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| 1 | Safflor yellow A protects neonatal rat cardiomyocytes against anoxia/reoxygenation injury in vitro显示文摘 | Jia-lin DUAN Jing-wen WANG Yue GUAN Ying YIN Guo WEI Jia CUI Dan ZHOU Yan-rong ZHU Wei QUAN Miao-miao XI Ai-dong WEN | 2013 | Acta Pharmacologica Sinica2013，34，4： | 27 |
| 2 | Prevalence of Thyroid Nodules and Its Relationship with Iodine Status in Shanghai:a Population-based Study显示文摘Objective This study was designed to evaluate the prevalence of thyroid nodules(TNs) and its relationship with urine iodine concentrations(UICs) after the regional rapid economic growth and lifestyle changes. Methods A cross-sectional survey was conducted in the general population aged 15-69 years. A questionnaire regarding general and personal characteristics and relevant information was administered. Ultrasonography of the thyroid was performed, and serum triiodothyronine(T3), tetraiodothyronine(T4), serum thyroid stimulating hormone(TSH), free triiodothyronine(FT3), free tetraiodothyronine(FT4), thyroglobulin antibody(Tg Ab), thyroid peroxidase antibody(TPOAb), and TSH receptor antibody(TRAb) levels were measured for each individual subject. Results The prevalence rates of TNs in the whole population, females and males were 27.76%, 34.04%, and 21.60%, respectively. The prevalence of multiple nodules increased with age, whereas the prevalence peaks differed between males and females. The median UICs in the whole population and females with non-TNs were higher than those of subjects with TNs(P=0.0035, P=0.0068). The median UICs in subjects with a single TN were higher than those in subjects with multiple TNs(P=0.0164, P=0.0127). The result showed a U-shaped curve relationship between UIC and prevalence of TNs. The prevalence of TNs was the lowest when the UIC was 140-400 μg/L. Conclusion The prevalence of TNs was nearly 30% and increased with age. The relationship between UIC and prevalence of TNs is U-shaped, with an increase in risk when the UIC was <140 μg/L and >400 μg/L. Very low or high UIC levels need attention and correction. | SONG Jun ZOU Shu Rong GUO Chang Yi ZANG Jia Jie ZHU Zhen Ni MI Ming HUANG Cui Hua YU Hui Ting LU Xi RUAN Ye WU Fan | 2016 | Biomedical and Environmental Sciences2016，29，6： | 25 |
| 3 | Progress of Air Pollution Control in China and Its Challenges and Opportunities in the Ecological Civilization Era显示文摘China’s past economic growth has substantially relied on fossil fuels,causing serious air pollution issues.Decoupling economic growth and pollution has become the focus in developing ecological civilization in China.We have analyzed the three-decade progress of air pollution controls in China,highlighting a strategic transformation from emission control toward air quality management.Emission control of sulfur dioxide(SO2)resolved the deteriorating acid rain issue in China in 2007.Since 2013,control actions on multiple precursors and sectors have targeted the reduction of the concentration of fine particulate matter(PM2.5),marking a transition to an air-quality-oriented strategy.Increasing ozone(O3)pollution further requires O3 and PM2.5 integrated control strategies with an emphasis on their complex photochemical interactions.Fundamental improvement of air quality in China,as a key indicator for the success of ecological civilization construction,demands the deep de-carbonization of China’s energy system as well as more synergistic pathways to address air pollution and global climate change simultaneously. | Xi Lu Shaojun Zhang Jia Xing Yunjie Wang Wenhui Chen Dian Ding Ye Wu Shuxiao Wang Lei Duan Jiming Hao | 2020 | Engineering2020，6，12： | 24 |
