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| 1 | Paeoniflorin Attenuates Myocardial Fibrosis in Isoprenaline-induced Chronic Heart F ailure Rats via Inhibiting P38 MA PK Pathway显示文摘Paconiflorin(Pae)is a monoterpenoid glycoside compound and has many biological activitics,such as immunosuppression,anti-inflammation and anti-cell proliferation.However,the effects and mechanisms of Pae on chronic heart failure(CHF)remain unclear.This study was conducted to assess the effects and mechanisms of Pae on myocardial fibrosis in isoprenaline(Iso)-induced CHF rats.Pae(20 mgkg)was intragastrically administrated to CHF rats for 6 weeks.Cardiac structure and function were assessed.The protein and mRNA levels of transforming growth factorβ1(TGF-β1)and p38 were detected.C ompared to Iso group,Pae could alleviate myocardial fbrosis and improve cardiac function in CHF rats.The levels of collagen volume fraction(13.75%+3.77%vs.30.97%+4.22%,P<0.001)and perivascular collagen volume area(14.32%+2.50%v8.28.31%+3.16%,P<0.001)were significantly reduced in Pae group as compared with those in Iso group.The expression of TGF-BI protein(0.30+0.07 vs.0.66+0.07,P<0.05)and mRNA(3.51+0.44 vs.7.58+0.58,P<0.05)decreased significantly in Pac group as compared with that in Iso group.The expression of p38 protein(0.36+0.12 vs.0.81+0.38,P<0.05)and mRNA(3.84+0.05 vs.4.40+0.17,P<0.05)also decreased markedly in Pae group as compared with that in Iso group.Pae could attenuate myocardial fibrosis and improve cardiac function in CHF rats by down-regulating the p38 MAPK signaling pathway. | Mao LIU Jie FENG Qian DU Jiao AI Zhan LV | 2020 | Current Medical Science2020，40，2： | 11 |
| 2 | Road Centrality and Landscape Spatial Patterns in Wuhan Metropolitan Area,China显示文摘Road network is a corridor system that interacts with surrounding landscapes,and understanding their interaction helps to develop an optimal plan for sustainable transportation and land use.This study investigates the relationships between road centrality and landscape patterns in the Wuhan Metropolitan Area,China.The densities of centrality measures,including closeness,betweenness,and straightness,are calculated by kernel density estimation(KDE).The landscape patterns are characterized by four landscape metrics,including percentage of landscape(PLAND),Shannon′s diversity index(SHDI),mean patch size(MPS),and mean shape index(MSI).Spearman rank correlation analysis is then used to quantify their relationships at both landscape and class levels.The results show that the centrality measures can reflect the hierarchy of road network as they associate with road grade.Further analysis exhibit that as centrality densities increase,the whole landscape becomes more fragmented and regular.At the class level,the forest gradually decreases and becomes fragmented,while the construction land increases and turns to more compact.Therefore,these findings indicate that the ability and potential applications of centrality densities estimated by KDE in quantifying the relationships between roads and landscapes,can provide detailed information and valuable guidance for transportation and land-use planning as well as a new insight into ecological effects of roads. | LIU Yaolin WANG Huimin JIAO Limin LIU Yanfang HE Jianhua AI Tinghua | 2015 | Chinese Geographical Science2015，25，4： | 9 |
| 3 | Validation of the China-PAR Equations for Cardio-cerebrovascular Risk Prediction in the Inner Mongolian Population显示文摘The objective of this study was to evaluate the usefulness of the China-PAR equations in predicting the 10-year risk of cardiovascular disease(CVD) in the Inner Mongolians population. A population-based, prospective cohort of 2,589 Mongolians were followed up from 2003 to 2012.Participants were categorized into 4 subgroups according to their 10-year CVD risks calculated using the China-PAR equations: < 5%, 5%-9.9%,10%-19.9%, and ≥ 20%. The China-PAR equations discriminated well with good C statistics(range,0.76-0.86). The adjusted hazard ratios for CVD showed an increasing trend among the 4 subgroups(P for trend < 0.01). However, the China-PAR equations underestimated the 10-year CVD risk in Mongolians, and the calibration was unsatisfactory(Hosmer-Lemeshow χ~2 = 19.98, P < 0.01 for men, χ~2 = 46.58, P < 0.001 for women). The performance of the China-PAR equations warrants further validation in other ethnic groups in China. | ZENG Ni Mei ZHENG Xiao Wei PENG Hao JIAO Yang LI Hong Mei ZHANG Ming Zhi WANG Ai Li ZHANG Yong Hong | 2018 | Biomedical and Environmental Sciences2018，31，6： | 6 |
