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| 1 | Small molecule inhibitors reveal allosteric regulation of USP14 via steric blockade显示文摘The ubiquitin system is important for drug discovery,and the discovery of selective small-molecule inhibitors of deubiquitinating enzymes (DUBs) remains an active yet extremely challenging task. With a few exceptions,previously developed inhibitors have been found to bind the evolutionarily conserved catalytic centers of DUBs,resulting in poor selectivity. The small molecule IU1 was the first-ever specific inhibitor identified and exhibited surprisingly excellent selectivity for USP14 over other DUBs. However,the molecular mechanism for this selectivity was elusive. Herein,we report the high-resolution co-crystal structures of the catalytic domain of USP14 bound to IU1 and three IU1 derivatives. All the structures of these complexes indicate that IU1 and its analogs bind to a previously unknown steric binding site in USP14,thus blocking the access of the C-terminus of ubiquitin to the active site of USP14 and abrogating USP14 activity. Importantly,this steric site in USP14 is very unique,as suggested by structural alignments of USP14 with several known DUB X-ray structures. These results,in conjunction with biochemical characterization,Indicate a coherent steric blockade mechanism for U5P14 inhibition by compounds of the IU series. In light of the recent report of steric blockade of USP7 by FT671,this work suggests a potential generally applicable allosteric mechanism for the regulation of DUBs via steric blockade,as showcased by our discovery of IU1-248 which is 10-fold more potent than IU1. | Yiwei Wang Yuxuan Jiang Shan Ding Jiawang Li Ningjing Song Yujing Ren Danning Hong Cai Wu Bin Li Feng Wang Wei He Jiawei Wang Ziqing Mei | 2018 | Cell Research2018，28，12： | 15 |
| 2 | Late Quaternary glacial cycle and precessional period of clay mineral assemblages in the Western Pacific Warm Pool显示文摘Variability of clay mineral assemblages in the Western Pacific Warm Pool(WPWP) over the past 370 ka shows the prominent glacial-interglacial cyclicity.Smectite(62%-91%) is the dominant clay mineral,with decreased contents during interglacials while increased in glacials.In contrast,variations in chlorite(4%-21%),illite(4%-12%),and kaolinite(2%-10%) share a similar pattern with higher contents during interglacials than glacials,mirroring to that of smectite.The results indicate that the smectite-dominated clay minerals derive mainly from the river detrital inputs of New Guinea.The glacial-interglacial cycle of clay mineral assemblages well correspond to the fluctuation of sea level.When the sea level was low,the river materials can travel more easily across the narrow shelf off the island of New Guinea,inject directly into the subsurface currents flowing westwards,then merge into the Equatorial Undercurrent(EUC),and eventually deposit on the central part of WPWP.Precessional periods of the smectite content indicate the intensity of mechanical erosion in its provenance of New Guinea,responding to the river runoff and precipitation,and this could also be linked to the meridional migration of the Intertropical Convergence Zone(ITCZ). | WU JiaWang LIU ZhiFei ZHOU Chao | 2012 | Chinese Science Bulletin2012，57，28： | 11 |
| 3 | Intelligent classification model of surrounding rock of tunnel using drilling and blasting method显示文摘Classification of surrounding rock is the cornerstone of tunnel design and construction.The traditional methods are mainly qualitative and manual and require extensive professional knowledge and engineering experience.To minimize the effect of the empirical judgment on the accuracy of surrounding rock classification,it is necessary to reduce human participation.An intelligent classification technique based on information technology and artificial intelligence could overcome these issues.In this regard,using 299 groups of drilling parameters collected automatically using intelligent drill jumbos in tunnels for the Zhengzhou-Wanzhou high-speed railway in China,an intelligent-classification surrounding-rock database is constructed in this study.Based on a machine learning algorithm,an intelligent classification model is then developed,which has an overall accuracy of 91.9%.Finally,using the core of the model,the intelligent classification system for the surrounding rock of drilled and blasted tunnels is integrated,and the system is carried by intelligent jumbos to perform automatic recording and transmission of drilling parameters and intelligent classification of the surrounding rock.This approach provides a foundation for the dynamic design and construction(both conventional and intelligent)of tunnels. | Mingnian Wang Siguang Zhao Jianjun Tong Zhilong Wang Meng Yao Jiawang Li Wenhao Yi | 2021 | Underground Space2021，6，5： | 5 |
