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| 1 | Extreme Cold Events from East Asia to North America in Winter 2020/21:Comparisons,Causes,and Future Implications显示文摘Three striking and impactful extreme cold weather events successively occurred across East Asia and North America during the mid-winter of 2020/21.These events open a new window to detect possible underlying physical processes.The analysis here indicates that the occurrences of the three events resulted from integrated effects of a concurrence of anomalous thermal conditions in three oceans and interactive Arctic-lower latitude atmospheric circulation processes,which were linked and influenced by one major sudden stratospheric warming(SSW).The North Atlantic warm blob initiated an increased poleward transient eddy heat flux,reducing the Barents-Kara seas sea ice over a warmed ocean and disrupting the stratospheric polar vortex(SPV)to induce the major SSW.The Rossby wave trains excited by the North Atlantic warm blob and the tropical Pacific La Nina interacted with the Arctic tropospheric circulation anomalies or the tropospheric polar vortex to provide dynamic settings,steering cold polar air outbreaks.The long memory of the retreated sea ice with the underlying warm ocean and the amplified tropospheric blocking highs from the midlatitudes to the Arctic intermittently fueled the increased transient eddy heat flux to sustain the SSW over a long time period.The displaced or split SPV centers associated with the SSW played crucial roles in substantially intensifying the tropospheric circulation anomalies and moving the jet stream to the far south to cause cold air outbreaks to a rarely observed extreme state.The results have significant implications for increasing prediction skill and improving policy decision making to enhance resilience in“One Health,One Future”. | Xiangdong ZHANG Yunfei FU Zhe HAN James E.OVERLAND Annette RINKE Han TANG Timo VIHMA Muyin WANG | 2022 | Advances in Atmospheric Sciences2022，39，4： | 7 |
| 2 | Hijacking antibody-induced CTLA-4 lysosomal degradation for safer and more effective cancer immunotherapy显示文摘It remains unclear why the clinically used anti-CTLA-4 antibodies, popularly called checkpoint inhibitors, have severe immunotherapy-related adverse effects (irAEs) and yet suboptimal cancer immunotherapeutic effects (CITE). Here we report that while irAE-prone Ipilimumab and TremeIgG1 rapidly direct cell surface CTLA-4 for lysosomal degradation, the non-irAE-prone antibodies we generated, HL12 or HL32, dissociate from CTLA-4 after endocytosis and allow CTLA-4 recycling to cell surface by the LRBA-dependent mechanism. Disrupting CTLA-4 recycling results in robust CTLA-4 downregulation by all anti-CTLA-4 antibodies and confers toxicity to a non-irAE-prone anti-CTLA-4 mAb. Conversely, increasing the pH sensitivity of TremeIgG1 by introducing designed tyrosine-to-histidine mutations prevents antibody-triggered lysosomal CTLA-4 downregulation and dramatically attenuates irAE. Surprisingly, by avoiding CTLA-4 downregulation and due to their increased bioavailability, pH-sensitive anti-CTLA-4 antibodies are more effective in intratumor regulatory T-cell depletion and rejection of large established tumors. Our data establish a new paradigm for cancer research that allows for abrogating irAE while increasing CITE of anti-CTLA-4 antibodies. | Yan Zhang Xuexiang Du Mingyue Liu Fei Tang Peng Zhang Chunxia Ai James K. Fields Eric J. Sundberg Olga S. Latinovic Martin Devenport Pan Zheng Yang Liu | 2019 | Cell Research2019，29，8： | 6 |
