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| 1 | Regression analysis of major parameters affecting the intensity of coal and gas outbursts in laboratory显示文摘Estimating the intensity of outbursts of coal and gas is important as the intensity and frequency of outbursts of coal and gas tend to increase in deep mining. Fully understanding the major factors contributing to coal and gas outbursts is significant in the evaluation of the intensity of the outburst. In this paper, we discuss the correlation between these major factors and the intensity of the outburst using Analysis of Variance(ANOVA) and Contingency Table Analysis(CTA). Regression analysis is used to evaluate the impact of these major factors on the intensity of outbursts based on physical experiments. Based on the evaluation, two simple models in terms of multiple linear and nonlinear regression were constructed for the prediction of the intensity of the outburst. The results show that the gas pressure and initial moisture in the coal mass could be the most significant factors compared to the weakest factor-porosity. The P values from Fisher's exact test in CTA are: moisture(0.019), geostress(0.290), porosity(0.650), and gas pressure(0.031). P values from ANOVA are moisture(0.094), geostress(0.077), porosity(0.420), and gas pressure(0.051). Furthermore, the multiple nonlinear regression model(RMSE: 3.870) is more accurate than the linear regression model(RMSE: 4.091). | Geng Jiabo Xu Jiang Nie Wen Peng Shoujian Zhang Chaolin Luo Xiaohang | 2017 | International Journal of Mining Science and Technology2017，27，2： | 7 |
| 2 | The Medium Energy X-ray telescope (ME) onboard the Insight-HXMT astronomy satellite显示文摘The Medium Energy X-ray telescope(ME) is one of the three main telescopes on board the Insight hard X-ray modulation telescope(Insight-HXMT) astronomy satellite. ME contains 1728 pixels of Si-PIN detectors sensitive in 5-30 ke V with a total geometrical area of 952 cm^2. The application specific integrated circuit(ASIC) chip, VA32TA6, is used to achieve low power consumption and low readout noise. The collimators define three kinds of field of views(FOVs) for the telescope, 1°×4°, 4°×4°,and blocked ones. Combination of such FOVs can be used to estimate the in-orbit X-ray and particle background components.The energy resolution of ME is ~3 ke V at 17.8 ke V(FWHM) and the time resolution is 255 μs. In this paper, we introduce the design and performance of ME. | XueLei Cao WeiChun Jiang Bin Meng WanChang Zhang Tao Luo Sheng Yang ChunLei Zhang YuDong Gu Liang Sun XiaoJing Liu JiaWei Yang Xian Li Ying Tan ShaoZhen Liu YuanYuan Du FangJun Lu YuPeng Xu Ju Guan ShuangNan Zhang HuanYu Wang TiPei Li ChengMo Zhang XiangYang Wen JinLu Qu LiMing Song XiaoBo Li MingYu Ge YuPeng Zhou ShaoLin Xiong Shu Zhang YongJie Zhang ZeHao Cheng Fei Zhang MaoShun Li XiaoHua Liang Min Gao EnBo Yang XiaoHang Liu HongWei Liu YiJung Yang Fan Zhang | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，4： | 5 |
| 3 | Engineering Cu^(+)/CeZrO_(x) interfaces to promote CO_(2) hydrogenation to methanol显示文摘Cu-based catalysts are widely employed for CO_(2) hydrogenation to methanol,which is expected as a promising process to achieving carbon neutrality.However,most Cu-based catalysts still suffer from low methanol yield with a passable CO_(2) conversion and lack insight into its reaction mechanism for guiding the design of catalysts.In this work,Cu^(+)/CeZrO_(x) interfaces are engineered by employing a series of ceria-zirconia solid solution catalysts with various Ce/Zr ratios,forming a Cu^(+)-O_(v)-Ce^(3+)structure where Cu^(+)atoms are bonded to the oxygen vacancies(O_(v))of ceria.Compared to Cu/CeO_(2) and Cu/ZrO_(2),the optimized catalyst(i.e.,Cu_(0.3)Ce_(0.3)Zr_(0.7))exhibits a much higher mass-specific methanol formation rate(192g_(MeOH)/kg_(cat)/h)at 240℃and 3 MPa.Through a series of in-situ and ex-situ characterization,it is revealed that oxygen vacancies in solid solutions can effectively assist the activation of CO_(2) and tune the electronic state of copper to promote the formation of Cu^(+)/CeZrO_(x) interfaces,which stabilizes the key*CO intermediate,inhibits its desorption and facilitates its further hydrogenation to methanol via the reverse watergas-shift(RWGS)+CO-Hydro pathway.Therefore,the concentration of*CO or the apparent Cu^(+)/(Cu^(+)+Cu^(0))ratio could be employed as a quantitative descriptor of the methanol formation rate.This work is expected to give a deep insight into the mechanism of metal/support interfaces in CO_(2) hydrogenation to methanol,offering an effective strategy to develop new catalysts with high performance. | Jingpeng Zhang Xiaohang Sun Congyi Wu Wenquan Hang Xu Hu Dawei Qiao Binhang Yan | 2023 | Journal of Energy Chemistry2023，，2： | 3 |