| 4 | Biodegradation behavior of magnesium and ZK60 alloy in artificial urine and rat models显示文摘In this work, the biodegradable and histocompatibility properties of pure Mg and ZK60 alloy wereinvestigated as new temporary implants for urinary applications. The corrosion mechanism in artificialurine was proposed using electrochemical impedance spectroscopy and potentiodynamic polarizationtests. The corrosion potential of pure magnesium and ZK60 alloy were -1820 and -1561 mV, respectively,and the corrosion current densities were 59.66 ± 6.41 and 41.94 ± 0.53 μA cm^-2, respectively. Thein vitro degradation rates for pure Mg and ZK60 alloy in artificial urine were 0.382 and 1.023 mm/y,respectively, determined from immersion tests. The ZK60 alloy degraded faster than the pure Mg in bothartificial urine and in rat bladders (the implants of both samples are ø 3 mm × 5 mm). Histocompatibilityevaluations showed good histocompatibility for the pure Mg and ZK60 alloy during the 3 weeks postimplantationin rat bladders, and no harm was observed in the bladder, liver and kidney tissues. Theresults provide key information on the degradation properties and corrosion mechanism of pure Mg andZK60 alloy in the urinary system. | Shiying Zhang Yanze Bi Jianye Li Zhenguo Wang Jingmin Yan Jiawang Song Haibo Sheng Heqing Guo Yan Li | 2017 | Bioactive Materials2017，2，2： | 4 |
| 5 | A novel inhibitor of N^(6)-methyladenosine demethylase FTO induces m RNA methylation and shows anti-cancer activities显示文摘N^(6)-methyladenosine(m^(6)A)modification is critical for m RNA splicing,nuclear export,stability and translation.Fat mass and obesity-associated protein(FTO),the first identified m^(6)A demethylase,is critical for cancer progression.Herein,we developed small-molecule inhibitors of FTO by virtual screening,structural optimization,and bioassay.As a result,two FTO inhibitors namely 18077 and 18097 were identified,which can selectively inhibit demethylase activity of FTO.Specifically,18097 bound to the active site of FTO and then inhibited cell cycle process and migration of cancer cells.In addition,18097 reprogrammed the epi-transcriptome of breast cancer cells,particularly for genes related to P53 pathway.18097 increased the abundance of m^(6)A modification of suppressor of cytokine signaling1(SOCS1)m RNA,which recruited IGF2 BP1 to increase m RNA stability of SOCS1 and subsequently activated the P53 signaling pathway.Further,18097 suppressed cellular lipogenesis via downregulation of peroxisome proliferator-activated receptor gamma(PPARγ),CCAAT/enhancer-binding protein alpha(C/EBPa),and C/EBPβ.Animal studies confirmed that 18097 can significantly suppress in vivo growth and lung colonization of breast cancer cells.Collectively,we identified that FTO can work as a potential drug target and the small-molecule inhibitor 18097 can serve as a potential agent against breast cancer. | Guoyou Xie Xu-Nian Wu Yuyi Ling Yalan Rui Deyan Wu Jiawang Zhou Jiexin Li Shuibin Lin Qin Peng Zigang Li Hongsheng Wang Hai-Bin Luo | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 4 |
| 6 | Enhanced piezo-response in copper halide perovskites based PVDF composite films显示文摘In-situ fabricated perovskite nanocrystals in polymeric matrix provide new generation composite materials for plenty of cutting edge technology. In this work, we report the in-situ fabrication of copper halide perovskite(MA_2CuCl_4, MA:CH_3NH_3^+) embedded poly(vinylidene fluoride)(PVDF) composite films. The optimized MA_2CuCl_4/PVDF composite films exhibit greatly enhanced piezo-response in comparasion with pure PVDF films. The enhancements were invesitgated and explained by applying piezo-response force microscopy(PFM) measurements and density functional theory(DFT) caculations. We proposed that the high piezoelectric properties of MA_2CuCl_4/PVDF composite films could be related to the large Cu off-centering displacement, the strong interactions between MA_2CuCl_4 and PVDF as well as large stress concentration around the MA_2CuCl_4 particles in the films. These piezoelectric composite films are expected to be suitable functional materials for flexible and/or wearable piezoelectrics. | Sheng Huang Gang Tang Hailong Huang Xian-gang Wu Puming Zhou Lin Zou Lei Xie Jianming Deng Xueyun Wang Haizheng Zhong Jiawang Hong | 2018 | Science Bulletin2018，63，19： | 4 |
