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| 1 | Lake eutrophication and its ecosystem response显示文摘China is a country with many lakes,about one-third of which are freshwater mainly distributed in the middle and lower reaches of the Yangtze River.Currently most of the lakes are mesotrophic or eutrophic.Lake eutrophication has become one of the major ecological and environmental problems faced by lakes in China and can lead to a series of abnormal ecosystem responses,including extinction of submerged plants,frequent occurrence of cyanobacterial blooms,increased microbial biomass and productivity,decreased biodiversity,accelerated cycles,and a change in the efficient use of nutrients.With development of eutrophication,the whole lake ecosystem suffers decreased biodiversity,simplification of biotic community structure,instability of the ecosystem,and ultimately the clear-water,macrophyte-dominated ecosystem gradually shifts to a turbid-water,algae-dominated ecosystem.This ecosystem succession mechanism is speculated to be caused by different nutrient utilization efficiencies of macrophytes and phytoplankton.The ultimate ecosystem succession trend of seriously eutrophic lakes is that a phytoplankton-dominated autotrophic lake shifts to a heterotrophic lake dominated by micro-organisms,protozoans. | QIN BoQiang GAO Guang ZHU GuangWei ZHANG YunLin SONG YuZhi TANG XiangMing XU Hai DENG JianMing | 2013 | Chinese Science Bulletin2013，58，9： | 63 |
| 2 | Why Lake Taihu continues to be plagued with cyanobacterial blooms through 10 years(2007–2017) efforts显示文摘With the expansion of urban, industry, and agriculture after World War II, eutrophication firstly emerged as a major water quality threat in small water bodies [1]. As the increasing magnitudes and scales of nutrient pollution and habitat alteration, many of the world's large lakes exhibit symptoms of eutrophication, e.g., toxic cyanobacterial blooms, deoxygenation, and habitat loss. | Boqiang Qin Hans W.Paerl Justin D.Brookes Jianguo Liu Erik Jeppesen Guangwei Zhu Yunlin Zhang Hai Xu Kun Shi Jianming Deng | 2019 | Science Bulletin2019，64，6： | 50 |
| 3 | Efficacy and safety of a novel anti-HER2 therapeutic antibody RC48 in patients with HER2-overexpressing,locally advanced or metastatic gastric or gastroesophageal junction cancer:a single-arm phase II study显示文摘Background:Current treatment options for human epidermal growth factor receptor 2(HER2)-overexpressing gastric cancer at third-line have shown limited clinical benefit.Further,there is no specific treatment for HER2 immunohistochemistry(IHC)2+and fluorescence in-situ hybridization-negative patients.Here,we report the efficacy and safety of a novel anti-HER2 antibody RC48 for patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer.Methods:Patients with HER2-overexpressing(IHC 2+or 3+),locally advanced or metastatic gastric or gastroesophageal junction cancer who were under at least second-line therapy were eligible and received RC482.5 mg/kg alone every 2 weeks.The primary endpoint was the objective response rate(ORR)assessed by an independent review committee.Secondary endpoints included progressionfree survival(PFS),overall survival(OS),duration of response,time to progression,disease control rate,and safety.Results:Of 179 patients screened,125 were eligible and received RC48 treatment.The ORR was 24.8%(95%confidence interval[CI]:17.5%-33.3%).The median PFS and OS were 4.1 months(95%CI:3.7-4.9 months)and 7.9 months(95%CI:6.7-9.9 months),respectively.The most frequently reported adverse events were decreased white blood cell count(53.6%),asthenia(53.6%),hair loss(53.6%),decreased