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| 1 | Macrophages in metabolic associated fatty liver disease显示文摘Metabolic associated fatty liver disease(MAFLD),formerly named non-alcoholic fatty liver disease is the most common liver disorder in many countries.The inflammatory subtype termed steatohepatitis is a driver of disease progression to cirrhosis,hepatocellular carcinoma,liver transplantation,and death,but also to extrahepatic complications including cardiovascular disease,diabetes and chronic kidney disease.The plasticity of macrophages in response to various environmental cues and the fact that they can orchestrate cross talk between different cellular players during disease development and progression render them an ideal target for drug development.This report reviews recent advances in our understanding of macrophage biology during the entire spectrum of MAFLD including steatosis,inflammation,fibrosis,and hepatocellular carcinoma,as well as for the extra-hepatic manifestations of MAFLD.We discuss the underlying molecular mechanisms of macrophage activation and polarization as well as cross talk with other cell types such as hepatocytes,hepatic stellate cells,and adipose tissue.We conclude with a discussion on the potential translational implications and challenges for macrophage based therapeutics for MAFLD. | Jawaher Alharthi Olivier Latchoumanin Jacob George Mohammed Eslam | 2020 | World Journal of Gastroenterology2020，26，16： | 5 |
| 2 | Biomarkers of Metabolic(Dysfunction)-associated Fatty Liver Disease:An Update显示文摘The prevalence of metabolic(dysfunction)-associated fatty liver disease(MAFLD)is rapidly increasing and affects up to two billion individuals globally,and this has also resulted in increased risks for cirrhosis,hepatocellular carcinoma,and liver transplants.In addition,it has also been linked to extrahepatic consequences,such as cardiovascular disease,diabetes,and various types of cancers.However,only a small proportion of patients with MAFLD develop these complications.Therefore,the identification of high-risk patients is paramount.Liver fibrosis is the major determinant in developing these complications.Although,liver biopsy is still considered the gold standard for the assessment of patients with MAFLD.Because of its invasive nature,among many other limitations,the search for noninvasive biomarkers for MAFLD remains an area of intensive research.In this review,we provide an update on the current and future biomarkers of MAFLD,including a discussion of the associated genetics,epigenetics,microbiota,and metabolomics.We also touch on the next wave of multiomic-based biomarkers. | Jawaher Alharthi Mohammed Eslam | 2022 | Journal of Clinical and Translational Hepatology2022，10，1： | 3 |
| 3 | The Protective Effect of Aged Garlic Extract on Nonsteroidal Anti-Inflammatory Drug-Induced Gastric Inflammations in Male Albino Rats显示文摘 | Gehan Moustafa Badr Jawaher Abdulaziz AL-Mulhim Juliano Ferreira | 2014 | Evidence-Based Complementary and Alternative Medicine2014，，： | 1 |
| 4 | Continuous enteral feeding impairs gallbladder emptying in infants显示文摘 | Shaw N Pierro A | 2001 | J Pediatr2001，138，6： | 1 |
| 5 | Metabolic outcomes 1 year after gastric bypass surgery in obese people with type 2 diabetes显示文摘 | Demssie YN Jawaheer J Farook S | 2012 | Med Princ Pract2012，21，2： | 1 |
| 6 | Gall bladder contractility in neonates:effects of parenteral and enteral feeding显示文摘 | Pierro A Lloyd D Shaw N | 1995 | Arch Dis Child1995，72，3： | 1 |
| 7 | Screening the genome for rheumatoid arthritis susceptibility genes A replication study and combined analysis of 512 multicase families显示文摘 | Jawaheer D Seldin MF Amos CI | 2003 | Artrhitis Rheum2003，48，4： | 1 |
| 8 | Esophageal atresia in the northern region congenital anomaly survey,1985 ~1997:prenatal diagnosis and outcome显示文摘 | Sparey C Jawaheer G Barrett AM | | 0，，2： | 1 |
| 9 | Gall bladder contractility in neonates: effects of parenteral and enteral feeding显示文摘 | Jawaheer G Pierro A Lloyd D A | 1995 | Archiv- es of Disease in Childhood-Fetal and Neonatal Edition1995，72，3： | 1 |
| 10 | Preva- lence and Impact of Anxiety and Depression on Type 2 Diabetes in Tunisian Patients over Sixty Years Old 显示文摘 | Jawaher Masmoudi Rahma Damak Hela Zouari | 2013 | Depression research and treatment2013，2013，34： | 1 |
| 11 | Metabolic associated fatty liver disease(MAFLD):a milestone in the history of fatty liver disease显示文摘With the widespread increase in energy intake and physical inactivity,the prevalence of metabolic health is declining.Consequently,metabolic associated fatty liver disease(MAFLD)[formerly known as non-alcoholic fatty liver disease(NAFLD)]has risen in prevalence and present a significant challenge to global health causing considerable morbidity and mortality,particularly when fibrosis is present(1). | Jawaher Alharthi Mohammed Eslam | 2021 | Hepatobiliary Surgery and Nutrition2021，10，5： | 1 |
| 12 | Docetaxel chemotherapy for metastatic hormone refractory prostate canceras first-line palliative chemotherapy and subsequent re-treatment: Birminghamexperience显示文摘 | Jawaher Ansari Syed Hussain Anjali Zarkar Jacob Tanguay Julie Bliss John Glaholm | 2008 | Oncology Reports2008，，4： | 1 |
| 13 | Day case laparoscopic chole- cystectomy in childhood: outcomes from a clinical care pathway 显示文摘 | Jawaheer G Evans K Marcus R | 2013 | Eur J Pediatr Surg2013，23，1： | 1 |
| 14 | Screening the genome for rheumatoid arthritis susceptibility genes:a replication study and combined analysis of 512 multicase families显示文摘 | Jawaheer D Seldin MF Amos CI | 2003 | Arthritis Rheum2003，48，4： | 1 |
| 15 | A genomewide screen in multiplex rheumatoid arthritis families suggests genetic overlap with other autoirmnune diseases显示文摘 | Jawaheer D Seldin MF Amos CI | 2001 | Am J Hum Genet2001，68，4： | 1 |
| 16 | Esophageal atresia in the Northern Region Congenital Anomaly Survey,1985-1997:prenatal diagnosis and outcome显示文摘 | Sparey C Jawaheer G Barrett AM | | 0，，02： | 1 |
| 17 | A genomewide screen in multiplex rheumatoid arthritis families suggests genetic overlap with other autoimmune diseases显示文摘 | Jawaheer D Seldin MF Amos CI | 2001 | Am J Hum Genet2001，68，4： | 1 |
| 18 | Strategies and policies from promoting the use of renewable energy resource in the UAE 显示文摘 | Jawaher A Bassam A | 2013 | Renewable and Sustainable Energy Reviews2013，26，： | 1 |
| 19 | Day-case laparoscopic cholecystectomy in childhood:outcomes from a clinical care pathway显示文摘 | Jawaheer G Evans K Marcus R | 2013 | Eur J Pediatr Surg2013，23，1： | 1 |
| 20 | Gender, body mass index and rheumatoid arthritis disease activity: results from the QUEST- RA Study显示文摘 | Jawaheer D Olsen J Lahiff M | 2010 | Clin Exp Rheumatol2010，28，4： | 1 |
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