|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Chinese Stroke Association guidelines for clinical management of cerebrovascular disorders: executive summary and 2019 update of clinical management of ischaemic cerebrovascular diseases显示文摘Aim Stroke is the leading cause of disability and death in China.Ischaemic stroke accounts for about 60%-80%of all strokes.It is of considerable significance to carry out multidimensional management of ischaemic cerebrovascular diseases.This evidence-based guideline aims to provide the latest detailed and comprehensive recommendations on the diagnosis,treatment and secondary prevention of ischaemic cerebrovascular diseases.Methods We had performed comprehensive searches of MEDLINE(via PubMed)(before 30 June 2019),and integrated the relevant information into charts and distributed to the writing group.Writing group members discussed and determined the recommendations through teleconference.We used the level of evidence grading algorithm of Chinese Stroke Association to grade each recommendation.The draft was reviewed by the Guideline Writing Committee of Chinese Stroke Association Stroke and finalised.This guideline is fully updated every 3 years.results This evidence-based guideline is based on the treatment,care and prevention of ischaemic cerebrovascular diseases,which emphasises on pathogenesis evaluation,intravenous thrombolysis,endovascular therapy,antiplatelet therapy,prevention and treatment of complications,and risk factor management.Conclusions This updated guideline presents a framework for the management of ischaemic cerebrovascular diseases.Timely first-aid measures,professional care in the acute stage,and proactive secondary prevention will be helpful to patients. | Liping Liu Weiqi Chen Hongyu Zhou Wanying Duan Shujuan Li Xiaochuan Huo Weihai Xu Li'an Huang Huaguang Zheng Jingyi Liu Hui Liu Yufei Wei Jie Xu Yongjun Wang | 2020 | Stroke & Vascular Neurology2020，5，2： | 42 |
| 2 | Precise nanomedicine for intelligent therapy of cancer显示文摘Precise nanomedicine has been extensively explored for efficient cancer imaging and targeted cancer therapy, as evidenced by a few breakthroughs in their preclinical and clinical explorations. Here, we demonstrate the recent advances of intelligent cancer nanomedicine, and discuss the comprehensive understanding of their structure-function relationship for smart and efficient cancer nanomedicine including various imaging and therapeutic applications, as well as nanotoxicity. In particular, a few emerging strategies that have advanced cancer nanomedicine are also highlighted as the emerging focus such as tumor imprisonment, supramolecular chemotherapy, and DNA nanorobot. The challenge and outlook of some scientific and engineering issues are also discussed in future development. We wish to highlight these new progress of precise nanomedicine with the ultimate goal to inspire more successful explorations of intelligent nanoparticles for future clinical translations. | Huabing Chen Zhanjun Gu Hongwei An Chunying Chen Jie Chen Ran Cui Siqin Chen Weihai Chen Xuesi Chen Xiaoyuan Chen Zhuo Chen Baoquan Ding Qian Dong Qin Fan Ting Fu Dayong Hou Qiao Jiang Hengte Ke Xiqun Jiang Gang Liu Suping Li Tianyu Li Zhuang Liu Guangjun Nie Muhammad Ovais Daiwen Pang Nasha Qiu Youqing Shen Huayu Tian Chao Wang Hao Wang Ziqi Wang Huaping Xu Jiang-Fei Xu Xiangliang Yang Shuang Zhu Xianchuang Zheng Xianzheng Zhang Yanbing Zhao Weihong Tan Xi Zhang Yuliang Zhao | 2018 | Science China Chemistry2018，61，12： | 19 |
| 3 | Meningeal lymphatic vessels regulate brain tumor drainage and immunity显示文摘Recent studies have shown that meningeal lymphatic vessels(MLVs),which are located both dorsally and basally beneath the skull,provide a route for draining macromolecules and trafficking immune cells from the central nervous system(CNS)into cervical lymph nodes(CLNs),and thus represent a potential therapeutic target for treating neurodegenerative and neuroinflammatory diseases.However,the roles of MLVs in brain tumor drainage and immunity remain unexplored.Here we show that dorsal MLVs undergo extensive remodeling in mice with intracranial gliomas or metastatic melanomas.RNA-seq analysis of MLV endothelial cells revealed changes in the gene sets involved in lymphatic remodeling,fluid drainage,as well as