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| 1 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 2 | The effect of beta-elemene on alpha-tubulin polymerization in human hepatoma HepG2 cells显示文摘Objective:To investigate the impact of beta-elemene injection on the growth and alpha-tubule of human hepatocarcinoma HepG2 cells.Methods:Cell proliferation was assessed by MTT assay.Cell cycle distribution was detected by flow cytometry(FCM).The mRNA expression of alpha-tubulin was measured by RT-PCR.Western blot analysis was used to determine protein expression of alpha-tubulin and the polymerization of tubulin.Results:Beta-elemene injection inhibited HepG2 cells proliferation in a dose-and time-dependent manner;FCM analysis indicated beta-elemene injection induced cell cycle arrested at S phase.RT-PCR and westernblot analysis showed that beta-elemene injection down-regulated alpha-tublin at both mRNA and protein levels,presenting a dose-dependent manner.Moreover,beta-elemene injection reduced the polymerization of microtubules in a dose-dependent manner.Conclusions:Beta-elemene injection can inhibit the proliferation of hepatoma HepG2 cells and induce cell apoptosis,the mechanism might be partly related to the down-regulation of alpha-tubulin and inhibition of microtubular polymerization. | Jielin Zhang Yuqiu Mao Li Hou Xiaonan Cui | 2013 | Chinese Journal of Cancer Research2013，25，6： | 17 |
| 3 | Fully-coupled simulations of thermally-induced cracking in pegmatite due to microwave irradiation显示文摘Fully-coupled thermo-mechanical simulations are implemented in COMSOL Multiphysics to investigate micro-scale stress-strain variability in pegmatite specimens subjected to thermal loading using microwaves. Thermally-induced compressive and tensile stresses increase as the microwave irradiation duration increases. The dielectric constant, coefficient of expansion, and type and size of mineralogical boundary have significant impacts on the responses of the rock to microwave irradiation. The maximum principal stress of the chlorite is the smallest, indicating that the chlorite experiences the most damage under microwave irradiation, followed by the quartz. The maximum principal stress values of plagioclase and orthoclase are larger, indicating that they are likely to incur the least damage. Where quartz or chlorite is dominant, the resulting von Mises stresses are consistently higher after 120 s of microwave irradiation. The rate of generation of von Mises stresses increases most rapidly along the interface between quartz and plagioclase, and the interface between quartz and orthoclase, followed by the interface between quartz and chlorite, and finally the interface between plagioclase and orthoclase. The presented modeling approach provides a practical method to investigate stress-strain relationships within mineralogical boundaries inside a rock thin section. | Jielin Li Rennie B.Kaunda Shrey Arora Philipp Hartlieb Priscilla P.Nelson | 2019 | Journal of Rock Mechanics and Geotechnical Engineering2019，11，2： | 8 |
| 4 | In vitro effects of recombinant human growth hormone on growth of human gastric cancer cell line BGC823 cells显示文摘To study the effects of recombinant human growth hormone (rhGH) on growth of human gastric cancer cell line in vitro. | Jia-YongChen Dao-MingLiang PingGan YiZhang JieLin | 2004 | World Journal of Gastroenterology2004，10，8： | 7 |
| 5 | Adaptive Application Offloading Decision and Transmission Scheduling for Mobile Cloud Computing显示文摘Offloading application to cloud can augment mobile devices' computation capabilities for the emerging resource-hungry mobile application, however it can also consume both much time and energy for mobile device offloading application remotely to cloud. In this paper, we develop a newly adaptive application offloading decision-transmission scheduling scheme which can solve above problem efficiently. Specifically, we first propose an adaptive application offloading model which allows multiple target clouds coexisting. Second, based on Lyapunov optimization theory, a low complexity adaptive offloading decision-transmission scheduling scheme has been proposed. And the performance analysis is also given. Finally, simulation results show that,compared with that all applications are executed locally, mobile device can save 68.557% average execution time and 67.095% average energy consumption under situations. | Junyi Wang Jie Peng Yanheng Wei Didi Liu Jielin Fu | 2017 | China Communications2017，14，3： | 6 |