neutrophil count(52.0%),anemia(49.6%),and increased aspartate aminotransferase level(43.2%).Serious adverse events(SAEs)occurred in 45(36.0%)patients,and RC48-related SAEs were mainly decreased neutrophil count(3.2%).Seven patients had adverse events that led to death were not RC48-related.Conclusions:RC48 showed promising activity with manageable safety,suggesting potential application in patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer who have previously received at least two lines of chemotherapy. | Zhi Peng Tianshu Liu Jia Wei Airong Wang Yifu He Liuzhong Yang Xizhi Zhang Nanfeng Fan Suxia Luo Zhen Li Kangsheng Gu Jianwei Lu Jianming Xu Qingxia Fan Ruihua Xu Liangming Zhang Enxiao Li Yuping Sun Guohua Yu Chunmei Bai Yong Liu Jiangzheng Zeng Jieer Ying Xinjun Liang Nong Xu Chao Gao Yongqian Shu Dong Ma Guanghai Dai Shengmian Li Ting Deng Yuehong Cui Jianmin Fang Yi Ba Lin Shen | 2021 | Cancer Communications2021，41，11： | 29 |
| 4 | Controlling cyanobacterial blooms by managing nutrient ratio and limitation in a large hypereutrophic lake: Lake Taihu, China显示文摘Excessive nitrogen(N) and phosphorus(P) loading of aquatic ecosystems is a leading cause of eutrophication and harmful algal blooms worldwide, and reducing nutrient levels in water has been a primary management objective. To provide a rational protection strategy and predict future trends of eutrophication in eutrophic lakes, we need to understand the relationships between nutrient ratios and nutrient limitations. We conducted a set of outdoor bioassays at the shore of Lake Taihu. It showed that N only additions induced phytoplankton growth but adding only P did not. Combined N plus P additions promoted higher phytoplankton biomass than N only additions, which suggested that both N and P were deficient for maximum phytoplankton growth in this lake(TN:TP = 18.9). When nutrients are present at less than 7.75–13.95 mg/L TN and 0.41–0.74 mg/L TP, the deficiency of either N or P or both limits the growth of phytoplankton. N limitation then takes place when the TN:TP ratio is less than 21.5–24.7(TDN:TDP was 34.2–44.3), and P limitation occurs above this. Therefore, according to this ratio, controlling N when N limitation exists and controlling P when P deficiency is present will prevent algal blooms effectively in the short term. But for the long term, a persistent dual nutrient(N and P) management strategy is necessary. | Jianrong Ma Boqiang Qin Pan Wu Jian Zhou Cheng Niu Jianming Deng Hailin Niu | 2015 | Journal of Environmental Sciences2015，27，1： | 20 |
| 5 | A new type of plunge pool―Multi-horizontal submerged jets显示文摘Based on the understanding of the mechanism of energy dissipation,a new type of plunge pool is presented with the advantages of high rate of energy dissipation,low impact pressure,and small close-to-bed velocity on the soleplate of the plunge pool.The first advantage owes to enlarged shearing energy dissipation areas in the plunge pool,while the other two are caused by the jet that enters in a nearly horizontal level to keep the soleplate from being scoured directly.All of the above arrangements make this new type of energy dissipator distinct from the underflow energy dissipation.Through experiments on the physical model,the authors found that the water flow maintained stable and submerged in horizontal direction when the flow was narrow in horizontal but thick in vertical direction.However,the wide flat nappe was ready to submerge or float as the downstream water level rised or dropped.The entire flow fields of multi-horizontal submerged jets into plunge pool were also numerically simulated.The numerical results of water surface curve,close-to-bed velocity and floor pressure agree well with the experimental data.The flow pattern in the plunge pool was analyzed after combining the laboratory data and numerical simulation. | DENG Jun,XU WeiLin,ZHANG JianMing,QU JinXue & YANG YongQuan State Key Laboratory of Hydraulics and Mountain River Engineering,Sichuan University,Chengdu 610065,China | 2008 | Science China(Technological Sciences)2008，51，12： | 12 |