| 3 | The RppC-AvrRppC NLR-effector interaction mediates the resistance to southern corn rust in maize显示文摘Southern corn rust(SCR),caused by the fungal pathogen Puccinia polysora,is a major threat to maize pro-duction worldwide.Efficient breeding and deployment of resistant hybrids are key to achieving durable control of SCR.Here,we report the molecular cloning and characterization of RppC,which encodes an NLR-type immune receptor and is responsible for a major SCR resistance quantitative trait locus.Further-more,we identified the corresponding avirulence effector,AvrRppC,which is secreted by P.polysora and triggers RppC-mediated resistance.Allelic variation of AvrRppC directly determines the effectiveness of RppC-mediated resistance,indicating that monitoring of AvrRppC variants in the field can guide the rational deployment of RppC-containing hybrids in maize production.Currently,RppC is the most frequently deployed SCR resistance gene in China,and a better understanding of its mode of action is crit-ical for extending its durability. | Ce Deng April Leonard James Cahill Meng Lv Yurong Li Shawn Thatcher Xueying Li Xiaodi Zhao Wenjie Du Zheng Li Huimin Li Victor Llaca Kevin Fengler Lisa Marshall Charlotte Harris Girma Tabor Zhimin Li Zhiqiang Tian Qinghua Yang Yanhui Chen Jihua Tang Xintao Wang Junjie Hao Jianbing Yan Zhibing Lai Xiaohong Fei Weibin Song Jinsheng Lai Xuecai Zhang Guoping Shu Yibo Wang Yuxiao Chang Weiling Zhu Wei Xiong Juan Sun Bailin Li Junqiang Ding | 2022 | Molecular Plant2022，15，5： | 6 |
| 4 | Purification and characterization of a novel anti-coagulant from the leech Hirudinaria manillensis显示文摘Protease inhibitors have been reported rarely from the leech Hirudinaria manillensis.In this study,we purified a novel protease inhibitor(bdellin-HM-2)with anticoagulant properties from H.manillensis.With a molecular weight of 1.4x104,bdellin-HM-2 was also characterized with three intra?molecular disulfide bridges at the N-terminus and multiple HHXDD and HXDD motifs at theC-terminus.cDNAcloning revealed that the putative nucleotide-encoding protein of bdellin-HM-2 contained 132 ami no acids and was encoded by a 399 bp open reading frame(ORF).Sequence alignment showed that bdellin-HM-2 shared similarity with the“non-classical'Kazal-type serine protease inhibitors,but had no inhibitory effect on trypsin,elastase,chymotrypsin,kallikrein,factor Xlla(FXIIa),factor Xia(FXIa),factor Xa(FXa),thrombin,or plasmin.Bdellin-HM-2 showed anticoagulant effects by proIonging the activated partial thromboplastin time(aPTT),indicating a role in enabling H.manillensis to obtain a blood meal from its host.Our results suggest that bdellin-HM丒2 may play a crucial role in blood-sucking in this leech species and may be a pote ntial can didate for the development of clinical anti-thrombotic drugs. | Ruo-Mei Cheng Xiao-Peng Tang Ai-Lin Long James Mwangi Ren Lai Rui-Pu Sun Cheng-Bo Long Zhen-Qing Zhang | 2019 | Zoological Research2019，40，3： | 5 |
| 5 | Structural, densitometric and biomechanical evaluations of Chinese patients with long-term bisphosphonate treatment显示文摘 | LEUNG Kwok-sui TANG Ning James Griffith CHOY Tak-Kee HUNG Vivian Wing-Yin MOK Hoi-Wa SHI Lin LEUNG Ping-Chung CHEUNG Wing-Hoi | 2013 | Chinese Medical Journal2013，，1： | 4 |
| 6 | Can nanoparticles and nano-protein interactions bring a bright future for insulin delivery?显示文摘Insulin therapy plays an essential role in the treatment of diabetes mellitus.However,frequent injections required to effectively control the glycemic levels lead to substantial inconvenience and low patient compliance.In order to improve insulin delivery,many efforts have been made,such as developing the nanoparticles (NPs)-based release systems and oral insulin.Although some improvements have been achieved,the ultimate results are still unsatisfying and none of insulin-loaded NPs systems have been approved for clinical use so far.Recently,nano?protein interactions and protein corona formation have drawn much attention due to their negative influence on the in vivo fate of NPs systems.As the other side of a coin,such interactions can also be used for constructing advanced drug delivery systems.Herein,we aim to provide an insight into the advance and flaws of various NPs-based insulin delivery systems.Particularly,an interesting discussion on nano?protein interactions and its potentials for developing novel insulin delivery systems is initiated. | Ting Zhang James Zhenggui Tang Xiaofan Fei Yanping Li Yi Song Zhiyong Qian Qiang Peng | 2021 | Acta Pharmaceutica Sinica B2021，11，3： | 3 |