| 4 | Prevalence of Metabolic Syndrome in Chinese Nickel-exposed Workers显示文摘The prevalence of metabolic syndrome(MS was investigated in Chinese nickel-exposed workers A total of 35 104 subjects were enrolled in this study.The age-adjusted prevalence of MS,BMI≥25diabetes,hypertension,and abnormal lipid was13.9%,29.5%,12.8%,27.5%,and 47.1%respectively.The prevalence of BMI≥25hyperglycemia,and hypertension increased | YANG Ai Min BAI Ya Na PU Hong Quan ZHENG Tong Zhang CHENG Ning LI Juan Sheng LI Hai Yan ZHANG Ya Wei DING Jiao SU Hui REN Xiao Wei HU Xiao Bin | 2014 | Biomedical and Environmental Sciences2014，27，6： | 5 |
| 5 | Time-Ordered Collaborative Filtering for News Recommendation显示文摘Faced with hundreds of thousands of news articles in the news websites,it is difficult for users to find the news articles they are interested in.Therefore,various news recommender systems were built.In the news recommendation,these news articles read by a user is typically in the form of a time sequence.However,traditional news recommendation algorithms rarely consider the time sequence characteristic of user browsing behaviors.Therefore,the performance of traditional news recommendation algorithms is not good enough in predicting the next news article which a user will read.To solve this problem,this paper proposes a time-ordered collaborative filtering recommendation algorithm(TOCF),which takes the time sequence characteristic of user behaviors into account.Besides,a new method to compute the similarity among different users,named time-dependent similarity,is proposed.To demonstrate the efficiency of our solution,extensive experiments are conducted along with detailed performance analysis. | XIAO Yingyuan AI Pengqiang Ching-Hsien Hsu WANG Hongya JIAO Xu | 2015 | China Communications2015，12，12： | 5 |
| 6 | 90d Exposure to Nonylphenol has Adverse Effects on the Spermatogenesis and Sperm Maturation of Adult Male Rats显示文摘This study was conducted to elucidate the reproductive effect of NP on testis,epididymis and epididymal sperm in vivo.Adult male SpragueDawley rats were gavaged with NP at 0,40,100,or 250 mg/kg body weight(bw) on alternate days for 90 d.The results showed that oral administration of NP may damage the structure and function of testis,induce apoptosis and oxidative stress in epididymis or even have cytotoxic effects on epididymal sperm. | LU Wei Chen WANG Ai Qing CHEN Xiao Ling YANG Guo LIN Yao CHEN Yi Ou HONG Cheng Jiao TIAN Hai Lin | 2014 | Biomedical and Environmental Sciences2014，27，11： | 3 |
| 7 | Heavy Metal Assessment among Chinese Nonferrous Metal-exposed Workers from the Jinchang Cohort Study显示文摘Environmental exposure to heavy metals has been linked to a wide range of human health hazards.We detected the levels of 15 metals in urine samples from 500 representative sub-samples in an ongoing occupational cohort study(Jinchang Cohort)to directly evaluate metal exposure levels.Fifteen metals,namely As,Ba,Be,Cd,Cs,Cr,Co,Cu,Pb,Mn,Ni,Se,Tl,U,and Zn,were detected by inductively coupled plasma quadruple mass spectrometry.The results showed that median creatinine adjustment and geometric mean urinary metal levels were higher in the heavy metal-exposed group,except Se and Zn,than other reported general or occupational populations.Further studies should address the effects of heavy metals on human health. | YANG Ai Min CHENG Zhi Yuan PU Hong Quan CHENG Ning LI Hai Yan LIU Si Min DING Jiao LI Juan Sheng HU Xiao Bin REN Xiao Wei ZHENG Tong Zhang BAI Ya Na | 2017 | Biomedical and Environmental Sciences2017，30，7： | 2 |
| 8 | Circulating microRNA-1 as a potential novel biomarker for acute myocardial infarction显示文摘 | Jing Ai Rong Zhang Yue Li Jielin Pu Yanjie Lu Jundong Jiao Kang Li Bo Yu Zhuqin Li Rongrong Wang Lihong Wang Qiang Li Ning Wang Hongli Shan Zhongyu Li Baofeng Yang | 2009 | Biochemical and Biophysical Research Communications2009，，： | 2 |
