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| 1 | Clinical analysis of 275 cases of acute drug-induced liver disease显示文摘In order to analyze the causative drugs,clinical manifestation and pathological characteristics of the patients with acute drug-induced liver disease,from January 2000 to December 2005,275 cases diagnosed as acute druginduced liver diseases according to Maria Criterion and hospitalized in Zhongshan Hospital of Fudan University were retrospectively reviewed.Each was determined by drug history,clinical symptoms and signs,laboratory tests and therapeutic effects.In 41 cases,the diagnosis was confirmed by liver biopsy.The proportion of acute drug-induced liver disease among all of the acute liver injuries was annually increased.The most common drugs which induced acute liver injuries were traditional Chinese herb medicine(23.3%,64/275 cases),antineoplastics(15.3%,42/275),hormones and other immunosuppressant agents(13.8%,38/275),antihypertensive drugs and other cardiovascular drugs(10.2%,28/275),NSAIDs(8.7%,24/275)respectively.Hepatocellular injury was the predominant type in these cases(132 cases,48%).The principal clinical manifestation included nausea(54.8%),fatigue(50.2%),jaundice(35.6%).27.9%patients were asymptomatic.Most patients were cured with good prognosis.The total effective rate was 94.2%after treatment.The clinicians should pay attention to the prevention,diagnosis and therapy of drug-induced liver disease. | LI Lei JIANG Wei WANG Jiyao | 2007 | Frontiers of Medicine2007，1，1： | 31 |
| 2 | The first observation of the atmospheric tides in the mesosphere and lower thermosphere over Hainan, China显示文摘Fuke (19.5°N, 109.1°E) meteor radar is the first radar of the low latitudes of China, which is used to detect the wind in the meso- sphere and lower thermosphere. In this paper, by using the wind data near three months (1 February-20 April, 2009), we first present the variation of the atmospheric diurnal tide, semidiurnal tide and mean wind in the height range 80-100 km over the low latitudes of China. The results from our analysis are summarized below. During spring months, there are quite strong tides in the mesopause region of Fuke. The diurnal tidal amplitude is significantly larger than the amplitude of semidiurnal tide, and the maximum amplitude (about 100 m/s) of diurnal tide appear in the meridional wind. The vertical phases of both diurnal tide and semidiurnal tide propagate downward. In addition, the observed tides are compared with the linear tide model (Global Scale Wave Model, GSWM02), and the results show that Fuke diurnal tide agrees well with the model, but there are many differences between Fuke semidiurnal tide and the results from model. | JIANG GuoYing XU JiYao SHI JianKui YANG GuoTao WANG Xiao YAN ChunXiao | 2010 | Chinese Science Bulletin2010，55，11： | 12 |
| 3 | Observations of the first meteorological rocket of the Meridian Space Weather Monitoring Project显示文摘On June 3,2010,the first meteorological rocket of the Meridian Space Weather Monitoring Project was successfully launched at the Hainan rocket launch site(19.5°N),China.This paper analyzes the vertical profiles of atmospheric temperature and wind recorded by the rocket and its supportive balloons,and investigates wind shear,gravity waves and atmospheric stability.In addition,we compare the vertical profiles of atmospheric temperature and wind with SABER/TIMED temperature measurements and the modeling results of MSIS00 and HWM07. | JIANG GuoYing XU JiYao SHI DongBo WEI Feng WANG LianZhong | 2011 | Chinese Science Bulletin2011，56，20： | 9 |
| 4 | Introduction to Chinese Meridian Project-PhaseⅡ显示文摘The Chinese Meridian Project is a ground-based space environment monitoring network,which is constructed in two steps.The first step(Phase I)of the project consists of 15 observation stations located roughly along 120°E longitude and 30°N latitude.The second step(Phase II)of the project will additionally deploy 16 stations to better cover China’s territory,and build a stereo monitoring capability to monitor the cause and effect of the space weather chain in the solar terrestrial system.Based on the existing two monitoring chains in Phase I,two more chains will be established along 100°E longitude and 40°N latitude,respectively,forming a double-cross network configuration.After the two-step construction,the whole project will run nearly 300 instruments deployed at 31 stations.Aside from standard instruments,quite a few innovative and powerful instruments will be developed,such as radioheliographs with a very wide frequency band,a 3-station incoherent scattering radar to make a 3D measurement of the ionosphere,and a helium lidar to measure atmosphere density up to an altitude of 1000 km. | WANG Chi Chen Zhiqing XU Jiyao | 2020 | 空间科学学报2020，40，5： | 7 |
