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| 1 | Postoperative adjuvant arterial chemoembolization improves survival of hepatocellular carcinoma patients with risk factors for residual tumor:A retrospective control study显示文摘AIM: To evaluate the effect of postoperative adjuvant transcatheter arterial chemoembolization (TACE) on the prognosis of hepatocellular carcinoma (HCC) patients with or without risk factors for the residual tumor. METHODS: From January 1995 to December 1998, 549 consecutive HCC patients undergoing surgical resection were included in this research. There were 185 patients who underwent surgical resection with adjuvant TACE and 364 patients who underwent surgical resection only. Tumors with a diameter more than 5 cm, multiple nodules, and vascular invasion were defined as risk factors for residual tumor and used for patient stratification. Kaplan-Meier method was used to analyze survival curve and Cox proportional hazard model was used to evaluate the prognostic significance of adjuvant TACE.RESULTS: In the patients without any risk factors for the residual tumor, the 1-, 3-, 5-year survival rates were 93.48%,75.85%, 62.39% in the control group and 97.39%, 70.37%,50.85% in the adjuvant TACE group, respectively. There was no significant difference in the survival between two groups (P = 0.3956). However, in the patients with risk factors for residual tumor, postoperative adjuvant TACE significantly prolonged the patients' survival. There was a statistically significant difference in survival between two groups (P= 0.0216). The 1-, 3-, 5-year survival rates were 69.95%, 49.86%, 37.40% in the control group and 89.67%,61.28%, 44.36% in the adjuvant TACE group, respectively. Cox proportional hazard model showed that tumor diameter and cirrhosis, but not the adjuvant TACE, were the significantly independent prognostic factors in the patients without risk factors for residual tumor. However, in the patients with risk factors for residual tumor adjuvant TACE, and also tumor diameter, AFP level, vascular invasion, were the significantly independent factors associated with the decreasing risk for patients' death from HCC. CONCLUSION: Postoperative adjuvant TACE can prolong the survival of patients with risk factors for residual tumor,but can not prolong the survival of patients without risk factors for residual tumor. | Zheng-GangRen Zhi-YingLin Jing-LinXia Sheng-LongYe Zeng-ChenMa Qing-HaiYe Lun-XiuQin Zhi-QuanWu JiaFan Zhao-YouTang | 2004 | World Journal of Gastroenterology2004，10，19： | 81 |
| 2 | Efficacy of different treatment strategies for hepatocellular carcinoma with portal vein tumor thrombosis显示文摘AIM: To evaluate the efficacy of different treatment strategies for hepatocellular carcinoma (HCC) with portal vein tumor thrombosis (PVTT) and investigate factors influencing prognosis.METHODS: One hundred and seventy-nine HCC patients with macroscopic PVTT were enrolled in this study. They were divided into four groups and underwent different treatments: conservative treatment group (n = 18),chemotherapy group (n = 53), surgical resection group (n = 24) and surgical resection with postoperative chemotherapy group (n = 84). Survival rates of the patients were analyzed by the Kaplan-Meier method. A log-rank analysis was performed to identify group differences. Cox's proportional hazards model was used to analyze variables associated with survival.RESULTS: The mean survival periods of the patients in four groups were 3.6, 7.3, 10.1, and 15.1 mo respectively.There were significant differences in the survival rates among the groups. The survival rates at 0.5-, 1-, 2-, and 3-year in surgical resection with postoperative chemotherapy group were 55.8%, 39.3%, 30.4%, and 15.6% respectively, which were significantly higher than those of other groups (P<0.001). Multivariate analysis revealed that the strategy of treatment (P<0.001) and the number of chemotherapy cycles (P = 0.012) were independent survival predictors for patients with HCC and PVTT.CONCLUSION: Surgical resection of HCC and PVTT combined with postoperative chemotherapy or chemoembolization is the most effective therapeutic strategy for the patients who can tolerate operation.Multiple chemotherapeutic courses should be given postoperatively to the patients with good hepatic function reserve. | JiaFan JianZhou Zhi-QuanWu Shuang-JianQiu Xiao-YingWang Ying-HongShi Zhao-YouTang | 2005 | World Journal of Gastroenterology2005，11，8： | 58 |