| 9 | Study on the liquid membrane oscillation of water/oil/water system containing TTAB and picric acid显示文摘新奇的水(水的 tetradecyl trimethyl ammoniumbromide, TTAB 和白酒答案) 的液体膜摆动 /oil (在氯仿答案的苦酸酸)/water (水的葡萄糖答案) 系统被调查。由使用自做的设备,有 TTAB 和苦酸酸,酒精的类型和在不同温度的另外的器官的溶剂的不同集中的各种各样的液体膜摆动的曲线被测量。结果证明水(水 TTAB 的 7 mmol/L 和 n-propanol 答案的 0.5 mol/L ) 系统执行了的 /water (水的葡萄糖解决方案) 支撑了的 /oil (在氯仿答案的苦酸酸的 0.5 mmol/L ) 并且马厩在 30 掳 C 的摆动。并且新奇系统能认出增加的氨基酸。 | Li Zhou Jiao Ning Tang Bo Liu Yi Guang Wu Ai Lian Wang Chuan Dong Liao | 2008 | Chinese Chemical Letters2008，19，7： | 2 |
| 10 | An RBD virus-like particle vaccine for SARS-CoV-2 induces cross-variant antibody responses in mice and macaques显示文摘Dear Editor,Since early 2020,severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has spread globally infecting over 500 million people and causing over 6 million deaths.The massive worldwide immunisation programmes and the arising clinical trial data present a unique opportunity to compare the vaccines and various delivery platforms(i.e.viral vector platform,mRNA platform and virus-like particle platform). | Yuanyuan Li Yanan Zhang Yu Zhou Yan Li Jiao Xu Yuanbao Ai Lei Xu Xiuli Xiao Bo Zhang Jing Jin | 2023 | Signal Transduction and Targeted Therapy2023，8，5： | 1 |
| 11 | Modeling Dravet syndromeusing induced pluripotent stem cells (iPSCs) and directlyconverted neurons 显示文摘 | JIAO J YANG Y SHI Y et ai | 2013 | Hum Mol Genet2013，22，21： | 1 |
| 12 | Clustering of Inflammatory Biomarkers and Risk of Hypertension in a Mongolian Population in China显示文摘Objective There is little knowledge on whether there is clustering of inflammatory biomarkers, such as C-reactive protein (CRP), soluble intracellular adhesion molecule1-1 (sICAM-1), and angiotensin Ⅱ (Ang Ⅱ), in individuals with hypertension in the Mongolian population. In the present study, we investigated this relationship in a Mongolian population in China. Methods A total of 2589 adult Mongolians, aged 20 years and older, were recruited as study participants. Data on demographics, lifestyle, family history of hypertension, blood pressure, and blood chemistry were collected, and inflammatory biomarkers were measured in all participants. Results The proportion of subjects with increased levels of two or three biomarkers was significantly higher in those with hypertension (21.0% and 6.0%, respectively) than in those with prehypertension (12.7% and 0.5%, respectively) or normotension (8.1% and 0.2%, respectively). The multivariate adjusted odds ratios (95% confidence interval) of hypertension associated with increased levels of one, two or three biomarkers were 0.94 (0.72-1.22), 1.42 (0.93-2.16), and 11.08 (1.45-84.80), respectively, compared with subjects with no increase in any biomarker. Conclusion Hypertension was associated with a cluster of inflammatory biomarkers in the Mongolian population. | ZHU Xiao Hong JIAO Yang LI Hong Mei WANG Ai Li WANG Gui Yan TONG Wei Jun ZHANG Yong Hong | 2012 | Biomedical and Environmental Sciences2012，25，5： | 1 |
| 13 | Prevalence and characteristics of the metabolic Syndrome among adults in beijing, china 显示文摘 | li G de Courten M Jiao S et aI | 2010 | Asia Pac JClinNure2010，19，1： | 1 |
| 14 | Clinical epidemiology and disease burden of bronchiolitis in hospitalized children in China:a national cross-sectional study显示文摘Background Bronchiolitis is a common acute lower respiratory tract infection(ALRTI)and the most frequent cause of hospitalization of infants and young children with ALRTI.Respiratory syncytial virus is the main pathogen that leads to severe bronchiolitis.The disease burden is relatively high.To date,few descriptions of the clinical epidemiology and disease burden of children hospitalized for bronchiolitis are available.This study reports the general clinical epidemiological characteristics and disease burden of bronchiolitis in hospitalized children in China.Methods This study included the face sheet of discharge medical records collected from 27 tertiary children’s hospitals from January 2016 to December 2020 that were aggregated into the FUTang Update medical REcords(FUTURE)database.The sociodemographic variables,length of stay(LOS)and