| 5 | 2022 Chinese national clinical practice guideline on Helicobacter pylori eradication treatment显示文摘Background:Helicobacter pylori(H.pylori)infection is an infectious disease with a prevalence rate of up to 50%worldwide.It can cause indigestion,gastritis,peptic ulcer,and gastric cancer.H.pylori eradication treatment can effectively control disease progression and reduce the risk of the above conditions.However,the escalating trend of antibiotic resistance presents a global challenge for H.pylori eradication.We aim to provide guidance on pharmacological treatment of H.pylori infection.Methods:This clinical practice guideline is developed following the World Health Organization’s recommended process,adopting Grading of Recommendations Assessment,Development and Evaluation in assessing evidence quality,and utilizing Evidence to Decision framework to formulate clinical recommendations,minimizing bias and increasing transparency of the clinical practice guideline development process.We used the Reporting Items for practice Guidelines in HealThcare(RIGHT)statement and The Appraisal of Guidelines for Research and Evaluation Ⅱ(AGREE Ⅱ)as reporting and conduct guides to ensure the guideline’s completeness and transparency.Results:Though decreasing in developed countries,the prevalence of H.pylori remains high in developing countries,causing a major public health burden.This clinical practice guideline contains 12 recommendations concerning pharmacological treatment for H.pylori eradication.Among them,it is worth highlighting that bismuth preparations are inexpensive,safe,and effective,consequently making bismuth quadruple therapy a preferred choice for initial and rescue treatment.In empirical treatment,high-dose dual therapy is equally effective compared with bismuth quadruple therapy.Conclusions:The 12 recommendations in this clinical practice guideline are formed with consideration for stakeholders’values and preferences,resource use,feasibility,and acceptability.Recommendations are generalizable to resource limited settings with similar antibiotic resistance pattern as China,and lower middle-income countries facing comparable sociological and technical challenges.Registration:Guidelines International Network(GIN)website,https://guidelines.ebmportal.com/node/69996. | Liya Zhou Hong Lu Zhiqiang Song Bin Lyu Ye Chen Jiyao Wang Jun Xia Zhan Zhao on behalf of Helicobacter Pylori Study Group of Chinese Society of Gastroenterology | 2022 | Chinese Medical Journal2022，135，24： | 5 |
| 6 | Enhancing rice grain production by manipulating the naturally evolved cis-regulatory element-containing inverted repeat sequence of OsREM20显示文摘Grain number per panicle(GNP)is an important agronomic trait that contributes to rice grain yield.Despite its importance in rice breeding,the molecular mechanism underlying GNP regulation remains largely unknown.In this study,we identified a previously unrecognized regulatory gene that controls GNP in rice,Oryza sativa REPRODUCTIVE MERISTEM 20(OsREM20),which encodes a B3 domain transcription factor.Through genetic analysis and transgenic validation we found that genetic variation in the CArG box-containing inverted repeat(IR)sequence of the OsREM20 promoter alters its expression level and contributes to GNP variation among rice varieties.Furthermore,we revealed that the IR sequence regulates OsREM20 expression by affecting the direct binding of OsMADS34 to the CArG box within the IR sequence.Interestingly,the divergent pOsREM20IR and pOsREM20ΔIR alleles were found to originate from different Oryza rufipogon accessions,and were independently inherited into the japonica and indica subspecies,respectively,during domestication.Importantly,we demonstrated that IR sequence variations in the OsREM20 promoter can be utilized for germplasm improvement through either genome editing or traditional breeding.Taken together,our study characterizes novel genetic variations responsible for GNP diversity in rice,reveals the underlying molecular mechanism in the regulation of agronomically important gene expression,and provides a promising strategy for improving rice production by manipulating the cis-regulatory element-containing IR sequence. | Xiaowei Wu Yan Liang Hengbin Gao Jiyao Wang Yan Zhao Lekai Hua Yundong Yuan Ahong Wang Xiaohui Zhang Jiafan Liu Jie Zhou Xiangbing Meng Dahan Zhang Shaoyang Lin Xuehui Huang Bin Han Jiayang Li Yonghong Wang | 2021 | Molecular Plant2021，14，6： | 3 |