| 4 | Discovery of Late Cretaceous foraminifera in the Songliao Basin: Evidence from SK-1 and implications for identifying seawater incursions显示文摘The Songliao Basin is the largest oil-bearing basin in China.In the absence of sufficient evidence,the possibility of seawater incursion(s) into the Songliao Basin remains controversial.Recently,we discovered relatively abundant foraminifera fossils from units 1 and 2 of the Nenjiang Formation of borehole SK-1.Benthic foraminifera (Gavlinella sp.,Anomalinoides sp.,Pullenia sp.,Haplophragmoides sp.,Karrorulina hokkaidoana,Clavulinoides sp.),as well as planktonic foraminifera (Archaeoglobigerina blowi,Archaeoglobigerina cretacea and Hedbergella flandrini),were identified.These fossils were widely distributed in the marine Cretaceous.According to the global distribution of the above-mentioned planktonic foraminifera,the age of these fossil bearing strata appears to be Late Coniacian to Santonian.More importantly,these foraminifera provide direct evidence for marine water incursions into the Songliao Basin during deposition of the Lower Nenjiang Formation. | XI DangPeng WAN XiaoQiao FENG ZhiQiang LI Shun FENG ZiHui JIA JianZhong JING Xia SI WeiMin | 2011 | Chinese Science Bulletin2011，56，3： | 21 |
| 5 | Diverse modes of clonal evolution in HBV-related hepatocellular carcinoma revealed by single-cell genome sequencing显示文摘Hepatocellular 癌(HCC ) 是癌症实质词法,基因并且 phenotypic 差异。然而,我们不理解在 intratumor 异质和肿瘤的联系词法 / 组织学的特征之间的关系。用介绍 96 个肿瘤房间(30-36 各个) 和 15 个正常的肝房间(5 各个) 的单个房间的整个染色体的定序,与联系 HBV 的 HCC 从三个男病人收集了,我们证实拷贝数字变化在 hepatocarcinogenesis 早发生,但是此后在整个肿瘤仍然保持相对稳定前进。重要地,我们证明特定的 HCC 能具有 monoclonal 或 polyclonal 起源。有汇合的 multinodular 形态学的肿瘤是典型 polyclonal 肿瘤并且显示最高的 intratumor 异质。除了 mutational 和拷贝数字侧面,我们把了用导出 HBV 的外国 genomic 标记的 HCC 的同种细胞的起源。在 monoclonal HCC,所有肿瘤单身者房间展出一样的 HBV 集成,显示 HBV 集成是一个早司机事件并且在肿瘤前进期间仍然保持极其稳定。另外,我们的结果显示那两个都转移,迟了的传播并且早播种当模特儿,在 HCC 有一个角色前进。尤其是,开始的克隆传播的早 intrahepatic 导致同步 multifocal 肿瘤的形成。同时,我们在 HCC 识别了潜在的司机基因 ZNF717,它展出变化的高频率在单个房间并且人口铺平,,通过调整 IL-6/STAT3 小径行动的肿瘤 suppressor。这些调查结果热点多重不同肿瘤在 HCC 的进化机制,它为特定的处理策略建议需要。 | Meng Duan, Shu Zhang, Zhichao Wang, Jieyi Shi, Longzi Liu, Xiaoying Wang, Aiwu Ke, Jian Zhou, Jia Fan, Qiang Gao Junfeng Hao, Chong Li Sijia Cui Daniel L Worthley Ya Cao Ruibin Xi Xiaoming Zhang Jian Zhou, Jia Fan Qiang Gao | 2018 | Cell Research2018，28，3： | 21 |
| 6 | Hypoxia-regulated microRNAs in human cancer显示文摘 | Guomin SHEN Xiaobo LI Yong-feng JIA Gary A PIAZZA Yaguang XI | 2013 | Acta Pharmacologica Sinica2013，34，3： | 18 |
| 7 | Characteristics and origin of abnormally high porosity zones in buried Paleogene clastic reservoirs in the Shengtuo area, Dongying Sag, East China显示文摘There are three abnormally high porosity zones developed in buried Paleogene nearshore subaqueous fan and sublacustrine fan clastic reservoirs at 2,800-3,200 m, 3,250-3,700 m and 3,900-4,400 m, respectively, within the Shengtuo area of the Dongying Sag. Here the porosity of reservoirs buried deeper than 4,000 m can still be greater than 20%. Investigation of these three abnormally high porosity(AHP) zones in the 3rd to 4th member of the Paleogene Shahejie Formation in the Shengtuo area was carried out with utilization of core observation, thin section identification, SEM observation, image analysis, core physical property testing and other technical methods. The results show that, the AHP zones in 2,800-3,200 m and 3,250-3,700 m are visible pores primary AHP zones dominated by significant primary intergranular pores(more than 50% of the total porosity), while secondary pores and micropores in authigenic clays may develop in some reservoirs. AHP reservoirs in the AHP zone of 3,900-4,400 m are dominated by micropores in matrix, visible pores are mainly grain dissolution pores but with low absolute content(< 1%), so this zone belongs to the micropores primary AHP