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| 1 | An analytical method for chlorinated paraffins and their determination in soil samples显示文摘Short chain chlorinated paraffins (SCCPs) are possibly persistent organic pollutants (POPs), and are candidate POPs of the Stockholm Convention. In this study, three quantitative methods for analyzing CPs were compared using a gas chromatograph-electron capture detector (GC-ECD), gas chromatograph-electron capture negative ion low resolution mass spectrometry (GC-ECNI-LRMS) and gas chromatograph-electron ionization tandem mass spectrometry (GC-EI-MS2). A quantitative method for the analysis of total CPs in soil samples was established. The environmental levels of CPs in an e-waste dismantling area in China were evaluated. | YUAN Bo WANG YaWei FU JianJie ZHANG QingHua JIANG GuiBin | 2010 | Chinese Science Bulletin2010，55，22： | 4 |
| 2 | Detection of tris-(2, 3-dibromopropyl) isocyanurate as a neuronal toxicant in environmental samples using neuronal toxicity-directed analysis显示文摘Neuronal toxic pollutants in environment possess hazards to human health. It is essential to determine the causative neuronal toxicants in environmental samples. In the present study, viability of primary cultured cerebellar granule neurons (CGNs), combined with sample extraction, chemical fractionation and identification, was applied for screening acid-resistant neuronal toxic substances in environmental samples. River sediments and agricultural soils along the river near a brominated flame retardant (BFR) manufacturing plant in South China were collected to screen the key neuronal toxicants. The results indicated that the manufacturing plant was a source of neuronal toxicity risks. In the sediment and soil near the plant, one of the causative toxicants was identified as tris-(2,3-dibromopropyl) isocyanurate (TBC) using HPLC-MS/MS. In addition, an unknown chemical possibly causing significant neuronal toxicity was isolated from all the soil samples in the region. | QU GuangBo SHI JianBo LI ZhuoNa RUAN Ting FU JianJie WANG Pu WANG Thanh JIANG GuiBin | 2011 | Science China Chemistry2011，54，10： | 3 |
| 3 | Alterations of endogenous metabolites in urine of rats exposed to decabromodiphenyl ether using metabonomic approaches显示文摘There is large usage of polybrominated diphenyl ethers(PBDEs) especially for decabromodiphenyl ether(BDE-209, Deca-BDE) in controlling the risks of fire. The toxicological effects of PBDEs are worth being concerned about. Female SD rats were daily gavaged with BDE-209 ether at the dose of 100 mg/kg for 20 days. Histological observation was performed for the screening of the target organs for BDE-209 exposure. The distribution and metabolism of PBDEs in the exposed main organs were evidenced by HRGC-HRMS. Alterations of the endogenous metabolite concentrations in urine were investigated using metabonomic approaches based on1H NMR spectrum. Histopathological changes including serious edema in kidney, hepatocellular spotty necrosis and perivasculitis in liver indicated that BDE-209 caused potential influences on endogenous metabolism in the exposed liver and the kidney. BDE-209 was found to be highly accumulated in lipid, ovary, kidney and liver after 20 days' exposure. Occurrence of other lower brominated PBDEs in the rats demonstrated that reductive debromination process happened in vivo. Hydroxylated and methoxylated–BDEs, as metabolism products, were also detected in the rat tissues. A total of 12 different endogenous metabolites showed obvious alterations in urine from the exposed rats, indicating the disturbance of the corresponding internal biochemical processes induced by BDE-209 exposure. These findings in vivo suggested the potential health risk might be of concern due to the toxicological effects of BDE-209 as a ubiquitous compound in the environment. | Weijin Yang Jianjie Fu Thanh Wang Hanxia Liu Yawei Wang Qunfang Zhou Guibin Jiang | 2014 | Journal of Environmental Sciences2014，26，4： | 3 |
