diffusion;(ii)the supreme catalyst-electrolyte contact area enhances the diffusion efficiency;and(iii)the electronic conductivity can be extensively increased owing to the unique construction block subunits for MOFs-derived electrocatalysis.Herein,the recent progress of MOFs-derived electrocatalysts including synthesis protocols,design engineering,DFT calculations roles,and energy applications is discussed and reviewed.It can be concluded that the elevated ORR,OER,and HER performances are attributed to an advantageously well-designed high-porosity structure,significant surface area,and plentiful active centers.Furthermore,the perspectives of MOF-derived electrocatalysts for the ORR,OER,and HER are presented. | Amr Radwan Huihui Jin Daping He Shichun Mu | 2021 | Nano-Micro Letters2021，13，9： | 4 |
| 5 | Sin1/mTORC2 regulate B cell growth and metabolism by activating mTORC1 and Myc显示文摘Proper control of B cell growth and metabolism is crucial for B-cell-mediated immunity,but the underlying molecular mechanisms remain incompletely understood.In this study,Sin1,a key component of mTOR complex 2(mTORC2),specifically regulates B cell growth and metabolism.Genetic ablation of Sin1 in B cells reduces the cell size at either the transitional stage or upon antigen stimulation and severely impairs metabolism.Sin1 deficiency also severely impairs B-cell proliferation,antibody responses,and anti-viral immunity.At the molecular level,Sin1 controls the expression and stability of the c-Myc protein and maintains the activity of mTORC1 through the Akt-dependent inactivation of GSK3 and TSC1/2,respectively.Therefore,our study reveals a novel and specific role for Sin1 in coordinating the activation of mTORC2 and mTORC1 to control B cell growth and metabolism. | Man Li Adam S.Lazorchak Xinxing Ouyang Huihui Zhang Hongzhi Liu Omotooke A.Arojo Lichong Yan Jingsi Jin Yuheng Han Guojun Qu Yuhong Fu Xiaocao Xu Xiaobo Liu Wenqian Zhang Zhengfeng Yang Chuan Ruan Qijun Wang Dou Liu Chuanxin Huang Lu Lu Shibo Jiang Fubin Li Bing Su | 2019 | Cellular & Molecular Immunology2019，16，9： | 4 |
| 6 | Development of Cryogenic Disinfectants Using in-18℃and-40℃Environments—Worldwide,2021显示文摘Introduction:Since the outbreak of coronavirus disease 2019(COVID-19)in Beijing Xinfadi Wholesale Market,a series of COVID-19 outbreaks has indicated the threat of transmission due to outer surfaces of objects under low temperatures.Therefore,2 kinds of chlorine-containing disinfectants for−18℃and−40℃were developed in order to solve the problem of low temperature disinfection.Methods:The properties of two cryogenic disinfectants were evaluated by low-temperature test.Staphylococcus aureus and Escherichia coli were used as two indicator microorganisms to evaluate the effects of the two cryogenic disinfectants in the laboratory and field tests according to Technical Specifications for Disinfection(2002 version)and Test method for bactericidal effect of disinfectants in laboratory(GB/T 38502-2020).Results:Two disinfectants could remain in the liquid state at−18℃or−40℃in 72 hours without crystallization and precipitation,and the average log values of microbial reduction before and after disinfection(the average killing log value)both on Staphylococcus aureus and Escherichia coli were>3 in the laboratory and field tests.Discussion:The results showed that these two disinfectants remained functional at low temperature to disinfect the packaging of imported cold chain food and surrounding packaging to prevent transmission of COVID-19 from material to people. | Huihui Sun Hongyang Duan Wei Zhang Chen Liang Luyao Li Yuan Lyu Yanyan Chen Jin Shen Liubo Zhang | 2021 | China CDC weekly2021，3，13： | 4 |
| 7 | Investigation of black phosphorus as a nano-optical polarization element by polarized Raman spectroscopy显示文摘 | Nannan Mao Shishu Zhang Jinxiong Wu Huihui Tian Juanxia Wu Hua Xu Hailin Peng Lianming Tong Jin Zhang | 2018 | Nano Research2018，11，6： | 4 |
| 8 | Exploring the network structure and nodal centrality of China’s air transport network: A complex network approach显示文摘 | Jiaoe Wang Huihui Mo Fahui Wang Fengjun Jin | 2010 | Journal of Transport Geography2010，，4： | 3 |
