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| 1 | Interaction between Rice stripe virus Disease- Specific Protein and Host PsbP Enhances Virus Symptoms显示文摘瑞斯条纹病毒(RSV ) 在许多东方亚洲国家在 Oryza sativa (米饭) 引起严重疾病。RSV 的疾病特定的蛋白质(SP ) 是非结构的蛋白质,它在米饭植物的 accumulationlevel 被显示决定 RSV 症状的严厉。这里,我们在米饭或 Nicotiana benthamiana 独自一个的 RSVSP 的那表情没生产可见症状的现在的证据。然而,在这二植物的 SP 的表示提高了 RSV- 或土豆病毒 X (PVX ) 导致了症状。通过酵母二混血儿的屏蔽, GST 下拉,和双分子的荧光互补试金,我们证明 RSV SP 与 PsbP 交往了, 23-kDa 演变氧的复杂蛋白质,在米饭和 N。benthamiana。而且,我们的调查证明在两植物的 PsbP 表示的 silencing 增加了疾病症状 severityand 病毒累积。共焦的显微镜学使用 N。benthamiana 原物证明 PsbP 在野类型的 N 在叶绿体主要积累了。benthamiana 房间。面对 RSV SP,大多数 PsbP 被招募进 assayed 房间的细胞质。另外, accumulationof SP 在 RSV 感染期间导致了叶绿体结构和功能的改变。我们的调查结果使位于 RSV 疾病症状 development.Key 词下面的 molecularmechanism 清楚些: | Lingfang Kong Jianxiang Wu Lina Lu Yi Xu Xueping Zhou | 2014 | Molecular Plant2014，7，4： | 13 |
| 2 | BRAF^(V600E) vs. TIRADS in predicting papillary thyroid cancers in Bethesda system Ⅰ, Ⅲ, and Ⅴ nodules显示文摘Objective: Bethesda System for Reporting Thyroid Cytopathology(BSRTC) categories Ⅰ, Ⅲ, and Ⅴaccount for a significant proportion of fine needle aspiration cytology(FNAC) diagnoses. This study aimed to compare the diagnostic efficacy of BRAF^(V600E) mutation and the Thyroid Imaging Reporting and Data System(TIRADS) classification in differentiating papillary thyroid cancers(PTCs) from benign lesions among BSRTC I, III, and V nodules.Methods: A total of 472 patients with 479 nodules were enrolled in this prospective study. Ultrasound, BRAF^(V600E) mutation testing, and FNAC were performed in each nodule, followed by surgery or regular ultrasound examination.Results: In the BSRTC I category, BRAF^(V600E) showed similar sensitivity, higher specificity, and lower accuracy when compared with TIRADS. In the BSRTC III/V category, the sensitivity, specificity, and accuracy of BRAF^(V600E) were similar to those of TIRADS. In comparison to BRAF^(V600E) alone, the combination of the two methods significantly improved sensitivity(BSRTC Ⅰ:93.6% vs. 67.7%, P < 0.01; BSRTC Ⅲ: 93.8% vs. 75.0%, P < 0.01; BSRTC V: 96.0% vs. 85.3%, P < 0.001). When compared with TIRADS alone, the combination improved sensitivity in BSRTC Ⅰ nodules(93.6% vs. 74.2%, P < 0.05), increased sensitivity and decreased accuracy in BSRTC III nodules(93.8% vs. 75.0%, P < 0.01, 91.0% vs. 93.6%, P < 0.01), and improved both sensitivity and accuracy in BSRTC V nodules(96.0% vs. 82.0%, P < 0.001; 94.2% vs. 81.3%, P < 0.001).Conclusions: BRAF^(V600E) exhibited higher specificity and lower accuracy compared with TIRADS in BSRTC Ⅰ nodules, while the two methods showed similar diagnostic value in BSRTC Ⅲ/Ⅴ nodules. The combination of the two methods distinctly improved sensitivity in the diagnosis of PTCs in BSRTC Ⅰ, Ⅲ, and Ⅴ nodules. | Ya Wu Ting Xu Xingyue Cao Xin Zhao Hongyan Deng Jianxiang Wang Xiao Li Qing Yao Xinhua Ye Meiping Shen Xiaohong Wu | 2019 | Cancer Biology & Medicine2019，16，1： | 9 |
| 3 | Artificial periosteum in bone defect repair--A review显示文摘Periosteum is a thin membrane that encases the surfaces of most bones.It is composed of an outer fibrous layer contains longitudinally oriented cells and collagen fibers and an inner cambial layer that consists of multipotent mesenchymal stem cells(MSCs)and osteogenic progenitor cells.Periosteum has a function of regulating cell and collagen arrangement,which is important to the integrity,modelling and remodelling of bone,particularly during bone defect repair.Apart from autograft and allograft,artificial periosteum,or tissue-engineered periosteum mimicking native periosteum in structure or function,made up of small intestinal submucosa,acellular dermis,induced membrane,cell sheets,and polymeric scaffolds,and so on,has been developed to be used in bone defect repair.In this review,we classify the artificial periosteum into three approaches based on the material source,that is,native tissues,scaffoldfree cell sheets and scaffold-cell composites.Mechanisms,methods and efficacy of each approach are provided.Existing obstacles and enabling technologies for future directions are also discussed. | Quan Wang Jianxiang Xu Haiming Jin Wenhao Zheng Xiaolei Zhang Yixing Huang Zhiyong Qian | 2017 | Chinese Chemical Letters2017，28，9： | 6 |