| 4 | Chlorination pattern effect on thermodynamic parameters and environmental degradability for C_(10)-SCCPs: Quantum chemical calculation based on virtual combinational library显示文摘Short-chain chlorinated paraffins(SCCPs) are still controversial candidates for inclusion in the Stockholm Convention.The inherent mixture nature of SCCPs makes it rather difficult to explore their environmental behaviors.A virtual molecule library of 42,720 C_(10)-SCCP congeners covering the full structure spectrum was constructed.We explored the structural effects on the thermodynamic parameters and environmental degradability of C_(10)-SCCPs through semi-empirical quantum chemical calculations.The thermodynamic properties were acquired using the AM1 method,and frontier molecular orbital analysis was carried out to obtain the E_(HOMO),E_(LUMO) and E_(LUMO)-E_(HOMO) for degradability exploration at the same level.The influence of the chlorination degree(N_(Cl) on the relative stability and environmental degradation was elucidated.A novel structural descriptor,μ,was proposed to measure the dispersion of the chlorine atoms within a molecule.There were significant correlations between thermodynamic values and N_(Cl),while the reported N_(Cl)-dependent pollution profile of C_(10)-SCCPs in environmental samples was basically consistent with the predicted order of formation stability of C_(10)-SCCP congeners.In addition,isomers with largeμ showed higher relative stability than those with small μ.This could be further verified by the relationship between μ and the reactivity of nucleophilic substitution and · OH attack respectively.The C_(10)-SCCP congeners with less Cl substitution and lower dispersion degree are susceptible to environmental degradation via nucleophilic substitution and hydroxyl radical attack,while direct photolysis of C_(10)-SCCP congeners cannot readily occur due to the large E_(LUMO)-E_(HOMO) values.The chlorination effect and the conclusions were further checked with appropriate density functional theory(DFT) calculations. | Yuzhen Sun Wenxiao Pan Yuan Lin Jianjie Fu Aiqian Zhang | 2016 | Journal of Environmental Sciences2016，28，1： | 2 |
| 5 | Experimental Study on Analgesia and Hemostasis of Paris polyphylla,Scutellaria baicalensis and Their Compatibility显示文摘[Objectives]The analgesic and hemostatic effects of Paris polyphylla,Scutellaria baicalensis,and their compatibility were studied.[Methods](i)In the experiment on the writhing of mice induced by acetic acid,60 Kunming SPF mice were randomly selected,and were randomly divided into 6 groups according to the male-to-female ratio of 1∶1,including blank control group,P.polyphylla group,S.baicalensis group,and three P.polyphylla and S.baicalensis compatibility groups(with the ratio of 1∶2,1∶1 and 1∶2).There were 10 mice in each group.In the experimental groups,the mice were given 1 g/mL Chinese medicine extract according to a dose of 20 mL/kg.In the control group,the mice were given 0.9%normal saline in equal volumes.Gavage was performed one time every 24 h and lasted for 14 d.1 h after the gavage on the 14th day,they were given 0.5%glacial acetic acid solution via intraperitoneal injection.(ii)In the hot plate experiment,60 Kunming SPF mice were selected,and the ratio of male to female,grouping,administration and gavage were the same as those of the glacial acetic acid-induced writhing experiment.Gavage was lasted for 14 d.1 h after the gavage on the 14th day,the mice were placed on a hot plate apparatus at(55±0.5)℃,and the time of licking hindfoot was measured.(iii)The hemostatic effect was explored through three experimental methods of tail hemostasis,femoral artery hemostasis and liver hemostasis.60 Kunming SPF mice were taken in each of the three experiments,and the male-female ratio and grouping were the same as above.The powder was covered on the surface of the wound sites,and the bleeding was observed.The hemostatic time was recorded,and the hemostatic time was recorded as 3 min if it exceeded 3 min.