| 4 | Molecular characterization of circulating tumor cells in pancreatic ductal adenocarcinoma:potential diagnostic and prognostic significance in clinical practice显示文摘Background:The clinical value of heterogeneous sub-populations of circulating tumor cells(CTCs)in pancreatic ductal adenocarcinoma(PDAC)remains unclear.Methods:Peripheral blood samples were obtained from 67 PDAC patients.CTCs were isolated by employing CD45 negative enrichment technique and further characterized for epithelial to mesenchymal transition(EMT)or human equilibrative nucleoside transporter-1(hENT-1).The relationships between CTCs sub-phenotypes with clinicopathological factors or post-operative recurrence in PDAC patients were analyzed.Results:EMT related CTCs could be isolated and identified from the 81%of patients(54/67),and both the total count(median:5 vs.17/mL,P<0.0001)and M-CTC percentage(median:0.2 vs.0.345,P=0.0244)of CTCs could differentiate local/regional with metastatic disease.Multivariate analysis showed that both AJCC stage(P=0.025)and M-CTC percentage(P=0.001)were independent prognostic indicators of recurrence free survival(RFS)in resected patients.Moreover,Kaplan-Meier survival analysis showed that M-CTC after 2 courses of chemotherapy was significantly associated with inferior RFS(49.5 weeks vs.undefined,P=0.0288).No significant correlation in hENT-1 expression was found between CTCs and matched tumor tissues,and further multivariate analysis suggested hENT-1 expression in CTCs as independent prognostic factor for RFS(P=0.016).Patients with low hENT-1 expression in CTCs had decreased RFS(32 weeks vs.undefined,P=0.0337).Conclusions:CTCs could be the promising diagnostic biomarkers in PDAC patients,and phenotypic profiling of CTCs based on EMT or hENT-1 could help establish novel prognostic biomarkers in resected patients undergoing adjuvant gemcitabine-based chemotherapy. | Xudong Zhao Yongsu Ma Xiu Dong Zhengkui Zhang Xiaodong Tian Xiaohang Zhao Yinmo Yang | 2021 | Hepatobiliary Surgery and Nutrition2021，10，6： | 3 |
| 5 | Sensor Fault Estimation and Fault-Tolerant Control for a Class of Takagi-Sugeno Markovian Jump Systems with Partially Unknown Transition Rates Based on the Reduced-Order Observer显示文摘This paper addresses the problem on sensor fault estimation and fault-tolerant control for a class of Takagi-Sugeno Markovian jump systems,which are subjected to sensor faults and partially unknown transition rates.First,the original plant is extended to a descriptor system,where the original states and the sensor faults are assembled into the new state vector.Then,a novel reduced- order observer is designed for the extended system to simultaneously estimate the immeasurable states and sensor faults.Second,by using the estimated states obtained from the designed observer,a state- feedback fault-tolerant control strategy is developed to make the resulting closed-loop control system stochastically stable.Based on linear matrix inequality technique,algorithms are presented to compute the observer gains and control gains.The effectiveness of the proposed observer and controller are validated by a numerical example and a compared study,respectively,and the simulation results reveal that the proposed method can successfully estimate the sensor faults and guarantee the stochastic stability of the resulting closed-loop system. | LI Xiaohang LU Dunke ZHANG Wei ZHU Fanglai | 2018 | Journal of Systems Science & Complexity2018，31，6： | 3 |
| 6 | High-throughput metabolomics reveals the perturbed metabolic pathways and biomarkers of Yang Huang syndrome as potential targets for evaluating the therapeutic effects and mechanism of geniposide显示文摘High-throughput metabolomics can clarify the underlying molecular mechanism of diseases via the qualitative and quantitative analysis of metabolites.This study used the established Yang Huang syndrome(YHS)mouse model to evaluate the efficacy of geniposide(GEN).Urine metabolic data were quantified by ultraperformance liquid chromatography-tandem mass spectrometry.The non-target screening of the massive biological information dataset was performed,and a total of 33 metabolites,including tyramine glucuronide,aurine,and L-cysteine,were identified relating to YHS.These differential metabolites directly participated in the disturbance of phase I reaction and hydrophilic transformation of bilirubin.Interestingly,they were completely reversed by GEN.While,as the auxiliary