inflammatory and immunological responses.Disruption of dorsal MLVs alone impaired intratumor fluid drainage and the dissemination of brain tumor cells to deep CLNs(dCLNs).Notably,the dendritic cell(DC)trafficking from intracranial tumor tissues to dCLNs decreased in mice with defective dorsal MLVs,and increased in mice with enhanced dorsal meningeal lymphangiogenesis.Strikingly,disruption of dorsal MLVs alone,without affecting basal MLVs or nasal LVs,significantly reduced the efficacy of combined anti-PD-1/CTLA-4 checkpoint therapy in striatal tumor models.Furthermore,mice bearing tumors overexpressing VEGF-C displayed a better response to anti-PD-1/CTLA-4 combination therapy,and this was abolished by CCL21/CCR7 blockade,suggesting that VEGF-C potentiates checkpoint therapy via the CCL21/CCR7 pathway.Together,the results of our study not only demonstrate the functional aspects of MLVs as classic lymphatic vasculature,but also highlight that they are essential in generating an efficient immune response against brain tumors. | Xueting Hu Qiuping Deng Lu Ma Qingqing Li Yidong Chen Yuhan Liao Fan Zhou Chen Zhang Linlin Shao Jun Feng Tubao He Weihai Ning Yan Kong Yingqing Huo Aibin He Bing Liu Jingjing Zhang Ralf Adams Yulong He Fuchou Tang Xiuwu Bian Jincai Luo | 2020 | Cell Research2020，30，3： | 11 |
| 4 | High-resolution MRI of intracranial large artery diseases:how to use it in clinical practice?显示文摘High-resolution MRI(HRMRI)has emerged as a useful tool for clinical research in recent years.Compared with traditional cranial and vessel imaging,HRMRI provides more additional valuable pathophysiology information that is helpful for the differential diagnosis of intracranial atherosclerosis,dissection and vasculitis.However,there are some points that a neurologist should keep in mind.First,although enhanced vessel wall imaging is widely applied for research purposes,it is not appropriate for routine clinical use.Any injury or inflammation within vessel wall can result in enhancement,which is unspecific for a diagnosis.Second,although plaque components identified on HRMRI arouse researchers’interest,they may have limited positive predictive value for future stroke.Ruptured plaques may have higher prevalence in asymptomatic patients than expected.More prospective observational studies are required.Third,the vessel wall morphology features remain the useful and reliable clue for a diagnosis.It is true that eccentric vessel wall lesions most likely represent atherosclerosis if vessel dissection is easily excluded.For concentric wall lesions,however,the underlying pathophysiology is complicated,either atherosclerotic or non-atherosclerotic.Fourth,HRMRI can show luminal thrombus directly and provide valuable details.All in all,when HRMRI is used by a neurologist,it should not be viewed as the only key for a diagnosis.The diagnosis should be made based on patient history,lab works,other imaging technique and even genetic examinations. | Weihai Xu | 2019 | Stroke & Vascular Neurology2019，4，2： | 10 |
| 5 | The cessation and detoxification effect of tea filters on cigarette smoke显示文摘To treat tobacco addiction,a tea filter was developed and studied for smoking cessation.This work reports the smoking cessation effect of tea when it was used as a component of cigarette filters.In one trial it was found that after using the tea filters for 2 months,the volunteer smokers decreased their cigarette consumption by 56.5%,and 31.7% of them stopped smoking.This work identified a new method and material,tea filter and theanine,which inhibit tobacco and nicotine addiction and provide an effective strategy for treating tobacco addiction. | YAN JingQi1,2,DI XiaoJing1,4,LIU CaiYi3,ZHANG HuiMin3,HUANG XiouQin3,ZHANG JunJing1,2,ZHAO Yan5,ZHANG LongZe1,CHANG YanZhong4,LIANG YongLin2$,TAO Ran3 & ZHAO BaoLu1,21 State Key Laboratory of Brain and Cognitive Science,Institute of Biophysics,Chinese Academy of Sciences,Beijing 100101,China 2 Key Laboratory of Mental Health,Institute of Psychology,Chinese Academy of Sciences,Beijing 100101,China 3 Addiction Branch,Beijing Military Region General Hospital,Beijing 100700,China 4 Institute of Molecular Neurobiology,Hebei Normal University,Shijiazhuang 050016,China 5 Department of Food Sciences and Technology,Harbin Institute of Technology at Weihai,Weihai 264209,China | 2010 | Science China(Life Sciences)2010，53，5： | 8 |