[Results](i)In the acetic acid-induced writhing experiment,compared with the blank control group,the pain of mice in the experimental groups was inhibited.Among them,P.polyphylla group,S.baicalensis group,compatibility 1∶2 group,compatibility 1∶1 group,and compatibility 2∶1 group had significant effects(P<0.05),and the inhibition rate of writhing was 20.43%,28.32%,52.30%,32.79%,and 39.02%,respectively.The analgesic effect of the compatibility 1∶2 group was the most obvious.(ii)In the hot plate experiment,compared with the blank control group,the experimental groups had analgesic effect.Among them,P.polyphylla group,S.baicalensis group,compatibility 1∶2 group,compatibility 1∶1 group,and compatibility 2∶1 group had significant effects(P<0.05),and the increase rate of pain threshold was 29.17%,47.83%,61.54%,and 50.61%,and 53.83%,respectively.The analgesic effect of the compatibility 2∶1 group was the most significant.(iii)In the hemostatic experiment,there was a significant difference in hemostatic time between the compatibility 1∶2 group and the blank control group,P.polyphylla group,and S.baicalensis group(P<0.05).The hemostatic effect of the compatibility 1∶2 group was the best.[Conclusions]P.polyphylla,S.baicalensis,and its compatibility had good analgesic and hemostatic effects,and the best compatibility ratio was 1∶2. | Shibo ZHAO Suoyi HUANG Zhenjing SI Lanlan GAN Shusheng HUANG Ye FU Jianjie LAN Xueying YU Yuekong CEN | 2020 | Medicinal Plant2020，11，2： | 2 |
| 6 | Mercury in alpine fish from four rivers in the Tibetan Plateau显示文摘As a global pollutant, high levels of mercury(Hg) have been found in remote ecosystem due to the long range atmospheric transport. In this study, a total of 60 fish samples were collected from four rivers across the Tibetan Plateau to study the accumulation of Hg in remote and high-altitude aquatic environment. The total Hg(THg) and methylmercury(MeHg) in fish muscles ranged from 11 to 2097 ng/g dry weight(dw)(average: 819 ng/g dw)and from 14 to 1960 ng/g dw(average: 756 ng/g dw), respectively. Significantly positive linear relationships were observed between the THg(r = 0.591, p < 0.01, n = 36) and MeHg concentrations(r = 0.473, p < 0.01, n = 36) with the trophic level of fish from Lhasa River,suggesting trophic transfer and biomagnification of Hg in this aquatic ecosystem. Moreover,the THg levels in fish had significantly positive correlations with the length(r = 0.316,p < 0.05, n = 60) and weight(r = 0.271, p < 0.05, n = 60) of fish. The high levels of Hg were attributed to the slow growth and long lifespan of the fish under this sterile and cold environment. Risk assessment revealed that the consumption of Oxygymnocypris stewartii,Schizothorax macropogon, Schizothorax waltoni, Schizopygopsis younghusbandi and Schizothorax o'connori would lead to a high exposure to Me Hg. | Junjuan Shao Jianbo Shi Bu Duo Chengbin Liu Yan Gao Jianjie Fu Ruiqiang Yang Guibin Jiang | 2016 | Journal of Environmental Sciences2016，28，1： | 1 |
| 7 | Long-range atmospheric transport and alpine condensation of short-chain chlorinated paraffins on the southeastern Tibetan Plateau显示文摘Pristine alpine regions are ideal regions for investigating the long-range atmospheric transport and cold trapping effects of short chain chlorinated paraffins(SCCPs).The concentrations and alpine condensation of SCCPs were investigated in lichen samples collected from the southeastern Tibetan Plateau.The concentrations of SCCPs ranged from 3098 to 6999 ng/g lipid weight(lw)and appeared to have an increasing trend with altitude.For congeners,C10 dominated among all the congener groups.The different environmental behavior for different congener groups was closely related to their octanol-air partition coefficient(Koa).C10 congeners