zone. The genesis of the three AHP zones was studied to distinguish between porosity enhancement and porosity preservation. Our research shows that, in deeply buried clastic reservoirs in the Shengtuo area, mineral dissolution occurred in a relatively closed diagenetic system with high temperature and high salinity. Reservoir rocks underwent extensive feldspar dissolution, while detrital carbonate grains and carbonate cements show no evidence of extensive dissolution. Although significant feldspar dissolution pores developed, feldspar dissolution enhanced porosity only a little due to the precipitation of almost isovolumetric dissolution products in the nearby primary intergranular pores in forms of authigenic clays and quartz cements. Net enhanced porosity originating from feldspar dissolution is generally less than 0.25%. Thus, the subsurface dissolution has little impact on the mid-deep buried high porosity reservoirs. Reservoirs in braided channels of middle fans in sublacustrine fans and reservoirs in the middle-front of fan bodies of nearshore subaqueous fans provide the basis for the development of AHP zones. The shallow development of fluid overpressure and early hydrocarbon emplacement have effectively retarded compaction and carbonate cementation, so that the high porosity in the superficial layers is preserved in the mid-deep layers. These are the main controlling factors in the development of AHP zones. | Cao Yingchang Yuan Guanghui Li Xiaoyan Wang Yanzhong Xi Kelai Wang Xiaoming Jia Zhenzhen Yang Tian | 2014 | Petroleum Science2014，11，3： | 18 |
| 8 | Impact of farmland changes on production potential in China during 1990-2010显示文摘The quantity and spatial pattern of farmland has changed in China, which has led to a major change in the production potential under the influence of the national project of ecological environmental protection and rapid economic growth during 1990–2010. In this study, the production potential in China was calculated based on meteorological, terrain elevation, soil and land-use data from 1990, 2000 and 2010 using the Global Agro-ecological Zones model. Then, changes in the production potential in response to farmland changes from 1990 to 2010 were subsequently analyzed. The main conclusions were the following. First, the total production potential was 1.055 billion tons in China in 2010. Moreover, the average production potential was 7614 kg/ha and showed tremendous heterogeneity in spatial pattern. Total production in eastern China was high, whereas that in northwestern China was low. The regions with high per unit production potential were mainly distributed over southern China and the middle and lower reaches of the Yangtze River. Second, the obvious spatiotemporal heterogeneity in farmland changes from 1990 to 2010 had a significant influence on the production potential in China. The total production potential decreased in southern China and increased in northern China. Furthermore, the center of growth of the production potential moved gradually from northeastern China to northwestern China. The net decrease in the production potential was 2.97 million tons, which occupied 0.29% of the national total actual production in 2010. Third, obvious differences in the production potential in response to farmland changes from 1990 to 2000 and from 2000 to 2010 were detected. The net increase in the production potential during the first decade was 10.11 million tons and mainly distributed in the Northeast China Plain and the arid and semi-arid regions of northern China. The net decrease in the production potential during the next decade was 13.08 million tons and primarily distributed in the middle and lower reaches of the Yangtze River region and the Huang-Huai-Hai Plain. In general, the reason for the increase in the production potential during the past two decades might be due to the reclamation of grasslands, woodlands and unused land, and the reason for the decrease in the production potential might be urbanization that occupied the farmland and Green for Grain Project, which returned farmland to forests and grasslands. | LIU Luo XU Xinliang LIU Jiyuan CHEN Xi NING Jia | 2015 | Journal of Geographical Sciences2015，25，1： | 16 |