| 6 | Global practical tracking for stochastic time-delay nonlinear systems with SISS-like inverse dynamics显示文摘This paper investigates the practical tracking problem of stochastic delayed nonlinear systems. The powers of the nonlinear terms are relaxed to a certain interval rather than a precisely known point. Based on the Lyapunov-Krasovskii(L-K) functional method and the modified adding a power integrator technique,a new controller is constructed to render the solutions of the considered system to be bounded in probability,and furthermore, the tracking error in sense of the mean square can be made small enough by adjusting some designed parameters. A simulation example is provided to demonstrate the validity of the method in this paper. | Lingrong XUE Weihai ZHANG Xuejun XIE | 2017 | Science China(Information Sciences)2017，60，12： | 8 |
| 7 | Organotin compounds in surface sediments from selected fishing ports along the Chinese coast显示文摘The concentrations and species of organotin compounds(OTCs) in 52 surface sediment samples from nine fishing ports along the Chinese coast were studied.Butyltins(BTs) and phenyltins(PhTs) were derivatized using sodium tetraethylborate(NaBEt 4) and determined by head-space solid-phase microextraction(HS-SPME) gas chromatography coupled with a flame photometric detector(GC-FPD).The concentrations of OTCs ranged from <3.6 to 194 ng(Sn) g-1 dry weight(dw) for monobutyltin(MBT),<2.3 to 41.5 ng(Sn) g-1 dw for dibutyltin(DBT),<0.7 to 86.0 ng(Sn) g-1 dw for tributyltin(TBT) and <5.1 to 66.1 ng(Sn) g-1 dw for monophenyltin(MPhT),respectively.The concentrations of diphenyltin(DPhT) and triphenyltin(TPhT) were below the limit of detection(LOD).BTs were the main species in the sediments except for the samples collected from Shazikou fishing port in Qingdao.The concentrations of MBT were higher than DBT and TBT.The concentrations of OTCs in the sediments varied widely among different sampling locations.The concentrations of BTs were much higher in the samples collected from fishing ports close to the South China Sea than those in coast of the East China Sea and the Yellow Sea.MPhT was prevalent in most sampling stations except for those in coast of the East China Sea.The environmental and ecotoxicological risks of TBT in most sediment samples were low. | ZHANG KeGang SHI JianBo HE Bin XU WeiHai LI XiangDong JIANG GuiBin | 2013 | Chinese Science Bulletin2013，58，2： | 7 |
| 8 | Mitochondrial DNA A1555G mutation screening using a testing kit method and its significance in preventing aminoglycoside-related hearing loss显示文摘To report a new screening method for mitochondrial DNA 1555A→G mutation and the results of genotype analysis in 19 maternal inherited deafness pedigrees. Method Five hundred and forty-six non-syndromic neuro-sensory hearing loss patients were tested for 1555A→G mutation using a new compact testing kit, which allows clear distinction between wild type and 1555 A→G mutated mtDNAs. Results Nineteen subjects among the 546 patients (3.48%) were found to carry mtDNA A1555G mutation. The results were confirmed by sequencing in an ABI 3100 Avant sequencer. Conclusions Maternal inherited deafness families are a frequently seen in outpatient group. The detection of mtDNA 1555 A→G mutation with a low cost, ready to use detection kit is needed and suitable in China for large scale screening and preventive testing before usage of aminoglycoside antibiotics. | LIU Xin,1 DAI Pu,1* HUANG Deliang,1 YUAN Huijun,1 LI Weiming,1 YU Fei,1 ZHANG Xin,1 KANG Dongyang,1 CAO Juyang,1 YANG Weiyan,1 HAN Dongyi,1 JIN Zhengce2, GUAN Minxin3 1. Department of Otolaryngology, Chinese PLA General Hospital, Beijing, China2. Weihai Aomaier Gene Technological CO.,LTD.,Weihai,Shandong 264200, China.3. Division and Program in Human Genetics and Center for Hearing and Deafness Research, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA | 2006 | Journal of Otology2006，1，1： | 7 |
