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| 1 | Monodisperse core-shell structured magnetic mesoporous aluminosilicate nanospheres with large dendritic mesochannels显示文摘合理设计和有一个定制的活跃核心和大、树枝状的、修改 mesoporous 的多功能的混合 nanostructures 的精确合成组织了壳能支持催化作用,精力存储,和生物应用。这里,油水双相层化涂层策略被开发了准备 monodisperse 磁性的树枝状的 mesoporous 硅石核心壳结构化的 nanospheres。这些复杂 Fe 3 O 4@SiO2@dendritic-mSiO2 nanospheres 特征大树枝状的开的毛孔(2.7 和 10.3 nm ) 。显著地,硅石壳能与未改变的孔, 14 的 Si/Al 臼齿的比率,和显著地强壮的酸的地点被变换成树枝状的 mesoporous 铝矽酸盐框架,通过一条合成以后的途径。另外,结果的磁性的树枝状的 mesoporous 铝矽酸盐 nanospheres 展览在从废水的磷酸盐移动的突出的性质和有希望的申请。 | Jianping Yang Dengke Shen Yong Wei Wei Li Fan Zhang Biao Kong Shaohua Zhang Wei Teng Jianwei Fan Weixian Zhang Shixue Dou Dongyuan Zhao | 2015 | Nano Research2015，8，8： | 11 |
| 2 | Petrophysical characteristics of rocks and sulfides from the SWIR hydrothermal field显示文摘Study of petrophysical properties of rocks in seafloor hydrothermal fields has great significance for investigation of seafloor hydrothermal activities,especially for polymetallic sulfides prospecting.In the present study,based on the current experimental conditions,we conducted systematic experiments to measure the magnetic susceptibility,electrical resistivity,porosity,density,as well as acoustic wave velocity of seafloor rocks and sulfides.Subsequently,we measured the physical characteristics of hydrothermal sulfides,basalts and peridotites which were collected from newly discovered seafloor hydrothermal fields at 49.6°E,50.5°E,51°E,63.5°E,and 63.9°E of the Southwest Indian Ridge(SWIR).Previously available and newly collected data were combined to characterize the physical differences between polymetallic sulfides and rocks.We also discussed the impact of hydrothermal alteration on the bedrock and demonstrated how these petrophysical properties of rocks can help in geophysical prospecting of seafloor hydrothermal fields as indicators. | TAO Chunhui WU Tao JIN Xiaobing DOU Bingjun LI Huaiming ZHOU Jianping | 2013 | Acta Oceanologica Sinica2013，32，12： | 5 |
| 3 | Cholecystectomy is associated with higher risk of recurrence after microwave ablation of hepatocellular carcinoma:a propensity score matching analysis显示文摘Objective:To explore the association between cholecystectomy and the prognostic outcomes of patients with hepatocellular carcinoma(H CC)who underwent microwave ablation(MWA).Methods:Patients with HCC(«=921)who underwent MWA were included and divided into cholecystectomy(n=114)and non-cholecystectomy groups(n=807).After propensity score matching(PSM)at a 1:2 ratio,overall survival(OS)and disease-free survival(DFS)rates were analyzed to compare prognostic outcomes between the cholecystectomy(«=114)and non-cholecystectomy groups(n=228).Univariate and multivariate Cox analyses were performed to assess potential risk factors for OS and DFS.Major complications were also compared between the groups.Results:After matching,no significant differences between groups were observed in baseline characteristics.The 1-,3-,and 5-year OS rates were 96.5%,82.1%,and 67.1%in the cholecystectomy group,and 97.4%,85.2%,and 74.4%in the non-cholecystectomy group(P=0.396);the 1-,3-,and 5-year DFS rates were 58.4%,34.5%,and 26.6%in the cholecystectomy group,and 73.6%,44.7%,and 32.2%in the non-cholecystectomy group(P=0.026),respectively.The intrahepatic distant recurrence rate in the cholecystectomy group was significantly higher than that in the non-cholecystectomy group(P=0.026),and the local tumor recurrence and extrahepatic recurrence rates did not significantly differ between the groups(P=0.609 and P=0.879).Multivariate analysis revealed that cholecystectomy(HR=1.364,95%Cl 1.023-1.819,P=0.035),number of tumors(2 vs.1:HR=2.744,95%Cl 1.925-3.912,P<0.001;3 vs.1:HR=3.411,95%Cl 2.021-5.759,P<0.001),and y-GT levels(HR=1.003,95%Cl 1.000-1.006,P<0.024)were independent risk factors for DFS.The best y-GT level cut-off value for predicting median DFS was 39.6 U/L(area under the curve=0.600,P<0.05).A positive correlation was observed