| 4 | Methyl jasmonate mediates melatonin-induced cold tolerance of grafted watermelon plants显示文摘Root–shoot communication has a critical role in plant adaptation to environmental stress.Grafting is widely applied to enhance the abiotic stress tolerance of many horticultural crop species;however,the signal transduction mechanism involved in this tolerance remains unknown.Here,we show that pumpkin-or figleaf gourd rootstock-enhanced cold tolerance of watermelon shoots is accompanied by increases in the accumulation of melatonin,methyl jasmonate(MeJA),and hydrogen peroxide(H_(2)O_(2)).Increased melatonin levels in leaves were associated with both increased melatonin in rootstocks and MeJA-induced melatonin biosynthesis in leaves of plants under cold stress.Exogenous melatonin increased the accumulation of MeJA and H_(2)O_(2) and enhanced cold tolerance,while inhibition of melatonin accumulation attenuated rootstock-induced MeJA and H_(2)O_(2) accumulation and cold tolerance.MeJA application induced H_(2)O_(2) accumulation and cold tolerance,but inhibition of JA biosynthesis abolished rootstock-or melatonin-induced H_(2)O_(2) accumulation and cold tolerance.Additionally,inhibition of H_(2)O_(2) production attenuated MeJA-induced tolerance to cold stress.Taken together,our results suggest that melatonin is involved in grafting-induced cold tolerance by inducing the accumulation of MeJA and H_(2)O_(2).MeJA subsequently increases melatonin accumulation,forming a self-amplifying feedback loop that leads to increased H_(2)O_(2) accumulation and cold tolerance.This study reveals a novel regulatory mechanism of rootstock-induced cold tolerance. | Hao Li Yanliang Guo Zhixiang Lan Kai Xu Jingjing Chang Golam Jalal Ahammed Jianxiang Ma Chunhua Wei Xian Zhang | 2021 | Horticulture Research2021，8，1： | 5 |
| 5 | Chinese expert consensus on the management of chimeric antigen receptor T cell therapy-associated coagulopathy显示文摘Chimeric antigen receptor T-cell(CAR-T)therapy has greatly improved the disease remission rate and long-term survival rate of patients with relapsed/refractory hematological malignancies.[1-3]Currently,several commercial CAR-T products are available in the market and numerous CAR-T clinical trials have been conducted.Attention should be paid to the safety of CAR-T therapy.The main adverse effects of CAR-T therapy are cytokine release syndrome(CRS)and immune effector cell-associated neurotoxicity syndrome(ICANS).[4] | Heng Mei Fangping Chen Yue Han Ming Hou He Huang Xiaojun Huang Yuhua Li Aibin Liang Qifa Liu Ting Niu Jun Peng Wenbin Qian Yongping Song Jianxiang Wang Ying Wang Depei Wu Kailin Xu Linhua Yang Renchi Yang Lei Zhang Liansheng Zhang Xi Zhang Xiaohui Zhang Weili Zhao Weidong Han Yu Hu | 2022 | Chinese Medical Journal2022，，14： | 4 |
