|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Highly fractionated granites:Recognition and research显示文摘Granite is one of the most important components of the continental crust on our Earth; it thus has been an enduring studied subject in geology. According to present knowledge, granite shows a great deal of heterogeneity in terms of its texture,structure, mineral species and geochemical compositions at different scales from small dike to large batholith. However, the reasons for these variations are not well understood although numerous interpretations have been proposed. The key point of this debate is whether granitic magma can be effectively differentiated through fractional crystallization, and, if so, what kind of crystallization occurred during the magmatic evolution. Although granitic magma has high viscosity because of its elevated SiO2 content, we agree that fractional crystallization is effectively processed during its evolution based on the evidence from field investigation,mineral species and its chemical variations, and geochemical compositions. These data indicate that crystal settling by gravitation is not the only mechanism dominating granitic differentiation. On the contrary, flow segregation or dynamic sorting may be more important. Accordingly, granite can be divided into unfractionated, fractionated(including weakly fractionated and highly fractionated) and cumulated types, according to the differentiation degree. Highly fractionated granitic magmas are generally high in primary temperature or high with various volatiles during the later stage, which make the fractional crystallization much easier than the common granitic melts. In addition, effective magmatic differentiation can be also expected when the magma emplaced along a large scale of extensional structure. Highly fractionated granitic magma is easily contaminated by country rocks due to its relatively prolonged crystallization time. Thus, granites do not always reflect the characteristics of the source areas and the physical and chemical conditions of the primary magma. We proposed that highly fractionated granites are an important sign indicating compositional maturity of the continental crust, and they are also closely related to the rare-elemental(metal) mineralization of W,Sn, Nb, Ta, Li, Be, Rb, Cs, REEs, etc. | WU FuYuan LIU XiaoChi JI WeiQiang WANG JiaMin YANG Lei | 2017 | Science China Earth Sciences2017，60，7： | 109 |
| 2 | Targeting slug-mediated non-canonical activation of c-Met to overcome chemo-resistance in metastatic ovarian cancer cells显示文摘Metastasis-associated drug resistance accounts for high mortality in ovarian cancer and remains to be a major barrier for effective treatment. In this study, SKOV3/T4, a metastatic subpopulation of ovarian cancer SKOV3 cells, was enriched to explore potential interventions against metastaticassociated drug resistance. Quantitative genomic and functional analyses were performed and found that slug was significantly increased in the SKOV3/T4 subpopulation and contributed to the high resistance of SKOV3/T4. Further studies showed that slug activated c-Met in a ligand-independent manner due to elevated levels of fibronectin and provoked integrin α V function, which was confirmed by the significant correlation of slug and p-Met levels in 121 ovarian cancer patient samples. Intriguingly,c-Met inhibitor(s) exhibited greatly enhanced anti-cancer effects in slug-positive ovarian cancer models both in vitro and in vivo. Additionally, IHC analyses revealed that slug levels were highly correlated with reduced survival of ovarian cancer patients. Taken together, this study not only uncovers the critical roles of slug in drug resistance in ovarian cancer but also highlights a promising therapeutic strategy by targeting the noncanonical activation of c-Met in slug-positive ovarian cancer patients with poor prognosis. | Linlin Chang Yan Hu Yingying Fu Tianyi Zhou Jun You Jiamin Du Lin Zheng Ji Cao Meidan Ying Xiaoyang Dai Dan Su Qiaojun He Hong Zhu Bo Yang | 2019 | Acta Pharmaceutica Sinica B2019，9，3： | 3 |
