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| 1 | Dynamic chromatin states in human ES cells reveal potential regulatory sequences and genes involved in pluripotency显示文摘Pluripotency,一个细胞的能力区分并且产生所有胚胎的系,定义象胚胎的茎(ES ) 那样的哺乳动物的细胞类型的一个小数字细胞。当它通常被保持了时,那 pluripotency 是 transcriptional 的产品激活并且维持关键干细胞基因的表达式的规章的网络,积累的证据在建立并且保卫 ES 房间的 pluripotency 为 epigenetic 进程正在指向一个关键角色,象维持区分的房间类型的身份一样。以便更好在 pluripotency 理解 epigenetic 机制的角色,我们检验了在经历区别进一个 mesendodermal 系的人的 ES 房间(hESCs ) 染色体宽的染色质修正的动力学。我们发现在倡导者的染色质修正在区别期间仍然保持大部分不变,除了在在在 H3K27 的 acetylation 和 methylation 之间的一个动态开关标记在基因表示的激活和 silencing 之间的转变的倡导者的一个小数字,建议在在大多数差别上的房间命运承诺的一个层次表示了基因。我们也在 50 000 潜在的 enhancers 上印射,并且在染色质修正,特别 H3K4me1 和 H3K27ac 观察了大得多的动力学,它与他们的潜在的目标基因的表示相关。这些 enhancers 的进一步的分析揭示了 pluripotency 和可以在 hESCs 授与发展胜任的一个平衡状态的一口染色质签名陈述语气的潜在地关键的 transcriptional 管理者。我们的结果提供在定义 enhancers 和 pluripotency 支持染色质修正的角色的新证据。 | R David Hawkins Gary C Hon Chuhu Yang Jessica E Antosiewicz-Bourget Leonard K Lee Que-Minh Ngo Sarit Klugman Keith A Ching Lee E Edsall Zhen Ye Samantha Kuan Pengzhi Yu Hui Liu Xinmin Zhang Roland D Green Victor V Lobanenkov Ron Stewart James A Thomson Bing Ren | 2011 | Cell Research2011，21，10： | 6 |
| 2 | Risk calculators for hepatocellular carcinoma in patients affected with chronic hepatitis B in Asia显示文摘Risk calculators are widely used in many clinical fields,and integrate several important risk factors through the conversion of a risk function into a single measure of risk.Several studies have been carried out to create risk calculators for the prediction of hepatocellular carcinoma(HCC)in patients with chronic hepatitis B(CHB).Most of them were hospital-based,with limited sample sizes and insufficient external validation.These study groups collaborated to establish the REACH-B risk score,which incorporated five clinical variables to predict HCC risk.This risk score was then validated ininternational clinical cohorts.Evidence suggests that quantitative serum HBsAg level provides additional predictability of HCC,especially in patients with low levels of hepatitis B virus DNA.This novel marker was incorporated into a risk calculator and was internally validated.This tool will hopefully be externally validated in the near future.Risk calculators can be used to support clinical practice,and to establish preventive measures;several'off-label'extension usages have also been implemented.Albeit beneficial,several precautions and discussions should be noted in using the risk calculators.The future development of risk calculators for CHB patients can be extended by applying them to additional CHB-related outcomes,and by incorporating emerging risk parameters. | Hwai-I Yang Mei-Hsuan Lee Jessica Liu Chien-Jen Chen | 2014 | World Journal of Gastroenterology2014，20，20： | 5 |
| 3 | Accuracy of colon tumor localization:Computed tomography scanning as a complement to colonoscopy显示文摘AIM:To determine the utility of computed tomography(CT) scanning in localizing colon tumors.METHODS:At a single tertiary care teaching hospital,a retrospective chart review was conducted on patients who underwent surgery for colon malignancies between January 2004 and May 2006.One hundred and four charts containing all of the following data were reviewed:preop erative colonoscopy report,preoperative CT report,surgical operative report,tumor pathology report.The colon was divided into five segments from the cecum to the sigmoid and the location