| 6 | Cost-efficient Thermal Management for a 48V Li-ion Battery in a Mild Hybrid Electric Vehicle显示文摘The 48V mild hybrid system is a cost-efficient solution for original equipment manufacturers to meet increasingly stringent fuel consumption requirements.However,hybrid functions such as auto-stop/start and brake regeneration are unavailablewhen a 48V battery is at very low temperature because of its limited charge and discharge capability.Therefore,it is important to develop cost-efficient thermal management to warm-up the battery of a 48V mild hybrid electric vehicle(HEV)to recover hybrid functions quickly in cold climate.Following the model-based“V”process,we first define the requirements and then design different mechanisms to heat a 48V battery.Afterward,we build a 48V battery model in LMS AMESim and conduct co-simulation with simplified battery management system and hybrid control unit algorithms in MATLAB Simulink for analysis.Finally,we carry out a series of vehicle experiments at low temperature and observe the effect of heating to validate the design.Both simulation results and experimental data show that a cold 48V battery placed in a cabin with hot air can be heated effectively in the developed“Enhanced Generator Mode with 48V Battery”mode.The entire design is in a newly developed software that cyclically charges and discharges a 48V battery for quick warm-up in cold temperature without needing any additional hardware such as a heater,making it a cost-efficient solution for HEVs. | Chao Yu Guangji Ji Chao Zhang John Abbott Mingshen Xu Pieter Ramaekers Jianxiang Lu | 2018 | Automotive Innovation2018，1，4： | 3 |
| 7 | 2022 Chinese expert consensus and guidelines on clinical management of toxicity in anti-CD19 chimeric antigen receptor T-cell therapy for B-cell non-Hodgkin lymphoma显示文摘Adoptive cellular immunotherapy with chimeric antigen receptor(CAR)T cells has emerged as a novel modality for treating relapsed and/or refractory B-cell non-Hodgkin lymphoma(B-NHL).With increasing approval of CAR T-cell products and advances in CAR T cell therapy,CAR T cells are expected to be used in a growing number of cases.However,CAR T-cell-associated toxicities can be severe or even fatal,thus compromising the survival benefit from this therapy.Standardizing and studying the clinical management of these toxicities are imperative.In contrast to other hematological malignancies,such as acute lymphoblastic leukemia and multiple myeloma,anti-CD19 CAR T-cell-associated toxicities in B-NHL have several distinctive features,most notably local cytokine-release syndrome(CRS).However,previously published guidelines have provided few specific recommendations for the grading and management of toxicities associated with CAR T-cell treatment for B-NHL.Consequently,we developed this consensus for the prevention,recognition,and management of these toxicities,on the basis of published literature regarding the management of anti-CD19 CAR T-cell-associated toxicities and the clinical experience of multiple Chinese institutions.This consensus refines a grading system and classification of CRS in B-NHL and corresponding measures for CRS management,and delineates comprehensive principles and exploratory recommendations for managing anti-CD19 CAR T-cell-associated toxicities in addition to CRS. | Ping Li Yang Liu Yun Liang Jian Bo Sujun Gao Yongxian Hu Yu Hu He Huang Xiaojun Huang Hongmei Jing Xiaoyan Ke Jianyong Li Yuhua Li Qifa Liu Peihua Lu Heng Mei Ting Niu Yongping Song Yuqin Song Liping Su Sanfang Tu Jianxiang Wang Depei Wu Zhao Wang Kailin Xu Zhitao Ying Qingming Yang Yajing Zhang Fengxia Shi Bin Zhang Huilai Zhang Xi Zhang Mingfeng Zhao Weili Zhao Xiangyu Zhao Liang Huang Jun Zhu Wenbin Qian Weidong Han Aibin Liang | 2023 | Cancer Biology & Medicine2023，20，2： | 3 |
| 8 | Learning From Biomarkers in Victims Accidentally Exposed to Ionizing Radiation显示文摘 | Yan Wang Liqing Du Chang Xu Qin Wang Zhiyi Song Jianxiang Liu Xu Su Qiang Liu | 2016 | 国际放射医学核医学杂志2016，40，2： | 1 |
| 9 | Pesticide-induced susceptibility of rice to brown planthopper Nilaparvata lugens显示文摘 | WU Jincai XU Jianxiang YUAN Shuzong | 2001 | Entomologia Experimentalis et Applicata2001，100，1： | 1 |