| 6 | An H3K27me3 demethylase-HSFA2 regulatory loop orchestrates transgenerational thermomemory in Arabidopsis显示文摘Global warming has profound effects on plant growth and fitness.Plants have evolved sophisticated epigenetic machinery to respond quickly to heat,and exhibit transgenerational memory of the heat-induced release of post-transtriptional gene silencing(PTGS).However,how thermomemory is transmitted to progeny and the physiological relevance are elusive.Here we show that heat-induced HEAT SHOCK TRANSCRIPTION FACTOR A2(HSFA2)directly activates the H3K27me3 demethylase RELATIVE OF EARLY FLOWERING 6(REF6),which in turn derepresses HSFA2.REF6 and HSFA2 establish a heritable feedback loop,and activate an E3 ubiquitin ligase,SUPPRESSOR OF GENE SILENCING 3(SGS3)-INTERACTING PROTEIN 1(SGIP1).SGIP1-mediated SGS3 degradation leads to inhibited biosynthesis of trans-acting siRNA(tasiRNA).The REF&HSFA2 loop and reduced tasiRNA converge to release HEAT-INDUCED TAS1 TARGET 5(HTT5),which drives early flowering but attenuates immunity.Thus,heat induces transmitted phe no types via a coordi nated epigenetic network involvi ng histone demethylases,tran scriptio n factors,and tasiRNAs,ensuring reproductive success and transgenerational stress adaptation. | Junzhong Liu Lili Feng Xueting Gu Xian Deng Qi Qiu Qun Li Yingying Zhang Muyang Wang Yiwen Deng Ertao Wang Yuke He Isabel Baurle Jianming Li Xiaofeng Cao Zuhua He | 2019 | Cell Research2019，29，5： | 10 |
| 7 | Evaluation of the safety and efficacy of a Pipeline Flex embolization device for treatment of large, wide-necked intracranial aneurysms显示文摘Objective: To investigate the safety and effectiveness of the Pipeline Flex embolization device(PFED) in the treatment of large and wide-necked aneurysms in the internal carotid artery(ICA). Methods: The clinical data of 78 cases of large and wide-necked aneurysms in the ICA treated with this Pipeline Flex embolization device in Shanghai Hospital of the Second Military Medical University and Southern Hospital of Southern Medical University from February 2017 to June 2018 were retrospectively analyzed. Results: A total of 66 cases were treated with a Pipeline Flex embolization device, 10 with a pipeline flex embolization device, and 2 with a double tubride stent(10 patients were treated with a pipeline stent-assisted coil embolization in; and 2 patients were treated with two pipeline stents). The patients were followed up for 3 to 18 months(average, 9.25 months). Among them, 63 cases had complete occlusion of the neck of the aneurysm(Raymondl Class I; MRS score 0; 80.8%). Aneurysms recurred in 12 cases(Raymondl Class Ⅱ; MRS score 1; 15.4%). Delayed ischemic complications were observed in 1 case(MRS score >2; 0.13%). There was 1 case of poor release of stent and 1 case of stent stenosis(0.13%). Conclusion: The treatment of large, wide-necked aneurysms in the ICA with PFED has a high total occlusion rate and good prognosis was better than coil embolization, but the placement of PFED still has some neurological complications. | Qiao Deng Wenfeng Feng Huanqi Hai Jianming Liu | 2018 | Journal of Interventional Medicine2018，1，4： | 5 |