| 9 | Prevalence, awareness, treatment, and control of hypertension in the non-dialysis chronic kidney disease patients显示文摘 | ZHENG Ying CAI Guang-yan CHEN Xiang-mei FU Ping CHEN Jiang-hua DING Xiao-qiang YU Xue-qing LIN Hong-li LIU Jian XIE Ru-juan WANG Li-ning NI Zhao-hui LIU Fu-you YIN Ai-ping XING Chang-ying WANG Li SHI Wei LIU Jian-she HE Ya-ni DING Guo-hua LI Wen-ge WU Guang-li MIAO Li-ning CHEN Nan SU Zhen MEI Chang-lin ZHAO Jiu-yang GU Yong BAI Yun-kai LUO Hui-min LIN Shan CHEN Meng-hua GONG Li YANG Yi-bin YANG Xiao-ping LI Ying WAN Jian-xin WANG Nian-song LI Hai-ying XI Chun-sheng HAO Li XU Yan FANG Jing-ai LIU Bi-cheng LI Rong-shan WANG Rong ZHANG Jing-hong WANG Jian-qin LOU Tan-qi SHAO Feng-min MEI Feng LIU Zhi-hong YUAN Wei-jie SUN Shi-ren ZHANG Ling ZHOU Chun-hua CHEN Qin-kai JIA Shun-lian GONG Zhi-feng GUAN Guang-ju XIA Tian ZHONG Liang-bao | 2013 | Chinese Medical Journal2013，，12： | 16 |
| 10 | A single Eu^(2+)-activated high-color-rendering oxychloride white-light phosphor for white-light-emitting diodes显示文摘Single-phased,high-color-rendering index(CRI)white-light phosphors are emerging as potential phosphor-converted white-light-emitting diodes(WLEDs)and as an alternative to blends of tricolor phosphors.However,it is a challenge to create a high CRI white light from a single-doped activator.Here,we present a high CRI(Ra 591)white-light phosphor,Sr_(5)(PO_(4))_(3-x)(BO_(3))_(x)Cl:Eu^(2+),composed of Sr5(PO4)3Cl as the beginning member and Sr_(5)(BO_(3))_(3)Cl as the end member.This work utilized the solid-solution method,and tunable Eu^(2+) emission was achieved.Color-tunable Eu^(2+) emissions in response to structural variation were observed in Sr_(5)(PO_(4))_(3-x)(BO_(3))_(x)Cl solid solutions.This was further confirmed using X-ray Rietveld refinement,electron paramagnetic resonance spectroscopy,and in the photoluminescence spectra.The color-tunable emissions included the white light that originated from the combination of the blue emission of Sr_(5)(PO_(4))_(3)Cl:Eu^(2+) and an induced Eu^(2+) yellow emission at approximately 550 nm in the solid solution.Importantly,the white-light phosphors showed a greater R9590.2 under excitation at 365 nm.This result has rarely been reported in the literature and is greater than that of(R9514.3)commercial Y_(3)A_(l5)O_(12):Ce^(3+)-based WLEDs.These findings demonstrate the great potential of Sr_(5)(PO_(4))_(3-x)(BO_(3))_(x)Cl:0.04Eu^(2+) as a white-light phosphor for near-UV phosphor-converted WLEDs.These results also provide a shortcut for developing a high CRI white-light phosphor from a single Eu^(2+)-doped compound. | Peng-Peng Dai Cong Li Xin-Tong Zhang Jun Xu Xi Chen Xiu-Li Wang Yan Jia Xiaojun Wang Yi-Chun Liu | 2016 | Light(Science & Applications)2016，5，1： | 14 |
| 11 | Splenic hamartoma: case report and review of literature显示文摘脾的 hamartoma 是由正常脾的元素的异常混合物组成的良性的畸形性。近似有肿瘤的病人的一半由尸体或脾切除术偶然无征状、诊断。肿瘤相关的肾的 hematological anddermatological 畸形能被肿瘤的移动对待。与包括额外膜的 glomerulonephritis, membrano-proliferativeglomerulonephritis 和肾的腺癌的肾的疾病有关的脾的 hamartoma 以前被报导了。在 2002 年 12 月,我们与由偶然检测的肾的骨盆的石头复杂的脾的 hamartoma 对待一个病人 byultrasonography。 | JIA Hong-bo LI Ying-ping HAN De-en LIU Yao ZHANG Bin WU De-quan CHEN Xi JIANG Ying ZHENG Long-xian DU Jin-rong JIANG Xue-hai | 2006 | Chinese Medical Journal2006，，16： | 13 |
