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| 1 | Cognitive disorder and dementia in type 2 diabetes mellitus显示文摘Insulin,a key pleiotropic hormone,regulates metabolism through several signaling pathways in target tissues including skeletal muscle,liver,and brain.In the brain,insulin modulates learning and memory,and impaired insulin signaling is associated with metabolic dysregulation and neurodegenerative diseases.At the receptor level,in aging and Alzheimer’s disease(AD)models,the amount of insulin receptors and their functions are decreased.Clinical and animal model studies suggest that memory improvements are due to changes in insulin levels.Furthermore,diabetes mellitus(DM)and insulin resistance are associated with age-related cognitive decline,increased levels ofβ-amyloid peptide,phosphorylation of tau protein;oxidative stress,pro-inflammatory cytokine production and dyslipidemia. Recent evidence shows that deleting brain insulin receptors leads to mildobesity and insulin resistance without influencing brain size and apoptosis development.Conversely, deleting insulin-like growth factor 1 receptor (IGF-1R) affects brain size anddevelopment, and contributes to behavior changes. Insulin is synthesized locally in the brain andis released from the neurons. Here, we reviewed proposed pathophysiological hypotheses toexplain increased risk of dementia in the presence of DM. Regardless of the exact sequence ofevents leading to neurodegeneration, there is strong evidence that mitochondrial dysfunctionplays a key role in AD and DM. A triple transgenic mouse model of AD showed mitochondrialdysfunction, oxidative stress, and loss of synaptic integrity. These alterations are comparable tothose induced in wild-type mice treated with sucrose, which is consistent with the proposal thatmitochondrial alterations are associated with DM and contribute to AD development. Alterationsin insulin/IGF-1 signaling in DM could lead to mitochondrial dysfunction and low antioxidantcapacity of the cell. Thus, insulin/IGF-1 signaling is important for increased neural processing andsystemic metabolism, and could be a specific target for therapeutic strategies to decreasealterations associated with age-related cognitive decline. | Genaro G Ortiz Miguel Huerta Héctor A González-Usigli Erandis D Torres-Sánchez Daniela LC Delgado-Lara Fermín P Pacheco-Moisés Mario A Mireles-Ramírez Blanca MG Torres-Mendoza Roxana I Moreno-Cih Irma E Velázquez-Brizuela | 2022 | World Journal of Diabetes2022，13，4： | 2 |
| 2 | Leuprolide acetate induces structural and functional recovery of injured spinal cord in rats显示文摘Gonadotropin-releasing hormone(Gn RH) and its synthetic analog leuprolide acetate, a Gn RH agonist, have neurotrophic properties. This study was designed to determine whether administration of leuprolide acetate can improve locomotor behavior, gait, micturition reflex, spinal cord morphology and the amount of microglia in the lesion epicenter after spinal cord injury in rats. Rats with spinal cord compression injury were administered leuprolide acetate or saline solution for 5 weeks. At the 5th week, leuprolide acetate-treated rats showed locomotor activity recovery by 38%, had improvement in kinematic gait and exhibited voiding reflex recovery by 60%, as compared with the 1st week. By contrast, saline solution-treated rats showed locomotor activity recovery only by 7%, but voiding reflex did not recover. More importantly, leuprolide acetate treatment reduced microglial immunological reaction and induced a trend towards greater area of white and gray matter in the spinal cord. Therefore, leuprolide acetate has great potential to repair spinal cord injury. | Carmen Díaz Galindo Beatriz Gómez-González Eva Salinas Denisse Calderón-Vallejo Irma Hernández-Jasso Eduardo Bautista J Luis Quintanar | 2015 | Neural Regeneration Research2015，10，11： | 2 |
| 3 | Comparison of the drought- stress responses of tolerant and sensitive wheat cultivars during grain filing:changes in flag leaf photosynthetic activity ABA levels, and gain yield显示文摘 | Adrienn G Irma T Agnes G | 2009 | Journal of Plant Growth Regulation2009，28，2： | 1 |
| 4 | Importance of Rhodospirillum rubrum H+-pyrophosphatase under low-energy conditions显示文摘 | RODOLFO G C HELIODORO C IRMA R | 2004 | Journal of Bacteriology2004，186，19： | 1 |
| 5 | Comprehensive molecular diagnosis of 179 Leber congenital amaurosis and juvenile retinitis pigmentosa patients by targeted next generation sequencing显示文摘 | Xia Wang Hui Wang Vincent Sun Han-Fang Tuan Vafa Keser Keqing Wang Huanan Ren Irma Lopez Jacques E Zaneveld Sorath Siddiqui Stephanie Bowles Ayesha Khan Jason Salvo Samuel G Jacobson Alessandro Iannaccone Feng Wang David Birch John R Heckenlively Gerald A | 2013 | Journal of Medical Genetics2013，，10： | 1 |
| 6 | Method of DNA extraction and application of multiplex polymerase chain reaction to detect toxigenic Vibrio cholerae O1 and O139 from aquatic ecosystems显示文摘 | Irma N G Rivera Erin K Lipp Ana Gil | 2003 | Environ Microbiol2003，5，7： | 1 |
| 7 | Method of DNA extraction and application of muhiplex polymerase chain reaction to detect toxigenic Vibrio cholerae O1 and 0139 from aquatic ecosystems 显示文摘 | Irma N G R Erin K L Ana G | 2003 | Environ Microbiol2003，5，7： | 1 |
| 8 | The effect of nutri-tion on the neural mechanisms potentially involved inmelatonin-stimulated LH secretion in female Mediter-ranean goats显示文摘 | Luis A Z Irma C Jose L G | 2011 | Journal of Endocrinology2011，211，： | 1 |
| 9 | Comparison of the drought stress responses of tolerant and sensitive wheat cultivars during grain filling:changes in flag leaf photosynthetic activity,ABA levels,and grain yield显示文摘 | Adrienn G Irma T Agnes G | 2009 | Journal of Plant Growth Regulation2009，28，2： | 1 |
| 10 | Absent in melanoma 2 triggers a heightened inflammasome response in ascitic fluid macrophages of patients with cirrhosis显示文摘 | Beatriz Lozano-Ruiz Victoria Bachiller Irma García-Martínez Pedro Zapater Isabel Gómez-Hurtado Alba Moratalla Paula Giménez Pablo Bellot Rubén Francés José Such José M. González-Navajas | 2014 | Journal of Hepatology2014，，： | 1 |
| 11 | Parental rearing styles and personality disorders in prisoners and forensic patients显示文摘 | Irma G H Timmerman P M G E | 2005 | Clinical Psychology & Psychotherapy2005，12，3： | 1 |
| 12 | Analysis of odour and taste problems in high-density polyethene显示文摘 | Kirsi V Anja V Irma G | 1997 | Journal of Chromatography A1997，791，12： | 1 |
| 13 | The interleukin-12 and interleukin-12 receptor system in normal and transformed human B-lymphocytes显示文摘 | Irma A Roberta G Giuseppe C | 2002 | Haematologica2002，87，： | 1 |
| 14 | Synthesis,characterization and bioactivity of polyoxometalates on osteoblasts in culture显示文摘 | Botto Irma L Barrio Daniel A Eguzquiza Maria G | 2004 | Metal Ions in Biology and Medicine2004，7，： | 1 |
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