| 7 | Dental remineralization via poly(amido amine) and restorative materials containing calcium phosphate nanoparticles显示文摘Tooth decay is prevalent,and secondary caries causes restoration failures,both of which are related to demineralization.There is an urgent need to develop new therapeutic materials with remineralization functions.This article represents the first review on the cutting edge research of poly(amido amine)(PAMAM) in combination with nanoparticles of amorphous calcium phosphate (NACP).PAMAM was excellent nucleation template,and could absorb calcium (Ca) and phosphate (P) ions via its functional groups to activate remineralization.NACP composite and adhesive showed acid-neutralization and Ca and P ion release capabilities.PAMAM +NACP together showed synergistic effects and produced triple benefits: excellent nucleation templates,superior acidneutralization,and ions release.Therefore,the PAMAM+NACP strategy possessed much greater remineralization capacity than using PAMAM or NACP alone.PAMAM+NACP achieved dentin remineralization even in an acidic solution without any initial Ca and P ions.Besides,the long-term remineralization capability of PAMAM+NACP was established.After prolonged fluid challenge,the immersed PAMAM with the recharged NACP still induced effective dentin mineral regeneration.Furthermore,the hardness of predemineralized dentin was increased back to that of healthy dentin,indicating a complete remineralization.Therefore,the novel PAMAM+NACP approach is promising to provide long-term therapeutic effects including tooth remineralization,hardness increase,and caries-inhibition capabilities. | Kunneng Liang Suping Wang Siying Tao Shimeng Xiao Han Zhou Ping Wang Lei Cheng Xuedong Zhou Michael D.Weir Thomas W.Oates Jiyao Li Hockin H.K.Xu | 2019 | International Journal of Oral Science2019，11，3： | 3 |
| 8 | Lidar observation campaigns on diurnal variations of the sodium layer in Beijing and Wuhan, China显示文摘Based on observations from daytime lidars in eastern China,diurnal cycles of the sodium layer over Wuhan(30.5°N,114.6°E)and Beijing(40.5°N,116°E)are investigated.Diurnal variations of Na density,root mean square(RMS)layer width,and centroid height of the sodium layer are analyzed.Results reveal that the large diurnal cycles of the sodium layer are controlled mainly by 24-hr oscillations at the two observation sites.The diurnal variation of the sodium layer over Wuhan was modulated mainly by tidal perturbations during the lidar observation campaign.Conversely,the diurnal variation over Beijing was controlled principally by photoionization and photochemistry effects during another campaign,and there was little evidence of direct tidal perturbations.These comparisons suggest that the diurnal variation of the sodium layer perhaps has obvious regional characteristics across China.The variation can be either controlled mainly by tidal perturbations or by photoionization and photochemistry effects in different seasons. | GONG ShaoHua YANG GuoTao CHENG XueWu GONG Shun Sheng XU JiYao LI FaQuan GONG Wei WANG JiHong | 2015 | Science China Earth Sciences2015，58，8： | 2 |