| 8 | Enhanced piezo-response in copper halide perovskites based PVDF composite films显示文摘In-situ fabricated perovskite nanocrystals in polymeric matrix provide new generation composite materials for plenty of cutting edge technology. In this work, we report the in-situ fabrication of copper halide perovskite(MA_2CuCl_4, MA:CH_3NH_3^+) embedded poly(vinylidene fluoride)(PVDF) composite films. The optimized MA_2CuCl_4/PVDF composite films exhibit greatly enhanced piezo-response in comparasion with pure PVDF films. The enhancements were invesitgated and explained by applying piezo-response force microscopy(PFM) measurements and density functional theory(DFT) caculations. We proposed that the high piezoelectric properties of MA_2CuCl_4/PVDF composite films could be related to the large Cu off-centering displacement, the strong interactions between MA_2CuCl_4 and PVDF as well as large stress concentration around the MA_2CuCl_4 particles in the films. These piezoelectric composite films are expected to be suitable functional materials for flexible and/or wearable piezoelectrics. | Sheng Huang Gang Tang Hailong Huang Xian-gang Wu Puming Zhou Lin Zou Lei Xie Jianming Deng Xueyun Wang Haizheng Zhong Jiawang Hong | 2018 | Science Bulletin2018，63，19： | 4 |
| 9 | Polluted lake restoration to promote sustainability in the Yangtze River Basin,China显示文摘China has sought to address water pollution in the last decade by introducing a wide range of laws and regulations(Table S1), which led to nationwide water quality improvement ^([1]). However, recent quantitative assessment of progress toward Sustainable Development Goals (SDGs) in China suggests that some SDGs underpinning goals for water pollution and biodiversity have not been met ^([2]). | Boqiang Qin Yunlin Zhang Jianming Deng Guangwei Zhu Jianguo Liu David P.Hamilton Hans W.Paerl Justin D.Brookes Tingfeng Wu Kai Peng Yizhou Yao Kan Ding Xiaoyan Ji | 2022 | National Science Review2022，9，1： | 4 |
| 10 | Effects of methylphenidate on resting-state brain activity in normal adults: an fMRI study显示文摘Methylphenidate (MPH) is one of the most commonly used stimulants for the treatment of attention deficit hyperactivity disorder (ADHD). Although several studies have evaluated the effects of MPH on human brain activation during specific cognitive tasks using functional magnetic resonance imaging (fMRI), few studies have focused on spontaneous brain activity. In the current study, we investigated the effect of MPH on the intra-regional synchronization of spontaneous brain activity during the resting state in 18 normal adult males. A handedness questionnaire and the Wechsler Adult Intelligence Scale were applied before medication, and a resting-state fMRI scan was obtained 1 h after medication (20 mg MPH or placebo, order counterbalanced between participants). We demonstrated that: (1) there were no significant differences in the performance of behavioral tasks between the MPH and placebo groups; (2) the left middle and superior temporal gyri had stronger MPH-related regional homogeneity (ReHo); and (3) the left lingual gyrus had weaker MPH-related ReHo. Our findings showed that the ReHo in some brain areas changes with MPH compared to placebo in normal adults, even though there are no behavioral differences. This method can be applied to patients with mental illness who may be treated with MPH, and be used to compare the difference between patients taking MPH and normal participants, to help reveal the mechanism of how MPH works. | Yihong Zhu Bin Gao Jianming Hua Weibo Liu Yichao Deng Lijie Zhang Biao Jiang Yufeng Zang | 2013 | Neuroscience Bulletin2013，29，1： | 4 |