| 9 | Comparisons of dosimetric properties between GD-300 series of radiophotoluminescent glass detectors and GR-200 series of thermoluminescent detectors显示文摘In order to compare the dosimetric properties of two kinds of solid state detectors used for monitoring ex- ternal exposures,experiments were performed for the GD-300 series of radiophotoluminescent glass detectors (RPLGD)and the GR-200 series of thermoluminescent detectors(TLD).X-rays and ^(137)Cs and ^(60)Coγ-rays were used to irradiate the RPLGDs and TLDs,their dose linearity,uniformity/reproducibility of signal,fading effect and energy dependence were compared.Both kinds of the detectors have generally good dosimetric properties.The dose linearity and energy dependence of the GD-351 dosimeters and the TLDs are nearly the same,but the RPLGD is much better than the TLD in terms of the uniformity and fading effect. | ZHUO Weihai LIU Weiqi HUANG Gang ZHU Guoying MA Guocai | 2007 | Nuclear Science and Techniques2007，18，6： | 6 |
| 10 | An indicator-guided photo-controlled drug delivery system based on mesoporous silica/gold nanocomposites显示文摘mesoporous 硅石 / 黄金(MSN/Au ) nanocomposite 为明确地目标为肿瘤房间的控制相片的药交货被设计。MSN/Au nanocomposite 由基于 MSN 的药搬运人组成,金 nanoparticle (AuNP ) 基于指示物。当基于 MSN 的药搬运人是 mesoporous 硅石时, nanoparticle 与相片可切换的偶氮苯使不能调动(偶氮) 一半,基于 AuNP 的指示物是与矩阵 metalloproteinase (MMP ) 修改的熄灭荧光的 AuNP 底层并且 poly (乙烯乙二醇) 。二种 nanoparticles 被连接由一, cyclodextrin (, CD ) 更暗淡的桥牌。在 vitro,研究证明 nanocomposite 明确地与肿瘤地点 overexpressing MMP-2 交往了,为释放的随后的紫外轻照耀的启用的指导它骗诱药。通过基于 AuNP 的指示物和基于 MSN 的药搬运人的集成, MSN/Au nanocomposite 能精确本地化释放的药到肿瘤地点,显著地从而改进治疗学的功效。 | Guofeng Luo Weihai Chen Huizhen Jia Yunxia Sun Han Cheng Renxi Zhuo Xianzheng Zhang | 2015 | Nano Research2015，8，6： | 6 |
| 11 | Observer-Based Controller Design for Singular Stochastic Markov Jump Systems with State Dependent Noise显示文摘This paper is concerned with the problem of observer-based controller design for singular stochastic Markov jump systems with state-dependent noise. Two concepts called 'non-impulsiveness'and 'mean square admissibility' are introduced, which are different from previous ones. Sufficient conditions for the open-and closed-loop singular stochastic Markov jump systems with state-dependent noise to be mean square admissible are provided in terms of strict LMIs. The controller gain and the observer gain which guarantee the resulting closed-loop error system to be mean square admissible are obtained in turn by solving the strict LMIs. A numerical example is presented to show the efficiency of the design approach. | ZHAO Yong ZHANG Weihai | 2016 | Journal of Systems Science & Complexity2016，29，4： | 6 |
| 12 | Diffusion Bonding of Ti_3Al Base Alloy显示文摘: The effects of diffusion bonding temperature and holding time on the joint strength of Ti3Al base alloy has been investigated in this paper. The shear strength of Ti-14Al-21Nb-3Mo-V alloy diffusion bonding joint under pressure of 12 MPa at 990℃ for 70 min was obtained to 797.6 MPa which approaches the base material strength. In addition, a short-time diffosion bonding process was studied in order to decrease the bonding cost. With the deformation of the specimens of 2.5% and the bonding temperature of 990℃ for 15 min, the bonding strength could reach 801 MPa. | Yi GUO Jinman ZHU Zhijing HE Pifen LIAN and Qing WU (Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110015, China)(To whom correspondence should be addressed)Hong ZHANG (Weihai University, Weihai 260000, China) | 1996 | Journal of Materials Science & Technology1996，12，6： | 5 |
| 13 | Study on stability in probability of general discrete-time stochastic systems显示文摘Dear editor,It is well-known that the stability should first be considered in system analysis and synthesis.Since Lyapunov first initiated his stability theory regarding ordinary differential equations(ODEs)in 1892,Lyapunov’s stability theory has been an important research topic in both mathematics and control theory. | Tianliang ZHANG Feiqi DENG Weihai ZHANG | 2020 | Science China(Information Sciences)2020，63，5： | 5 |
