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| 1 | Cyclosporine Metabolite Cross-Reactivity in Different Cyclosporine Assays显示文摘 | Jayasimha N Murthy Randall W Yatscoff Steven J Soldin | 1998 | Clinical Biochemistry1998，，3： | 1 |
| 2 | Crosslinked chitosan membranes: characteriza- tion and study of dimethylhydrazine dehydration by pervaporation显示文摘 | Sridhar S Susheela G Jayasimha Reedy G | 2001 | Polymer International2001，50，10： | 1 |
| 3 | New Service Development (NSD) : Role of Customer Contact Executives 显示文摘 | Jayasimha K R Nargundkar R Murugaian V | 2007 | The Journal of Business Perspective2007，11，2： | 1 |
| 4 | Root canal morphology ofmaxillary second premolars in an Indian population 显示文摘 | Jayasimha Raj U Mylswamy S | 2010 | JConserv Dent2010，13，3： | 1 |
| 5 | Preparation of poly (methyl methacrylate)nanocomposites with superior impact strength 显示文摘 | SINGH D JAYASIMHA T RAI K N | 2007 | Journal of Applied Polymer Science2007，105，6： | 1 |
| 6 | A Necessary and Sufficient Condition for Deadleck-Free Wormhole Routlng显示文摘 | L Schwieber D N Jayasimha | 1996 | Journal of Parallel and Distributed Computing1996，32，1： | 1 |
| 7 | Solving Evaluation of i-STAT portable clinical analyzer in a neonatal and pediatric intensive care unit 显示文摘 | Jayasimha N Murthy Jocelyn M Hieksb Steven J | 1997 | Clinical Biochemistry1997，30，5： | 1 |
| 8 | Crosslinked Chitosan Membranes: Characterization and Study of Dimethyl- hydrazine Dehydration by Pervaporation 显示文摘 | Sridhar S Susheela G Jayasimha R G | 2001 | Polym lnt2001，50，10： | 1 |
| 9 | Preparation of poly (methyl methacrylate) nanocomposites with superior impact strength显示文摘 | Singh D Jayasimha T Rai K N | 2007 | Journal of Applied Polymer Science2007，105，6： | 1 |
| 10 | Integration challenges and trade-offs for tera-scale architectures显示文摘 | Azimi M Cherukuri N Jayasimha D | 2007 | Intel Technology Journal2007，11，3： | 1 |
| 11 | New Service Development (NSD): Role of Customer Contact Executives显示文摘 | JAYASIMHA K R NARGUNDKAR R MURUGAIAH V | 2007 | The Journal of Business Perspective2007，11，2： | 1 |
| 12 | Information integration and synchronization in distributed sensor network显示文摘 | Jayasimha D N Iyengar S S Kashyap R L | 1991 | IEEE Transaction on Systems Man and Cybernetics1991，21，5： | 1 |
| 13 | A Review of Magnetostrictive Iron-galliumalloys显示文摘 | Jayasimha Atulasimha Alison B Flatau | 2011 | Smart Materials and Structures2011，20，43： | 1 |
| 14 | A systematic review of Gymnema sylvestre in obesity and diabetes management显示文摘 | Ramesh Pothuraju Raj Kumar Sharma Jayasimha Chagalamarri Surender Jangra Praveen Kumar Kavadi | 2014 | J. Sci. Food Agric2014，，： | 1 |
| 15 | A review of magnetostrictive iron–gallium alloys显示文摘 | Jayasimha Atulasimha Alison B Flatau | 2011 | Smart Materials and Structures2011，，4： | 1 |
| 16 | Integration challenges and trade-offs for tera-scale architectures显示文摘 | A zimi M Cherukuri N Jayasimha D | 2007 | Intel Technology Journal2007，11，3： | 1 |
| 17 | New service development:role of customer contact executives显示文摘 | JAYASIMHA K R NARGUNDKAR R MURUGAIAH V | | 0，，02： | 1 |
| 18 | Effects of omega-3 supplementation on components of the endocannabinoid system and metabolic and inflammatory responses in adipose and liver of peripartum dairy cows显示文摘Background:Dietary supplementation of omega-3 fatty acids can reduce the activation of the endocannabinoid system(ECS)by decreasing the availability of arachidonic acid,thus lowering endocannabinoids(e CBs)levels.The ECS is a modulator of energy metabolism,stress response and inflammation in mammals,yet there is little information on the roles of the ECS in transition dairy cows.During the periparturient period,the adipose tissue and liver are the main metabolic organs that participate in the adaptations of dairy cows to onset of lactation;however,exceeded adipose tissue lipolysis and accumulation of lipids in the liver have adverse effects on cows'physiology.Here we aimed to examine whether omega-3 supplementation during the transition period will modulate ECS activation and affect metabolic and inflammatory indices in postpartum dairy cows,by supplementing twenty-eight transition Holstein dairy cows with either saturated fat(CTL)or encapsulated flaxseed oil(FLX).Components of the ECS,metabolic and inflammatory markers were measured in blood,liver,and subcutaneous adipose tissue.Results:FLX supplementation reduced feed intake by 8.1%(P<0.01)and reduced plasma levels of arachidonic acid(by 44.2%;P=0.02)and anandamide(by 49.7%;P=0.03)postpartum compared to CTL.The m RNA transcription levels of the cannabinoid receptor 1(CNR1/CB1)tended to be lower(2.5 folds)in white blood cells of FLX than in CTL(P=0.10),and protein abundance of ECS enzyme monoacylglycerol lipase was higher in peripheral blood mononuclear cells of FLX than in CTL(P=0.04).In adipose tissue,palmitoylethanolamide levels were lower in FLX than in CTL(by 61.5%;P=0.02),relative m RNA transcription of lipogenic genes were higher,and the protein abundance of cannabinoid receptor 2(P=0.08)and monoacylglycerol lipase(P=0.10)tended to be higher in FLX compared to CTL.Hepatic 2-arachidonoylglycerol tended to be higher(by 73.1%;P=0.07),and interlukin-6 m RNA transcription level was 1.5 folds lower in liver of FLX than in CTL(P=0.03).Conclusions:Nutritional supplementation of omega-3 fatty acids seems to partly modulate ECS activation,which could be related to lower feed intake.The altered ECS components in blood,adipose tissue and liver are associated with moderate modulations in lipid metabolism in the adipose and inflammation in liver of peripartum dairy cows. | Gitit Kra Jayasimha Rayalu Daddam Uzi Moallem Hadar Kamer Radka Kočvarova Alina Nemirovski GAndres Contreras Joseph Tam Maya Zachut | 2023 | Journal of Animal Science and Biotechnology2023，14，1： | 0 |