| 6 | Reduced function and disassembled microtubules of cultured cardiomyocytes in spaceflight显示文摘Lack of gravity during spaceflight has profound effects on cardiovascular system, but little is known about how the cardiomyocytes respond to microgravity. In the present study, the effects of spaceflight on the structure and function of cultured cardiomyocytes were reported. The primary cultures of neo- natal rat cardiomyocytes were carried on Shenzhou-6 spacecraft and activated at 4 h in orbit. 8 samples were fixed respectively at 4, 48 and 96 h after launching for immunofluorescence of cytoskeleton, and 2 samples remained unfixed to analyze contractile and secretory functions of the cultures. Ground sam- ples were treated in our laboratory in parallel. After 115 h spaceflight, video recordings displayed that the number of spontaneous beating sites in flown samples decreased significantly, and the cells in the beating aggregate contracted in fast frequency without synchrony. Radioimmunoassay of the medium showed that the atrial natriuretic peptide secreted from flown cells reduced by 59.6%. Confocal images demonstrated the time-dependant disassembly of mirotubules versus unchanged distribution and or- ganization of microfilaments. In conclusion, above results indicate reduced function and disorganized cytoskeleton of cardiomyocytes in spaceflight, which might provide some cellular basis for further investigations to probe into the mechanisms underlying space cardiovascular dysfunction. | YANG Fen LI YingHui DING Bai NIE JieLin WANG HongHui ZHANG XiaoYou WANG ChunYan LING ShuKuan NI ChengZhi DAI ZhongQuan TAN YingJun WAN YuMin | 2008 | Chinese Science Bulletin2008，53，8： | 5 |
| 7 | Agglutinative Language Speech Recognition Using Automatic Allophone Deriving显示文摘Agglutinative language involves agglutination extensively, which results in the significant pronunciation variations in different contexts. Therefore, it is a problem to use phoneme sets translated from their written forms as basic units for acoustic modeling, due to the incapability to capture the pronunciation variations in Large-vocabulary continuous speech recognition(LVCSR).This paper presented a novel approach called Automatic allophone deriving(AAD) to create allophone candidates without any linguistic prior knowledge. Furthermore, an enhanced approach AAD-LT is proposed in which longtime features are used in AAD approach. Experiments are conducted on three languages which contains two agglutinative ones and an analytic one. The experiments suggest that AAD Long-time(AAD-LT) is very effective for the agglutinative languages in which more than 10% relative CER reduction is obtained. | XU Ji PAN Jielin YAN Yonghong | 2016 | Chinese Journal of Electronics2016，25，2： | 4 |
| 8 | In situ AFM observation of BSA adsorption on HOPG with nanobubble显示文摘Nanobubbles have been proven existent at the liquid/solid interface, and become a focus of research on varied interfacial processes. In the present work, by observing in situ with atomic force microscope (AFM), we found that nanobubbles could influence the adsorption process of bovine serum albumin (BSA) on hydrophobic surface of highly ordered pyrolytic graphite (HOPG). BSA could adsorb evenly, and coexist with nanobubbles at water/HOPG interface. After removing nanobubbles by injecting ethanol, some hollows were found in the BSA layers at the same positions of nanobubbles existing previously. These hollows were about 8 nm in depth and dozens of nanometers in diameter. The correlation coefficient between the areas of nanobubbles and that of the corresponding hollows reached 0.88―0.94, which strongly supported the assumption that the hollows were indeed caused by the nanobubbles. Moreover, the BSA molecules formed rings around the nanobubbles, suggesting the preference of BSA adsorption onto the contact line at water/HOPG interface. | WU ZhiHua ZHANG XueHua ZHANG XiaoDong SUN JieLin DONG YaMing HU Jun | 2007 | Chinese Science Bulletin2007，52，14： | 3 |