| 9 | Epithelial-mesenchymal transition status of circulating tumor cells in breast cancer and its clinical relevance显示文摘Objective:Circulating tumor cells(CTCs)play a critical role in cancer metastasis,but their prevalence and significance remain unclear.This study attempted to track the epithelial-mesenchymal transition(EMT)status of CTCs in breast cancer patients and investigate their clinical relevance.Methods:In this study,the established negFACS-IF:E/M platform was applied to isolate rare CTCs and characterize their EMT status in breast cancer.A total of 89 breast cancer patients were recruited,including stage 0–III(n=60)and late stage(n=29)cases.Results:Using the negFACS-IF:E/M platform,it was found that in human epidermal growth factor receptor 2(HER2)+patients,mesenchymal CTCs usually exhibited a high percentage of HER2+cells.Stage IV breast cancer patients had considerably more CTCs than stage 0–III patients.Among stage 0–III breast cancers,the HER2 subtype included a significantly higher percentage of mesenchymal and biphenotypic(epithelial and mesenchymal)CTCs than the luminal A or B subtypes.Among stage IV patients,CTCs were predominantly epithelial in cases with local recurrence and were more mesenchymal in cases with distant metastasis.By applying a support vector machine(SVM)algorithm,the EMT status of CTCs could distinguish between breast cancer cases with metastasis/local recurrence and those without recurrence.Conclusions:The negFACS-IF:E/M platform provides a flexible and generally acceptable method for the highly sensitive and specific detection of CTCs and their EMT traits in breast cancer.This study demonstrated that the EMT status of CTCs had high clinical relevance in breast cancer,especially in predicting the distant metastasis or local recurrence of breast cancer. | Jiaojiao Zhou Xuan Zhu Shijie Wu Jingxin Guo Kun Zhang Chunjing Xu Huihui Chen Yuxi Jin Yuting Sun Shu Zheng Yiding Chen | 2020 | Cancer Biology & Medicine2020，17，1： | 3 |
| 10 | Monitoring the Effective Sterilization of Low-Temperature Hydrogen Peroxide Gas Plasma Sterilizers in 58 Hospitals——22 PLADs,China,June 2015-December 2019显示文摘Summary What is already known on this topic?Hydrogen peroxide sterilizeation is widely used for luminal devices.However,the low penetrability of the sterilant is of major concern.What is added by this report?This report investigated the effective sterilization of low-temperature hydrogen peroxide gas plasma sterilizers and compared the applicability of different biological monitoring methods based on medical luminal devices. | Jiaqi Wang Baoying Zhang Huihui Sun Jian Zhang Hongyang Duan Haiqun Ban Jin Shen Liubo Zhang | 2021 | China CDC weekly2021，3，29： | 3 |
| 11 | Ultra-small platinum nanoparticles segregated by nickle sites for efficient ORR and HER processes显示文摘In the electrochemical process,Pt nanoparticles(NPs)in Pt-based catalysts usually agglomerate due to Oswald ripening or lack of restraint,ultimately resulting in reduction of the active sites and catalytic efficiency.How to uniformly disperse and firmly fix Pt NPs on carbon matrix with suitable particle size for catalysis is still a big challenge.Herein,to prevent the agglomeration and shedding of Pt NPs,Ni species is introduced and are evenly dispersed in the surface of carbon matrix in the form of Ni-N-C active sites(Ni ZIF-NC).The Ni sites can be used to anchor Pt NPs,and then effectively limit the further growth and agglomeration of Pt NPs during the reaction process.Compared with commercial Pt/C catalyst,Pt@Ni ZIF-NC,with ultralow Pt loading(7 wt%)and ideal particle size(2.3 nm),not only increases the active center,but also promotes the catalysis kinetics,greatly improving the ORR and HER catalytic activity.Under acidic conditions,its half-wave potential(0.902 V)is superior to commercial Pt/C(0.861 V),and the mass activity(0.38 A per mg Pt)at 0.9 V is 4.7 times that of Pt/C(0.08 A per mg Pt).Besides,it also shows outstanding HER performance.At 20 and 30 mV,its mass activity is even 2 and 6 times that of Pt/C,respectively.Whether it is under ORR or HER conditions,it still shows excellent durability.These undoubtedly indicate the realization of dual-functional catalysts with low-Pt and high-efficiency properties. | Lvhan Liang Huihui jin Huang Zhou Bingshuai Liu Chenxi Hu Ding Chen Jiawei Zhu Zhe Wang Hai-Wen Li Suli Liu Daping He Shichun Mu | 2022 | Journal of Energy Chemistry2022，31，2： | 2 |