| 9 | Young Yum pill inhibits inflammatory mediators and nuclear factor-kappa B signaling in lipopolysaccharide-stimulated RAW 264.7 macrophages显示文摘OBJECTIVE: To investigate the effect of Young Yum pill (YYP) on inflammatory mediators in cultured RAW 264.7 cells and elucidate the nuclear factor- kappa B (NF-κB)-related mechanism behind the action. METHODS: YYP was extracted with 95% ethanol Lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages were used to evaluate the effect of YYP on inflammatory mediators. Production of nitric oxide (NO) and prostaglandin E2 (PGE2) were measured by Griess test and enzyme-linked immunosorbent assay, respectively. The levels of genes and proteins involved in the generation of inflammatory mediators were examined using real-time polymerase chain reaction and Western blotting, respectively. RESULTS: YYP dose-dependently suppressed LPS-induced production of NO, PGE2 and tumor necrosis factor-α(TNF-α), and elevation of mRNA and protein levels of inducible NO synthase and cyclooxygenase- 2 in RAW 264.7 macrophages. These observations were associated with decreased NF-κB p65 phosphorylation and nuclear localization, enhanced Akt (protein kinase B) phosphorylation, as well as reduced inhibitor of κB (IκB)α degradation and IκB kinase α/β phosphorylation. CONCLUSION: The present study demonstrated an inhibitory effect of YYP on the NF-κB-regulated inflammatory mediators NO, PGE2 and TNF-α in LPS-stimulated RAW 264.7 macrophages, providing a pharmacological basis for the use of YYP in treating inflammatory disorders. | Yin Chengle Muhammad Jahangir Hossen Anfernee Kai-Wing Tse Su Tao Fu Xiuqiong Li Ting Guo Hui Zhu Peili Li Junkui Chou Jiyao Wang Yaping Yu Zhiling | 2019 | Journal of Traditional Chinese Medicine2019，39，5： | 2 |
| 10 | Transcriptome dynamics of hippocampal neurogenesis in macaques across the lifespan and aged humans显示文摘Whether adult hippocampal neurogenesis(AHN)persists in adult and aged humans continues to be extensively debated.A major question is whether the markers identified in rodents are reliable enough to reveal new neurons and the neurogenic trajectory in primates.Here,to provide a better understanding of AHN in primates and to reveal more novel markers for distinct cell types,droplet-based single-nucleus RNA sequencing(snRNA-seq)is used to investigate the cellular heterogeneity and molecular characteristics of the hippocampi in macaques across the lifespan and in aged humans.All of the major cell types in the hippocampus and their expression profiles were identified.The dynamics of the neurogenic lineage was revealed and the diversity of astrocytes and microglia was delineated.In the neurogenic lineage,the regulatory continuum from adult neural stem cells(NSCs)to immature and mature granule cells was investigated.A group of primate-specific markers were identified.We validated ETNPPL as a primate-specific NSC marker and verified STMN1 and STMN2 as immature neuron markers in primates.Furthermore,we illustrate a cluster of active astrocytes and microglia exhibiting proinflammatory responses in aged samples.The interaction analysis and the comparative investigation on published datasets and ours imply that astrocytes provide signals inducing the proliferation,quiescence and inflammation of adult NSCs at different stages and that the proinflammatory status of astrocytes probably contributes to the decrease and variability of AHN in adults and elderly individuals. | Wei Wang Mengdi Wang Meng Yang Bo Zeng Wenying Qiu Qiang Ma Xiaoxi Jing Qianqian Zhang Bosong Wang Chonghai Yin Jiyao Zhang Yuxin Ge Yufeng Lu Weizhi Ji Qian Wu Chao Ma Xiaoqun Wang | 2022 | Cell Research2022，32，8： | 2 |
| 11 | TEST METHOD FOR SINGLE INTERIOR RIGHT ANGLE IN A CORNER CUBE PRISM显示文摘A new test method for single interior right angle in a corner cube prism is presented. Some key points and parameters are analyzed and derived. The advantage of this method is concluded by comparing with some current conventional methods. | Weng Xingtao He Ping'an Li Song Wang Jiyao | 2000 | Geo-Spatial Information Science2000，3，3： | 1 |
| 12 | Statistical characteristics of atmospheric gravity wave in the mesopause region observed with a sodium lidar at Beijing, China显示文摘 | Shaohua Gong Guotao Yang Jiyao Xu Jihong Wang Sai Guan Wei Gong Jun Fu | 2013 | Journal of Atmospheric and Solar-Terrestrial Physics2013，，： | 1 |
| 13 | Characteristics and mechanisms of the annual asymmetry of thermospheric mass density显示文摘在这份报纸,全球性平均, thermospheric 总数团密度,在从 1967 ~ 2006 被追踪的 250, 400,和 550 km 源于 5000 个目标的轨道,习惯于份量上学习 thermospheric 质量的年度不对称现象密度和它的机制。结果证明那 thermospheric 团密度有重要年度不对称现象,它从年改变了到年。在三高度的年度不对称现象同时地变化了,它的绝对值与高度增加了。结果建议在被差别在一年以内在在二至和太阳的活动的随机的变化之间的太阳地球远处引起的太阳的 EUV 放射有年度不对称现象。在在在 thermospheric 温度并且这样的一个年度变化的放射结果的这个变化中立气体的规模高度,并且是 thermospheric 质量的年度不对称现象的主要原因密度。因为变化的积累的效果,集体密度的年度不对称现象在垂直方向在中立温度和规模高度与高度增加。 | MA RuiPing XU JiYao WANG WenBin CHEN GuangMing YUAN Wei LEI JiuHou Alan G BURNS JIANG GuoYing | 2015 | Science China Earth Sciences2015，58，4： | 1 |
