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| 1 | 5-Hydroxymethylcytosine signatures in circulating cell-free DNA as diagnostic biomarkers for human cancers显示文摘象 5-methylcytosine (5mC ) 和 5-hydroxymethylcytosine (5hmC ) 那样的 DNA 修正是知道在哺乳动物影响全球基因表示的 epigenetic 标记。在人的染色体,与基因表示的靠近的关联和高化学的稳定性给他们的流行,这些 DNA epigenetic 标记能为癌症用作理想的 biomarkers 诊断。利用一种高度敏感、选择的化学标记技术,我们这里报导在传播没有房间的 DNA ( cfDNA )并且在从最近与 colorectal 诊断的 260 个病人的一个队收集的配对的肿瘤和邻近的纸巾的 genomic DNA ( gDNA )的 5hmC 的染色体宽的介绍,胃,胰腺,从 90 个健康个人的肝或甲状腺癌症和正常纸巾。5hmC 主要在与开的染色质和容许的 histone 修正重合的 transcriptionally 活跃的区域被散布。柔韧的联系癌症的 5hmC 签名在 cfDNA 被识别为特定的癌症类型是特征的。传播 cfDNA 的 5hmC 底 biomarkers colorectal 和胃的癌症是高度预兆的并且比常规 biomarkers 优异并且比得上从织物活体检视的 5hmC biomarkers。因此,这新策略能从血样品的分析为癌症的诊断和预后导致有效、最低限度地侵略的方法的发展。 | Wenshuai Li Xu Zhang Xingyu Lu Lei You Yanqun Song Zhongguang Luo Jun Zhang Ji Nie Wanwei Zheng Diannan Xu Yaping Wang Yuanqiang Dong Shulin Yu Jun Hong Jianping Shi Hankun Hao Fen Luo Luchun Hua Peng Wang Xiaoping Qian Fang Yuan Lianhuan Wei Ming Cui Taiping Zhang Quan Liao Menghua Dai Ziwen Liu Ge Chen Katherine Meckel Sarbani Adhikari Guifang Jia Marc B Bissonnette Xinxiang Zhang Yupei Zhao Wei Zhang Chuan He Jie Liu | 2017 | Cell Research2017，27，10： | 30 |
| 2 | Molecular mechanism of SCARB2-mediatec attachment and uncoating of EV71显示文摘 | Minghao Dang Xiangxi Wang Quan Wang Yaxin Wang Jianping Lin Yuna Sun Xuemei Li Liguo Zhang Zhiyong Lou Junzhi Wang Zihe Rao | 2014 | Protein & Cell2014，5，9： | 13 |
| 3 | Multi-objective optimal preliminary planning of multi-debris active removal mission in LEO显示文摘The goal of this paper is to develop a preliminary plan for a multi-nanosatellite active debris removal platform(Mn ADRP) for low-Earth-orbit(LEO) missions. A dynamic multi-objective traveling salesman problem(TSP) scheme is proposed in which three optimization objectives, i.e., the debris removal priority,the Mn ADRP orbital transfer energy, and the number of required nanosatellites are modeled respectively. A modified genetic algorithm(GA) is also proposed to solve the dynamic multi-objective TSP. Finally, numerical experiments involving partially real-world the debris data set are conducted to verify the efficacy of the proposed models and the solution method. | Yong LIU Jianan YANG Yizhou WANG Quan PAN Jianping YUAN | 2017 | Science China(Information Sciences)2017，60，7： | 4 |
| 4 | Memristive Artificial Synapses for Neuromorphic Computing显示文摘Neuromorphic computing simulates the operation of biological brain function for information processing and can potentially solve the bottleneck of the von Neumann architecture.This computing is realized based on memristive hardware neural networks in which synaptic devices that mimic biological synapses of the brain are the primary units.Mimicking synaptic functions with these devices is critical in neuromorphic systems.In the last decade,electrical and optical signals have been incorporated into the synaptic devices and promoted the simulation of various synaptic functions.In this review,these devices are discussed by categorizing them into electrically stimulated,optically stimulated,and photoelectric synergetic synaptic devices based on stimulation of electrical and optical signals.The working mechanisms of the devices are analyzed in detail.This is followed by a discussion of the progress in mimicking synaptic functions.In addition,existing application scenarios of various synaptic devices are outlined.Furthermore,the performances and future development of the synaptic devices that could be significant for building efficient neuromorphic systems are prospected. | Wen Huang Xuwen Xia Chen Zhu Parker Steichen Weidong Quan Weiwei Mao Jianping Yang Liang Chu Xing’ao Li | 2021 | Nano-Micro Letters2021，13，5： | 4 |