| 12 | Facile ultrasonic-assisted synthesis of micro–nanosheet structure Bi_4Ti_3O_(12)/g-C_3N_4 composites with enhanced photocatalytic activity on organic pollutants显示文摘The Bi_4Ti_3O_(12)/g-C_3N_4 composites with microsheet and nanosheet structure were prepared through facile ultrasonic-assisted method. The SEM and TEM results suggested that the nanosheets g-C_3N_4 were stacked on the surface of regular Bi_4Ti_3O_(12) sheets. Comparing with pure Bi_4Ti_3O_(12) and g-C_3N_4, the Bi_4Ti_3O_(12)/g-C_3N_4 composites showed significant enhancement in photocatalytic efficiency for the degradation of RhB in solution. With the mass ratio of g-C_3N_4 increasing to 10 wt%, the Bi_4Ti_3O_(12)/g-C_3N_4-10% presented the best photocatalytic activity. Its photocatalysis reaction constant was approximately 2 times higher than the single component Bi_4Ti_3O_(12) or g-C_3N_4. Meanwhile, good stability and durability for the Bi_4Ti_3O_(12)/g-C_3N_4-10% were confirmed by the recycling experiment and FT-IR analysis. The possible mechanism for the improvements was the matched band positions and the effective separation of photo-excited electrons(e-) and holes(h+). Furthermore, based on the results of active species trapping, photo-generated holes(h+) and superoxide radical(·O2-) could be the main radicals in reaction. | Huihui Gan Futao Yi Huining Zhang Yongxing Qian Huixia Jin Kefeng Zhang | 2018 | Chinese Journal of Chemical Engineering2018，26，12： | 2 |
| 13 | Spatiotemporal evolution of China’s railway network in the 20th century: An accessibility approach显示文摘 | Jiaoe Wang Fengjun Jin Huihui Mo Fahui Wang | 2009 | Transportation Research Part A2009，，8： | 1 |
| 14 | Enhanced compression of femtosecond pulse in hollow-core photonic bandgap fibers显示文摘 | Yichang Meng Shumin Zhang Chunjiang Jin Huihui Li Xinzhan Wang | 2010 | Optics Communications2010，，11： | 1 |
| 15 | Spatiotemporal evolution of China’s railway network in the 20th century: An accessibility approach显示文摘 | Jiaoe Wang Fengjun Jin Huihui Mo Fahui Wang | 2009 | Transportation Research Part A2009，，8： | 1 |
| 16 | Multi-omics of Circular RNAs and Their Responses to Hormones in Moso Bamboo(Phyllostachys edulis)显示文摘Circular RNAs(circRNAs)are endogenous non-coding RNAs with covalently closed structures,which have important functions in plants.However,their biogenesis,degradation,and function upon treatment with gibberellins(GAs)and auxins(1-naphthaleneacetic acid,NAA)remain unknown.Here,we systematically identified and characterized the expression patterns,evolutionary conservation,genomic features,and internal structures of circRNAs using RNase R-treated libraries from moso bamboo(Phyllostachys edulis)seedlings.Moreover,we investigated the biogenesis of circRNAs dependent on both cis-and trans-regulation.We explored the function of circRNAs,including their roles in regulating microRNA(miRNA)-related genes and modulating the alternative splicing of their linear counterparts.Importantly,we developed a customized degradome sequencing approach to detect miRNA-mediated cleavage of circRNAs.Finally,we presented a comprehensive view of the participation of circRNAs in the regulation of hormone metabolism upon treatment of bamboo seedlings with GA and NAA.Collectively,our study provides insights into the biogenesis,function,and miRNA-mediated degradation of circRNAs in moso bamboo. | Yongsheng Wang Huihui Wang Huiyuan Wang Ruifan Zhou Ji Wu Zekun Zhang Yandong Jin Tao Li Markus V.Kohnen Xuqing Liu Wentao Wei Kai Chen Yubang Gao Jiazhi Ding Hangxiao Zhang Bo Liu Chentao Lin Lianfeng Gu | 2023 | Genomics, Proteomics & Bioinformatics2023，21，4： | 1 |
