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| 1 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 2 | Core-shell lipid-polymer nanoparticles as a promising ocular drug delivery system to treat glaucoma显示文摘Nowadays,tremendous researches have been focused on the core-shell lipid-polymer nanoparticles(LPNs) due to the advantages of both liposomes and polymer nanoparticles.In this work,LPNs were applied to encapsulate brinzolamide(Brz-LPNs) for achieving sustained drug release,improving drug corneal permeation and enhancing drug topical therapeutic effect.The structure of Brz-LPNs was composed of poly(lactic-co-glycolic) acid(PLGA) nanocore which encapsulated Brz(Brz-NPs) and lipid shell around the core.Brz-LPNs were prepared by a modified thin-film dispersion method.With the parameters optimization of Brz-LPNs,optimal Brz-LPNs showed an average particle size of151.23±1.64 nm with a high encapsulation efficiency(EE) of 86.7%±2.28%.The core-shell structure of Brz-LPNs were confirmed by transmission electronic microscopy(TEM).Fourier transformed infrared spectra(FTIR) analysis proved that Brz was successfully entrapped into Brz-LPNs.Brz-LPNs exhibited obvious sustained release of Brz,compared with AZOPT^■ and Brz-LPs.Furthermore,the corneal accumulative permeability of Brz-LPNs significantly increased compared to the commercial available formulation(AZOPT^■) in vitro.Moreover,Brz-LPNs(1 mg/mL Brz) showed a more sustained and effective intraocular pressure(IOP) reduction than Brz-LPs(1 mg/mL) and AZOPT^■(10 mg/mL Brz) in vivo.In conclusion,Brz-LPNs,as promising ocular drug delivery systems,are well worth developing in the future for glaucoma treatment. | Yang Zhou Aiping Fang Fazhan Wang Huili Li Quansheng Jin Lingjing Huang Chunmei Fu Jun Zeng Zhaohui Jin Xiangrong Song | 2020 | Chinese Chemical Letters2020，31，2： | 3 |
| 3 | Limited Spatial Transferability of the Relationships Between Kriging Variance and Soil Sampling Spacing in Some Grasslands of Ireland:Implications for Sampling Design显示文摘Sampling plays an important role in acquiring precise soil information required in modern agricultural production worldwide, which determines both the cost and quality of final soil mapping products. For sampling design, it has been proposed possibile to transfer the relationships between kriging variance and sampling grid spacing from an area with existing information to other areas with similar soil-forming environments. However, this approach is challenged in practice because of two problems: i) different population vaxiograms among similar areas and ii) sampling errors in estimated variograms. This study evaluated the effects of these two problems on the transferability of the relationships between kriging variance and sampling grid spacing, by using spatial data simulated with three variograms and soil samples collected from four grasslands in Ireland with similar soil-forming environments. Results showed that the variograms suggested by different samples collected with the same grid spacing in the same or similar areas were different, leading to a range of mean kriging variance (MKV) for each grid spacing. With increasing grid spacing, the variation of MKV for a specific grid spacing increased and deviated more from the MKV generated using the population variograms. As a result, the spatial transferability of the relationships between kriging variance and grid spacing for sampling design was limited. | SUN Xiaolin WANG Huili Dermot FORRISTAL FU Weijun Hubert TUNNEY Chaosheng ZHANG | 2019 | Pedosphere2019，29，5： | 3 |
| 4 | Hollow Gradient-Structured Iron-Anchored Carbon Nanospheres for Enhanced Electromagnetic Wave Absorption显示文摘In the present paper,a microwave absorber with nanoscale gradient structure was proposed for enhancing the electromagnetic absorption performance.The inorganic-organic competitive coating strategy was employed,which can effectively adjust the thermodynamic and kinetic reactions of iron ions during the solvothermal process.As a result,Fe nanoparticles can be gradually decreased from the inner side to the surface across the hollow carbon shell.The results reveal that it offers an outstanding reflection loss value in combination with broadband wave absorption and flexible adjustment ability,which is superior to other relative graded distribution structures and satisfied with the requirements of lightweight equipment.In addition,this work elucidates the intrinsic microwave regulation mechanism of the multiscale hybrid electromagnetic wave absorber.The excellent impedance matching and moderate dielectric parameters are exhibited to be the dominative factors for the promotion of microwave absorption performance of the optimized materials.This strategy to prepare gradient-distributed microwave absorbing materials initiates a new way for designing and fabricating wave absorber with excellent impedance matching property in practical applications. | Cao Wu Jing Wang Xiaohang Zhang Lixing Kang Xun Cao Yongyi Zhang Yutao Niu Yingying Yu Huili Fu Zongjie Shen Kunjie Wu Zhenzhong Yong Jingyun Zou Bin Wang Zhou Chen Zhengpeng Yang Qingwen Li | 2023 | Nano-Micro Letters2023，15，1： | 2 |
