| 1 | Tropoelastin improves adhesion and migration of intra-articular injected infrapatellar fat pad MSCs and reduces osteoarthritis progression显示文摘Intra-articular injection of mesenchymal stem cells(MSCs)is a promising strategy for osteoarthritis(OA)treatment.However,more and more studies reveal that the injected MSCs have poor adhesion,migration,and survival in the joint cavity.A recent study shows that tropoelastin(TE)regulates adhesion,proliferation and phenotypic maintenance of MSCs as a soluble additive,indicating that TE could promote MSCs-homing in regenerative medicine.In this study,we used TE as injection medium,and compared it with classic media in MSCs intra-articular injection such as normal saline(NS),hyaluronic acid(HA),and platelet-rich plasma(PRP).We found that TE could effectively improve adhesion,migration,chondrogenic differentiation of infrapatellar fat pad MSCs(IPFP-MSCs)and enhance matrix synthesis of osteoarthritic chondrocytes(OACs)in indirect-coculture system.Moreover,TE could significantly enhance IPFP-MSCs adhesion via activation of integrin β1,ERK1/2 and vinculin(VCL)in vitro.In addition,intra-articular injection of TE-IPFP MSCs suspension resulted in a short-term increase in survival rate of IPFP-MSCs and better histology scores of rat joint tissues.Inhibition of integrin β1 or ERK1/2 attenuated the protective effect of TE-IPFP MSCs suspension in vivo.In conclusion,TE promotes performance of IPFP-MSCs and protects knee cartilage from damage in OA through enhancement of cell adhesion and activation of integrin β1/ERK/VCL pathway.Our findings may provide new insights in MSCs intra-articular injection for OA treatment. | Junjun Yang Xin Wang Yahan Fan Xiongbo Song Jiangyi Wu Zhenlan Fu Tao Li Yang Huang ZheXiong Tang Shuo Meng Na Liu Jiajia Chen Pingju Liu Liu Yang Xiaoyuan Gong Cheng Chen | 2022 | Bioactive Materials2022，7，4： | 4 |
| 2 | 基于贝叶斯网络信任构建来缓解MANET网络安全威胁显示文摘由于移动Ad hoc(MANET)网络具有无固定基础设施、通信信道不可靠、节点随机移动等特性,对其安全问题的研究一直富有挑战性。信任机制结合加密技术可以有效缓解各类网络攻击(例如丢包攻击)。考虑到MANET网络的特性,需采取智能化方法来实现信任构建,进而发现攻击者的恶意行为。文章侧重缓解丢包攻击与数据包篡改攻击威胁,提出了一种基于贝叶斯网络的可信度评估构建机制,该机制可有效进行因果推理。文章提出的信任模型可有效区别导致网络丢包的不同原因:是由于网络信道不可靠,还是由于遭受恶意攻击。这样,即可计算出更精确的可信度。最后,仿真结果表明文章所提算法在恶劣网络环境中可行且有效。 | Zhexiong Wei Helen Tang F.Richard Yu Peter Mason 李笑 张春磊 | 2015 | 通信对抗2015，34，3： | 0 |
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