| 7 | An infrastructure with user-centered presentation data model for integrated management of materials data and services显示文摘With scientific research in materials science becoming more data intensive and collaborative after the announcement of the Materials Genome Initiative,the need for modern data infrastructures that facilitate the sharing of materials data and analysis tools is compelling in the materials community.In this paper,we describe the challenges of developing such infrastructure and introduce an emerging architecture with high usability.We call this architecture the Materials Genome Engineering Databases(MGED).MGED provides cloud-hosted services with features to simplify the process of collecting datasets from diverse data providers,unify data representation forms with user-centered presentation data model,and accelerate data discovery with advanced search capabilities.MGED also provides a standard service management framework to enable finding and sharing of tools for analyzing and processing data.We describe MGED’s design,current status,and how MGED supports integrated management of shared data and services. | Shilong Liu Yanjing Su Haiqing Yin Dawei Zhang Jie He Haiyou Huang Xue Jiang Xuan Wang Haiyan Gong Zhuang Li Hao Xiu Jiawang Wan Xiaotong Zhang | 2021 | npj Computational Materials2021，，1： | 4 |
| 8 | Publisher's note to“Texture engineering of mono-crystalline silicon via alcohol-free alkali solution for efficient PERC solar cells”[J.Energy Chem.71(2022)104-107显示文摘The publisher regrets that the page range of this paper was incorrect due to production error,and we added al-a5 after page 107 to the pdf version to correct this mistake. | Danni Zhang Jiawang Chen Rui Jia Zhibo Gao Ke Tao Longjie Wang Huayun Ge Xinpu Li Xing Li | 2022 | Journal of Energy Chemistry2022，31，8： | 3 |
| 9 | Influence of temperature on the transformation and self-control of energy during sandstone damage:Experimental and theoretical research显示文摘The surrounding rock in tunnelling engineering and coal mining will sometimes be exposed to high temperature. Rock failure is the result of energy dissipation, and the study of the evolution and transformation behavior of energy is of great significance for the in-depth understanding of the deformation and failure of rock after high temperature. This study analyzed the intrinsic connection between mechanical properties and acoustic emission(AE) energy under temperature effect. Based on the energy dissipation and release theory, the distribution and transformation of energy was analyzed, and the energy selfincentive and self-inhibition(EII) model was further established. The main findings are that temperature effect affects the confidence interval trend and the value of AE energy rate, which is related to the change in mechanical properties. The ability of sandstone to store elastic strain energy after exposure to high temperature is independent of the mechanical properties. In this study, the ratio of dissipated energy to elastic energy is used to characterize the stable state of the sandstone system, which can be used as the energy indicator of rock failure precursor. During the absorption, storage, and release of energy before the peak stress, there exists self-incentive and self-inhibition of energy(control behavior). | Lan Qiao Jiawang Hao Zhiyi Liu Qingwen Li Naifu Deng | 2022 | International Journal of Mining Science and Technology2022，32，4： | 3 |