| 12 | Synthesis of CuO nanometer powder by one step solid state reaction at room temperature显示文摘Copper oxide nanometer powder was synthesized by one step solid state reaction of CuCl-2·2H-2O with NaOH at room temperature. The solid product CuO was characterized by X-ray diffraction and a transmission electron microscope. It has been found that the particles of prepared copper oxide are spherical with average diameter of 20 nm. This new method has the advantages of convenience and high yield compared with literature methods. | Dianzeng Jia Jianqun Yu Xi Xia | 1998 | Chinese Science Bulletin1998，43，7： | 11 |
| 13 | Combining Endometrium Sampling Device and SurePath Preparation to Screen for Endometrial Carcinoma: A Validation Study显示文摘 | Jia Wen Rui Chen Jian Zhao Yin Dong Xi Yang Qin-Ping Liao | 2015 | Chinese Medical Journal2015，，5： | 11 |
| 14 | TaqMan Real-time RT-PCR Assay for Detecting and Differentiating Japanese Encephalitis Virus显示文摘Objective To detect Japanese encephalitis virus(JEV) rapidly and distinguish its genotypes, a TaqMan-based reverse transcriptase quantitative polymerase chain reaction(RT-PCR) detection system was developed.Methods By aligning the full-length sequences of JEV(G1-G5), six sets of highly specific TaqMan real-time RT-PCR primers and probes were designed based on the highly conserved NS1, NS2, and M genes of JEV, which included one set for non-specific JEV detection and five sets for the detection of specific JEV genotypes. Twenty batches of mosquito samples were used to evaluate our quantitative PCR assay.Results With the specific assay, no other flavivirus were detected. The lower limits of detection of the system were 1 pfu/mL for JEV titers and 100 RNA copies/μL. The coefficients of variation of this real-time RT-PCR were all < 2.8%. The amplification efficiency of this method was between 90% and 103%.Conclusion A TaqMan real-time RT-PCR detection system was successfully established to detect and differentiate all five JEV genotypes. | SHAO Nan LI Fan NIE Kai FU Shi Hong ZHANG Wei Jia HE Ying LEI Wen Wen WANG Qian Ying LIANG Guo Dong CAO Yu Xi WANG Huan Yu | 2018 | Biomedical and Environmental Sciences2018，31，3： | 10 |
| 15 | Exceeding the limit of plasmonic light trapping in textured screen-printed solar cells using Al nanoparticles and wrinkle-like graphene sheets显示文摘The solar cell market is predominantly based on textured screen-printed solar cells.Due to parasitic absorption in nanostructures,using plasmonic processes to obtain an enhancement that exceeds 2.5%of the short-circuit photocurrent density is challenging.In this paper,a 7.2%enhancement in the photocurrent density can be achieved through the integration of plasmonic Al nanoparticles and wrinkle-like graphene sheets.For the first time,we experimentally achieve Al nanoparticle-enhanced solar cells.An innovative thermal evaporation method is proposed to fabricate low-coverage Al nanoparticle arrays on solar cells.Due to the ultraviolet(UV)plasmon resonance of Al nanoparticles,the performance enhancement of the solar cells is significantly greater than that from Ag nanoparticles.Subsequently,we deposit wrinkle-like graphene sheets over the Al nanoparticle-enhanced solar cells.Compared with planar graphene sheets,the bend carbon layer also exhibits a broadband light-trapping effect.Our results exceed the limit of plasmonic light trapping in textured screen-printed silicon solar cells. | Xi Chen Baohua Jia Yinan Zhang Min Gu | 2013 | Light(Science & Applications)2013，2，1： | 9 |