showed an increasing trend with altitude,whereas C13 congeners were negatively correlated with altitude.Volumetric bioconcentration factors(BCF)of SCCPs reached 8.71 in lichens,which were higher than other semivolatile organic compounds(SVOCs)such as organochlorine pesticides(OCPs),polybrominated diphenyl ethers(PBDEs),polychlorinated biphenyls(PCBs),and hexabromocyclododecane(HBCD).These results suggested that SCCPs were prone to accumulate in the lichen from the air and provided evidence for the role of lichens as a suitable atmospheric indicator in the Tibetan Plateau. | Huijuan Li Duo Bu Yan Gao Nali Zhu Jing Wu Xiangfeng Chen Jianjie Fu Yawei Wang Aiqian Zhang Guibin Jiang | 2021 | Journal of Environmental Sciences2021，33，1： | 1 |
| 8 | Characteristic accumulation and soil penetration of polychlorinated biphenyls and polybrominated diphenyl ethers in wastewater irrigated farmlands显示文摘 | Thanh Wang Yawei Wang Jianjie Fu Pu Wang Yingming Li Qinghua Zhang Guibin Jiang | 2010 | Chemosphere2010，，8： | 1 |
| 9 | Experimental demonstration of both inverted and non-inverted wavelength conversion based on transient cross phase modulation of SOA显示文摘 | Songnian Fu Jianji Dong P Shum Liren Zhang | 2006 | Optics Express2006，14，17： | 1 |
| 10 | Distribution of perfluorooctane sulfonate and other perfluorochemicals in the ambient environment around a manufacturing facility in China显示文摘 | Wang Yawei Fu Jianjie Wang Thanh | 2010 | Environmental Science and Technology2010，44，21： | 1 |
| 11 | Biomonitoring:An appealing tool for assessment of metalpollution in the aquatic ecosystem显示文摘 | Qunfang Zhou Jianbin Zhang Jianjie Fu Jianbo Shi Guibin Jiang | | 0，，： | 1 |
| 12 | Environmental and biological influences on the stability of silver nanoparticles显示文摘Silver nanoparticles (Ag NPs) are easily dispersed and stable, and their application has become widespread. Consequently, concern has arisen regarding their potential effects on the environment and human health. However, the current understanding on the stability of Ag NPs is limited. Therefore, in this study the influence of environmental and biological factors, such as ionic strength, valence, biological molecules, pH and temperature, on the properties of Ag NPs was investigated. The absorption spectra, size, zeta potential, and release of silver ions were evaluated. Ionic strength, valence, Dulbecco’s Modified Eagle’s Medium (DMEM), without fetal bovine serum (FBS), reduced the stability of the Ag NPs. However, in DMEM with 10% FBS, the Ag NPs maintained their stability and nanoscale characteristics. These findings provide an essential insight into the environmental and biological factors that should be evaluated in a risk assessment of Ag NPs. | LIU Wei ZHOU QunFang LIU JiYan FU JianJie LIU SiJin JIANG GuiBin | 2011 | Chinese Science Bulletin2011，56，19： | 1 |
| 13 | Bioaccumulation of PCDD/Fs, PCBs and PBDEs by earthworms in field soils of an E-waste dismantling area in China显示文摘 | Hongtao Shang Pu Wang Thanh Wang Yawei Wang Haidong Zhang Jianjie Fu Daiwei Ren Weihai Chen Qinghua Zhang Guibin Jiang | 2013 | Environment International2013，，： | 1 |
| 14 | Single SOA based all-optical adder assisted by optical bandpass filter: Theoretical analysis and performance optimization显示文摘 | Dong Jianji Fu Songnian Zhang Xinliang | 2007 | Optics Communications2007，270，2： | 1 |