| 3 | Diagnosis and surgical treatments of hepatocellular carcinoma with tumor thrombosis in bile duct:Experience of 34 patients显示文摘AIM: Hepatocellular carcinoma (HCC) with bile duct tumor thrombosis (BDT) is a rare event. The prognosis of this type of patients is very dismal. The aim of this study was to share the experience in the diagnosis and treatment of HCC with BDT, to further improve the prognosis of these patients.METHODS: Thirty-four patients of HCC with BDT received surgical treatment in authors' institute from July 1987 to January 2003 were reviewed retrospectively. The experience in the diagnosis and treatment, and the outcome of this type of HCC patients were summarized.RESULTS: Thirty of the 34 patients (88.2%) were positive for alpha-fetoprotein (AFP) (>20 μg/L), and 12 patients (35.3%) were found having obstructive jaundice before operation, 18 cases were suspected of 'obstruction of bile duct' preoperatively. The primary tumors were frequently located at the left medial (13 cases) or right anterior lobe(14 cases). Thirty-one patients received liver resections and removal of BDT, while the other 3 patients received removal of BDT combined with hepatic artery ligation and cannulation(HAL+HAI), or only removal of BDT because their liver function reservation and general condition could not tolerate the primary tumor resection. The 1-year survival rate was 71.4%(20/28). The longest disease-free survival was over 15 years. The intrahepatic tumor recurrence within 1 year after operation was found in 14 patients (14/28, 50.0%).CONCLUSION: Surgical removal of primary tumors and BDT is safe and beneficial to the HCC patients with BDT. Early detection, diagnosis, and surgical treatment are the key points to prolong the survival time of patients. | Lun-XiuQin Zeng-ChenMa Zhi-QuanWu JiaFan Xin-DaZhou Hui-ChuanSun Qing-HaiYe LuWang Zhao-YouTang | 2004 | World Journal of Gastroenterology2004，10，10： | 27 |
| 4 | GW5-Like, a homolog of GW5, negatively regulates grain width, weight and salt resistance in rice显示文摘Grain size is an important determinant of yield potential in crops. We previously demonstrated that natural mutations in the regulatory sequences of qSW5/GW5 confer grain width diversity in rice. However, the biological function of a GW5 homolog, named GW5-Like(GW5 L), remains unknown. In this study, we report on GW5 L knockout mutants in Kitaake, a japonica cultivar(cv.)considered to have a weak gw5 variant allele that confers shorter and wider grains. GW5 L is evenly expressed in various tissues, and its protein product is localized to the plasma membrane. Biochemical assays verified that GW5 L functions in a similar fashion to GW5. It positively regulates brassinosteroid(BR) signaling through repression of the phosphorylation activity of GSK2. Genetic data show that GW5 L overexpression in either Kitaake or a GW5 knockout line, Kasaorf3(indica cv. Kasalath background), causes more slender, longer grains relative to the wild-type. We also show that GW5 L could confer salt stress resistance through an association with calmodulin protein OsCa M1-1. These findings identify GW5 L as a negative regulator of both grain size and salt stress tolerance, and provide a potential target for breeders to improve grain yield and salt stress resistance in rice. | Peng Tian Jiafan Liu Changling Mou Cuilan Shi Huan Zhang Zhichao Zhao Qibing Lin Jie Wang Jiulin Wang Xin Zhang Xiuping Guo Zhijun Cheng Shanshan Zhu Yulong Ren Cailin Lei Haiyang Wang Jianmin Wan | 2019 | Journal of Integrative Plant Biology2019，61，11： | 9 |
| 5 | Enhancing rice grain production by manipulating the naturally evolved cis-regulatory element-containing inverted repeat sequence of OsREM20显示文摘Grain number per panicle(GNP)is an important agronomic trait that contributes to rice grain yield.Despite its importance in rice breeding,the molecular mechanism underlying GNP regulation remains largely unknown.In this study,we identified a previously unrecognized regulatory gene that controls GNP in rice,Oryza sativa REPRODUCTIVE MERISTEM 20(OsREM20),which encodes a B3 domain transcription factor.Through genetic analysis and transgenic validation we found that genetic variation in the CArG box-containing inverted repeat(IR)sequence of the OsREM20 promoter alters its expression level and contributes to GNP variation among rice varieties.Furthermore,we revealed that the IR sequence regulates OsREM20 expression by affecting the direct binding of OsMADS34 to the CArG box within the IR sequence.Interestingly,the divergent pOsREM20IR and pOsREM20ΔIR alleles were found to originate from different Oryza rufipogon accessions,and were independently inherited into the japonica and indica subspecies,respectively,during domestication.Importantly,we demonstrated that IR sequence variations in the OsREM20 promoter can be utilized for germplasm improvement through either genome editing or traditional breeding.Taken together,our study characterizes novel genetic variations responsible for GNP diversity in rice,reveals the underlying molecular mechanism in the regulation of agronomically important gene expression,and provides a promising strategy for improving rice production by manipulating the cis-regulatory element-containing IR sequence. | Xiaowei Wu Yan Liang Hengbin Gao Jiyao Wang Yan Zhao Lekai Hua Yundong Yuan Ahong Wang Xiaohui Zhang Jiafan Liu Jie Zhou Xiangbing Meng Dahan Zhang Shaoyang Lin Xuehui Huang Bin Han Jiayang Li Yonghong Wang | 2021 | Molecular Plant2021，14，6： | 3 |