| 5 | The chimeric gene atp6c confers cytoplasmic male sterility in maize by impairing the assembly of the mitochondrial ATP synthase complex显示文摘Cytoplasmic male sterility(CMS)is a powerful tool for the exploitation of hybrid heterosis and the study of signaling and interactions between the nucleus and the cytoplasm.C-type CMS(CMS-C)in maize has long been used in hybrid seed production,but the underlying sterility factor and its mechanism of action remain unclear.In this study,we demonstrate that the mitochondrial gene atp6c confers male sterility in CMS-C maize.The ATP6C protein shows stronger interactions with ATP8 and ATP9 than ATP6 during the assembly of F1F0-ATP synthase(F-type ATP synthase,ATPase),thereby reducing the quantity and activity of assem-bled F_(1)F_(o)-ATP synthase.By contrast,the quantity and activity of the F1'component are increased in CMS-C lines.Reduced F1F0-ATP synthase activity causes accumulation of excess protons in the inner membrane space of the mitochondria,triggering a burst of reactive oxygen species(ROS),premature programmed cell death of the tapetai cells,and pollen abortion.Collectively,our study identifies a chimeric mitochondrial gene(ATP6C)that causes CMS in maize and documents the contribution of ATP6C to F1F0-ATP synthase assembly,thereby providing novel insights into the molecular mechanisms of male sterility in plants. | Huili Yang Yadong Xue Bing Li Yanan Lin Haochuan Li Zhanyong Guo Weihua Li Zhiyuan Fu Dong Ding Jihua Tang | 2022 | Molecular Plant2022，15，5： | 2 |
| 6 | Design, synthesis, and structure–activity relationship studies of conformationally restricted mutilin 14-carbamates显示文摘 | Liqiang Fu Xin Liu Chenyu Ling Jianjun Cheng Xingsheng Guo Huili He Shi Ding Yushe Yang | 2011 | Bioorganic & Medicinal Chemistry Letters2011，，2： | 1 |
| 7 | Technology Development Analysis on Low Carbon for Power of Heavy-Duty Commercial Vehicle显示文摘Commercial vehicle industry worldwide is facing challenges from environmental pressures,stringent limits of CO_(2) emission,governmental regulations as well as ever-increased customer demands.This paper analyzes the above-mentioned challenges,especially in China,including the potential improvement to increase the brake thermal efficiency(BTE),with five levels of BTE proposed,ranging from current 45 to 60%in future,corresponding to China fuel consumption regulation(CFCR)in different phases.The authors also proposed the technology roadmaps to meet the upcoming CFCR3 and CFCR4;finally,the authors draw the conclusions to conform with ever-stringent regulation in China. | Jiangwei Liu Jun Li Yongjun Wang Dalu Dong Yansheng Yin Huayu Jin Shijie Sun Huili Dou Yanbo Shi Lei Fu Fei Ge | 2019 | Automotive Innovation2019，2，1： | 1 |
| 8 | Determination of Two Pesticides in Soils by Dispersive Liquid–Liquid Microextraction Combined with LC-Fluorescence Detection显示文摘 | Lingyan Fu Xiujuan Liu Jia Hu Xinna Zhao Huili Wang Changjiang Huang Xuedong Wang | 2009 | Chromatographia (-)2009，，11： | 1 |
| 9 | Welding deformation control of medium-thickness structures made by advanced high strength steel显示文摘 | Fu Ling Wang Xiaoteng Ren Huili Tan Xing Dai Xili | 2014 | China Welding2014，23，2： | 0 |
| 10 | A review of physicochemical properties of dissolved organic carbon and its impact over mountain glaciers显示文摘Investigating the characteristics and transformation of water-soluble carbonaceous matter in the cryosphere regions is important for understanding biogeochemical process in the earth system.Water-soluble carbonaceous matter is a heterogeneous mixture of organic compounds that is soluble in aquatic environments.Despite its importance,we still lack systematic understanding for dissolved organic carbon(DOC)in several aspects including exact chemical composition and physical interactions with microorganisms,glacier meltwater.This review presents the chemical composition and physical properties of glacier DOC deposited through anthropogenic emission,terrestrial,and biogenic sources.We present the molecular composition of DOC and its effect over snow albedo and associated radiative