| 11 | Importance and vulnerability of lakes and reservoirs supporting drinking water in China显示文摘Drinking water is closely related to human health,disease and mortality,and contaminated drinking water causes 485,000 deaths from diarrhea each year worldwide.China has been facing increasingly severe water scarcity due to both water shortages and poor water quality.Ensuring safe and clean drinking water is a great challenge and top priority,especially for China with 1.4 billion people.In China,more than 4000 centralized drinking water sources including rivers,lakes and reservoirs,and groundwater have been established to serve urban residents.However,there is little knowledge on the percentage,serving population and water quality of three centralized drinking water source types.We collected nationwide centralized drinking water sources data and serving population data covering 395 prefecture-level and county-level cities and water quality data in the two most populous provinces(Guangdong and Shandong)to examine their contribution and importance.Geographically,the drinking water source types can be classified into three clear regions exhibiting apparent differences in the respective contributions of rivers,lakes and reservoirs,and groundwater.We further found that overall,lakes and reservoirs account for 40.6%of the centralized drinking water sources vs.river(30.8%)and groundwater(28.6%)in China.Lakes and reservoirs are particularly important in the densely populated eastern region,where they are used as drinking water sources by 51.0%of the population(318 million).Moreover,the contribution to the drinking water supply from lakes and reservoirs is increasing due to their better water quality and many cross-regional water transfer projects.These results will be useful for the government to improve and optimize the establishment of centralized drinking water sources,which provide safe and clean drinking water in China to safeguard people's lives and health and realize sustainable development goals. | Yunlin Zhang Jianming Deng Boqiang Qin Guangwei Zhu Yinjun Zhang Erik Jeppesen Yindong Tong | 2023 | Fundamental Research2023，3，2： | 3 |
| 12 | Spatial pattern and its evolution of Chinese provincial population: Methods and empirical study显示文摘中国一直在经历一个崭新的都市化过程。在 2011,瓷器城市的人口与 51.27% 的都市化率到达了 6.91 亿。都市化水平被期望在 2030 在中国增加到 70% ,反映将近 3 亿个人将从农村区域移植到在这个时期上的城市的区域的设计。同时,瓷器人口的全部的富饶率由于经济生长,环境带能力,和现代社会知觉的联合效果正在衰退。中国政府由允许生育夫妇只要他们的任何一个来自一个一个孩子家庭,有第二个孩子逐渐地松开了它的一个孩子政策。在如此的很快发展中的国家,自然生长和空间移植将一致地重塑人口的空间模式。未来的精确预言人口和它的进化趋势的空间模式是批评的给政策制定的过程并且包括都市化,陆地使用发展,生态的保存和环境保护的在中国的空间计划调音。在这份报纸,一个自顶向下的方法被开发从 2010 ~ 2050 在省的水平和省的迁居与两自然人口生长的考虑投射瓷器未来人口的空间分发。这上的大楼,空间模式和中国省的人口的进化趋势被分析。结果建议中国人口的全面空间模式将是不大可能的在下四十年变化了,与有最高的人口密度的东方区域并且由中央区域,东北和西方区域列在后面。在东方,上海,北京,天津和江苏的四个省,将以人口密度仍然是顶在中国,和 Xinjiang, Qinghai 和西藏将继续有人口的最低密度。我们介绍了一个索引系统以省的人口密度分类中国省进三个范畴:快变化的占据区域(FCPR ) ,低变化占据区域(LCPR ) 和不活跃的占据区域(IPR ) 。在 FCPR,瓷器人口被投射继续在网移民集中收到将近 99% 新积累的流动人口的领先的类型(NILT ) 区域。上海的人口密度,北京,浙江将在 2030 达到顶点,当在广东的人口密度将不停地增加直到 2035 时。为 75% 移民人口让移民赚领先的类型(NELT ) 区域愿望报道,包括河南省,安徽,重庆和湖北。自然生长将在带类型区域的自然生长起一个主导的作用,例如辽宁和山东,因为将有很少移民人口。由于大量动人外面劳动和逐渐地衰退的富饶率, LCPR 区域的人口密度展出一向下趋势,除了福建和海南。西方的省的多数将是可能的仍然是相对低的人口密度,与平均价值仅仅 100 个人每 km 2 。 | DENG Yu LIU Shenghe CAI Jianming LU Xi Chris P NIELSEN | 2015 | Journal of Geographical Sciences2015，25，12： | 2 |