| 5 | STRUCTURE DESIGN OF THE BEIJING SPECTROMETERⅢBEAM PIPE显示文摘The Beijing spectrometerⅢ(BESⅢ)beam pipe is in the center of the BESⅢ,which is the detector of the upgrade project of Beijing electron and positron collider(BEPCⅡ).Electrons and positrons collide in the BESⅢbeam pipe.According to the demands of the BEPCⅡ,a key program of Chinese Academy of Sciences,the BESⅢbeam pipe is designed based on the finite elements analysis.The BESⅢbeam pipe is installed in the inner cylinder of the BESⅢdrift chamber.As a vacuum tube,the BESⅢbeam pipe is designed as 1000 mm in length,63 mm in inner diameter and 114 mm in outer diameter,respectively.The BESⅢbeam pipe consists of a central beryllium pipe cooled by EDM-1,the oil No.1 for electric discharge machining,and two extended copper pipes cooled by deionized water(DW).The three parts are jointed by vacuum welding.Factors taken into account in the design are as follows.①The wall thickness of the central beryllium pipe should be designed as small as possible to reduce the multi-scattering and improve the particle momentum resolution.And the wall thickness of the extended copper pipe should be designed as large as possible to protect the detectors from the backgrounds.②The BESⅢbeam pipe must be sufficiently cooled to avoid the damage and prevents its influence to the BESⅢdrift chamber(DC)operation.The inner surface temperature of the DC inner cylinder must be maintained at 293±2 K.③The magnetic permeability of the materials used in the BESⅢbeam pipe must be less than 1.05 H/m to avoid large magnetic field distortions.④The static pressure of the vacuum chamber of the BESⅢbeam pipe must be less than 800μPa.The simulating results show that the designed structure oftbe BESⅢbeam pipe satisfies the requirements mentioned above.The structure design scheme is evaluated and adopted by the headquarters of BEPCⅡ. | ZHENG Lifang JI Quan WANG Li LI xunfeng XU Shaowang DONG Sujun ZHAO Libin LIU Jianping | 2008 | Chinese Journal of Mechanical Engineering2008，21，3： | 3 |
| 6 | Field study on occupants’ thermal comfort and residential thermal environment in a hot-humid climate of China显示文摘 | Jie Han Guoqiang Zhang Quan Zhang Jinwen Zhang Jianlong Liu Liwei Tian Cong Zheng Junhong Hao Jianping Lin Yanhui Liu Demetrios. J. Moschandreas | 2006 | Building and Environment2006，，12： | 1 |
| 7 | Earliest domestication of common millet(Panicummiliaceum)in East Asia extended to 10 000 years ago显示文摘 | Houyuan Lu Jianping Zhang Kam-biu Liu Naiqin Wu Yumei Li Kunshu Zhou Maolin Ye Tianyu Zhang Hai-jiang Zhang Xiaoyan Yang Licheng Shen Deke Xu Quan Li | 2009 | PNAS2009，106，18： | 1 |
| 8 | Earliest domestication of common millet(Panicummiliaceum)in East Asia extended to 10 000 years ago 显示文摘 | Houyuan Lu Jianping Zhang Kam-biu Liu Naiqin Wu Yumei Li Kunshu Zhou Maolin Ye Tianyu Zhang Hai-jiang Zhang Xiaoyan Yang Licheng Shen Deke Xu Quan Li | 2009 | Proceedings of the National Academy of Sciences of the Unit-ed States of America2009，106，： | 1 |
| 9 | Genome-wide association analysis reveals genetic loci and candidate genes associated with intramuscular fat in Duroc pigs显示文摘Intramuscular fat(IMF) is a major meat-quality trait in pigs. The content of IMF is directly associated with the taste and flavor of pork. As a complex trait, there could be multiple genes affecting IMF content in pork. Genomewide association study is a powerful tool to detect genomic regions associated with phenotypic variations. The objectives of the present study were to identify or refine the positions of genomic regions affecting IMF, and to characterize candidate genes and pathways that may influence this trait. Of note, we identified a significant region in longissium dorsi muscle in a Duroc pig population for IMF content with Porcine SNP60 v2 Bead Chip. This region spans 1.24 Mb on chromosome 8 and had been identified as a quantitative trait locus for IMF in Pietrain, Large White, Landrace, and Leicoma pigs. In this region, eight SNPs were significantly associated with IMF content. Three genes proximal to these significant SNPs were considered candidate genes, including ZDHHC16, LOC102162218 and PCDH7. Our results confirm several previous findings and highlight several genes that may contribute to IMF variation in Duroc pigs. | Xingwang WANG Rongrong DING Jianping QUAN Linxue YANG Ming YANG Enqin ZHENG Dewu LIU Gengyuan CAI Zhenfang WU Jie YANG | 2017 | Frontiers of Agricultural Science and Engineering2017，4，3： | 1 |