of the lesions was categorized into one of these areas.The tumor location was considered 'erroneous' if its location determined during surgery differed from the location determined by colonoscopy or CT.RESULTS:Over all,tumor location was accurately determined via colonoscopy in 83/104 cases(79.8%) and erroneously in 21/104(20.2%) of cases.CT scan accurately localized colon tumors in 52/104(50.0%) of cases,incorrectly localized tumors in 18/104(17.3%) of cases,and did not detect known tumors in 34/104(32.7%) of cases.Of the 21 tumors erroneously located by colonoscopy,11(52.4%) were accurately localized by CT scan.The average tumor size for all patients in this study was 5.72(+/-3.11) cm.The average size of tumors properly located by colonoscopy and CT was 5.39(+/-3.34) cm and 6.79(+/-3.48) cm,respectively.The average size of the tumors not detected by CT was 3.98(+/-1.75) cm.CONCLUSION:CT scanning may be used in concert with colonoscopy to help localize colon tumors. | Jessica Lee Anthony Voytovich William Pennoyer Kristy Thurston Robert A Kozol | 2010 | World Journal of Gastrointestinal Surgery2010，2，1： | 3 |
| 4 | Prediction models of long‐term Cirrhosis and hepatocellular carcinoma risk in chronic hepatitis B patients: Risk scores integrating host and virus profiles显示文摘 | Mei‐Hsuan Lee Hwai‐I. Yang Jessica Liu Richard Batrla‐Utermann Chin‐Lan Jen Uchenna H. Iloeje Sheng‐Nan Lu San‐Lin You Li‐Yu Wang Chien‐Jen Chen | 2013 | Hepatology2013，，2： | 3 |
| 5 | A Predictive Scoring System for the Seroclearance of HBsAg in HBeAg-seronegative Chronic Hepatitis B Patients with Genotype B or C Infection显示文摘 | Jessica Liu Mei-Hsuan Lee Richard Batrla-Utermann Chin-Lan Jen Uchenna H. Iloeje Sheng-Nan Lu Li-Yu Wang San-Lin You Chuhsing K. Hsiao Hwai-I. Yang Chien-Jen Chen | 2012 | Journal of Hepatology2012，，： | 2 |
| 6 | Robotic assisted laparoscopic simple suprapubic prostatectomy--The Smith Institute for Urology experience with an evolving technique显示文摘Objective:Despite a multitude of minimally invasive surgical options available for benign prostatic enlargement,open simple prostatectomy(OSP)remains the standard for large prostates(typically greater than 100 g).OSP,however,is associated with significant morbidity.Recently,a few reports touting robotic application to simple prostatectomy have been published.Herein,we reviewed our series of robotic assisted laparoscopic simple suprapubic prostatectomy(RALSSP)and detailed modifications in our technique as our experience increased.Methods:All RALSSP cases performed between January 2013 and January 2014 were reviewed for demographics,pre-operative features,and perioperative outcomes.All parameters were tabulated and mean values were calculated.Student’s t-test was utilized with p<0.05 deemed significant.Details regarding surgical technique were reviewed and highlighted.Results:Fifteen patients underwent RALSSP during this period.Mean age of these men was 68.7 years.Mean body mass index(BMI)was 28.5 kg/m^2.American Society of Anesthesiologists(ASA)score was on average 2.6.Average International Prostate Symptom Score(IPSS)was 16.2 with the majority of men experiencing some adverse clinical sequela of such benign prostatic hyperplasia(BPH).For those patients not in retention,preoperative post-void residual(PVR)was 428 mL.All patients underwent successful RALSSP without need for conversion or need for blood transfusion.Mean estimated blood