| 10 | Research progress in artificial upwelling and its potential environmental effects显示文摘Artificial upwelling, as a geoengineering tool, has received worldwide attention because it may actualize ocean fertilization in a sustainable way, which could potentially alleviate the pressures on the fish stocks and human-driven climate change in the ocean. We reviewed the current knowledge on the development of an artificial upwelling system and its potential environmental effects. Special attention was given to the research progress on the air-lift concept artificial upwelling by Zhejiang University. The research on artificial upwelling over the past few decades has generated a range of devices that have been successfully applied in the field for months. Based on field experiments and the associated modeling results, part of them reported positive effects on increasing primary production and enhancing CO2 sequestration. However, as a significant disturbance to the environment, especially for large-scale applications, the uncertainties related to the potential effects on ecosystem remain unsolved. Zhejiang University has overcome the technical challenges in designing and fabricating a robust and high efficiency artificial upwelling device which has been examined in two field experiments in Qiandao Lake and one sea trial in the East China Sea. It was investigated that cold and hypoxic deep ocean water(DOW) could be uplifted to the euphotic layer, which could potentially change the nutrient distribution and adjust the N/P ratio. Both simulation and field experiments results confirmed that utilizing self-powered energy to inject compressed air to uplift DOW was a valid and efficient method. Therefore, further field-based research on artificial upwelling, especially for long-term field research is required to test the scientific hypothesis. | PAN YiWen FAN Wei ZHANG DaHai CHEN JiaWang HUANG HaoCai LIU ShuXia JIANG ZongPei DI YaNan TONG MengMeng CHEN Ying | 2016 | Science China Earth Sciences2016，59，2： | 3 |
| 11 | A TiO_(2)nanotubes film with excellent antireflective and near-perfect self-cleaning performances显示文摘SiO_(2)/TiO_(2)composite films have been frequently used to realize the functions of self-cleaning and antireflection.Increasing the TiO_(2)volume ratio in SiO_(2)/TiO_(2)composite film is beneficial to enhance the self-cleaning effect,while high TiO_(2)content leads to a strong Rayleigh scattering and depresses the antireflective performance,resulting in a bottleneck problem for the dual-functional application.Here,we have achieved a high-quality TiO_(2)nanotubes film with excellent antireflective and near-perfect selfcleaning performances.Ultrasound assisted pickling method has been developed to effectively prepare the well-dispersed protonated titanate nanotubes colloid.After spin-coating and annealing treatment,glass substrate coated with double-side TiO_(2)nanotubes film has a peak transmittance of 99.2%and average transmittance of 97.4%at 400-800 nm.Ultra-high porosity of TiO_(2)nanotubes film(80%)and ultra-fine size of TiO_(2)nanotubes(8.6 nm in outer diameter)lead to excellent antireflective performance.With high UV absorptivity(80%at 254 nm)and formal quantum efficiency of stearic acid(10.9×10^(-3)),TiO_(2)nanotubes film shows near-perfect self-cleaning performance.A persistent anti-fogging ability is also presented.This study demonstrates the feasibility to fabricate pure TiO_(2)antireflective coating for glass substrate,extends application field of the classic TiO_(2)nanotubes,and sheds lights on the practical applications of high-powered TiO_(2)nanotube-based multi-functional films. | Kaibin Li Ming Li Chang Xu Zengyan Du Jiawang Chen Fengxia Zou Chongwen Zou Sichao Xu Guanghai Li | 2021 | Journal of Materials Science & Technology2021，，29： | 3 |
| 12 | A MULTI-OBJECTIVE ROBUST OPERATION MODEL FOR ELECTRONIC MARKET ENABLED SUPPLY CHAIN WITH UNCERTAIN DEMANDS显示文摘 | Jiawang XU Xiaoyuan HUANG Nina YAN | 2007 | Journal of Systems Science and Systems Engineering2007，16，1： | 3 |
| 13 | An Approximation Bound Analysis for Lasserre’s Relaxation in Multivariate Polynomial Optimization显示文摘Suppose f,g1,…,gm are multivariate polynomials in x∈R^(n)and their degrees are at most 2d.Consider the problem:Minimize f(x)subject to g1(x)≥0,…,gm(x)≥0.Let f_(min)(resp.,f_(max))be the minimum(resp.,maximum)of f on the feasible set S,and f_(sos)be the lower bound of_(fmin)given by Lasserre’s relaxation of order d.This paper studies its approximation bound.Under a suitable condition on g1,…,gm,we prove that(f_(max)−f_(sos))≤Q(f_(max)−f_(min))with Q a constant depending only on g1,…,gm but not on f.In particular,if S is the unit ball,Q=O(n^(d));if S is the hypercube,Q=O(n^(2d));if S is the boolean set,Q=O(n^(d)). | Jiawang Nie | 2013 | Journal of the Operations Research Society of China2013，1，3： | 2 |