between cholecystectomy and y-GT level(r=0.108,95%Cl-0.001-0.214,P=0.047).Subgroup analysis showed that the DFS rates were significantly higher in the non-cholecystectomy group than the cholecystectomy group when Y-GT>39.6 U/L(i3=0.044).The 5-,10-,15-,20-,and 25-year recurrence rates from the time of cholecystectomy were 2.63%,21.93%,42.11%,58.77%,and 65.79%,respectively.A significant positive correlation was observed between cholecystectomy and the time from cholecystectomy to recurrence(r=0.205,95%Cl 0.016-0.379,P=0.029).There were no significant differences in complications between groups(P=0.685).Conclusions:Patients with HCC who underwent cholecystectomy were more likely to develop intrahepatic distant recurrence after MWA,an outcome probably associated with increased y-GT levels.Moreover,the recurrence rates increased with time. | Hongcai Yang Yi Yang Jianping Dou Rui Cui Zhigang Cheng Zhiyu Han Fangyi Liu Xiaoling Yu Xiang Zhou Jie Yu Ping Liang | 2020 | Cancer Biology & Medicine2020，17，2： | 3 |
| 4 | Combination therapy using microwave ablation and d-mannose-chelated iron oxide nanoparticles inhibits hepatocellular carcinoma progression显示文摘Despite being a common therapy for hepatocellular carcinoma(HCC),insufficient thermal ablation can leave behind tumor residues that can cause recurrence.This is believed to augment M2 inflammatory macrophages that usually play a pro-tumorigenic role.To address this problem,we designed D-mannose-chelated iron oxide nanoparticles(man-IONPs) to polarize M2-like macrophages into the antitumor Ml phenotype.In vitro and in vivo experiments demonstrated that man-IONPs specifically targeted M2-like macrophages and accumulated in peri-ablation zones after macrophage infiltration was augmented under insufficient microwave ablation(MWA).The nanoparticles simultaneously induced polarization of pro-tumorigenic M2 macrophages into antitumor M1 phenotypes,enabling the transformation of the immunosuppressive microenvironment into an immunoactivating one.Post-MWA macrophage polarization exerted robust inhibitory effects on HCC progression in a well-established orthotopic liver cancer mouse model.Thus,combining thermal ablation with man-IONPs can salvage residual tumors after insufficient MWA.These results have strong potential for clinical translation. | Rui Cui Luo Wang Dongyun Zhang Kun Zhang Jianping Dou Linan Dong Yixuan Zhang Jiapeng Wu Longfei Tan Jie Yu Ping Liang | 2022 | Acta Pharmaceutica Sinica B2022，12，9： | 2 |
| 5 | Boron doping-induced interconnected assembly approach for mesoporous silicon oxycarbide architecture显示文摘Despite desirable progress in various assembly tactics, the main drawback associated with current assemblies is the weak interparticle connections limited by their assembling protocols. Herein, we report a novel boron doping-induced interconnection-assembly approach for fabricating an unprecedented assembly of mesoporous silicon oxycarbide nanospheres, which are derived from periodic mesoporous organosilicas. The as-prepared architecture is composed of interconnected, strongly coupled nanospheres with coarse surfaces. Significantly, through delicate analysis of the as-formed boron doped species, a novel melt-etching and nucleation-growth mechanism is proposed, which offers a new horizon for the developing interconnected assembling technique. Furthermore, such unique strategy shows precise controllability and versatility, endowing the architecture with tunable interconnection size, surface roughness and switchable primary nanoparticles. Impressively, this interconnected assembly along with tunable surface roughness enables intrinsically dual(both structural and interfacial) stable characteristics, achieving extraordinary long-term cycle life when used as a lithium-ion battery anode. | Guanjia Zhu Rui Guo Wei Luo Hua Kun Liu Wan Jiang Shi Xue Dou Jianping Yang | 2021 | National Science Review2021，8，6： | 1 |