| 7 | Exploring in vitro roles of siRNA in cardiovascular disease显示文摘RNA 干扰( RNAi )是通过 搁浅whichdouble 的 RNA 沉默的适应防卫机制在顺序特定的 manner.It 的血缘的基因被采用了在功能的 genomics 的一个强大的工具学习的 widelyas ,目标确认并且治疗学 productdevelopment.Similarly ,到涉及心血管的疾病的 引起thedisease 基因的 silencing 的小介入的 RNA ( siRNA )的申请使大 progress.In 成为了 thisoverview 。 | Yu TANG Yu-zhi GE James Q YIN | 2007 | Acta Pharmacologica Sinica2007，28，1： | 3 |
| 8 | Brain MRI of hippocampal volumetry in patients with refractory temporal lobe epilepsy显示文摘Objective To detect for hippocampal sclerosis presurgically in a group of patients with refractory temporal lobe epilepsy Methods Eighty four consecutive patients with refractory temporal lobe epilepsy were subjected to brain MRI of hippocampal volumetry A ratio of smaller to larger hippocampal volume was determined and unilateral hippocampal atrophy (HA) was diagnosed if the ratio is less than 0 91 Results Unilateral HA was diagnosed in 42 patients (50%) and bilateral HA in 1 patient Other MRI abnormalities were detected in 18 patients with or without coexisting HA Conclusions Hippocampal sclerosis can be detected presurgically in many patients by brain MRI Additional abnormalities not detected by brain CT can also be | Ka Kui Philip Ng, Kwok Wing Tang, Yuk Ling James Cheung and Patrick Chung Ki Li | 2000 | Chinese Medical Journal2000，，3： | 3 |
| 9 | Lymphopenia Association With Gross Tumor Volume and Lung V5 and Its Effects on Non-Small-Cell Lung Cancer Patient Outcomes显示文摘 | Chad Tang Zhongxing Liao Daniel Gomez Lawrence Levy Yan Zhuang Rediet A. Gebremichael David S. Hong Ritsuko Komaki James W. Welsh | 2014 | International Journal of Radiation Oncology, Biology, Physics2014，，： | 2 |
| 10 | Transferrin plays a central role in coagulation balance by interacting with clotting factors显示文摘Coagulation balance is maintained through fine-tuned interactions among clotting factors,whose physiological concentrations vary substantially.In particular,the concentrations of coagulation proteases(pM to nM)are much lower than their natural inactivator antithrombin(AT,〜3μM),suggesting the existence of other coordinators.In the current study,we found that transferrin(norm plasma concentration〜40 μM)interacts with fibrinogen,thrombin,factor Xlla(FXlla),and AT with different affinity to maintain coagulation balance.Normally,transferrin is sequestered by binding with fibrinogen(normal plasma concentration〜10 μM)at a molar ratio of 4:1.In atherosclerosis,abnormally up-regulated transferrin interacts with and potentiates thrombin/FXlla and blocks ATs inactivation effect on coagulation proteases by binding to AT,thus inducing hypercoagulability.In the mouse model,transferrin overexpression aggravated atherosclerosis,whereas transferrin inhibition via shRNA knockdown or treatment with antitransferrin antibody or designed peptides interfering with transferrin-thrombin/FXlla interactions alleviated atherosclerosis.Collectively,these findings identify that transferrin is an important clotting regulator and an adjuster in the maintenance of coagulation balance and modifies the coagulation cascade. | Xiaopeng Tang Zhiye Zhang Mingqian Fang Yajun Han Gan Wang Sheng Wang Min Xue Yaxiong Li Li Zhang Jian Wu Biqing Yang James Mwangi Qiumin Lu Xiaoping Du Ren Lai | 2020 | Cell Research2020，30，2： | 2 |