| 14 | Cycle number of neoadjuvant chemotherapy might influence survival of patients with T1-4N2-3M0 nasopharyngeal carcinoma显示文摘Objective: Stage N2-3 nasopharyngeal carcinoma(NPC) shows a high risk of distant metastasis, which will finally cause death. This study aimed to evaluate the impact of neoadjuvant chemotherapy(NACT) of various cycles before radical radiotherapy on distant metastasis and survival of patients with stage N2-3 diseases.Methods: In this study, a total of 1,164 consecutive patients with non-metastatic N2-3 NPC were recruited and prospectively observed. Then 231 patients who received NACT of 4 cycles(NACT=4 group) were matched 1:2:1 to 462 patients treated with NACT of 2 cycles(NACT=2 group) and 231 patients treated without NACT(NACT=0 group), according to age, histological subtype, N stage and NACT regimen. Five candidate variables(sex, T stage, concurrent chemotherapy, intensity-modulated radiation therapy and cycle number of NACT) were analyzed for their association with patients' survival.Results: After matching, the overall survival(OS), disease-free survival(DFS), local-recurrence-free survival(RFS) and distant-metastasis-free survival(MFS) of the NACT=4 group(89.2%, 81.0%, 83.3% and 84.8%,respectively) were better than those of the NACT=2 group(83.3%, 72.5%, 81.2% and 77.9%, respectively) and the NACT=0 group(74.0%, 63.2%, 74.0% and 68.8%, respectively). In multivariate analysis, the cycle number of NACT maintained statistical significance on the OS, DFS, RFS and MFS(all P<0.05).Conclusions: For N2-3 NPC, cycle number of NACT appeared to be an independent factor associated with an improvement of survival. | Jiawang Wei Huixia Feng Weiwei Xiao Qiaoxuan Wang Bo Qiu Shiliang Liu Meiling Deng Lixia Lu Hui Chang Yuanhong Gao | 2018 | Chinese Journal of Cancer Research2018，30，1： | 2 |
| 15 | More Detailed Disturbance Measurement and Active Disturbance Rejection Altitude Control for a Flapping Wing Robot Under Internal and External Disturbances显示文摘With the goal of designing a biologically inspired robot that can hold a stable hover under internal and external disturbances.We designed a tailless Flapping-wing Micro Aerial Vehicle(FMAV)with onboard 3D velocity perception.In this way,the wind disturbance caused by the relative motion of the FMAV can be quantified in real time based on the established altitudinal dynamics model.For the rest of the total disturbance,an active disturbance rejection controller is proposed to estimate and suppress those disturbances.In comparison with the traditional PID controller,this proposed approach has been validated.The results show that,in the hovering flight with the internal unmodeled dynamics,the root-mean-square of height controlled is only 2.53 cm.Even with the different weights of loads mounting on the FMAV,the ascending trajectory of flights remains impressively consistent.In the forward flight with the external disturbance,the root-mean-square error of height controlled is 2.78 cm.When the FMAV flies over a ladder introducing an abrupt external disturbance,the maximum overshoot is only half of that controlled by the PID controller.To our best knowledge,this is the first demonstration of FMAVs with the capability of sensing motion-generated wind disturbance onboard and handling the internal and external disturbances in hover flight. | Jiawang Mou Weiping Zhang Kexin Zheng Yao Wang Chaofeng Wu | 2022 | Journal of Bionic Engineering2022，19，6： | 2 |
| 16 | Sum of squares methods for minimizing polynomial forms over spheres and hypersurfaces显示文摘这份报纸学习最小化一个同类的多项式(形式) 的问题在联合起来的范围 \mathbbSn 上的 f (x)- 1 ={ x 吗?\mathbbRn :|x || 2 = 1 }\mathbb { S }^{ n - 1 }=\left\{{ x \in \mathbb { R }^ n :\left\|x \right\|_2 = 1 }\right\} 。当 f (x) 有度 3 时,这个问题是 NP 难的或更高。由 f 表示 min (分别地 f 最大) 最小(分别地最大)\mathbbSn 上的 f (x) 的价值 - 1 \mathbb { S }^{ n - 1 } 。首先,当 f (x) 是度 2d 的一种平形式时,我们学习广场(求救) 的标准和为发现最小的 f min 的更低的界限的松驰:maxgs.t。f (x )- g 湥汣獯摥戠 ?? 楰' 填ⅹ???畣癲e 飐?飐?? | Jiawang NIE | 2012 | Frontiers of Mathematics in China2012，7，2： | 2 |