| 10 | Microsurgical treatment of posterior inferior cerebellar aneurysms based on angioarchitecture supplemented by high-resolution vessel wall MRI:a case series report显示文摘Background Surgical treatment of posterior inferior cerebellar artery(PICA)aneurysms is challenging because many are nonsaccular and atherosclerotic.We report our tailored approach to PICA aneurysms,which is based on angioarchitecture supplemented by high-resolution vessel wall MRI(HR-VW MRI)findings.Methods From March 2010 to September 2020,27 patients with 29 PICA aneurysms underwent surgical treatment in our institution.Since October 2016,HR-VW MRI has been used for aneurysmal wall assessment.Clinical characteristics,radiological data and surgical outcomes were analysed.Results Nineteen proximal PICA aneurysms(vertebral artery(VA),P1,P2 and P3)were treated using the far-lateral approach.Ten distal PICA aneurysms(P4,P5)were treated using the suboccipital midline approach.Direct clipping or clip reconstruction was achieved in 19 aneurysms.Ten were trapped in conjunction with extracranial-intracranial or intracranial-intracranial bypass,including three occipital artery-PICA reimplantations,three PICA-VA reimplantations,two PICA-PICA side-to side anastomoses,one PICA-PICA reimplantation and one PICA-PICA reanastomosis.All aneurysms were eventually completely obliterated and all bypasses remained patent.At the last follow-up,26 patients(96.2%)achieved a good outcome(modified Rankin Scale score<3).Eight patients underwent HR-VW MRI.Among these,the six aneurysms with focal wall enhancement required bypass and the two with negative enhancement were successfully clipped.Conclusion PICA aneurysms have a higher frequency of complex features such as large or giant size and fusiform or dissecting morphology.Favourable outcomes were achieved with individualised microsurgical strategies based on angioarchitecture.HR-VW MRI may be used as a promising technique to predict aneurysmal atherosclerosis. | Zixiao Yang Jianping Song Kai Quan Peiliang Li Qingzhu An Yuan Shi Peixi Liu Guo Yu Yanlong Tian Liangfu Zhou Wei Zhu | 2022 | Stroke & Vascular Neurology2022，7，4： | 1 |
| 11 | Component and simulation of the 4,000-year-old noodles excavated from the archaeological site of Lajia in Qinghai,China显示文摘Noodles are a global food,but the periods when and places where they were made and originated,as well as their ingredients and the cooking methods used to manufacture them,have remained contentious.In the 2005 edition of the journal Nature,we wrote a summary of the millet noodle specimens found in the Late Neolithic Qijia cultural stratum of the Lajia archaeological site in Qinghai Province,China.However,how the ancient people made millet noodles remains controversial.This paper provides a systematic analysis of the remains of noodles found withinan earthenware bowl at the Lajia ‘‘noodle house'' in terms of their plant composition including phytoliths,starch and biomarkers.It provides evidence of how people used millet4,000 years ago and,most specifically,of the principal methods used for producing millet-based noodles.Further,we show how we used traditional hele tools to make hele millet noodles,with especial reference to the gelatinized hydrogel-forming method,to simulate morphology consistent with the composition and form of the unearthed millet noodles.The results of this study provide new evidence and new insights into the cultural characteristics of the prehistoric human diet. | Houyuan L Yumei Li Jianping Zhang Xiaoyan Yang Maolin Ye Quan Li Can Wang Naiqin Wu | 2014 | Chinese Science Bulletin2014，59，35： | 1 |