| 9 | Application of image alignment and time averaging methods in AFM detection for single DNA molecules显示文摘Enhancement of the SNR (signal to noise ratio) in single-molecule imaging is significantly important for improving image resolu-tion and distinguishing the fine structures of single molecules at a higher precision level.Image processing techniques have dem-onstrated the remarkable capability to improve the SNR and the resolution level by breaking through some inherent limitations unresolved by instrument hardware optimization.In this paper, we focus on single-biomolecule imaging using atomic force mi-croscopy (AFM), a unique method in separated single-biomolecule imaging, and there was few suitable image processing tech-niques reported to increase the SNR of a single molecule’s AFM image.With the typical samples of separately dispersed DNA molecules, we replaced the classified averaging method, which is usually used when the molecules’ structure can be easily and repeatedly prepared, with the time averaging method to improve the SNR in a single molecule’s AFM imaging.Combining the time averaging technique with the image alignment method for the series of time-lapse AFM images of a single DNA molecule, we were able to improve the image’s SNR and recover some buried signals from the background noises.Furthermore, the fine structures of single molecules can potentially be further resolved if other image processing techniques are applied collaboratively with some newly developed imaging methods like Vibrating Mode Scanning Polarization Force Microscopy (VSPFM), and such combination will also be advantageous for the manipulation of single-biomolecules by AFM.In addition, the proposed algorithms for the estimations of drift, distortion and SNR are applicable for quantitative status characterization of AFM imaging. | WANG ChunMei SUN JieLin LONG Fei ZHAO Jun HU Jun | 2010 | Chinese Science Bulletin2010，55，16： | 3 |
| 10 | A Prefix Tree Based n-best List Re-scoring Strategy for Recurrent Neural Network Language Model显示文摘In this paper, issues of speeding up Recurrent neural network language model(RNNLM) in the testing phase are explored so that RNNLMs can be used to re-rank a large n-best list in real-time systems which could obtain better performance. A new n-best list rescoring framework, Prefix tree based n-best list re-scoring(PTNR), is proposed to hundred percent eliminate the repeated computations which makes n-best list re-scoring ineffective. At the same time, the bunch mode technique,widely-used in speeding up the training of Feed-forward neural network language model(FF-NNLM), is combined with PTNR and the speed is further improved. Experimental results show that our approach is much faster than basic n-best list re-scoring. Take 1000-best as an example, our approach is almost 11 times faster than the basic n-best list re-scoring. | SI Yujing LI Ta PAN Jielin YAN Yonghong | 2014 | Chinese Journal of Electronics2014，23，1： | 3 |
| 11 | Host HDAC4 regulates the antiviral response by inhibiting the phosphorylation of IRF3显示文摘Class II HDACs, such as HDAC4, are critical regulators of the immune response in various immune cells;however, its role in innate immunity remains largely unknown.Here, we report that the overexpression of HDAC4 suppresses the production of type I interferons triggered by pattern-recognition receptors (PRRs). HDAC4 repressed the translocation of transcription factor IRF3 to the nucleus, thereby decreasing IRF3-mediated IFN-β expression. In particular, we also determined that HDAC4 can be phosphorylated and simultaneously block the phosphorylation of IRF3 at Ser386 and Ser396 by TBK1 and IKKε, respectively, by interacting with the kinase domain of TBK1 and IKKε. Furthermore, IFN-β may stimulate the expression of HDAC4. Our findings suggest that HDAC4 acts as a regulator of PRR signaling and is a novel mechanism of negative feedback regulation for preventing an overreactive innate immune response. | Qi Yang Jielin Tang Rongjuan Pei XiaoXiao Gao Jing Guo Chonghui Xu Yun Wang QianWang Chunchen Wu Yuan Zhou Xue Hu He Zhao Yanyi Wang Xinwen Chen Jizheng Chen | 2019 | Journal of Molecular Cell Biology2019，11，2： | 2 |