loss(EBL)was 290 mL.Five patients underwent other concurrent procedures(e.g.,cystolithotomy).Mean length of hospital stay(LOS)was 2.4 days and only five patients required continuous bladder irrigation(CBI)postoperatively.Postoperative PVR improved to a mean of 33 mL and IPSS improved to 4.5(p<0.001).No major complications were identified.Adaptation of low transverse cystotomy,utilization of a robotic tenaculum in the#3 arm with its control by a surgeon on a second console,and the utilization of mucosal advancement have all subjectively aided in performance of RALSSP and perioperative outcomes.Conclusion:RALSSP allows for feasible performance of prostate adenoma enucleation with low risk of blood transfusion,short LOS,and significant improvement in IPSS and PVR;all while maintaining a minimally invasive approach.The use of a robotic tenaculum controlled by the secondary console and the mucosal advancement facilitate excellent outcomes and may play a role in minimizing hematuria and need for CBI. | Sammy E.Elsamra Nikhil Gupta Haris Ahmed David Leavitt Jessica Kreshover Louis Kavoussi Lee Richstone | 2014 | Asian Journal of Urology2014，1，1： | 2 |
| 7 | Drug screening: zebrafish as a tool for studying epileptic-related chemical compounds显示文摘 | Sha-Sha Zhao (1) (2) Yi-Liao Wang (3) Ming-Zhu Sun (3) Lu Lu (1) (2) Ya-Nan Wang (1) Delaney Pfister (4) Jessica Lee (4) Xin Zhao (3) Xi-Zeng Feng (1) Lei Li (4) | 2015 | Protein & Cell2015，6，11： | 1 |
| 8 | Survival of hydroxyapatite-coated implants: a meta-analytic review显示文摘 | Jessica J Lee Beime OR | 2000 | J Oral Maxillofac Surg2000，58，12： | 1 |
| 9 | Nursing handoffs : A systematic review of the literature 显示文摘 | Lee A Jessica L Janet M | 2010 | Am J Nurs2010，110，4： | 1 |
| 10 | Characterizing Alzheimer’s disease using a hypometabolic convergence index显示文摘 | Kewei Chen Napatkamon Ayutyanont Jessica B.S. Langbaum Adam S. Fleisher Cole Reschke Wendy Lee Xiaofen Liu Dan Bandy Gene E. Alexander Paul M. Thompson Leslie Shaw John Q. Trojanowski Clifford R. Jack Susan M. Landau Norman L. Foster Danielle J. Harvey Mi | 2011 | Neuroimage2011，，1： | 1 |
| 11 | In Vitro-Differentiated Embryonic Stem Cells Give Rise to Male Gametes that Can Generate Offspring Mice显示文摘 | Karim Nayernia Jessica Nolte Hans W. Michelmann Jae Ho Lee Kristina Rathsack Nadja Drusenheimer Arvind Dev Gerald Wulf Ingrid E. Ehrmann David J. Elliott Vera Okpanyi Ulrich Zechner Thomas Haaf Andreas Meinhardt Wolfgang Engel | 2006 | Developmental Cell2006，，1： | 1 |
| 12 | Molecular pathogen detection in biosolids with a focus on quantitative PCR using propidium monoazide for viable cell enumeration显示文摘 | Jessica K van Frankenhuyzen Jack T Trevors Hung Lee | 2011 | Journal of Microbiological Methods2011，87，： | 1 |
| 13 | Human Alveolar Macrophage Gene Responses to Mycobacterium tuberculosis Strains H37Ra and H37Rv显示文摘 | Silver Richard F Walrath Jessica Lee Hung Jacobson Bruce A Horton Heidi Bowman Michael R Nocka Karl Sypek Joseph P | 2009 | American Journal of Respiratory Cell and Molecular Biology2009，，： | 1 |
| 14 | The MicroRNA Spectrum in 12 Body Fluids显示文摘 | Weber Jessica A Baxter David H Zhang Shile Huang David Y Huang Kuo How Lee Ming Jen Galas David J Wang Kai | 2010 | Clinical Chemistry2010，，： | 1 |
| 15 | Rhabdomyolysis and Hyponatremia: A Cluster of Five Cases at the 161-km 2009 Western States Endurance Run显示文摘 | Bruso Jessica Rose Hoffman Martin D Rogers Ian R Lee Linda Towle Gary Hew-Butler Tamara | 2010 | Wilderness & Environmental Medicine2010，，4： | 1 |