| 6 | NOVEL 6-DOF WEARABLE EXOSKELETON ARM WITH PNEUMATIC FORCE-FEEDBACK FOR BILATERAL TELEOPERATION显示文摘A particular emphasis is put on a novel wearable exoskeleton arm,ZJUESA,with 6 degrees of freedom,which is used for the robot teleoperation with the force-feedback in the unknown environment.In this external structure mechanism,the 3-revolution-prismatic-spherical(3RPS) parallel mechanism is devised from the concept of the human upper-limb anatomy and applied for the shoulder 3-DOF joint.Meanwhile,the orthogonal experiment design method is introduced for its optimal design.Aiming at enhancing the performance of teleoperation,the force feedback is employed by the pneumatic system on ZJUESA to produce the vivid feeling in addition to the soft control interface.Due to the compressibility and nonlinearity of the pneumatic force feedback system, a novel hybrid fuzzy controller for the precise force control is proposed and realized based on the Mega8 microcontroller units as the units of the distributed control system on ZJUESA.With the results of several experiments for master-slave control with force feedback,the feasibility of ZJUESA system and the effect of its hybrid fuzzy controller are verified. | ZHANG Jiafan FU Hailun DONG Yiming ZHANG Yu YANG Canjun CHEN Ying | 2008 | Chinese Journal of Mechanical Engineering2008，21，3： | 3 |
| 7 | Identifying interlinkages between urbanization and Sustainable Development Goals显示文摘Urbanization and Sustainable Development Goals(SDGs)are important global issues in the current“Anthropocene”.Climate change and the COVID-19 pandemic have exacerbated global urban problems and hindered the ability to meet SDGs on time,while the broad interlinkages between urbanization and the SDGs remain poorly understood.This study shows that among the interlinkages of urbanization with 17 SDGs,synergies are observed with 151 targets(89%),among which 67(40%)have stronger synergies,and trade-offs are observed with 66 targets(39%),among which 31(18%)have stronger trade-offs.Furthermore,the synergies and trade-offs between urbanization and the achievement of SDGs are specifically analyzed based on four fundamental interaction fields:(a)public health and social welfare equality;(b)energy consumption and economic growth;(c)natural resource use and ecological/environmental impacts;and(d)international cooperation for development.Finally,based on these analyses,we propose four recommendations for sustainable urbanization,including(a)shared well-being and spatial justice for urban and rural residents;(b)guiding green and low-carbon urban development;(c)building resilient cities;and(d)promoting multilateral cooperation in cities,which can contribute to the achievement of SDGs by 2030. | Mingxing Chen Liangkan Chen Jiafan Cheng Jianhui Yu | 2022 | Geography and Sustainability2022，3，4： | 2 |
| 8 | Three-dimensional contrast-enhanced MR angiography in diagnosis of portal vein involvement by hepatic tumors显示文摘AIM: To assess the accuracy of three-dimensional contrastenhanced magnetic resonance angiography (3D CE MRA) in evaluation of the portal vein involvement in patients with hepatic tumors.METHODS: 3D CE MlRA was performed in 62 patients with hepatic tumors to assess the patency of the main, right and left portal veins before hepatic surgery. A total of 186 veins were examined for encasement, occlusion and tumor thrombosis. The results of 3D CE NRA diagnosis were then correlated with the surgical-pathological and intra-operative sonographic findings.RESULTS: 3D CE MRA correctly detected 48 of 49 involved and 135 of 137 noninvolved portal veins with the sensitivity of 98 %, specificity of 99 %, positive predictive value of 96 % and negative predictive value of 99 %.CONCLUSION: 3D CE NRA is accurate in evaluation of the portal vein involvement in patients with hepatic tumors. | JiangLin Kang-RongZhou Zu-WangChen Jian-HuaWang Zhi-QuanWu JiaFan | 2003 | World Journal of Gastroenterology2003，9，5： | 2 |
