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| 1 | Quantum chemical studies on antimalarial of artemisinin (qinghaosu) derivatives显示文摘In this paper theoretical studies were performed on artemisinin (qinghaosu) derivatives with semiempirical quantum chemical methods AMI and PM3. The antimalarial activity -logC has an obvious correlation with the net charge of C(16) and bond orders of bonds O(1)-C(10), O(2)-C(6), O(1)-O(2) and O(5)-C(16). According to the calculation results, we derived structure-activity relationship, presented the probable pharmacophore of qinghaosu derivatives and the interaction fashion between the drugs and the plasmodium receptor. | JIANG, HL CHEN, KX TANG, Y CHEN, JZ JI, RY | 1995 | Chinese Journal of Chemistry1995，13，2： | 5 |
| 2 | 3D-QSAR STUDY ON HUPERZINE A ANALOGS WITH MOLECULAR MODELING AND COMPARATIVE MOLECULAR FIELD ANALYSIS(COMFA) METHODS显示文摘3D-QSARSTUDYONHUPERZINEAANALOGSWITHMOLECULARMODELINGANDCOMPARATIVEMOLECULARFIELDANALYSIS(COMFA)METHODS￥HuaLiangJIANG;KaiXianC... | Jiang, HL Chen, KX Chen, JZ Tang, Y Wang, QM Li, Q Shen, X Ji, RY | 1996 | Chinese Chemical Letters1996，7，3： | 2 |
| 3 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 4 | CYCLIC VOLTAMMETRY STUDY ON ANTIMALARIAL MECHANISM OF ARTEMISININ(QINGHAOSU)DERIVATIVES显示文摘CYCLICVOLTAMMETRYSTUDYONANTIMALARIALMECHANISMOFARTEMISININ(QINGHAOSU)DERIVATIVES￥HuaLiangJIANG;KaiXianCHEN;YunTANG;JianZhongC... | Jiang, HL Chen, KX Tang, Y Chen, JZ Li, Y Wang, QM Li, Q Ji, RY Zhuang, QK | 1996 | Chinese Chemical Letters1996，7，7： | 2 |
| 5 | Cavernous sinus syndrome: Clinical features and differential diagnosis with MR imaging显示文摘 | Jeong HL Ho KL Ji KP | 2003 | AJR2003，181，： | 1 |
| 6 | Regulation of immunoglobulin production in hyperimmunoglobulin E recurrent-infection syndrome by interferon γ显示文摘 | Gallin JI Malech HL | 1989 | Proc Natl Acad Sci USA1989，86，10： | 1 |
| 7 | Puerarin inhibbits tetrodotoxin-resistant sodium current in rat dorsal root ganglion neurons显示文摘 | Ji HL Wang TY | 1996 | Acta Pharmacol Sin1996，17，2： | 1 |
| 8 | Itraeonazole to prevent fungal infections in chronic granulomatous disease 显示文摘 | Gallin JI Ailing DW Malech HL | 2003 | N Engl J Med2003，348，： | 1 |
| 9 | Molecular cloning and transmembrane structure of hCLCA2 from human lung, trachea, and mammary gland 显示文摘 | Gruber AD Schreur KD Ji HL | 1999 | Am J Physiol1999，276，61： | 1 |
| 10 | A retrospective study of continu- ous renal replacement therapy versus intermittent hemodialysis in severe acute renal failure 显示文摘 | Ji DX Gong DH Xie HL | 2001 | Chin Med J2001，114，11： | 1 |
| 11 | Crush syndrome after the Wenchuan earthquake: new experience with regional citrate anticoagulation continuous veno-venous hemofiltration 显示文摘 | Xie HL Ji DX Hu WX | 2010 | Int J ArtifOrgans2010，33，2： | 1 |
| 12 | Cation selectivity and inhibition of malignant glioma Na+ channels by psalmotoxin 1显示文摘 | James KB Ji HL Gillespie GY | 2004 | Am J Physiol Cell Physiol2004，287，5： | 1 |
| 13 | Two cases of eosinophilic fasciitis显示文摘 | Ji HC Kyung HL Mi SS | 2011 | Annals of Dermatology2011，23，1： | 1 |
| 14 | Family History of cancer and risk of lung cancer among nonsmoking Chinese women显示文摘 | Zhang Y Shu XO Gao YT Ji BT Yang G Li HL Kilfoy B Rothman N Zheng W Chow WH | 2007 | Cancer Epidemiol Biomarkers Prev2007，16，： | 1 |
| 15 | Heparan sulfate proteoglycans participate in hepaticli- pase and apolipoprotein E- mediated binding and uptake of plasma lipoproteins, including high density lipoproteins显示文摘 | Dichel HL Miranda RD | 1997 | J Biol Chen1997，272，31： | 1 |
| 16 | Cation selectivity and inhibition of malignant glioma Na + channels by Psalmotoxin-1 显示文摘 | JAMES KB JI HL GILLESPIE GY | 2004 | Am J Physiol Cell Physiol2004，287，5： | 1 |
| 17 | Beta-HPV 5 and 8 E6 promote p300 degradation by blocking AKT/p300 association显示文摘 | Howie HL Koop JI Weese J | 2011 | PLoS Pathog2011，7，10： | 1 |
| 18 | δ-Subunit confers novel biophysical features to αβγ-human epithelial sodium channel (enac) via a physical interaction显示文摘 | Ji HL Su XF Kedar S | 2006 | J Biol Chem2006，281，12： | 1 |
| 19 | Degenerin sites mediate proton activation of δ-epithelial sodium channel显示文摘 | Ji HL Benos DJ | 2004 | J Biol Chem2004，279，26： | 1 |
| 20 | The role of pre-H2 domains of α-and δ-epithelial Na+ channels in ion permeation,conductance,and amiloride sensitivity显示文摘 | Ji HL Bishop LR Anderson SJ | 2004 | J Biol Chem2004，279，9： | 1 |
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