| 12 | Author Correction: 5-Hydroxymethylcytosine signatures in circulating cell-free DNA as diagnostic biomarkers for human cancers显示文摘In the initial published version of this article, there was a mistake in the P value for the correlation between gene-expression changes and 5 hmC changes in tumors. The correct P value should be same as the P value shown in Fig. S6A: 9.8?×?10?6 (mistakenly shown as “9.8?×?106” in the main text). This correction does not affect the description of results or the conclusions of this study, since the range of P value is between 0 and 1. | Wenshuai Li Xu Zhang Xingyu Lu Lei You Yanqun Song Zhongguang Luo Jun Zhang Ji Nie Wanwei Zheng Diannan Xu Yaping Wang Yuanqiang Dong Shulin Yu Jun Hong Jianping Shi Hankun Hao Fen Luo Luchun Hua Peng Wang Xiaoping Qian Fang Yuan Lianhuan Wei Ming Cui Taiping Zhang Quan Liao Menghua Dai Ziwen Liu Ge Chen Katherine Meckel Sarbani Adhikari Guifang Jia Marc B Bissonnette Xinxiang Zhang Yupei Zhao Wei Zhang Chuan He Jie Liu | 2019 | Cell Research2019，29，7： | 1 |
| 13 | A Knowledge Based Approach to Integrated Battle Damage Assessment and Repair Analysis显示文摘BDAR analysis is a kind of very complex analysis technology which can be used todetermine the battle damage mode of equipment and relevant decision strategy BDAR analysis isbased on the information about W, MA(maintenance analysis), FTA(fault treeanalysis) and vulnerability analysis. These information and analysis,esults are obtained on thebasis of the domain expert’s experience and heowledge- Upon the basis of the sumnlary ofBDARA methods, this paper provides applied knowledge database, puts forward BDARA’sintegrated thinking, implementing methods, and the key technology for IBDARA’ knowledgedatabase ’s | Shi Quan Li Jianping Wang Runsheng(Department of Management Engineering, Shijiazhuang Mechanical Engineering College No.97, West Heping Rkad, Shijiazhuang ,Hebei, P.R.China, 050003E-mail:shiquan @sj-user.he.cninfo.net) | 2000 | International Journal of Plant Engineering and Management2000，5，2： | 1 |
| 14 | Comparative urbanization of birds in China and Europe based on birds associated with trees显示文摘Urbanization effects on living organisms are spatially heterogeneous.Here we quantified the abundance of birds per tree in forested urban and rural habitats for 85,829 trees mainly in China and Europe.A population model was based on the assumption that:1)birds have a normally distributed habitat preference;2)an increase in population size linked to the habitat preference;3)a population size dependent on the habitat preference;and 4)the removal of a certain fraction of individuals giving rise to extinction.We tested for large-scale differences in the impact of urbanization on the frequency distribution of the difference in abundance between urban and rural habitats in China and parts of Europe.The difference in the frequency distribution of urban population density of birds in trees minus rural population density of birds in trees in China and Europe was statistically significant suggesting that the abundance of birds differed between trees in urban and rural habitats,but more so in China than in Europe.We hypothesize that more pronounced differences in China than in Europe may have arisen due to the Four Pests Campaign in 1958-1962 that resulted in death of hundreds of millions of birds(mainly tree sparrows Passer monfanus,but also numerous other less common species that were starting to become urbanized around 1960).Species that were less common in 1960 could not sustain reductions in population size in urban areas and hence these species are still rare or absent in urban areas today 60 years later. | Anders Pape MOLLER Canwei XIA Bo ZHOU Xianli CHE Xingzhi CHE Changzhang FENG Karsten LAURSEN Federico MORELLI Wangming LI Jianping LIU Qing QUAN Min ZHANG Qiang ZHANG Qiangwen ZHAN Laikun MA Haitao WANG Fasheng ZOU Wei LIANG | 2019 | Current Zoology2019，65，6： | 0 |