| 14 | An adaptive locomotion controller for a hexapod robot: CPG, kinematics and force feedback显示文摘Insects can perform versatile locomotion behaviors such as multiple gaits, adapting to different terrains, fast escaping, etc. However, most of the existing bio-inspired legged robots do not possess such walking ability, especially when they walk on irregular terrains. To tackle this challenge, a central pattern generator(CPG)-based locomotion control methodology is proposed, integrated with a contact force feedback function. In this approach, multiple gaits are produced by the CPG module. After passing through a post-processing circuit and a delay-line, the control signal is fed into six trajectory generators to generate predefined feet trajectories for the six legs. Then, force feedback is employed to adjust these trajectories so as to adapt the robot to rough terrains. Finally the regulated trajectories are sent to inverse kinematics modules such that the position control instructions are generated to control the actuators. In both simulations and real robot experiments, we consistently show that the robot can perform sophisticated walking patterns. What is more, the robot can use the force feedback mechanism to deal with the irregularity in rough terrain. With this mechanism, the stability and adaptability of the robot are enhanced. In conclusion, the CPG-base control is an effective approach for legged robots and the force feedback approach is able to improve walking ability of the robots, especially when they walk on irregular terrains. | CHEN WeiHai REN GuanJiao WANG JianHua LIU Dong | 2014 | Science China(Information Sciences)2014，57，11： | 4 |
| 15 | ON THE OBSERVABILITY AND DETECTABILITY OF LINEAR STOCHASTIC SYSTEMS WITH MARKOV JUMPS AND MULTIPLICATIVE NOISE显示文摘This paper presents the notions of exact observability and exact detectability for Markovjump linear stochastic systems of Ito type with multiplicative noise (for short,MJLSS).StochasticPopov-Belevith-Hautus (PBH) Criterions for exact observability and exact detectability are respectivelyobtained.As an application,stochastic H_2/H_∞ control for such MJLSS is discussed under exactdetectability. | Yuanhua NI Weihai ZHANG Haitao FANG | 2010 | Journal of Systems Science & Complexity2010，23，1： | 4 |
| 16 | Solution processed inorganic V20x as interfacial function materials for inverted planar-heterojunction perovskite solar cells with enhanced efficiency显示文摘 | Haitao Peng Weihai Sun Yunlong Li Senyun Ye Haixia Rao Weibo Yan Huanping Zhou Zuqiang Bian Chunhui Huang | 2016 | Nano Research2016，9，10： | 4 |
| 17 | Effectiveness of flesh-moistening paste in psoriasis vulgaris patients with symptom pattern of blood stasis:a randomized and parallel-controlled trial显示文摘OBJECTIVE:To evaluate the efficacy and safety of flesh-moistening paste for treating psoriasis vulgaris in patients with blood stasis pattern in terms of Traditional Chinese Medicine(TCM).METHODS:Eudipleural rashes on both the left and right side of the same patients with psoriasis vulgaris,diagnosed via TCM as blood stasis pattern,were selected as the targeted skin lesions.A randomized,double-blind,parallel-controlled,multicenter controlled trial was conducted.The targeted skin lesions were categorized into either the treatment or control group.The treatment group used the flesh-moistening paste;the control group used a placebo.Both the paste and the placebo were topically applied twice daily for eight weeks.The patients were examined biweekly to evaluate the effects.The two groups were compared in terms of the psoriasis area and severity index(PASI)of the targeted skin lesions,which is scored according to erythema,desquamation,infiltration,area,pruritus,and improvement of skin barrier function.Adverse events were recorded during the study period.SPSS 21.0 was used to analyze the data.RESULTS:Fifty-six patients were enrolled between February 2016 and October 2017.Two were complicated by cardio-cerebrovascular disease and were excluded;thus,54 outpatients were finally enrolled in the study.Four dropped out during the study period:three failed to complete their follow-up visits for unknown reasons,and one exited due to an adverse event.The final trial comprised 50 of the 56 originally selected patients,with a 92.6%completion rate.After 8 weeks of treatment,the targeted skin lesion scores differed significantly(P<0.05).The PASI scores of the targeted skin lesions differed significantly beginning at week 6(P<0.05).The treatment group presented better results than those of the control group.Only one patient had an adverse reaction associated with the treatment.Improvements in skin barrier function differed significantly(P<0.05).CONCLUSION:The flesh-moistening paste demonstrated a reliable curative effect and safety for treating psoriasis vulgaris in patients with blood stasis patterns.The topical paste improved the barrier function of the skin lesions. | Guo Xinwei Lang Na Li Guanru Li Ping Qu Jianhua Zhou Dongmei Wang Ping Cang Zhang Deng BingXu Lou Weihai Xu Jingna Lan Haibing Liu Yumin Zhang Weishu Sun Liyun | 2020 | Journal of Traditional Chinese Medicine2020，40，6： | 4 |