| 3 | The application of proton spectrometers at the SG-III facility for ICF implosion areal density diagnostics显示文摘Charged particle diagnostics is one of the required techniques for implosion areal density diagnostics at the SG-III facility.Several proton spectrometers are under development, and some preliminary areal density diagnostics have been carried out. The response of the key detector, CR39, to charged particles was investigated in detail. A new track profile simulation code based on a semi-empirical model was developed. The energy response of the CR39 detector was calibrated with the accelerator protons and alphas from a241 Am source. A proton spectrometer based on the filtered CR39 detector was developed, and D–D primary proton measurements were implemented. A step range filter spectrometer was developed,and preliminary areal density diagnostics was carried out. A wedged range filter spectrometer array made of Si with a higher resolution was designed and developed at the SG-III facility. A particle response simulation code by the Monte Carlo method and a spectra unfolding code were developed. The capability was evaluated in detail by simulations. | Xing Zhang Jianhua Zheng Ji Yan Zhenghua Yang Ming Su Yudong Pu Pin Yang Xufei Xie Li Chen Ming Chen Tianxuan Huang Shao'en Jiang Shenye Liu Jiamin Yang | 2015 | High Power Laser Science and Engineering2015，3，4： | 1 |
| 4 | The crosstalk between ferroptosis and anti-tumor immunity in the tumor microenvironment:molecular mechanisms and therapeutic controversy显示文摘The advent of immunotherapy has significantly reshaped the landscape of cancer treatment,greatly enhancing therapeutic outcomes for multiple types of cancer.However,only a small subset of individuals respond to it,underscoring the urgent need for new methods to improve its response rate.Ferroptosis,a recently discovered form of programmed cell death,has emerged as a promising approach for anti-tumor therapy,with targeting ferroptosis to kill tumors seen as a potentially effective strategy.Numerous studies suggest that inducing ferroptosis can synergistically enhance the effects of immunotherapy,paving the way for a promising combined treatment method in the future.Nevertheless,recent research has raised concerns about the potential negative impacts on anti-tumor immunity as a consequence of inducing ferroptosis,leading to conflicting views within the scientific community about the interplay between ferroptosis and anti-tumor immunity,thereby underscoring the necessity of a comprehensive review of the existing literature on this relationship.Previous reviews on ferroptosis have touched on related content,many focusing primarily on the promoting role of ferroptosis on anti-tumor immunity while overlooking recent evidence on the inhibitory effects of ferroptosis on immunity.Others have concentrated solely on discussing related content either from the perspective of cancer cells and ferroptosis or from immune cells and ferroptosis.Given that both cancer cells and immune cells exist in the tumor microenvironment,a one-sided discussion cannot comprehensively summarize this topic.Therefore,from the perspectives of both tumor cells and tumor-infiltrating immune cells,we systematically summarize the current conflicting views on the interplay between ferroptosis and anti-tumor immunity,intending to provide potential explanations and identify the work needed to establish a translational basis for combined ferroptosis-targeted therapy and immunotherapy in treating tumors. | Yichen Zheng Lingqi Sun Jiamin Guo Ji Ma | 2023 | Cancer Communications2023，43，10： | 1 |
| 5 | Genetic Diversity and Differentiation of Aquilaria sinensis (Lour.) Gilg Revealed by ISSR and SRAP Markers显示文摘 | Zou Meiling Xia Zhiqiang Lu Cheng Wang Haiyan Ji Jiamin Wang Wenquan | 2012 | EN2012，，5： | 1 |
| 6 | Enhanced Production of Natural Carotenoids from Genetically Engineered Rhodobacter sphaeroides Overexpressing CrtA显示文摘Carotenoids act as precursors of vitamin A,antioxidants,enhancers of immunity,and are thus widely used in food and pharmaceutical industry.Microbial fermentation is one of the most important solutions for production of natural carotenoids.Rhodobacter sphaeroides is one of most promising bacteria employed for large scale production of carotenoids.In the present study,crtA located in the carotenoids biosynthesis pathway in R.sphaeroides was amplified by PCR.The overexpression vector pRKcrtA was constructed and subsequently transferred into R.sphaeroides,producing the genetically engineered strain R.sphaeroides 2.4.1/pRKcrtA overexpressing crtA.The carotenoid production from the genetically engineered strain was significantly increased.Fermentation procedure was optimized for further enhanced carotenoids production. | Zhiping ZHAO Jiahui DU Hongfan CHEN Lili JI Jiamin ZHANG Wei WANG | 2020 | Agricultural Biotechnology2020，9，2： | 1 |