| 16 | GNOM-LIKE 2, Encoding an Adenosine Diphosphate-Ribosylation Factor-Guanine Nucleotide Exchange Factor Protein Homologous to GNOM and GNL1, is Essential for Pollen Germination in Arabidopsis显示文摘In flowering plants, male gametes are delivered to female gametophytes by pollen tubes. Although it is important for sexual plant reproduction, little is known about the genetic mechanism that controls pollen germination and pollen tube growth. Here we report the identification and characterization of two novel mutants, gnom-like 2-1 (gnl2-1) and gnl2-2 in Arabidopsis thaliana, in which the pollen grains failed to germinate in vitro and in vivo. GNL2 encodes a protein homologous to the adenosine diphosphate-ribosylation factor-guanine nucleotide exchange factors, GNOM and GNL1 that are involved in endosomal recycling and endoplasmic reticulum-Golgi vesicular trafficking. It was prolifically expressed in pollen grains and pollen tubes. The results of the present study suggest that GNL2 plays an important role in pollen germination. | Dong-Jie Jia Xi Cao Wei Wang Xiao-Yun Tan Xue-Qin Zhang Li-Qun Chen De Ye | 2009 | Journal of Integrative Plant Biology2009，51，8： | 8 |
| 17 | Scalable volumetric imaging for ultrahigh-speed brain mapping at synaptic resolution显示文摘The speed of high-resolution optical imaging has been a rate-limiting factor for meso-scale mapping of brain structures and functional circuits,which is of fundamental importance for neuroscience research.Here,we describe a new microscopy method of Volumetric Imaging with Synchronized on-the-fly-scan and Readout(VISo R)for high-throughput,high-quality brain mapping.Combining synchronized scanning beam illumination and oblique imaging over cleared tissue sections in smooth motion,the VISo R system effectively eliminates motion blur to obtain undistorted images.By continuously imaging moving samples without stopping,the system achieves high-speed 3D image acquisition of an entire mouse brain within1.5 hours,at a resolution capable of visualizing synaptic spines.A pipeline is developed for sample preparation,imaging,3D image reconstruction and quantification.Our approach is compatible with immunofluorescence methods,enabling flexible cell-type specific brain mapping and is readily scalable for large biological samples such as primate brains.Using this system,we examined behaviorally relevant whole-brain neuronal activation in 16 c-Fos-sh EGFP mice under resting or forced swimming conditions.Our results indicate the involvement of multiple subcortical areas in stress response.Intriguingly,neuronal activation in these areas exhibits striking individual variability among different animals,suggesting the necessity of sufficient cohort size for such studies. | Hao Wang Qingyuan Zhu Lufeng Ding Yan Shen Chao-Yu Yang Fang Xu Chang Shu Yujie Guo Zhiwei Xiong Qinghong Shan Fan Jia Peng Su Qian-Ru Yang Bing Li Yuxiao Cheng Xiaobin He Xi Chen Feng Wu Jiang-Ning Zhou Fuqiang Xu Hua Han Pak-Ming Lau Guo-Qiang Bi | 2019 | National Science Review2019，6，5： | 7 |
| 18 | Reliable grading robust stabilization for uncertain time-varying systems via dynamic compensator显示文摘A new general model for uncertain time-varying parameters and a new measure sensor failure model are presented, and the problems of both grading robust stabilization and reliable grading robust stabilization for such systems are studied. By the Lyapunov stability theory and matrix algebra method, some sufficient criteria for the above two control problems are established in quasi-linear matrix inequalities (Q-LMIS) forms. In view of linear matrix inequality (LMI) approach, a solving procedure for the Q-LMIS problem is proposed. The solvability of the Q-LMIS problem can be improved obviously by adding some LMI constraints to the Q-LMIS. Based on the two Q-LMIS criteria, a grading robust stable control strategy, namely, the controller with different energy is acted on the system with different uncertain parameter range, is presented. The numerical simulating results show that the grading robust stable control strategy for the robust stabilization of uncertain systems has important theoretical and practical significance. | JIA Xinchun and ZHENG Nanning(Institute of Artificial Intelligence and Robotics, Xi’an Jiaotong University, Xi’an 710049, China) | 2002 | Progress in Natural Science:Materials International2002，12，10： | 7 |