technical means,we also focused on the molecular prediction and docking results in network pharmacological and integrated analysis part.We used integrated analysis to communicate the multiple results of metabolomics and network pharmacology.This study is the first to report that GEN indirectly regulates the metabolite“tyramine glucuronide”through its direct effect on the target heme oxygenase 1 in vivo.Meanwhile,heme oxygenase-1,a prediction of network pharmacology,was the confirmed metabolic enzyme of phase I reaction in hepatocytes.Our study indicated that the combination of high-throughput metabolomics and network pharmacology is a robust combination for deciphering the pathogenesis of the traditional Chinese medicine(TCM)syndrome. | Heng Fang Aihua Zhang Xiaohang Zhou Jingbo Yu Qi Song Xijun Wang | 2020 | Frontiers of Medicine2020，14，5： | 3 |
| 7 | Hollow Gradient-Structured Iron-Anchored Carbon Nanospheres for Enhanced Electromagnetic Wave Absorption显示文摘In the present paper,a microwave absorber with nanoscale gradient structure was proposed for enhancing the electromagnetic absorption performance.The inorganic-organic competitive coating strategy was employed,which can effectively adjust the thermodynamic and kinetic reactions of iron ions during the solvothermal process.As a result,Fe nanoparticles can be gradually decreased from the inner side to the surface across the hollow carbon shell.The results reveal that it offers an outstanding reflection loss value in combination with broadband wave absorption and flexible adjustment ability,which is superior to other relative graded distribution structures and satisfied with the requirements of lightweight equipment.In addition,this work elucidates the intrinsic microwave regulation mechanism of the multiscale hybrid electromagnetic wave absorber.The excellent impedance matching and moderate dielectric parameters are exhibited to be the dominative factors for the promotion of microwave absorption performance of the optimized materials.This strategy to prepare gradient-distributed microwave absorbing materials initiates a new way for designing and fabricating wave absorber with excellent impedance matching property in practical applications. | Cao Wu Jing Wang Xiaohang Zhang Lixing Kang Xun Cao Yongyi Zhang Yutao Niu Yingying Yu Huili Fu Zongjie Shen Kunjie Wu Zhenzhong Yong Jingyun Zou Bin Wang Zhou Chen Zhengpeng Yang Qingwen Li | 2023 | Nano-Micro Letters2023，15，1： | 2 |
| 8 | DNA damage stress induces the dissociation of Smurf1/2 from MDM2 in a slow manner显示文摘The tumor suppressor p53 locates at the key point of cell growth or apoptosis balance, and the expression level of p53 is tightly controlled by ubiquitin ligases including MDM2. Upon DNA damage stresses, p53 was accumulated and activated, leading to cell cycle arrest or apoptosis. We previously showed that Smad ubiquitylation regulatory factor 1/2 (Smurf1/2) promotes p53 degradation by interacting with and stabilizing MDM2, and consequently enhancing MDM2-mediated ubiquitylation of p53. However, it is unclear how the Smurf1-MDM2 interaction is regulated in response to DNA damage stress. Here, we show that in response to etoposide treatment Smurf1 dissociates from MDM2, resulting in MDM2 destabilization and p53 accumulation. The negative regulation of Smurf1 on apoptosis is released. Notably, this dissociation is a slow process rather than a rapid response, implicating high expression of Smurf1 might confer the resistance against p53 activation. Consistent with this notion, we observed that Smurf1/2 ligases are highly expressed in colon cancer, esophageal squamous cell carcinoma and pancreatic cancer tissues, suggesting the oncogenic tendency of Smurf1/2. | NIE Jing LIU Lin ZHAO XiaoHang XIE Ping ZHOU PingKun XING GuiChun LIU XiangJun HE FuChu HAN WeiDong ZHANG LingQiang | 2011 | Chinese Science Bulletin2011，56，30： | 2 |
| 9 | Characteristics and Possible Formation Mechanisms of Severe Storms in the Outer Rainbands of Typhoon Mujigae(1522)显示文摘To better understand how severe storms form and evolve in the outer rainbands of typhoons, in this study, we investigate the evolutionary characteristics and possible formation mechanisms for severe storms in the rainbands of Typhoon Mujigae, which occurred during 2–5 October 2015, based on the NCEP–NCAR reanalysis data, conventional observations, and Doppler radar data. For the rainbands far from the inner core(eye and eyewall) of Mujigae(distance of approximately 70–800 km), wind speed first increased with the radius expanding from the inner core, and then decreased as the radius continued to expand. The