forcings.Results indicate that DOC in snow/ice is made up of aromatic protein-like species,fulvic acid-like materials,and humic acid-like materials.Light-absorbing impurities in surface snow and glacier ice cause considerable albedo reduction and the associated radiative forcing is definitely positive.Water-soluble carbonaceous matter dominated the carbon transport in the high-altitude glacial area.Owing to prevailing global warming and projected increase in carbon emission,the glacial DOC is expected to release,which will have strong underlying impacts on cryosphere ecosystem.The results of this work have profound implications for better understanding the carbon cycle in high altitude cryosphere regions.A new compilation of globally distributed work is required,including large-scale measurements of glacial DOC over high-altitude cryosphere regions,to overcome and address the scientific challenges to constrain climate impacts of light-absorbing impurities related processes in Earth system and climate models. | NIU Hewen CHEN Mengxue KANG Shichang SHUKLA Tanuj QIN Huili GAO Wanni HUANG Shihai ZHANG Fu | 2024 | Journal of Mountain Science2024，21，1： | 0 |
| 11 | Microglial glutaminase 1 mediates chronic restraint stress-induced depression-like behaviors and synaptic damages显示文摘Dear Editor,Major depressive disorder(MDD)is one of the most common psychiatric illnesses that significantly increase the risk of suicide.1 Stress-triggered dysfunctions of microglia have been identified as a commonly occurred pathological feature of MDD.1–3 Microglial dysfunction contributes to the pathogenesis of MDD via immunoresponses/neuroinflammation-mediated neural damage and pathological synapse loss-mediated neural circuit disruption.1 Although the involvement of microglia in MDD has been widely investigated,the molecular mechanisms underlying microglial dysfunction remain largely unknown.Recently,we identified glutaminase 1(Gls1)as one key protein that participates in microglial dysfunction.4–6 Gls1 catalyzes the hydrolysis of glutamine to produce glutamate in the brain.4 Besides its well-known role in excitatory neurotoxicity,we found Gls1 up-regulation in microglia in animal models of Alzheimer’s disease and ischemic stroke.4,7 Gls1 activates microglia to overproduce cytokines and release inflammatory extracellular vesicles,therefore leading to neuroinflammation in animal models of Alzheimer’s disease and ischemic stroke.4–6 More importantly,Gls1 has been found to be up-regulated in the brains of MDD patients,and microglial Gls1 deficiency mitigated LPS-induced depression-like behaviors.8 However,LPS exposure is not an appropriate model to mimic MDD phenotypes,leaving the involvement of Gls1 in MDD an undetermined question. | Huili Chen Shengyang Fu Xiangyu Li Meng Shi Jiazhen Qian Shu Zhao Ping Yuan Lu Ding Xiaohuan Xia Jialin C.Zheng | 2024 | Signal Transduction and Targeted Therapy2024，9，1： | 0 |
| 12 | Engineering trienzyme cascade-triggered fluorescent immunosensor platform by sequentially integrating alkaline phosphatase, tyrosinase and horseradish peroxidase显示文摘Mulit-enzyme cascades are a major type of chemical transformations and play a crucial role in biological signal transduction and metabolism. Herein, a trienzyme cascade-triggered fluorescent immunosensor platform was constructed by sequentially integrating alkaline phosphatase(ALP), tyrosinase(TYR)and horseradish peroxidase(HRP). The proposed platform was based on HRP-induced a rapid in situ fluorogenic reaction between dopamine(DA) and 1,5-dihydroxynaphthalene(DHA) to produce a strong yellow azamonardine fluorescent compound(AFC). The obtained AFC was clearly characterized by highresolution mass spectrum,1H NMR,^(13)C NMR and theoretical calculations. The integration of the twoenzyme system(TYR and HRP) or three-enzyme system(ALP, TYR and HRP) led to a maximum of 400.0-fold and 250.0-fold fluorescence enhancements, respectively. Using cardiac troponin I(c Tn I) as the model antigen, a trienzyme cascade-triggered fluorescent immunosensor platform was developed for quantitative detecting c Tn I in a wide linear range from 2 ng/m L to 150 ng/m L with a detection limit of 0.67ng/m L. In addition, the proposed platform was successfully applied in detection of c Tn I in serum of clinical patients. Overall, the developed fluorescent immunosensor performs powerful implications for researching enzyme cascade systems in the field of biomedicine. | Yujie Sun Lei Wen Huili Ma Wenlin Ma Zhenqian Fu Yinhui Li Chengwu Zhang Lin Li Jinhua Liu | 2023 | Chinese Chemical Letters2023，34，4： | 0 |
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