| 19 | Subchronic Oral Toxicity Evaluation of Lanthanum: A 90-day, Repeated Dose Study in Rats显示文摘Objective The present study was undertaken to evaluate the subchronic toxicity of lanthanum and to determine the no observed adverse effect level(NOAEL),which is a critical factor in the establishment of an acceptable dietary intake(ADI).Methods In accordance with the Organization for Economic Co-operation and Development(OECD) testing guidelines,lanthanum nitrate was administered once daily by gavage to Sprague-Dawley(SD) rats at dose levels of 0,1.5,6.0,24.0,and 144.0 mg/kg body weight(BW) per day for 90 days,followed by a recovery period of 4 weeks in the 144.0 mg/kg BW per day and normal control groups.Outcome parameters were mortality,clinical symptoms,body and organ weights,serum chemistry,and food consumption,as well as ophthalmic,urinary,hematologic,and histopathologic indicators.The benchmark dose(BMD) approach was applied to estimate a point of departure for the hazard risk assessment of lanthanum.Results Significant decreases were found in the 144.0 mg/kg BW group in the growth index,including body weight,organ weights,and food consumption.This study suggests that the NOAEL of lanthanum nitrate is 24.0 mg/kg BW per day.Importantly,the 95% lower confidence value of the benchmark dose(BMDL) was estimated as 9.4 mg/kg BW per day in females and 19.3 mg/kg BW per day in males.Conclusion The present subchronic oral exposure toxicity study may provide scientific data for the risk assessment of lanthanum and other rare earth elements(REEs). | FANG Hai Qin YU Zhou ZHI Yuan FANG Jin LI Chen Xi WANG Yi Mei PENG Shuang Qing JIA Xu Dong | 2018 | Biomedical and Environmental Sciences2018，31，5： | 7 |
| 20 | Metabolic Disorders Increase the Risk to Incident Cardiovascular Disease in Middle-aged and Elderly Chinese显示文摘Objective The association of metabolic syndrome (MetS) with cardiovascular diseases (CVD) has not been adequately explored in middle-aged and elderly Chinese.This study aimed to investigate MetS' prevalence and its impact on the CVD incidence in this specific population group.Methods A data set of a community-based prospective cohort study was analyzed.A total of 2300 subjects aged 40-94 years were followed up for the CVD events.MetS defined according to the JCDCG criteria was assessed at baseline,and the middle-aged and elderly groups were classified by the WHO definition.Results As compared with the middle-aged group,the prevalence of MetS increased by 0.6 times (34.6% vs.21.3%) and the incidence density of CVD increased by 4.9 times in the elderly group (52.3/1000 person-year vs.8.9/1000 person-year).Furthermore,the multivariate Cox regression revealed that the risk to CVD incidence was independently related to increased waist circumference in the middle-aged group (HR=2.23,P<0.01) and to elevated blood glucose in the elderly group (HR=1.39,P<0.01).Conclusion MetS was highly prevalent in middle-aged and elderly Chinese.MetS significantly increased the risk to CVD incidence in the elderly.All individuals with metabolic disorders should receive active clinical care to reduce the incidence of CVD. | ZHANG Ming Liang HOU Xu Hong ZHU Yun Xia LU Jun Xi PENG Liang Pu GU Hui Lin JIA Wei Ping | 2012 | Biomedical and Environmental Sciences2012，25，1： | 7 |
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