| 7 | Mycotoxins in Chinese Traditional Cured Meats: A Review显示文摘Chinese cured meats are popular in the world,which are not only meat products but also cultures in China.Fungi can grow on the surface of the traditional cured meats easily during the processing and storage.Some fungi contribute to the specific flavors,color and sensory characteristics of cured meats,while others produce mycotoxins like aflatoxins,ochratoxins,and deoxynivalenol,which will lead to cancer.Although the mycotoxins limits in food have been published by national standard in China,the limits in cured meats are still in blank.Therefore,it is reasonable to identify and reduce the mycotoxins in Chinese cured meats and meat products.This review analyzed the causes of mycotoxins,identification and control methods for Chinese cured meats. | Lili JI Dan HE Benting HUANG Rui WANG Ting BAI Jiamin ZHANG Lin CHEN Wei WANG | 2020 | Agricultural Biotechnology2020，9，2： | 1 |
| 8 | Endogenous peroxynitrite activated fluorescent probe for revealing anti-tuberculosis drug induced hepatotoxicity显示文摘Py^(+)razinamide (PZA), isoniazid (INH) and rifampicin (RFP) are all commonly used anti-tuberculosis drugs in clinical practice, and long-term medication may cause severe liver damage and toxicity. The level of peroxynitrite (ONOO^(-)) generated in liver has long been regarded as a biomarker for the prediction and measurement of drug-induced liver injury (DILI). In this article, we constructed a BODIPY-based fluorescent probe (BDP-Py^(+)) that enabled quickly and sensitively detect and image ONOO^(-) in vivo. Utilizing this probe, we demonstrated the change of ONOO^(-) content in cells and mice model of DILI induced by acetaminophen (APAP), and for the first time revealed the mechanism of liver injury induced by antituberculosis drug PZA. Moreover, BDP-Py^(+) could be applied to screen out and evaluate the hepatotoxicity of different anti-tuberculosis drugs. Comparing with the existing serum enzymes detection and H&E staining, the probe could achieve early diagnosis of DILI before solid lesions in liver via monitoring the up-regulation of ONOO^(-) levels. Collectively, this work will promote the understanding of the pathogenesis of anti-tuberculosis drug induced liver injury (ATB-DILI), and provide a powerful tool for the early diagnosis and treatment of DILI. | Nannan Wang Han Wang Jian Zhang Xin Ji Huihui Su Jinying Liu Jiamin Wang Weili Zhao | 2022 | Chinese Chemical Letters2022，33，3： | 1 |
| 9 | Dynamic modeling of tectonic carbon processes:State of the art and conceptual workflow显示文摘Plate tectonics plays a critical role in modulating atmospheric CO_(2)concentration on the geological timescale(≥106year).A growing consensus on tectonic and Earth’s CO_(2)history in the Cenozoic and deeper time provides solid restrictions and standards for testing tectonic carbon processes against global measurements.Despite this,modeling the causal relationship between tectonic events and atmospheric CO_(2)levels remains a challenge.We examine the current state of the global tectonic CO_(2)research and suggest a conceptual workflow for numerical experiments that integrates plate tectonics and deep carbon dynamics.Future tectonic carbon cycle modeling should include at least four modules:(1)simulation of carbon-carrying processes,such as carbon ingassing and outgassing at the scale of minerals;(2)calculation of CO_(2)fluxes in tectonic settings like subduction,mantle plume,and plate rifting;(3)reconstruction of carbon cycling within the plates-scale tectonic scenario,particularly involving the processes of supercontinent convergence and dispersion;and(4)comparison with atmospheric CO_(2)history data and iterations,aiming to find the coincidental link between different tectonic carbon fluxes and climate changes.According to our analysis,the recent advancements in each of the four modules have paved the path for a more general assembly.We envision that the large variety of carbon transportation parameters across more than ten orders of magnitude in both time and space is the primary technical hurdle in simulating tectonic carbon dynamics.We propose a boundary-condition-connected approach for simulating the global carbon cycle to realize carbon exchange between the solid earth and surface spheres. | Liang ZHAO Zhengtang GUO Huaiyu YUAN Xinxin WANG Hao SHEN Jianfeng YANG Baolu SUN Ning TAN Hui ZHANG Yonggang LIU Yang LI Jiamin WANG Weiqiang JI Rixiang ZHU | 2023 | Science China Earth Sciences2023，66，3： | 1 |