Rankine Vortex Model was used to explore such variations in wind speed. The areas of strong stormy rainbands were mainly located in the northeast quadrant of Mujigae, and overlapped with the areas of high winds within approximately 300–550 km away from the inner core, where the strong winds were conducive to the development of strong storms. A severe convective cell in the rainbands developed into waterspout at approximately 500 km to the northeast of the inner core, when Mujigae was strengthening before it made landfall. Two severe convective cells in the rainbands developed into two tornadoes at approximately350 km to the northeast of the inner core after Mujigae made landfall. The radar echo bands enhanced to 60 d BZ when mesocyclones occurred in the rainbands and induced tornadoes. The radar echoes gradually weakened after the mesocyclones weakened. The tops of parent clouds of the mesocyclones elevated at first, and then suddenly dropped about 20 min before the tornadoes appeared. Thereby, the cloud top variation has the potential to be used as an early warning of tornado occurrence. | Bingyun WANG Ming WEI Wei HUA Yongli ZHANG Xiaohang WEN Jiafeng ZHENG Nan LI Han LI Yu WU Jie ZHU Mingjun ZHANG | 2017 | Journal of Meteorological Research2017，31，3： | 2 |
| 10 | Causal analysis of competing atomistic mechanisms in ferroelectric materials from high-resolution scanning transmission electron microscopy data显示文摘Machine learning has emerged as a powerful tool for the analysis of mesoscopic and atomically resolved images and spectroscopy in electron and scanning probe microscopy,with the applications ranging from feature extraction to information compression and elucidation of relevant order parameters to inversion of imaging data to reconstruct structural models.However,the fundamental limitation of machine learning methods is their correlative nature,leading to extreme susceptibility to confounding factors.Here,we implement the workflow for causal analysis of structural scanning transmission electron microscopy(STEM)data and explore the interplay between physical and chemical effects in a ferroelectric perovskite across the ferroelectric–antiferroelectric phase transitions. | Maxim Ziatdinov Christopher T.Nelson Xiaohang Zhang Rama K.Vasudevan Eugene Eliseev Anna N.Morozovska Ichiro Takeuchi Sergei V.Kalinin | 2020 | npj Computational Materials2020，，1： | 2 |
| 11 | Recent progress on the modification of high nickel contentNCM:Coating,doping,and single crystallization显示文摘High nickel content layered cathodes,represented by NCM(LiNi_(x)Co_(y)Mn_(z)O_(2),x+y+z=1),are now widely employed in the market of electric vehicles,owing to their high energy density.With the gradual increase of nickel content and capacity,the issues on cycling life and safety become more serious.In this review,various strategies for improving the performance of high nickel NCM are summarized on the aspects of surface coating,ionic doping,and singlecrystal NCM.The coating strategy was separately described according to the physical property of coating species,including inert material coating,Li^(+)-conductor coating,electronic conductor coating,and mixed conductor coating.These coating species help to suppress the interfacial oxidation of electrolytes by NCM,improving the cycling life and safety.The elemental doping in the crystal lattice of NCM is then presented in the aspects of cation,anion,and mixed-ion doping,which are beneficial to stabilize the layered structure during charge–discharge and so promote the electrochemical performance.In quite recent years,the strategy of single-crystal NCM was demonstrated to be a promising pathway,owing to the dramatically reduced surface area and grain boundary.Finally,the remaining unsolved challenges and future strategies for further development of NCM cathode materials are outlined. | Junqing Yan Hao Huang Junfan Tong Wei Li Xiaohang Liu Haoxuan Zhang Heqin Huang Weidong Zhou | 2022 | Interdisciplinary Materials2022，1，3： | 2 |