| 15 | Insights into the rheological modeling of semi-solid metals:Theoretical and simulation study显示文摘The power law model is the most widely used model for the rheological behavior of semi-solid metals(SSMs)in the numerical simulation of semi-solid processing.However,it is still not known why the anomalous negative flow exponent exists in the power law model for SSMs and its influence on the simulation.In this research,the rheological behavior of semi-solid Al-7Si-0.3Mg aluminum alloy is experimentally studied followed by modeling.The power law model fitting results show flow curves deviate from the experimental data and negative flow exponents,which are physically nonsensical and inapplicable to the simulation of SSMs flow proved by hydrodynamic analysis.This drawback of the power law model stems from neglecting the yield stress of SSMs.By contrast,the model referring Herschel-Bulkley(HB)theory which takes yield stress into consideration has reasonable flow exponent and yields good agreement between the fitting and experimental results.Furthermore,the simulation of die filling process is conducted,suggesting that the power law model over-optimistically predicts the tendency of blistering and misrun defects at low temperature and high filling velocity during semi-solid processing. | Zhen Ma Huarui Zhang Hanwei Fu Yanzhao Yang Jianji Wang Ming Du Hu Zhang | 2022 | Journal of Materials Science & Technology2022，，5： | 0 |
| 16 | Inhibition of thrombin by functionalized C_(60)nanoparticles revealed via in vitro assays and in silico studies显示文摘The studies on the human toxicity of nanoparticles(NPs) are far behind the rapid development of engineered functionalized NPs. Fullerene has been widely used as drug carrier skeleton due to its reported low risk. However, different from other kinds of NPs, fullerene-based NPs(C_(60) NPs) have been found to have an anticoagulation effect, although the potential target is still unknown. In the study, both experimental and computational methods were adopted to gain mechanistic insight into the modulation of thrombin activity by nine kinds of C_(60) NPs with diverse surface chemistry properties. In vitro enzyme activity assays showed that all tested surface-modified C_(60) NPs exhibited thrombin inhibition ability. Kinetic studies coupled with competitive testing using 3 known inhibitors indicated that six of the C_(60) NPs, of greater hydrophobicity and hydrogen bond(HB) donor acidity or acceptor basicity, acted as competitive inhibitors of thrombin by directly interacting with the active site of thrombin. A simple quantitative nanostructure-activity relationship model relating the surface substituent properties to the inhibition potential was then established for the six competitive inhibitors.Molecular docking analysis revealed that the intermolecular HB interactions were important for the specific binding of C_(60) NPs to the active site canyon, while the additional stability provided by the surface groups through van der Waals interaction also play a key role in the thrombin binding affinity of the NPs. Our results suggest that thrombin is a possible target of the surface-functionalized C_(60) NPs relevant to their anticoagulation effect. | Yanyan Liu Jianjie Fu Wenxiao Pan Qiao Xue Xian Liu Aiqian Zhang | 2018 | Journal of Environmental Sciences2018，30，1： | 0 |
| 17 | 肝癌细胞模型库及其药物基因组学“蓝图”显示文摘文章简介原发性肝癌异质性显著,耐药性突出,预后不良。不同国家地区之间肝癌致病因素差异明显,对肝癌的精准治疗带来严重挑战。全球每年超过50%的新增病例和死亡病例均发生在中国。由大量细胞系构成的细胞系平台在乳腺癌、肺癌等癌症研究中证明细胞系平台能够模拟癌症的遗传异质性和药物响应,通过细胞系平台可以发现与药物敏感性相关的分子标志物。 | 邱志欣 李虹 章正涛 Zhenfeng Zhu Sheng He Xujun Wang Pengcheng Wang Jianjie Qin Liping Zhuang Wei Wang Fubo Xie Ying Gu Keke Zou Chao Li Chun Li Chenhua Wang Jin Cen Xiaotao Chen Yajing Shu Zhao Zhang Lulu Sun Lihua Min Yong Fu Xiaowu Huang Hui Lv He Zhou Yuan Ji Zhigang Zhang Zhiqiang Meng 施晓雷 张海斌 李亦学 惠利健 | 2020 | 科学新闻2020，，2： | 0 |
| 18 | Occurrence and Health Risk of Perfluoroalkyl Acids in Popular Shellfish from a Typical Coastal Area of the East China显示文摘As crucial homologous members of per-and polyfluoroalkyl substances(PFASs),perfluoroalkyl acids(PFAAs)have aroused wide public concern because of their unique properties(persistence,bioaccumulation,long-distance migration and toxicity).Studies have shown their potential hazard to wildlife and humans,with food consumption as one of the primary routes of PFAA exposure for general population,especially seafood intake.In this study,17 PFAAs were quantified in 9 shellfish species from Yuhuan City,a typical