| 15 | Two Cluster-Based Coordination Polymers Derived from [Et_(4)N][Tp*WS_(3)(CuBr)_(3)] and CuCN: Isolation, Structures and Amplified Third-Order Nonlinear Optical Responses显示文摘Treatment of a W/Cu/S precursor[Et_(4)N][Tp*WS_(3)(CuBr)_(3)](1)with three equiv.of CuCN in DMF/MeCN/benzonitrile(or α-tolunitrile)yielded two[Tp*WS_(3)Cu_(3)(μ_(3)-DMF)]-based coordination polymers,[Tp*WS_(3)Cu_(3)(μ_(3)-DMF)(CN)_(3)Cu]_(2)•2DMF(2•2DMF)and[Tp*WS_(3)Cu_(3)(μ_(3)-DMF)(CN)_(3)Cu(α-tolunitrile)]_(2)•3MeCN(3•3MeCN),respectively.Structural analysis revealed that 2 adopts a 2D network with a 4.8^(2) topology while 3 has a 1D ladder-type chain.The third-order nonlinear optical responses of 2 and 3 in DMF were 10 times enhanced compared to those of the precursor cluster 1. | Quan Liu Wenhua Zhang Zhenrong Sun Jianping Lang | 2014 | Chinese Journal of Chemistry2014，32，10： | 0 |
| 16 | Dynamic evaluation of traffic flows on city roads显示文摘This paper presents an analysis of the random fluctuations, deferred conduction effect and periodicity of road traffic based on the basic features of road networks. It also discusses the limitations of road network evaluation theories based on road 'V/C'. In addition, it proposes a set of theoretical and technical methods for the real-time evaluation of traffic flows for entire road networks, and for solving key technical issues, such as real-time data collection and processing in areas with no blind zones, the spatial-temporal dynamic analysis of road network traffic, and the calibration of key performance index thresholds. It also provides new technical tools for the strategic transportation planning and real-time diagnosis of road traffic. The new tools and methodology presented in this paper are validated using a case study in Beijing. | Quan Yongshen Guo Jifu Wen Huimin Sun Jianping | 2012 | Engineering Sciences2012，10，4： | 0 |
| 17 | Butterfly and Nest-Shaped Tp*-W-Cu-S Cluster Monomers and Dimers with Hexamethylenetetramine as Ligand:Anion-Dependent Structures and Nonlinear Optical Properties显示文摘Main observation and conclusion The assembly of[Et4N][Tp*WS3](1)with CuX(Tp*=hydridotris(3,5-dimethylpyrazol-1-yl)borate;X=Cl,Br,andI)or[Cu(MeCN)][PF6]in the presence of tetratopic ligand hexamethylenetetramine(HMT)afforded an array of four cluster-based compounds,which are either neutral or anionic.These compounds include[Tp*WSzCu3Cl2(HMT)](2,monomer,neutral),[Tp*WSzCugBr2(HMT)](3,monomer,neutral),[Tp*WSzCu3l1 s(HMT)21(4,dimer,anionic),and[Tp*WSzCu2(HMT)]2(PFc)2(5,dimer,anionic).The size of the halogen is found to dictate the structures(2/3 versus 4),and the presence/absence of halogen also affects the utiliation of coordinate site of HMT(4 versus 5)by creating more available CuOite in the case of 5.The structures of 2-5 are also characterized using elemental analysis,Fourier-transform infrared(FT-IR)spectra,and ultraviolet-visible(UV-Vis)spectroscopy,with the dimeric structure of 5 also selected for the third-order nonlinear optical(NLO)property investigations.The NLO measurement results suggest that the hyperpola rizability value(v)of 5,reflecting its NLO properties as a neat material,features 2.12×10^(-30)esu,and it is comparable to other W/Cu/S clus-terbased molecular entities,rendering 5 a promising NLO-active material. | Quan Liu Mingie Lu Lice Yu Yinglin Song Jianping Lang | 2021 | Chinese Journal of Chemistry2021，39，3： | 0 |