disease burden of children with bronchiolitis were analyzed and compared using appropriate statistical tests.Results In total,42,928 children aged 0–3 years were hospitalized due to bronchiolitis from January 2016 to December 2020,accounting for 1.5%of the total number of hospitalized children of the same age in the database during the period and 5.31%of the hospitalizations for ALRTI.The male to female ratio was 2.01:1.Meanwhile,more boys than girls were observed in different regions,age groups,years,and residences.The 1–2 year age group had the greatest number of hospitalizations for bronchiolitis,while the 29 days–6 months group had the largest proportion of the total inpatients and inpatients with ALRTI in the same age group.In terms of region,the hospitalization rate of bronchiolitis was the highest in East China.Overall,the number of hospitalizations from 2017 to 2020 showed a decreasing trend from that in 2016.Seasonally,the peak hospitalizations for bronchiolitis occurred in winter.Hospitalization rates in North China in autumn and winter were higher than those in South China,while hospitalization rates in South China were higher in spring and summer.Approximately,half of the patients with bronchiolitis had no complications.Among the complications,myocardial injury,abnormal liver function and diarrhea were more common.The median LOS was 6 days[interquartile range(IQR)=5–8],and the median hospitalization cost was 758 United States dollars(IQR=601.96–1029.53).Conclusions Bronchiolitis is a common respiratory disease in infants and young children in China,and it accounts for a higher proportion of both total hospitalizations and hospitalizations due to ALRTI in children.Among them,children aged 29 days–2 years are the main hospitalized population,and the hospitalization rate of boys is significantly higher than that of girls.The peak season for bronchiolitis is winter.Bronchiolitis causes few complications and has a low mortality rate,but the burden of this disease is heavy. | Jiao Tian Xin‑Yu Wang Lin‑Lin Zhang Meng‑Jia Liu Jun‑Hong Ai Guo‑Shuang Feng Yue‑Ping Zeng Ran Wang Zheng‑De Xie | 2023 | World Journal of Pediatrics2023，19，9： | 1 |
| 15 | The cross talk between cGMP signal pathway and PKC in pulmonary endothelial cell angiogenesis显示文摘 | Zeng Z Li YC Jiao ZH et aI | 2014 | IntJ Mol Sci2014，15，10： | 1 |
| 16 | Circulating microRNA-1 as a potential novel biomarker for acute myocardial infarction显示文摘 | Ai J Zhang R Li Y Pu J Lu Y Jiao J | 2010 | Biochem Biophys Res Commun2010，391，： | 1 |
| 17 | Generation of Hierarchical Pores in Metal-Organic Frameworks by Introducing Rigid Modulator显示文摘The fabrication of hierarchically porous metal-organic frameworks(HP-MOFs)that combine tunable mesopore sizes with high stability is highly desired but remains a technical challenge.Herein,a facile and versatile“rigid modular-assisted defect formation”strategy has been developed to transform microporous MOFs into their corresponding HP-MOFs.By controlling the modulator dose and acid amount,the pore size and mesopore percentage can be finely regulated.Based on the hierarchical pores,the mass transfer of molecules with large sizes is significantly promoted.As a result,the representative HP-UiO-66-NH_(2)-OTf,decorated with a trifluoromethanesulfonate(OTf)group to enhance Lewis acidity,exhibits excellent activity and selectivity in tandem catalysis,far superior to pristine UiO-66-NH_(2).This work provides a novel strategy to the general synthesis of stable HP-MOFs. | Zhiwen Ai Long Jiao Jingxue Wang Hai-Long Jiang | 2022 | CCS Chemistry2022，4，12： | 1 |
| 18 | Cross sectional study of attitudes about suicide among psychiatrists in Shanghai显示文摘 | Jiao Y Phillips M R Sheng Y et ai | 2014 | BMC Psychiatry2014，14，： | 1 |
| 19 | Long-term results of op- eration for 420 patients with early squamous cell esophageal car- cinoma discovered by screening 显示文摘 | Wang GQ Jiao GG Chang FB et aI | 2004 | Ann Thorac Surg2004，77，5： | 1 |
| 20 | SAR Change Detection Based on Intensity and Texture Changes显示文摘 | GONG Maoguo LI Yu JIAO Licheng et aI | 2014 | ISPRS Journal of Photogrammetry and Remote Sensing2014，93，： | 1 |
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