| 13 | SUSTAINABLE SUGARCANE CROPPING IN CHINA显示文摘Demand for sugar is projected to grow in China for the foreseeable future.However,sugarcane production is unlikely to increase due to increasing production cost and decreasing profit margin.The persisting sugarcane yield plateau and the current cropping system with fertilizer overuse,soil acidification and pests and diseases remain the major productivity constraints.Sugarcane agriculture supports the livelihood of about 28 million farmers in South China;hence,sustaining it is a socioeconomic imperative.More compellingly,to meet the ever-increasing Chinese market demand,annual sugar production must be increased from the current 10 Mt to 16 Mt by 2030 of which 80% to 90% comes from sugarcane.Therefore,increasing sugar yield and crop productivity in an environmentally sustainable way must be a priority.This review examines the current Chinese sugarcane production system and discuss options for its transition to a green,sustainable cropping system,which is vital for the long-term viability of the industry.This analysis shows that reducing chemical inputs,preventing soil degradation,improving soil health,managing water deficit,provision of clean planting material,and consolidation of small farm holdings are critical requirements to transform the current farming practices into an economically and environmentally sustainable sugarcane cropping system. | Ting LUO Prakash LAKSHMANAN Zhongfeng ZHOU Yuchi DENG Yan DENG Linsheng YANG Dongliang HUANG Xiupeng SONG Xihui LIU Wen-Feng CONG Jianming WU Xinping CHEN Fusuo ZHANG | 2022 | Frontiers of Agricultural Science and Engineering2022，9，2： | 1 |
| 14 | Molecular diagnosis and treatment of meningiomas:an expert consensus(2022)显示文摘Meningiomas are the most common primary intracranial neoplasm with diverse pathological types and complicated clinical manifestations.The fifth edition of the WHO Classification of Tumors of the Central Nervous System(WHO CNS5),published in 2021,introduces major changes that advance the role of molecular diagnostics in meningiomas.To follow the revision of WHO CNS5,this expert consensus statement was formed jointly by the Group of Neuro-Oncology,Society of Neurosurgery,Chinese Medical Association together with neuropathologists and evidence-based experts.The consensus provides reference points to integrate key biomarkers into stratification and clinical decision making for meningioma patients. | Jiaojao Deng Lingyang Hua Liuguan Bian Hong Chen Ligang Chen Hongwei Cheng Changwu Dou Dangmurenjiapu Geng Tao Hong Hongming Ji Yugang Jiang Qing Lan Gang Li Zhixiong Liu Songtao Qi Yan Qu Songsheng Shi Xiaochuan Sun Hajun Wang Yongping You Hualin Yu Shuyuan Yue Jianming Zhang Xiaohua Zhang Shuo Wang Ying Mao Ping Zhong Ye Gong Group of Neuro-Oncology Society of Neurosurgery Chinese Medical Association | 2022 | Chinese Medical Journal2022，135，16： | 1 |
| 15 | Broad spectrum alkynyl inhibitors of T315I Bcr-Abl显示文摘 | Xianming Deng Sang Min Lim Jianming Zhang Nathanael S. Gray | 2010 | Bioorganic & Medicinal Chemistry Letters2010，，14： | 1 |
| 16 | MCMG: a 3-D multigroup P3 Monte Carlo code and its benchmarks显示文摘 | Deng Li Xie Zhongsheng Zhang Jianming | 2001 | J Nucl Sci Tech2001，37，7： | 1 |
| 17 | MCMG: A 3-D muhigroup P3 Monte Carlo code and its benchmarks 显示文摘 | DENG Li XIE Zhongsheng ZHANG Jianming | 2001 | J Nucl Sci Technol2001，37，7： | 1 |
| 18 | BRCA2 promoter polymorphism is associated with breast cancer prognosis in Chinese women显示文摘 | Liu Lu Fang Yi Fan Jianlin Hu Jianming Xu Xiaoting Jin Xiaohong Wang Xiuzhen Deng Min Wang Jing Liu Wei | 2014 | Chinese Medical Journal2014，，11： | 1 |
| 19 | MCMG : A 3 D multigroup Monte-Carlo code and its benchmarks显示文摘 | DENG Li XIE Zhongsheng ZHANG Jianming | 2000 | J Nucl Sci Tech2000，37，7： | 1 |
| 20 | MCMG: A 3-D multigroup P3 Monte Carlo code and its benchmarks显示文摘 | DENG Li XIE Zhongsheng ZHANG Jianming | 2000 | Journal of Nuclear Sci- ence and Technology2000，37，7： | 1 |
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