| 10 | Teaching Reform and Practice of Animal Products Processing under the Background of Intelligent Agriculture显示文摘Effective food professional personnel training strategies are explored and implemented,and interdisciplinary talents of food science and engineering in accordance with the background of intelligent agriculture are cultivated from the aspects of construction of teaching staff,reform of teaching content,upgrading of teaching model,construction of industry-education integration platform,which is of great significance to the modernization development of Chinese animal products processing industry. | Zhoulin WU Wei WANG Lili JI Bo HOU Ting BAI Jiamin ZHANG | 2022 | Asian Agricultural Research2022，14，11： | 0 |
| 11 | A modular hierarchical array camera显示文摘Array cameras removed the optical limitations of a single camera and paved the way for high-performance imaging via the combination of micro-cameras and computation to fuse multiple aperture images.However,existing solutions use dense arrays of cameras that require laborious calibration and lack flexibility and practicality.Inspired by the cognition function principle of the human brain,we develop an unstructured array camera system that adopts a hierarchical modular design with multiscale hybrid cameras composing different modules.Intelligent computations are designed to collaboratively operate along both intra-and intermodule pathways.This system can adaptively allocate imagery resources to dramatically reduce the hardware cost and possesses unprecedented flexibility,robustness,and versatility.Large scenes of real-world data were acquired to perform human-centric studies for the assessment of human behaviours at the individual level and crowd behaviours at the population level requiring highresolution long-term monitoring of dynamic wide-area scenes. | Xiaoyun Yuan Mengqi Ji Jiamin Wu David JBrady Qionghai Dai Lu Fang | 2021 | Light(Science & Applications)2021，10，4： | 0 |
| 12 | Analysis of Food Safety Supervision and Spot-Check in Sichuan Province in 2019显示文摘Through the analysis on 211614 batches of samples from 35 categories of food safety supervision and inspection in Sichuan Province by Administration for Market Regulation of Sichuan Province in 2019,four suggestions were finally put forward.The analysis results showed that in 2019,the overall trend of food safety in Sichuan Province was stable and improved.A total of 30 categories of unqualified samples were detected,and a total of 12135 batches of unqualified samples were detected,with an average sample unqualified rate of 5.73%.Among them,the main problems of unqualified samples were as follows:the use of food additives beyond the scope and limit,accounting for 40.17%of the total number of unqualified samples,microbial contamination in food,accounting for 23.61%of the total unqualified samples,the residue index of agricultural and veterinary drugs in food not meeting the standard,accounting for 15.61%of the total unqualified samples,the quality index in food not meeting the standard,accounting for 8.51%of the total number of unqualified samples,and heavy metals and other pollutants in food exceeding the standard,accounting for 7.10%of the total unqualified samples. | Pengyu CHEN Wei WANG Xueli WU Lili JI Jiamin ZHANG Zhipin ZHAO Rui ZHANG Ting BAI Bo HOU Yixi YANG Lin CHEN | 2022 | Agricultural Biotechnology2022，11，2： | 0 |