| 11 | Yielding to (cyber)-temptation: Exploring the buffering role of self-control in the relationship between organizational justice and cyberloafing behavior in the workplace显示文摘 | Simon Lloyd D. Restubog Patrick Raymund James M. Garcia Lemuel S. Toledano Rajiv K. Amarnani Laramie R. Tolentino Robert L. Tang | 2011 | Journal of Research in Personality2011，，2： | 2 |
| 12 | Patient and provider perceptions of diabetes: Measuring and evaluating differences显示文摘 | James T. Fitzgerald R. Brent Stansfield Tricia Tang Mary Oh Alice Frohna Betty Armbruster Larry Gruppen Robert Anderson | 2007 | Patient Education and Counseling2007，，1： | 1 |
| 13 | Epigenomic Profiling Reveals DNA-Methylation Changes Associated with Major Psychosis显示文摘 | Jonathan Mill Thomas Tang Zachary Kaminsky Tarang Khare Simin Yazdanpanah Luigi Bouchard Peixin Jia Abbas Assadzadeh James Flanagan Axel Schumacher Sun-Chong Wang Arturas Petronis | 2008 | The American Journal of Human Genetics2008，，3： | 1 |
| 14 | Shanghai' sdevelopment as an international Financial Center 显示文摘 | James Laurenceson and Kam Ki Tang | 2005 | Review of Pacific Basin Financial Markets and Policies2005，8，1： | 1 |
| 15 | Revaluation of absorption of carbenoxolone using and in situ rat intestinal technique显示文摘 | James Blanchard Lisa M Tang Margaret E Earle | 1990 | Journal of Pharmaceutical Sciences1990，79，5： | 1 |
| 16 | Mid-pregnancy circulating immune biomarkers in women with preeclampsia and normotensive controls显示文摘 | Brandie D. Taylor Gong Tang Roberta B. Ness J?rn Olsen David M. Hougaard Kristin Skogstrand James M. Roberts Catherine L. Haggerty | 2015 | Pregnancy Hypertension: An International Journal2015，，： | 1 |
| 17 | Fouling of reverse osmosis and nanofihration membranes by humic acid-Effects of solution composition and hydrodynamic conditions显示文摘 | Chuyang Y Tang Young-Nam Kwon James O Leckie | 2007 | J Membr Sci2007，290，12： | 1 |
| 18 | Isolation and preparative purification of microcystin variants 显示文摘 | Sundar Ramanan James Tang Ajoy Velayudhan | 2000 | Chromatogr A2000，883，： | 1 |
| 19 | Feasibility of prospectively ECG-triggered high-pitch coronary CT angiography with 30 mL iodinated contrast agent at 70 kVp: initial experience显示文摘 | Long Jiang Zhang Li Qi Jing Wang Chun Xiang Tang Chang Sheng Zhou Xue Man Ji James V. Spearman Carlo Nicola Cecco Felix G. Meinel U. Joseph Schoepf Guang Ming Lu | 2014 | European Radiology2014，，： | 1 |
| 20 | Scalar transport by propagation of an internal solitary wave over a slope-shelf显示文摘Internal solitary waves(ISWs)of depression are commonly found in the coastal environment and are believed to re-suspend sediments in coastal regions where the waves break.In this research,the direct numerical simulation is used to study the scalar transport induced by the ISWs of depression propagating over a slope-shelf topography.The scalar in this paper is considered to represent the concentrations of very fine suspended solids or pollutants.Vortices are observed from the numerical results at the bottom boundary layer on the slope during the ISW shoaling process,resulting in a scalar transport.All in cident ISWs of depression are observed to produce a waveform inversion on the shelf.The scalar transport from a slope to a shelf is the consequence of the combined vortices at the bottom boundary layer and the overturning of the ISWs of depression,and the latter was commonly ignored in previous studies.This study shows that the ISW-induced scalar transport consists of the following four stages:the slip transport,the wash transport,the vortex transport,and the secondary transport.A dimensionless time scales of the four stages are calculated,and the beginning times of the wash transport and the secondary transport are found to be uncorrelated with the slope gradients,taking values of 1.26,4,respectively. | Jin Xu Ling-ling Wang Hong-wu Tang Zhu Hai John James Reginald Williams | 2019 | Journal of Hydrodynamics2019，31，2： | 1 |
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