| 17 | Variable elliptical vibrating screen: Particles kinematics and industrial application显示文摘Traditional vibrating screen usually adopts the linear centralized excitation mode,which causes the difficulty in particles loosening and low screening efficiency.The variable elliptical vibrating screen(VEVS)trajectory is regulated to adapt the material mass along the direction of the screen length,improving the particles distribution as well as the screening efficiency.In this work,a theoretical model was developed for analyzing the screen surface motion law during VEVS-based screening process.An equation was obtained to show the relationship between the horizontal amplitude and the vertical amplitude.The materials kinetic characteristics were studied by using high-speed camera during screening process.Compared with equal-amplitude screen(EAS),the material moving velocity was increased by 13.03%on the first half but decreased by 3.52% on the second half,and the total screening time was reduced by 9.42% by using VEVS.In addition,-6 mm screening test was carried out.At the length of VEVS equaled to 1.2 m,the screening efficiency and the total misplaced material content were 92.50% and 2.90%,respectively.However,the screening efficiency was 89.91% and the total misplaced material content was 3.76% during EAS-based screening process.Furthermore,when external moisture is 5.96%,the screening efficiency of VEVS could reach 86.95%.The 2 TKB50113 type VEVS with double-layered screen surface used in Huoshizui Coal Mine was 5.0 m in width and 11.3 m in length.The areas of single layer and double layer were 56.5 and 113 m~2,respectively.In industrial production,the processing capacity was 2500-3000 t/h and the screening efficiency was larger than 90%. | Chenlong Duan Jiale Yuan Miao Pan Tao Huang Haishen Jiang Yuemin Zhao Jinpeng Qiao Weinan Wang Shijie Yu Jiawang Lu | 2021 | International Journal of Mining Science and Technology2021，31，6： | 2 |
| 18 | Deformation Analysis and Fixture Design of Thin-walled Cylinder in Drilling Process Based on TRIZ Theory显示文摘Thin-walled cylindrical workpiece is easy to deform during machining and clamping processes due to the insufficient rigidi.Moreover,it’s also difficult to ensure the perpendicularity of flange holes during drilling process.In this paper,the element birth and death technique is used to obtain the axial deformation of the hole through finite element simulation.The measured value of the perpendicularity of the hole was compared with the simulated value to verify then the rationality of the simulation model.To reduce the perpendicularity error of the hole in the drilling process,the theory of inventive principle solution(TRIZ)was used to analyze the drilling process of thin-walled cylinder,and the corresponding fixture was developed to adjust the supporting surface height adaptively.Three different fixture supporting layout schemes were used for numerical simulation of drilling process,and the maximum,average and standard deviation of the axial deformation of the flange holes and their maximum hole perpendicularity errors were comparatively analyzed,and the optimal arrangement was optimized.The results show that the proposed deformation control strategy can effectively improve the drilling deformation of thin-walled cylindrical workpiece,thereby significantly improving the machining quality of the parts. | Fulin WANG Bo SHENG Yongwen WU Jiawang LI Zhou XU Zhaoxia ZHU | 2021 | Mechanical Engineering Science2021，3，1： | 1 |
| 19 | A Potentiometric Flow Biosensor Based on Ammonia - Oxidizing Bacteria fi:r the Detection of Toxicity in Water显示文摘 | Qianyu Zhang Jiawang Ding Lijuan Kou | 2013 | Sensors2013，13，6： | 1 |
| 20 | One-dimensional micro/nanomotors for biomedicine:delivery,sensing and surgery显示文摘The rapid development of artificial micro/nanomachines brings promising strategies to overcome challenges in biomedicine,including delivery,sensing and surgery.One-dimensional(1D)micro/nanomotors are one of the most attractive micro/nanomachines due to their high specific surface area,powerful impetus and weak rotation diffusion.In this review,different propulsion mechanisms and motion control strategies of 1D micro/nanomotors are summarized,and recent efforts towards their fabrication methods and biomedical applications are discussed.We envision the multidisciplinary research efforts in the field of 1D micro/nanomotors will pave their way to practical applications in bioimaging and biomedicine. | Jiawang Guo Yuan Lin | 2020 | Biomaterials Translational2020，1，1： | 1 |
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