| 13 | Characteristics and health risks of population exposure to phthalates via the use of face towels显示文摘The production of face towels is growing at an annual rate of about 4%in China,reaching 1.13 million tons by 2021.Phthalates(PAEs)are widely used in textiles,and face towels,as an important household textile,may expose people to PAEs via the skin,further leading to health risks.We collected new face towels and analyzed the distribution characterization of PAEs in them.The changes of PAEs were explored in a face towel use experiment and a simulated laundry experiment.Based on the use of face towels by 24 volunteers,we calculated the estimated daily intake(EDI)and comprehensively assessed the hazard quotient(HQ),hazard index(HI),and dermal cancer risk(DCR)of PAEs exposure in the population.PAEs were present in new face towels at total concentrations of | Wenhui Zhang Na Zheng Sujing Wang Siyu Sun Qirui An Xiaoqian Li Zimeng Li Yining Ji Yunyang Li Jiamin Pan | 2023 | Journal of Environmental Sciences2023，，8： | 0 |
| 14 | Suggestions on Curriculum Reform of Food Major in the Context of Educational Reform显示文摘The food major is an application-oriented major that involves a wide range of professional knowledge and disciplines,and provides applied talents with food production,inspection,and sales skills to the society.With the rapid development of society,the demand of social employers for talents also shows a diversified trend.For the cultivation of food professionals in the new era,it is necessary to improve their innovative spirit and practical ability,in order to adapt to the diverse development needs of society.Under the background of education reform,this paper briefly analyzed the teaching strategies of food major,and put forward specific reform suggestions,hoping to promote education reform to effectively promote the sustainable development of food major,and effectively improve the quality of education. | Jie CHENG Ruiqi CAO Lili JI Bo HOU Dayu LIU Jiamin ZHANG | 2023 | Agricultural Biotechnology2023，12，2： | 0 |
| 15 | Effects of Heat Treatment on Processing Characteristics of Pork显示文摘[Objectives]This study was conducted to explore the effects of heat treatment on processing characteristics of pork.[Methods]The effects of low-temperature long-term cooking(LTLT),high-temperature vacuum cooking,high-temperature cooking and high-temperature steaming on some indexes of pork products were studied,and principal component analysis was carried out.[Results]LTLT had significant effects on the total sensory score,moisture content,cooking loss rate,a value,shear force,and TBARS of pork,and the corresponding optimal product indicators were 71.40 points,72.36%,14.20%,4.79,7089.87 g,and 0.05 mg/kg,respectively.The microstructure changes in the LTLT group were relatively small,as the muscle fiber structure was relatively dense and uniform,and the gaps between muscle fibers were small.A total of 30 volatile flavor compounds were detected in the four groups,mainly alcohols,alkenes,alkanes,lipids,ketones,and aldehydes,and the LTLT group had more types and high contents.PCA analysis showed that the sensory evaluation,moisture content,elasticity,a value and LTLT were positively correlated with principal component 1.[Conclusions]Various indexes comprehensively showed that the LTLT group had better meat color,flavor,texture characteristics and lower oxidation degree than traditional cooking and steaming methods,which provides a theoretical reference for its large-scale application in the processing of prepared meat products. | Ting BAI Li TANG Lei WANG Ying ZHANG Bowen ZAN Wei WANG Lili JI Jiamin ZHANG | 2023 | Agricultural Biotechnology2023，12，5： | 0 |
| 16 | Outdoor Feeding Without Antibiotics,a Better Pattern for the Liver Health of Gushi Chicken显示文摘A 180 d feeding trial was conducted to evaluate the effect of different feeding modes on liver of Gushi chicken.The chickens from 1-day-old were fed in the warm house for 30 d,and then divided into four groups by different feeding modes(O-noant,outdoor without antibiotics;O-ant,outdoor with antibiotics;D-noant,indoor without antibiotics;D-ant,indoor with antibiotics),respectively,to evaluate the effect on liver.The results showed that different feeding modes significantly influenced the growth,liver weight,subcutaneous fat thickness,liver fat and liver free amino acid contents.The outdoor feeding without antibiotic reflected remarkably(P﹤0.05)low liver weight and fat content with normal morphology.While,other groups showed different levels of fat metabolism disorder in the liver.Based on chicken liver healthy,the outdoor feeding without antibiotic was the optimal feeding mode for Gushi chicken. | Lili JI Wei WANG Lin CHEN Bo HOU Jiamin ZHANG Ting BAI | 2020 | Agricultural Biotechnology2020，9，4： | 0 |