| 18 | Chinese guidelines for the application of colon cancer staging recognition systems based on artificial intelligence platforms (2021)显示文摘The incidence and mortality of colon cancer in China are increasing each year.At present,treatment selection for colon cancer patients mainly depends on imaging results,which require a large number of radiologists to interpret.In China,there is a shortage and uneven distribution of experienced radiologists,which leads to delays and bias in the evaluation of imaging data.Based on these considerations,the Colorectal Surgery Group of the Surgery Branch of the Chinese Medical Association in collaboration with experts at Beihang University has independently developed an artificial intelligence(AI)-based recognition system for the preoperative determination of colon cancer stage to partially replace the work of and relieve the pressure on radiologists.These guidelines aim to standardize the use of AI-based recognition systems in the preoperative staging of colon cancer and guide their clinical application. | Yun Lu Shuai Li Yuan Gao Yong Dai Bo Feng Fanghai Han Jiagang Han Jingjing He Xinxiang Li Guole Lin Qian Liu Guiying Wang Quan Wang Zhenning Wang Zheng Wang Aiwen Wu Bin Wu Yingchi Yang Hongwei Yao Wei Zhang Jianping Zhou Aimin Hao Zhongtao Zhang 无 | 2021 | Intelligent Medicine2021，1，1： | 0 |
| 19 | Composition,function,and timing:exploring the early‑life gut microbiota in piglets for probiotic interventions显示文摘Background The establishment of a robust gut microbiota in piglets during their early developmental stage holds the potential for long-term advantageous effects.However,the optimal timeframe for introducing probiotics to achieve this outcome remains uncertain.Results In the context of this investigation,we conducted a longitudinal assessment of the fecal microbiota of 63 piglets at three distinct pre-weaning time points.Simultaneously,we gathered vaginal and fecal samples from 23 sows.Employing 16S rRNA gene and metagenomic sequencing methodologies,we conducted a comprehensive analysis of the fluctuation patterns in microbial composition,functional capacity,interaction networks,and colonization resistance within the gut microbiota of piglets.As the piglets progressed in age,discernible modifications in intestinal microbial diversity,composition,and function were observed.A source-tracking analysis unveiled the pivotal role of fecal and vaginal microbiota derived from sows in populating the gut microbiota of neonatal piglets.By D21,the microbial interaction network displayed a more concise and efficient configuration,accompanied by enhanced colonization resistance relative to the other two time points.Moreover,we identified three strains of Ruminococcus sp.at D10 as potential candidates for improving piglets’weight gain during the weaning phase.Conclusions The findings of this study propose that D10 represents the most opportune juncture for the introduction of external probiotic interventions during the early stages of piglet development.This investigation augments our comprehension of the microbiota dynamics in early-life of piglets and offers valuable insights for guiding forthcoming probiotic interventions. | Jianping Quan Cineng Xu Donglin Ruan Yong Ye Yibin Qiu Jie Wu Shenping Zhou Menghao Luan Xiang Zhao Yue Chen Danyang Lin Ying Sun Jifei Yang Enqin Zheng Gengyuan Cai Zhenfang Wu Jie Yang | 2024 | Journal of Animal Science and Biotechnology2024，15，2： | 0 |
| 20 | Critical thinking of Alzheimer's transgenic mouse model:current research and future perspective显示文摘Transgenic models are useful tools for studying the pathogenesis of and drug development for Alzheimer's Disease(AD).AD models are constructed usually using overexpression or knock-in of multiple pathogenic gene mutations from familial AD.Each transgenic model has its unique behavioral and pathological features.This review summarizes the research progress of transgenic mouse models,and their progress in the unique mechanism of amyloid-βoligomers,including the first transgenic mouse model built in China based on a single gene mutation(PSEN1 V97L)found in Chinese familial AD.We further summarized the preclinical findings of drugs using the models,and their future application in exploring the upstream mechanisms and multi-target drug development in AD. | Xinyue Li Meina Quan Yiping Wei Wei Wang Lingzhi Xu Qi Wang Jianping Jia | 2023 | Science China(Life Sciences)2023，66，12： | 0 |
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