| 17 | A new strategy to access Co/N co-doped carbon nanotubes as oxygen reduction reaction catalysts显示文摘Carbon nanotubes(CNTs),as one-dimensional nanomaterials,show great potential in energy conversion and storage due to their efficient electrical conductivity and mass transfer.However,the security risks,time-consuming and high cost of the preparation process hinder its further application.Here,we develop that a negative pressure rather than a following gas environment can promote the generation of cobalt and nitrogen co-doped CNTs(Co/N-CNTs) by using cobalt zeolitic imidazolate framework(ZIF-67) as a precursor,in which the negative pressure plays a key role in adjusting the size of cobalt nanoparticles and stimulating the rearragement of carbon atoms for forming CNTs.Importantly,the obtained Co/N-CNTs,with high content of pyridinic nitrogen and abundant graphitized structure,exhibit superior catalytic activity for oxygen reduction reaction(ORR) with half-wave potential(E_(1/2)) of 0.85 V and durability in terms of the minimum current loss(2%) after the 30,000 s test.Our development provides a new pathway for large-scale and cost-effective preparation of metal-doped CNTs for various applications. | Bingshuai Liu Huang Zhou Huihui Jin Jiawei Zhu Zhe Wang Chenxi Hu Lvhan Liang Shichun Mu Daping He | 2021 | Chinese Chemical Letters2021，32，1： | 1 |
| 18 | Spatiotemporal evolution of China' s railway network in the 20th century: an accessibility approach显示文摘 | Wang Jiaoe Jin Fengjun Mo Huihui | 2009 | Transportation Research Part A2009，43，： | 1 |
| 19 | Exploring the network structure and nodal centrality of China’s air transport network: A complex network approach显示文摘 | Jiaoe Wang Huihui Mo Fahui Wang Fengjun Jin | 2010 | Journal of Transport Geography2010，，4： | 1 |
| 20 | Liver Fibrosis Scoring Systems as Novel Tools for Predicting Recurrent Cardiovascular Events in Patients with a Prior Cardiovascular Event显示文摘Objective:Regarding the secondary prevention of cardiovascular disease(CVD),there is great interest in preventing recurrent cardiovascular events(RCVEs).The prognostic importance of liver fibrosis scores(LFSs)has previously been reported in variousCVDs.We hypothesized that LFSs might also be useful predictors for RCVEs in patients with prior cardiovascular events(CVEs).Herein,we aimed to evaluate the associations of LFSs with RCVEs in a large,real-world cohort of coronary artery disease(CAD)patients with a prior CVE.Methods:In this multicenter prospective study,6527 consecutive patients with angiography-diagnosed CAD who had experienced a prior CVE(acute coronary syndrome,stroke,percutaneous coronary intervention,or coronary artery bypass grafting)were enrolled.LFSs were computed according to the published formulas:non-alcoholic fatty liver disease fibrosis score(NFS)includes age,body mass index(BMI),impaired fasting glycemia or diabetes mellitus(DM),aspartate aminotransferase(AST)/alanine aminotransferase(ALT)ratio,platelets,and albumin;fibrosis-4(FIB-4)includes age,AST,ALT,and platelets;Forns score includes age,gamma-glutamyltransferase(GGT),and platelets;BARD includes BMI,AST/ALT ratio,and DM;GGT/platelet ratio includes GGT and platelets;AST/ALT ratio includes AST and ALT;and AST/platelet ratio index includes AST and platelets.The originally reported cutoffs were used for the categorization of low-,intermediate-,and high-score subgroups.All patients were followed up for the occurrence of RCVEs(comprising cardiovascular death,non-fatal myocardial infarction,and stroke).Cox and Poisson regression analyses were used to assess the relationship of baseline LFSs with the risk of RCVE.Results:During a mean follow-up of(54.67±18.80)months,532(8.2%)RCVEs were recorded.Intermediate and high NFS,FIB-4,Forns,and BARD scores were independently associated with an increased risk of RCVE(hazard ratios ranging from 1.42 to 1.75 for intermediate scores and 1.35 to 2.52 for high scores).In the subgroup analyses of sex,age,BMI,DM,and hypertension status,the increased risk of RCVEs with high LFSs(NFS,FIB-4,Forns,and BARD)was maintained across the different subgroups(all P<0.05).Conclusion:This study showed that LFSs are indeed independently associated with RCVEs,suggesting that LFSs may be used as novel tools for risk stratification in CAD patients with a prior CVE. | Huihui Liu Yexuan Cao Jinglu Jin Yuanlin Guo Chenggang Zhu Naqiong Wu Qi Hua Yanfang Li Lifeng Hong Qian Dong Jianjun Li | 2021 | Cardiology Discovery2021，1，4： | 1 |
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