| 19 | In vitro and in silico studies of salicylic acid on systemic induced resistance against bacterial leaf blight disease and enhancement of crop yield显示文摘Salicylic acid(SA)is an effective elicitor to promote plant defenses and growth.This study aimed to investigate rice(Oryza sativa L.)cv.Khao Dawk Mali 105 treated with salicylic acid(SA)-Ricemate as an enhanced plant protection mechanism against bacterial leaf blight(BLB)disease caused by Xanthomonas oryzae pv.oryzae(Xoo).Results indicated that the use of SA-Ricemate as a foliar spray at concentrations of more than 100 mg L^(-1)can reduce the severity of BLB disease by 71%.SA-Ricemate treatment also increased the hydrogen peroxide(H_(2)O_(2))content of rice leaf tissues over untreated samples by 39–61%.Malondialdehyde(MDA)in rice leaves treated with SA-Ricemate also showed an increase of 50–65%when comparing to non-treated samples.The differential development of these defense compounds was faster and distinct when the SA-Ricemate-treated rice was infected with Xoo,indicating plant-induced resistance.Besides,SA-Ricemate elicitor at a concentration of 50–250 mg L^(-1)was correlated with a substantial increase in the accumulation of total chlorophyll content at 2.53–2.73 mg g^(-1)of fresh weight which suggests that plant growth is activated by SA-Ricemate.The catalase-and aldehyde dehydrogenase-binding sites were searched for using the CASTp server,and the findings were compared to the template.Chemsketch was used to design and optimize SA,which was then docked to the catalase and aldehyde dehydrogenase-binding domains of the enzymes using the GOLD 3.0.1 Software.SA is shown in several docked conformations with the enzymes catalase and aldehyde dehydrogenase.All three catalase amino acids(GLN7,VAL27,and GLU38)were discovered to be involved in the creation of a strong hydrogen bond with SA when SA was present.In this mechanism,the aldehyde dehydrogenase amino acids LYS5,HIS6,and ASP2 were all implicated,and these amino acids created strong hydrogen bonds with SA.In field conditions,SA-Ricemate significantly reduced disease severity by 78%and the total grain yield was significantly increased which was an increase of plant height,tiller per hill,and panicle in three field trials during Aug–Nov 2017 and 2018.Therefore,SA-Ricemate can be used as an alternative elicitor on replacing harmful pesticides to control BLB disease with a high potential of increasing rice defenses,growth,and yield components. | Wannaporn THEPBANDIT Narendra Kumar PAPATHOTI Jayasimha Rayulu DADDAM Nguyen Huy HOANG Toan LE THANH Chanon SAENGCHAN Kumrai BUENSANTEAI | 2023 | Journal of Integrative Agriculture2023，22，1： | 0 |
| 20 | Particle-Mediated Histotripsy for the Targeted Treatment of Intraluminal Biofilms in Catheter-Based Medical Devices显示文摘Objective.This paper is an initial work towards developing particle-mediated histotripsy(PMH)as a novel method of treating catheter-based medical device(CBMD)intraluminal biofilms.Impact Statement.CBMDs commonly become infected with bacterial biofilms leading to medical device failure,infection,and adverse patient outcomes.Introduction.Histotripsy is a noninvasive focused ultrasound ablation method that was recently proposed as a novel method to remove intraluminal biofilms.Here,we explore the potential of combining histotripsy with acoustically active particles to develop a PMH approach that can noninvasively remove biofilms without the need for high acoustic pressures or real-time image guidance for targeting.Methods.Histotripsy cavitation thresholds in catheters containing either gas-filled microbubbles(MBs)or fluid-filled nanocones(NCs)were determined.The ability of these particles to sustain cavitation over multiple ultrasound pulses was tested after a series of histotripsy exposures.Next,the ability of PMH to generate selective intraluminal cavitation without generating extraluminal cavitation was tested.Finally,the biofilm ablation and bactericidal capabilities of PMH were tested using both MBs and NCs.Results.PMH significantly reduced the histotripsy cavitation threshold,allowing for selective luminal cavitation for both MBs and NCs.Results further showed PMH successfully removed intraluminal biofilms in Tygon catheters.Finally,results from bactericidal experiments showed minimal reduction in bacteria viability.Conclusion.The results of this study demonstrate the potential for PMH to provide a new modality for removing bacterial biofilms from CBMDs and suggest that additional work is warranted to develop histotripsy and PMH for treatment of CBMD intraluminal biofilms. | Christopher Childers Connor Edsall Isabelle Mehochko Waleed Mustafa Yasemin Yuksel Durmaz Alexander L.Klibanov Jayasimha Rao Eli Vlaisavljevich | 2022 | Biomedical Engineering Frontiers2022，3，1： | 0 |
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