| 9 | Mechatronic integration and implementation of in situ multipoint temperature measurement for seafloor hydrothermal vent显示文摘In order to provide firsthand reference data for model building and analysis of temperature field of seafloor hydrothermal vent, a temperature measurement sys- tem is designed, which can be used to measure the temperature of seafloor hydrothermal vent. The system can implement in situ multipoint temperature measurement and work for 15 days on the seafloor, so low power consumption design principle of the integrated circuit board is adopted. To enable the system to endure the high pressure on the seafloor, mechanical structure of the system is designed in terms of design principle of pressure container. The pressure test ex- periment was performed in the authoritative institution, and the results indicated that the system was safe and could work reliably on the seafloor. In the first Sino-American Joint Dive Cruise, the instruments were carried to the seafloor to work by Alvin. The experiment in the sea was successful, and the results indicated that the system could survive in the high pressure and high temperature environ- ment and record the temperature activities of hydrothermal vents. About 710000 groups of temperature data were acquired, and these are of importance for further scientific researches. | WU HuaiChao CHEN Ying YANG CanJun ZHANG JiaFan ZHOU HuaiYang PENG XiaoTong JI FuWu | 2007 | Science China(Technological Sciences)2007，50，2： | 2 |
| 10 | p38 mitogen-activated protein kinase activation is required for human neutrophil function triggered by TNF-γ or FMLP stimulation显示文摘 | Jiafan Q Annette G | 1998 | J Immunol1998，160，： | 1 |
| 11 | Numerical simulation of stochastic road process using white noise filtration 显示文摘 | Zhang Yonglin Zhang Jiafan | 2006 | Mechanical Systems and Signal Processing2006，20，2： | 1 |
| 12 | Looking at the Effects of Language Contact With Hakka as Reflected by the Characteristics of the Pingshan Zhanmi Dialect显示文摘The special Economic Zone of Shenzhen has been endowed with plentiful of language resources. Apart from various Yue dialects in the west and Hakka dialect in the east, there are also many indigenous Chinese dialects such as the Dapeng dialect (大鹏话), the Danjia dialect (疍家话) and also the Zhanmi dialect (占米话). The last one is not ever reported. Out of curiosity, we went to investigate the dialect which is spoken in isolate patches in the easternmost townships of Pingshan (坪山), Kengzi (坑梓) and Pingdi (坪地). The Pingshan Zhanmi dialect (PZD)seems to be an intermediate between Yue and Hakka dialects. According to our observation, PZD is quite similar to the Dongguan-Baoan Yue dialects (DBYD, 莞宝片粤语) in the western part of the city and has obvious correspondence with them, such as having the onset [m] in the Middle Chinese (MC) Wei (微) characters, little literal/colloquial discrepancies in the Fei Group (非组), [a/?] contrast, literal/colloquial readings in the Geng rime group all with [?/k] as codas, etc. However, because of long term contact with the surrounding Hakka dialects, PZD has also a lot of characteristics of Hakka, such as aspirated readings in all MC voiced stops and affricates onsetsafter devoicing, lack of rounded frontal vowels, no Ying-yang contrast in the Shang tone. More influences of Hakka can be found in the vocabulary, which PZD has been borrowing for centuries. | Lau Chun-Fat Zhou Jiafan | 2017 | Journal of Literature and Art Studies2017，7，2： | 1 |
| 13 | Numerical simu-lation of stochastic road process using white noise fil-tration显示文摘 | ZHANG Yonglin ZHANG Jiafan | 2006 | Mechanical Systems and Signal Process-ing2006，20，2： | 1 |
| 14 | A review of exoskeleton-type systems and their key technologies 显示文摘 | Yang Chanjun Zhang Jiafan Chen Ying | 2008 | Journal of Mechanical Engineering Science2008，222，8： | 1 |
| 15 | Exoskeleton arm with force feedback for robot bilateral teleoperation显示文摘自由(DOF ) 的 A 小说 6 度便携皮骨骼手臂, ZJUESA,基于人与机器的系统被介绍。它能在机器人被使用是的双边的电视操作有力量反馈的主人手臂。与介绍 revolute-prismatic-spherical (RPS ) 平行机制和行星的齿轮机制,它基于解剖被设计人上面手足。与这外部机械结构上的传感器,人的操作符运动被检测并且变换成奴隶机器人控制命令。另外,它上的灵魂系统由使用混合模糊控制产生力量反馈。作为结果,人的操作员可以有直接做工作的感情。 | Zhang Jiafan Yang Canjun Chen Ying | 2007 | Progress in Natural Science:Materials International2007，17，8： | 1 |
| 16 | Numerical simulation of stochastic road process using white noise filtration显示文摘 | Zhang Yonglin Zhang Jiafan | 2006 | Mechanical Systems and Signal Processing2006，20，2： | 1 |
| 17 | Numerical simulation of stochastic road process using white noise filtration 显示文摘 | Zhang Yonglin Zhang Jiafan | 2006 | Mechanical Systems and Signal Processing2006，20，2： | 1 |
| 18 | A review of exoskeleton-type systems and their key technologies显示文摘 | YANG Canjun ZHANG Jiafan CHEN Ying | 2008 | Proceedings of the Institution of Mechanical Engineers Part C: Journal of Mechanical Engineering Science2008，222，8： | 1 |
| 19 | Numerical simulation of stochastic road process using white noise filtration 显示文摘 | ZHANG Yonglin ZHANG Jiafan | 2006 | Mechanical System and Signal Processing2006，20，2： | 1 |
| 20 | Numerical simulation of stochastic road process using white noise filtration 显示文摘 | Zhang Yonglin Zhang Jiafan | 2006 | Mechanical Systems and Signal Processing2006，20，： | 1 |
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