| 6 | 淋巴细胞密度及分布与直肠癌新辅助治疗反应的关系显示文摘背景:研究认为,淋巴细胞密度与直肠癌预后相关;但新辅助治疗前淋巴细胞分布模式对预后的影响尚不清楚。本研究旨在评估淋巴细胞的分布及密度与直肠癌新辅助治疗反应的关系。方法:对前瞻性队列中接受新辅助治疗的134例直肠癌患者进行回顾性分析。对新辅助治疗前活检标本进行免疫组化染色(CD4和CD8)。评估瘤内腺体周围淋巴细胞(IPL)和肿瘤浸润淋巴细胞(TIL)的密度。采用logistic回归模型(包括临床病理特征、分子特征及治疗方案)评估不同淋巴细胞的密度与肿瘤退缩分级(TRG)的关系。结果:CD8^(+)TIL密度高的患者接受新辅助治疗后获得了更佳的TRG(OR=0.23,95%CI:0.07-0.76,P<0.001)。而CD8^(+)IPL(P=0.033)、CD4^(+)IPL(P=0.156)和CD4^(+)TIL(P=0.170)则与TRG无明显相关性。敏感性分析未发现CD8^(+)TIL与新辅助放疗(P_(相互作用)=0.831)或化疗(P_(交互作用)=0.879)对TRG的影响存在交互作用。结论:本研究结果显示,CD8^(+)TIL而不是CD8^(+)IPL,可独立影响直肠癌新辅助治疗反应,这种影响不受放疗或化疗方案的干扰。 | Sicong Lai Xiaoying Lou Xinjuan Fan Weipeng Sun Yanhong Deng Jianping Wang Yan Huang Ruoxu Dou | 2020 | Gastroenterology Report2020，8，6： | 1 |
| 7 | Graph theory-based approach to optimize single-product flow-line configurations of RMS显示文摘 | DOU Jianping DAI Xianzhong MENG Zhengda | 2009 | International Journal of Advanced Manufacturing Technology2009，41，9： | 1 |
| 8 | Microwave ablation vs. surgical resection for treatment naïve hepatocellular carcinoma within the Milan criteria: a follow-up of at least 5 years显示文摘Objective:Thermal ablation poses challenges in the surgical resection(SR)of small hepatocellular carcinoma(HCC),and its therapeutic outcomes for larger lesions remain debated.Methods:This retrospective study evaluated 729 patients with HCC meeting the Milan criteria,who were treated with curative SR or microwave ablation(MWA)between 2008 and 2014.Overall survival(OS),cancer-specific survival(CSS),disease-free survival(DFS),and local tumor progression(LTP)were compared after propensity score matching(PSM).Co-variates associated with OS,CSS,LTP,and DFS were identified.The risk of death and tumor progression were compared.Results:During the median follow-up of 78.6 months,253 patients were included in each group after PSM.For tumors≤3.0 cm and 3.1–4.0 cm,MWA achieved comparable results in terms of OS,CSS,DFS,and LTP.For tumors 4.1–5.0 cm,MWA had lower OS,CSS,and DFS rates(all P<0.05)than SR.Higher LTP rates were observed in the MWA group for tumors 4.1–5.0 cm,although the difference was not significant(P=0.18).Complication rates(P=0.41)were similar,but MWA led to less estimated blood loss(P<0.01)and shorter postoperative hospitalization times(P<0.01).Conclusions:MWA achieved comparable long-term oncologic outcomes with SR for≤4 cm HCC,with lower complication rates and faster recovery. | Jianping Dou Zhigang Cheng Zhiyu Han Fangyi Liu Zhen Wang Xiaoling Yu Jie Yu Ping Liang | 2022 | Cancer Biology & Medicine2022，19，7： | 0 |
| 9 | 直肠癌指南对比:例外反证规则?显示文摘临床实践指南正在全球范围内推动着早期或局部进展期直肠癌的治疗规范,但不同指南间的巨大差异也造成了认识上的混乱。我们比较了5个来自专业协会/机构的最新临床实践指南:美国国立综合癌症网络(NCCN)、美国结直肠外科医师学会(ASCRS)、欧洲肿瘤内科学会(ESMO)、中国国家卫生健康委员会(NHC)及中国临床肿瘤学会(CSCO)。本文对一些造成差异的关键证据进行了梳理,以帮助读者更好地理解一些看似矛盾的指南推荐。 | Ruoxu Dou Siqi He Yanhong Deng Jianping Wang | 2021 | Gastroenterology Report2021，9，4： | 0 |
| 10 | High-performance ZnO humidity sensor synthesized by coprecipitation with PVP as surfactant for human respiration detection显示文摘A high-performance zinc oxide(ZnO)/polyvinylpyrrolidone(PVP)humidity sensor was prepared by simple coprecipitation method with PVP as surfactant.The coprecipitation method has low reaction temperature,little energy consumption and simple preparation,which is suitable for large-scale production.The PVP makes sample’s surface with more hydroxyl and oxygen vacancies than pure ZnO,which can absorb more water molecules and promote the decomposition of water molecules into H3O+to form effective ion conduction.When the molar ratio of PVP to ZnO is 1:1,the ZnO/PVP humidity sensor has low hysteresis(~4.2%),short response/recovery time(9/10 s),excellent stability and high sensitivity with more than 4 orders of magnitude in relative humidity(RH)range from 11%to 95%.Moreover,the ZnO/PVP humidity sensor can distinguish different respiratory states of human body,which has a potential in monitoring and prevention of respiratory diseases. | MAN Jianping GU Weiyuan HU Ziyan DOU Xiaozong ZHANG Hongyan | 2023 | Optoelectronics Letters2023，19，1： | 0 |
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