| 12 | ZIF-7@carbon composites as multifunctional interlayer for rapid and durable Li-S performance显示文摘The notorious'shuttle effect'of polysulfide during charge-discharge process induces grievous capacity fading,while the sluggish polysulfide conversion kinetics significantly hinders the development of practically viable lithium-sulfur(Li-S)batteries.In this study,a novel ZIF-7@carbon composite with ZIF-7 sheets vertically rooted on carbon cloth was developed as multifunctional interlayer to address these issues.The composite shows directional layered structure with outstanding compactness,and thus can provide massive active sites for accelerated redox reactions.The pore channels are perpendicular to the square surface,resulting in extremely high utilization of one-dimensional channels.Therefore,this structure can not only maintain the structural stability during the charge-discharge process by providing enough space for volume expansion,but also contribute to efficient exposure and utilization of active sites for the physical/chemical adsorption and catalytic conversion of polysulfide.As a result,Li-S batteries with the as-developed interlayer deliver a considerable areal capacity of 4.75 mAh cm^(-2) at an elevated sulfur loading of 5.5 mg cm^(-2),and an impressive cyclability with an extremely low capacity-fading rate of merely 0.04%per cycle over 500 cycles at 1 C. | Xingbo Wang Yan Zhao Feichao Wu Shuming Liu Zisheng Zhang Zhaoyang Tan Xiaohang Du Jingde Li | 2021 | Journal of Energy Chemistry2021，30，6： | 2 |
| 13 | Building Virtual Entertain- ment Environment with Tiled Display Wall and MotionTracking显示文摘 | Liangjie Zhang Xiaohang Jiang Kaibin Lei | 2013 | Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)2013，7544，： | 1 |
| 14 | Hg 2+ reduction and re-emission from simulated wet flue gas desulfurization liquors显示文摘 | Jingjing Wo Meng Zhang Xiaoya Cheng Xiaohang Zhong Jiang Xu Xinhua Xu | 2009 | Journal of Hazardous Materials2009，，2： | 1 |
| 15 | Malignant characteristics of circulating tumor cells and corresponding primary tumor in a patient with esophageal squamous cell carcinoma before and after surgery显示文摘 | Chuanli Ren Ping He Jinqiang Zhang Zhaoxu Zheng Yuanyuan Qiao Xiaohang Zhao | 2011 | Cancer Biology & Therapy2011，，： | 1 |
| 16 | Real-time contrast-enhanced ultrasonography of resected and immunohistochemically proven hepatic angiomyolipomas显示文摘 | Rui Li Xiaohang Zhang Xing Hua Ping Cai Hua Zhong Yanli Guo Shiyi Ding XiaoChu Yan | 2010 | Abdominal Imaging2010，，6： | 1 |
| 17 | Selectivity of polymer adsorbent in adsorptive separations of stevia diterpene glycosides显示文摘 | Tianhong Chen Yang Zhang Xiaohang Liu Zuoqing Shi Juntan Sun Binglin He | 1998 | Science in China Series B: Chemistry1998，，4： | 1 |
| 18 | Deep learning-based rapid generation of broadly reactive antibodies against SARS-CoV-2 and its Omicron variant显示文摘Dear Editor,The COVID-19 pandemic has been ongoing for nearly two and half years,and new variants of concern(VOCs)of SARS-CoV-2 continue to emerge,which urges the development of broadly neutralizing antibodies.1,2 Variants such as the delta(B.1.617.2 lineage)and Omicron(BA.1 and BA.2)were reported to exhibit immune evasion to some of the current therapeutic antibodies. | Hantao Lou Jianqing Zheng Xiaohang(Leo)Fang Zhu Liang Meihan Zhang Yu Chen Chunmei Wang Xuetao Cao | 2023 | Cell Research2023，33，1： | 1 |
| 19 | Development of a multi-component drug from turmeric using central composite design显示文摘基于繁体中文药开发多部件药的方法论用中央合成设计被开发了。从繁体中文药沉金的几个活跃部件在多部件 antitumor 药为使用被选择。反应表面方法论基于一个中央合成图案被使用决定量的作文活动关系以便在这药优化每个部件的数量。MTT (3-(4,5-dimethylthiazol-2-yl )-2,5-diphenyltetrazolium 溴化物) 试金被用来作为反应价值测量药理学活动。最佳联合的试验性的 antitumor 活动在 MTT 试金和上级是 92.85% 到每个单个部件的活动。这些结果证明那反应表面方法论对多部件药的设计基于一个中央合成图案合适。 | Xiaohang ZHANG Shengnan HAN Yan LI Jianlan JIANG | 2014 | Frontiers of Chemical Science and Engineering2014，8，3： | 1 |
| 20 | Exploring Enterprise Performance Indicators Network: A Case Study of China Telecommunication Industry显示文摘Performance indicators play some important roles in enterprise operation.Both researchers and managers have recently pointed out that the identification of correlation between different performance indicators may lead to a better understanding of business.However,it is becoming more and more difficult to measure and analyze these indicators since the fast growing number of performance indicators and the complex relationships between them.The existing categories failed to reflect these changes in an adequate way,and the quantitative analysis methods for identifying the characters of those performance indicators are still worthy of investigation.The main objective of this paper is to propose a practical methodology for managing and analyzing performance indicators in enterprises,which focuses on building up a performance indicator system and discovering the characters of those performance indicators by applying complex network methods.The empirical results of a telecommunication enterprise show that the proposed method can be effective in understanding the correlations between performance indicators. | Shi Wenhua Du Yu Zhang Xiaohang | 2012 | China Communications2012，9，12： | 1 |
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