| 18 | State and Output Feedback Finite-time Guaranteed Cost Control of Linear It Stochastic Systems显示文摘The problem of guaranteed cost control based on finite-time stability for stochastic system is first investigated in this paper.The motivation of solving this problem arises from an observation that finite/infinite-horizon guaranteed cost control does not consider the transient performance of the closed-loop system,but guaranteed cost control based on finite-time stability involves this practical requirement.In order to explain this problem explicitly,a concept of the stochastic finite-time guaranteed cost control is introduced,and then some new sufficient conditions for the existence of state and output feedback finite-time guaranteed cost controllers are derived,which guarantee finite-time stochastic stability of closed-loop systems and an upper bound of a quadratic cost function.Furthermore,this problem is reduced to a convex optimization problem with matrix inequality constraints and a new solving algorithm is given.Finally,an example is given to illustrate the effectiveness of the proposed method. | YAN Zhiguo ZHANG Guoshan WANG Jiankui ZHANG Weihai | 2015 | Journal of Systems Science & Complexity2015，28，4： | 4 |
| 19 | Organic Matters and Lipid Biomarkers in Surface Sediments from the Northern South China Sea:Origins and Transport显示文摘In this study,content and distribution of organic matters(OM)and lipid biomarkers in surface sediments from northern South China Sea(SCS)were identified to reveal the sources and transport of fine-grained sediments.Organic matters and lipid biomarkers exhibited distinct spatial variation in northern SCS.Terrestrial discharge from the Pearl River and some mountainous rivers in southwestern Taiwan may contribute to the relatively high organic matters in the corresponding sea areas.The detection of unsaturated fatty acid homologues suggested the algal and/or bacterial OM contribution to surface sediments.The composites and distribution of lipid biomarkers indicate their mixed sources from terrestrial plants,marine algae and bacterial.Together with the proof of clay mineral composites in the sediments,the results suggested that the currents,including the Guangdong Coastal Current and Kuroshio Current,control the transport and distribution of terrestrial sediment and the sedimentary environment in the northern SCS. | Weihai Xu Wen Yan Zhong Chen Han Chen Weixia Huang Tian Lin | 2014 | Journal of Earth Science2014，25，1： | 4 |
| 20 | Environmentally responsive dual-targeting nanotheranostics for overcoming cancer multidrug resistance显示文摘The development of multiple drug resistance(MDR) to chemotherapy and subsequent treatment failures are major obstacles in cancer therapy. An attractive option for combating MDR is inhibiting the expression of P-glycoprotein(P-gp) in tumor cells. Here, we report a novel chemosensitizing agent, XMD8-92,which can down-regulate P-gp. To enhance the specificity of MDR chemotherapy, a promising nanotheranostic micelle system based on poly(ethylene glycol)-blocked-poly(L-leucine)(PEG-b-Leu) was developed to simultaneously carry the anticancer drug doxorubicin, chemosensitizing agent XMD8-92, and superparamagnetic iron oxide nanoparticles(SPIOs). Featured with MDR environmentally responsive dual-targeting capability, controllable drug delivery, and efficient magnetic resonance(MR) imaging characteristics, the prepared nanotheranostics(DXS@NPs) showed outstanding in vitro cytotoxicity on MDR cells(SCG 7901/VCR) with only 53% of cells surviving compared to 90% of DOX-treated cells.Furthermore, efficient tumor inhibition and highly reduced systemic toxicity were exhibited by MDR tumor-bearing mice treated with DXS@NPs. Overall, the environmentally responsive dual-targeting nanotheranostics represent a promising approach for overcoming cancer MDR. | Caixia Yang Xin Pang Weihai Chen Xiaoyong Wang Gan Lin Chengchao Chu Xianzheng Zhang Xianming Deng Xiaoyuan Chen Gang Liu | 2019 | Science Bulletin2019，64，10： | 3 |
您所在的机构暂未开通此部分的功能，请联系管理员