coastal area of the East China.The total mean concentrations of PFAAs were in the range of 5.03–381 ng/g dry weight(dw),with the highest concentration found in Neverita didyma and the lowest in Babylonia lutosa.Concentrations and composition profiles of PFAAs varied significantly among different species,indicating differences in the bioaccumulation potential of PFAAs among species.Perfluorooctanoic acid(PFOA)was presented as the most abundant PFAA in this study,followed by perfluorobutanoic acid(PFBA).Significant positive correlations were observed among some individual PFAAs(p<0.05),indicating that they may share similar pollution sources or undergo similar compound behaviors.Health risk assessment indicated a relatively high threat for local residents exposed to PFAAs through shellfish consumption. | LIU Ruolin LIU Mei ZHAO Chuxuan FU Jianjie ZHOU Wei ZHANG Qinghua Martin HANSEN DONG Yin | 2023 | Chemical Research in Chinese Universities2023，39，3： | 0 |
| 19 | Association between serum levels of TSH and free T4 and per- and polyfluoroalkyl compounds concentrations in pregnant women显示文摘Many per-and polyfluoralkyl substances(PFASs)may disrupt maternal thyroid hormone homeostasis in pregnancy.Concerns should be raised regarding the PFASs exposure in pregnant women because thyroid hormones are involved in the early development of the fetus.In this study,we measured the concentrations of 13 PFASs,including five novel shortchain PFASs,in serum from 123 pregnant women in Beijing,China.Linear regression models were used to investigate the association between thyroid-stimulating hormone(TSH)or free thyroxine(FT4)levels and PFASs concentrations under consideration of the impacts of pregnancy-induced physiological factors.We found that perfluorobutanoic acid(PFBA)(β=0.189,95%CI=-0.039,0.417,p=0.10)and perfluorodecanoic acid(PFDA)(β=-0.554,95%CI=-1.16,0.049,p=0.071)were suggestive of significant association with TSH in thyroid peroxidase antibody(TPOAb)negative women.No association was observed between all PFASs and FT4 levels after controlling for these confounding factors,such as BMI,gestational weight gain and maternal age.These findings suggest that it should pay more attention to the association between thyroid hormone levels and short-chain PFASs concentrations.Future studies could consider a greater sample and the inclusion of other clinical indicators of thyroid function,such as free T3 and total T3. | Aijing Li Jian Hou Jianjie Fu YinanWang Yifei Hu Taifeng Zhuang Menglong Li Maoyong Song Guibin Jiang | 2023 | Journal of Environmental Sciences2023，，2： | 0 |
| 20 | Trophic transfer of mercury and methylmercury in an aquatic ecosystem impacted by municipal sewage effluents in Beijing, China显示文摘Gaobeidian Lake, located in Beijing, China, serves as a recipient lake for efluents from a large municipal sewage treatment plant (MSTP). In order to evaluate the effects of discharging MSTP efluent on the mercury contamination of the local aquatic ecosystem, sediment cores, water, plankton, fish, and turtle samples were collected from Gaobeidian Lake for mercury speciation analysis. High concentrations of total mercury (T-Hg) were detected in sediment cores (5.24–17.0 μg/g dry weight (dw), average: 10.1 μg/g). The ratio of methylmercury (MeHg) to T-Hg was less than 0.3% in sediments and ranged from 35% to 76% in biota samples. The highest level of T-Hg and MeHg were found in aquatic bryophyte and crucian carp (3673 and 437 ng/g dw, respectively). The relative contents of MeHg were significantly correlated with trophic levels (R2 = 0.5506, p < 0.001), which confirmed that MeHg can be bio-transferred and biomagnified via food chain in this aquatic ecosystem. | Jianjie Fu, Yawei Wang, Qunfang Zhou, Guibin Jiang State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China. | 2010 | Journal of Environmental Sciences2010，22，8： | 0 |
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