| 17 | Sulfate Binding with a Tripodal Tris(4-pyridylurea) Receptor显示文摘tris (2-aminoethyl ) 胺(tren ) 基于 tris (4-pyridylurea ) 受体 L 被综合了,它的阴离子绑定性质被学习。ligand 形式有 MgSO4 的 2:1 (主人 / 客人) 建筑群,[SO42L2 ] ,在哪个一个硫酸盐离子被六个脲组通过多重氢契约从二 ligands 包含。金属离子不协调到 pyridyl 组,但是作为水合物存在[Mg (H2O ) 6 ]2+ 并且交往与[SO4L2 ] 在到形式的外部协作范围的囊三维的扩大结构。在解决方案的 ligand L 的阴离子绑定行为被学习。 | Rui Zhang Yanlei Zhang Jiamin Wang Liguo Ji Xiaojuan Huang Biao Wu | 2013 | Chinese Journal of Chemistry2013，31，5： | 0 |
| 18 | Npac Is A Co-factor of Histone H3K36me3 and Regulates Transcriptional Elongation in Mouse Embryonic Stem Cells显示文摘Chromatin modification contributes to pluripotency maintenance in embryonic stem cells(ESCs).However,the related mechanisms remain obscure.Here,we show that Npac,a'reader'of histone H3 lysine 36 trimethylation(H3K36me3),is required to maintain mouse ESC(mESC)pluripotency since knockdown of Npac causes mESC differentiation.Depletion of Npac in mouse embryonic fibroblasts(MEFs)inhibits reprogramming efficiency.Furthermore,our chromatin immunoprecipitation followed by sequencing(ChIP-seq)results of Npac reveal that Npac co-localizes with histone H3K36me3 in gene bodies of actively transcribed genes in mESCs.Interestingly,we find that Npac interacts with positive transcription elongation factor b(p-TEFb),Ser2-phosphorylated RNA PolⅡ(RNA PolⅡSer2P),and Ser5-phosphorylated RNA PolⅡ(RNA PolⅡSer5 P).Furthermore,depletion of Npac disrupts transcriptional elongation of the pluripotency genes Nanog and Rif1.Taken together,we propose that Npac is essential for the transcriptional elongation of pluripotency genes by recruiting p-TEFb and interacting with RNA PolⅡSer2P and Ser5P. | Sue Yu Jia Li Guanxu Ji Zhen Long Ng Jiamin Siew Wan Ning Lo Ying Ye Yuan Yuan Chew Yun Chau Long Wensheng Zhang Ernesto Guccione Yuin Han Loh Zhi-Hong Jiang Henry Yang Qiang Wu | 2022 | Genomics, Proteomics & Bioinformatics2022，20，1： | 0 |
| 19 | Optimization of Coenzyme Q10Production Procedure from Genetic Engineered Rhodobacter sphaeroides Overexpressing UbiG显示文摘In the present study, single factors including fermentation temperature, inoculate amount, fermentation duration, and ratio of fermentation medium volume to total flask volume(dissolved oxygen tension) were optimized for enhancing the production of coenzyme Q10 from genetic engineered Rhodobacter sphaeroides overexpressing UbiG. The experimental results suggested that optimal single factors were: inoculate amount 2%, fermentation temperature 30 ℃, fermentation duration 48 h, and ratio of fermentation medium volume to total flask volume 80%. The present study will promote the large scale production of CoQ10 from microorganisms. | Zhiping ZHAO Xinning XU Ziyi YE Lili JI Jiamin ZHANG Wei WANG | 2020 | Agricultural Biotechnology2020，9，1： | 0 |
| 20 | Band alignment and interlayer hybridization in monolayer organic/WSe_(2) heterojunction显示文摘Semiconducting heterojunctions(HJs),comprised of atomically thin transition metal dichalcogenides(TMDs),have shown great potentials in electronic and optoelectronic applications.Organic/TMD hybrid bilayers hold enhanced pumping efficiency of interfacial excitons,tunable electronic structures and optical properties,and other superior advantages to these inorganic HJs.Here,we report a direct probe of the interfacial electronic structures of a crystalline monolayer(ML)perylene-3,4,9,10-tetracarboxylic-dianhydride(PTCDA)/ML-WSe_(2) HJ using scanning tunneling microscopy,photoluminescence,and first-principle calculations.Strong PTCDAAA/Se_(2) interfacial interactions lead to appreciable hybridization of the WSe_(2) conduction band with PTCDA unoccupied states,accompanying with a significant amount of PTCDA-to-WSe_(2) charge transfer(by 0.06 e/PTCDA).A type-ll band alignment was directly determined with a valence band offset of-1.69 eV,and an apparent conduction band offset of-1.57 eV.Moreover,we found that the local stacking geometry at the HJ interface differentiates the hybridized interfacial states. | Yanping Guo Linlu Wu Jinghao Deng Linwei Zhou Wei Jiang Shuangzan Lu Da Huo Jiamin Ji Yusong Bai Xiaoyu Lin Shunping Zhang Hongxing Xu Wei Ji Chendong Zhang | 2022 | Nano Research2022，15，2： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员