| 16 | Development of a model-based clinical sepsis biomarker for critically ill patients显示文摘 | Jessica Lin Jacquelyn D. Parente J. Geoffrey Chase Geoffrey M. Shaw Amy J. Blakemore Aaron J. LeCompte Christopher Pretty Normy N. Razak Dominic S. Lee Christopher E. Hann Sheng-Hui Wang | 2010 | Computer Methods and Programs in Biomedicine2010，，2： | 1 |
| 17 | Pharmacodynamic effect and clinical efficacy of clopidogrel and prasugrel with or without a proton-pump inhibitor: an analysis of two randomised trials显示文摘 | Michelle L O’Donoghue Eugene Braunwald Elliott M Antman Sabina A Murphy Eric R Bates Yoseph Rozenman Alan D Michelson Raymond W Hautvast Peter N Ver Lee Sandra L Close Lei Shen Jessica L Mega Marc S Sabatine Stephen D Wiviott | 2009 | The Lancet2009，，9694： | 1 |
| 18 | Wear of an experimental metal - on - metal artificial disc for the lumbar spine 显示文摘 | Lee Jessica L Billi Sangiorgio | 2008 | Spine2008，33，6： | 1 |
| 19 | Routine human papillomavirus genotyping byDNA sequencing in community hospital laboratories显示文摘 | Sin Hang Lee Veronica S Vigliotti Jessica S Vigliotti | 2007 | Infectious Agents and Cancer2007，2，1： | 1 |
| 20 | Circulating immune cell landscape in patients who had mild ischaemic stroke显示文摘Introduction Patients who had a mild ischaemic stroke who present with subtle or resolving symptoms sometimes go undiagnosed,are excluded from treatment and in some cases clinically worsen.Circulating immune cells are potential biomarkers that can assist with diagnosis in ischaemic stroke.Understanding the transcriptomic changes of each cell population caused by ischaemic stroke is critical because they work closely in a complicated relationship.In this study,we investigated peripheral blood mononuclear cells(PBMCs)transcriptomics of patients who had a stroke using a single-cell RNA sequencing to understand peripheral immune response after mild stroke based on the gene expression in an unbiased way.Methods Transcriptomes of PBMCsfrom 10 patients who had an acute ischaemic stroke within 24 hours after stroke onset were compared with 9 race-matched/age-matched/gender-matched controls.Individual PBMCs were prepared with ddSeqTM(Illumina-BioRad)and sequenced on the Illumina NovaSeq 6000 platform.Results Notable population changes were observed in patients who had a stroke,especially in NK cells and CD14+monocytes.The number of NK cells was increased,which was further confirmed by flow cytometry.Functional analysis implied that the activity of NK cells also is enhanced in patients who had a stroke.CD14+monocytes were clustered into two groups;dendritic cell-related CD14+monocytes and NK cell-related CD14+monocytes.We found CD14+monocyte subclusters were dramatically reduced in patients who had a stroke.Discussion This is the first study demonstrating the increased number of NK cells and new monocyte subclusters of mild ischaemic stroke based on the transcriptomic analysis.Our findings provide the dynamics of circulating immune response that could assist diagnosis and potential therapeutic development of mild ischaemic stroke. | Young-Eun Cho Hyangkyu Lee Heekyong R.Bae Hyungsuk Kim Sijung Yun Rany Vorn Ann Cashion Mary Jo Rucker Mariam Afzal Lawrence Latour Jessica Gill | 2022 | Stroke & Vascular Neurology2022，7，4： | 1 |
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