| 14 | Quantum dots for tracking cellular transport of lectin-functionalized nanoparticles显示文摘 | Xiaoling Gao Tao Wang Bingxian Wu Jun Chen Jiyao Chen Yang Yue Ning Dai Hongzhuan Chen Xinguo Jiang | 2008 | Biochemical and Biophysical Research Communications2008，，1： | 1 |
| 15 | The Experts Consensus for Patient Management of Neurosurgical Critical Care Unit in China (2015)显示文摘 | Zhao, Ji-Zong Zhou, Ding-Biao Zhou, Liang-Fu Wang, Ren-Zhi Zhang, Jian-Ning Wang, Shuo Li, Xin-Gang Hua-Feng Liu, Jian Jiang, Jiyao Zhang, Sai Zhang, Jun-Ting Zhang, Jian-Min Hou, Lijun Hong, Tao Yuan, Xian-Rui Gao, Guo-Dong Kang, De-Zhi You, Chao Bao, Shengde Qi, Song-Tao Zhao, Shi-Guang Zhao, Yuan-Li Hu, Jin Cui, Li-ying Peng, Bin Liu, Da-Wei Guo, Shu-Bin Lin, Yuan-Xiang Sun, Shi-Zhong Gao, Liang Jiang, Rong-Cai Shi, Guang-Zhi Chai, Wen-Zhao Wang, Ning Zhao, Yuan-Li Wei, Jun-Ji | 2015 | Chinese Medical Journal2015，，9： | 1 |
| 16 | Characteristics of low altitude ionospheric electric field over Hainan Island,China显示文摘A sounding rocket experiment undertaken by the Chinese Meridian Project from a low latitude station on Hainan Island(19.5°N,109.1°E),China,measured the DC electric field during 05:45-05:52 LT on April 5,2013.The data observed using a set of electric field double probes,as part of the rocket's scientific payload,revealed the special profile of how the vectors of the DC electric field vary with altitude between 130 and 190 km.During the experiment,the vertical electric field was downward,and the maximum vertical electric field was nearly 5.1 mV/m near the altitude of 176 km.The zonal electric field was eastward and slightly less than 0.6 mV/m.The plasma drift velocity was estimated from the E×B motion,and the zonal drift velocity was eastward and of the order of 100 m/s.The zonal wind velocity was also estimated using the drift velocity near the maximum density height in the F1-region,and it was found to be nearly 120 m/s.This work constituted the first in situ measurement of the DC electric field conducted within the Fl-region(between 130 and 190 km) in the East Asian Sector. | LI RenKang CHEN Tao MAN Feng JIANG XiuJie LUO Jing HE ZhaoHai ZHANG HuiMing WANG LinFeng LIU Cheng Francisco Carlos de MENESES WANG GuoJun XU JiYao | 2017 | Science China Earth Sciences2017，60，4： | 1 |
| 17 | Mechanism of triethanolamine on Portland cement hydration process and microstructure characteristics 显示文摘 | Han Jianguo Wang Kejin Jiyao Shi | 2015 | Construction and Building Materials2015，9，15： | 1 |
| 18 | Evidence-based medicine in China显示文摘 | Jiyao Wang | 2010 | The Lancet2010，，9714： | 1 |
| 19 | Construction Progress of Chinese Meridian Project PhaseⅡ显示文摘The Chinese Meridian Project(CMP)is the Space Environment Ground Based Comprehensive Monitoring Network of China,a national major science and technology infrastructure project.The CMP consists of the Space Environment Monitoring System,Data Communication System,and Science Application System.Its construction has been divided into two steps:the PhaseⅠwas from 2008 to 2012;the PhaseⅡstarted at the end of 2019,expected to be completed at the end of 2023.Beyond 2023,the CMP as a whole will be in operation to make observations.This report introduces the construction progress of CMP PhaseⅡin the past two years,covering the construction progress of both the Data Communication System and the Science Application System.As for the Space Environment Monitoring System,this report mainly gives an introduction to the construction progress of large-scale advanced monitoring equipment,such as,the solar radio telescope,interplanetary scintillation telescope,incoherent scatter radar,high frequency radar,MST radar,and large-aperture Helium Lidar.In addition,this paper presents the construction plan for the next two years and the future outlook as well. | WANG Chi XU Jiyao LÜDaren YUE Xinan XUE Xianghui CHEN Gang YAN Jingye YAN Yihua LAN Ailan WANG Jiangyan WANG Xin TIAN Yufang | 2022 | 空间科学学报2022，42，4： | 1 |
| 20 | Effcts of potenlini and IFNα on mRNA expression of procollagen typeⅠ,Ⅲ and collagenase in liver injury and hepetic fibrosis model 显示文摘 | Guo Jinsheng Wang Jiyao Liu Weitian | 1997 | Gut1997，41，4： | 1 |
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