| 12 | Handling OOV Words in Mandarin Spoken Term Detection with an Hierarchical n-Gram Language Model显示文摘In this paper, an hierarchical n-gram Language model(LM) combining words and characters is explored to improve the detection of Out-of-vocabulary(OOV) words in Mandarin Spoken term detection(STD).The hierarchical LM is based on a word-level LM, with a character-level LM estimating probabilities of OOV words in a class-based way. The region containing OOV words in the sentence to be decoded is detected with the help of the word-level LM and the probabilities of OOV words are derived from the character-level LM. The implementation of the proposed approach is based on a dynamic decoder. The proposed approach is evaluated in terms of Actual term weighted value(ATWV) on two Mandarin data sets. Experiment results show that more than 10% relative improvement for OOV word detection is achieved on both sets. In addition, the detection of In-vocabulary(IV) words is barely influenced as well. | WANG Xuyang ZHANG Pengyuan NA Xingyu PAN Jielin YAN Yonghong | 2017 | Chinese Journal of Electronics2017，26，6： | 2 |
| 13 | Circulating microRNA-1 as a potential novel biomarker for acute myocardial infarction显示文摘 | Jing Ai Rong Zhang Yue Li Jielin Pu Yanjie Lu Jundong Jiao Kang Li Bo Yu Zhuqin Li Rongrong Wang Lihong Wang Qiang Li Ning Wang Hongli Shan Zhongyu Li Baofeng Yang | 2009 | Biochemical and Biophysical Research Communications2009，，： | 2 |
| 14 | Histone Deacetylase 3 Inhibitor Suppresses Hepatitis C Virus Replication by Regulating Apo-A1 and LEAP-1 Expression显示文摘Histone deacetylase (HDAC) inhibitors show clinical promise for the treatment of cancers, including hepatocellular carcinoma (HCC). In this study, we investigated the effect of HDAC inhibitor treatment on hepatitis C virus (HCV)replication in Huh7 human liver cells and in a mouse model of HCV infection. Viral replication was markedly suppressed by the HDAC3 inhibitor at concentrations below 1 mmol/L, with no cellular toxicity. This was accompanied by upregulation of liver-expressed antimicrobial peptide 1 (LEAP-1) and downregulation of apolipoprotein-A1 (Apo-A1), as determined by microarray and quantitative RT-PCR analyses. Moreover, HDAC3 was found to modulate the binding of CCAAT-enhancer-binding protein a (C/EBPa), hypoxia-inducible factor 1 a (HIF1 a), and signal transducer and activator of transcription 3 (STAT3) to the LEAP-1 promoter. HDAC3 inhibitor treatment also blocked HCV replication in a mouse model of HCV infection. These results indicate that epigenetic therapy with HDAC3 inhibitor may be a potential treatment for diseases associated with HCV infection such as HCC. | Yuan Zhou Qian Wang Qi Yang Jielin Tang Chonghui Xu Dongwei Gai Xinwen Chen Jizheng Chen | 2018 | Virologica Sinica2018，33，5： | 2 |
| 15 | Analysis of risk factors associated with endoscopic retrograde cholangiopancreatography for patients with liver cirrhosis: a multicenter, retrospective, clinical study显示文摘Background:Endoscopic retrograde cholangiopancreatography(ERCP)is the endoscopic modality of choice for the treatment of biliary and pancreatic diseases.However,patients with cirrhosis,particularly those with decompensated cirrhosis,are believed to be at increased risk for complications associated with ERCP.There is a paucity of literature describing the outcomes of ERCP for patients with cirrhosis.This study aimed to investigate the outcomes of ERCP for cirrhosis patients,especially adverse events,and evaluated its safety and efficacy.Methods:We performed a multicenter,retrospective study of all patients at Beijing Friendship Hospital affiliated to Capital Medical University,Xijing Hospital affiliated to Air Force Military Medical University,Beijing Youan Hospital affiliated to Capital Medical University,and the Fifth Medical Center of the People’s Liberation Army General Hospital from June 2003 to August 2019.The adverse events of inpatient ERCP for patients with(n=182)and without liver cirrhosis(controls;n=385)were compared.Results:A total of 567 patients underwent ERCP between January 2003 and December 2019 were enrolled in this study.Compared to patients without cirrhosis,patients with cirrhosis were at higher risk for postoperative complications(odds ratio[OR],4.172;95%confidence interval[CI],1.232–7.031;P<0.001)such as postoperative pancreatitis(OR,2.026;95%CI,1.002–4.378;P=0.001)and cholangitis(OR,3.903;95%CI,1.001–10.038;P=0.036).The