| 10 | GENOME EDITING:A GROUND BREAKING RESEARCH HAS BEEN RANKED TOP 10 ENGINEERING FRONTS FROM 2017 TO 2021显示文摘‘Global Engineering Fronts’ is a report released by the Chinese Academy of Engineering(CAE) every year since 2017, which aims to assemble talents in the field of engineering science and technology to represent the global engineering research and development fronts by reviewing global papers, patents, and other data. The results are also expected to provide a reference for people on responding to global challenges and achieving sustainable development. | Jianxiang XU Yunzhou LI Yinkun YAO Jie ZHAO Jingyue TANG Zixuan FENG | 2022 | Frontiers of Agricultural Science and Engineering2022，9，2： | 1 |
| 11 | Animal stem cells: the engineering development front of 2018显示文摘The Engineering Fronts reports are important guidelines for the future development directions of engineering science and technology. The Chinese Academy of Engineering (CAE) has been conducting studies relevant to Engineering Fronts for two years since 2017. | Wenye YUAN Jianxiang XU Chenying LI Lijuan SHI Aidong YANG Yan WANG Lu XING Shaozhong KANG | 2019 | Frontiers of Agricultural Science and Engineering2019，6，1： | 1 |
| 12 | Effects of herbicides on rice resistance and multiplication and feeding of brown planthopper(BPH), Nilaparvata lugens (Stal) (Homptera: Delphacidae)显示文摘 | Wu Jincai Xu Jianxiang Yuan Shuzhong | 2001 | International Journal of Pest Management2001，47，2： | 1 |
| 13 | Pesticide-induced susceptibility of rice to brown planthopper Nilaparvata lugens显示文摘 | Wu Jincai Xu Jianxiang Yuan Shuzhong | 2001 | Entomologia Experimentalis et Appicata2001，100，： | 1 |
| 14 | Pesticide-induced susceptibility of rice tobrown planthopper Nilaparvata lugens显示文摘 | WU JINCAI XU JIANXIANG YUAN SHUZONE | 2001 | Entomologic Experimentalis etApplicata2001，100，： | 1 |
| 15 | Pcs- ticid-induced susceptibility of rice to brown planthoppcr Nilaparvata Lugens显示文摘 | Wu Jincai Xu Jianxiang Yuan Shuzong | 2001 | Entomologia Experimentalis et Applicata2001，100，1： | 1 |
| 16 | Pes- ticide-induced susceptibility of rice to brown planthopper Nalaparvata lugens 显示文摘 | WU Jincai XU Jianxiang YUAN Shuzong | 2001 | Entomologia Experimentalis et Applicata2001，100，： | 1 |
| 17 | Effects of herbicides on rice resistance and on multipli- cation and feeding of brown planthopper ( BPH), Ni- laparvata lugens ( Sta1 ) ( Homoptera: Delphacidae ) 显示文摘 | WU Jincai XU Jianxiang YUAN Shuzong | 2001 | Internation Journal of Pest Management2001，47，： | 1 |
| 18 | Hemicelluloses negatively affect lignocellu- lose crystallinity for high biomass digestibility under NaOH and H2SO4 pretreatments in Miscanthus 显示文摘 | Ning Xu Wei Zhang Shuanfeng Ren Fei Liu Chunqiao Zhao Haofeng Liao Zhengdan Xu Jiangfeng Huang Qing Li Ynanyuan Tu Bin Yn Yanting Wang Jianxiang Jiang Jingping Qin Liangcai Peng | 2012 | Biotechnology for Biofu- els2012，5，： | 1 |
| 19 | A DECADE REVIEW OF FASE显示文摘Frontiers of Agricultural Science and Engineering(FASE),launched in 2014,is an authoritative source of information for professionals with interests encompassing agricultural science and engineering,supervised by Chinese Academy of Engineering(CAE),administered by CAE,China Agricultural University(CAU)and Higher Education Press(HEP),and published by HEP on a quarterly basis in English.The journal is published both in print and online. | Jianxiang XU | 2023 | Frontiers of Agricultural Science and Engineering2023，10，1： | 1 |
| 20 | Concomitant chemoradiotherapy using pemetrexed and carboplatin for unresectable stage III non-small cell lung cancer (NSCLC): Preliminary results of a phase II study显示文摘 | Yaping Xu Shenglin Ma Yongling Ji Xiaojiang Sun Hao Jiang Jianxiang Chen Xianghui Du Yuanda Zheng Guoqin Qiu | 2010 | Lung Cancer2010，，3： | 1 |
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