main indications for ERCP for patients with cirrhosis in this study included choledocholithiasis(101 cases;55.5%),benign bile duct strictures(46 cases;25.3%),and malignant bile duct strictures(28 cases;15.4%).Among them,23 patients(12.6%)underwent balloon dilation and 79 patients(43.4%)underwent sphincterotomy.Of the patients with cirrhosis,delayed bleeding occurred in ten patients(5.5%),postoperative pancreatitis occurred in 80 patients(44.0%),and postoperative cholangitis occurred in 25 patients(13.7%).An additional multivariate analysis showed that the total bilirubin(TBIL)level(OR,4.58;95%CI,2.37–6.70)and Child-Pugh score of C(OR,3.11;95%CI,1.04–5.37)were risk factors for postoperative complications in patients with cirrhosis.Conclusions:Compared with the general population of patients undergoing ERCP,patients with cirrhosis were more prone to postoperative pancreatitis and cholangitis.TBIL levels and Child-Pugh scores were risk factors for postoperative complications in patients with cirrhosis. | Jielin Li Jiexuan Hu Peng Li Yongdong Wu Yongjun Wang Ming Ji Haiyang Hua Wenbin Ran Yanglin Pan Shutian Zhang | 2022 | Chinese Medical Journal2022，135，19： | 2 |
| 16 | Prostate cancer risk-associated genetic markers and their potential clinical utility显示文摘前列腺癌症(PCa ) 是在在西方的发达国家的人之中的最普通的癌症之一,它的发生在世界的许多另外的部分更加增加了,包括中国。PCa 的病原学大部分是未知的,但是被认为是 multifactorial,在继承遗传起一个重要作用的地方。在这篇文章,我们简短首先从家庭聚集和基因危险性的研究考察结果到 PCa。我们然后,从连接的稀罕、高外显率的 PCa 危险性基因的翻新的胎面钥匙调查结果在 PCa 家庭学习。我们把这篇文章的重要部分奉献给在 PCa 情况和控制中从基因协会研究总结普通、低外显率的 PCa 联系风险的单个核苷酸的多型性(SNP ) 的发现,特别那些从染色体宽的协会研究(GWAS ) 。这篇文章的一个强壮的焦点是在这些含有的基因标记的潜在的临床的用途上考察文学。大多数这些出版研究用在为前列腺活体检视决定需要从多重联系风险的 SNP 和它的用途导出的一个基因分数描述了 PCa 风险评价。最后,我们评论基因分数的最新建议的概念;观点是为基因倾向把它当作一个标记,类似于家庭历史,而非一个诊断标记到从非癌症病人区别 PCa 病人。到日期的可得到的证据建议那个基因分数比家庭历史是一个目的和 PCa 的继承风险的更好的测量。这篇文章的另一个唯一的特征是在中国、日本的人口的 PCa 的基因协会研究的包括。 | Jianfeng Xu Jielin Sun S Lilly Zheng | 2013 | Asian Journal of Andrology2013，15，3： | 2 |
| 17 | Acoustic characteristics of stop consonants in fluent reading Chinese Putonghua speech of adult stutterers显示文摘This study investigated whether adults who stutter and normal adult speakers differ in the production of stop consonants in fluent reading Chinese Putonghua speech.Voice onset time(VOT) was measured and the spectral moments at the stop burst were calculated for the stutterers(both before and after the speech therapy) and also for the nonstutterers. The statistical results showed that there were no significant differences in VOT between the nonstutterers and stutterers either prior to or after therapy,although the mean VOT of the stutterers was slightly greater than that of the nonstutterers.The results also indicated that both the obstruction place and the subsequent syllabic final exhibited an influence to a greater extent on VOT for the stutterers.In the spectral domain,the spectral mean of the stuttering participants before therapy was significantly different from that of the normal participants, whereas the group difference became insignificant after the therapy session.The smaller spectral mean for the stutterers might be interpreted as a more posterior occlusion in the oral cavity when producing alveolars and velars.In addition,productions of the stutterers scattered with a wider range in the space of spectral moments.Furthermore,the smaller main effect of syllabic finals on the mean spectral frequency of the burst suggested that the stutterers exhibited weaker anticipatory coarticulation than the nonstutterers. | FENG Yongqiang YAN Qian GAO Xinglong PAN Fuping XING Lili LIN Chunlan PAN Jielin | 2013 | Chinese Journal of Acoustics2013，32，3： | 1 |
| 18 | Cleaning using nanobubbles: Defouling by electrochemical generation of bubbles显示文摘 | Zhihua Wu Hongbing Chen Yaming Dong Huiling Mao Jielin Sun Shenfu Chen Vincent S.J. Craig Jun Hu | 2008 | Journal of Colloid And Interface Science2008，，1： | 1 |
| 19 | The preparationand properties of SiCw/B4C composites infiltrated with molten silicon 显示文摘 | WANG Jielin LIN Wensong JIANG Ziwang | 2014 | Ceramics International2014，40，5： | 1 |
| 20 | Mixed Noise Removal by Weighted Encoding with Sparse Nonlocal Regularization 显示文摘 | Jiang Jielin Zhang Lei Yang Jian | 2014 | IEEE Transactions on Image Pro- cessing2014，23，6： | 1 |
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