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| 1 | Delivery of Tapasin-modified CTL epitope peptide via cytoplasmic transduction peptide induces CTLs by JAK/STAT signaling pathway in vivo显示文摘特定的细胞毒素的 T 淋巴细胞(CTL ) 玩的肝炎 B 病毒(HBV ) 在病毒的控制和清理的一个重要角色。最近的研究阐明了那 Tapasin, endoplasmic 蜂窝胃女伴,是看起来在装载肽的过程必要的一个著名分子。Janus kinase/signal 变换器和小径玩的抄写(JAK/STAT ) 的使活跃之物在有免疫力的反应的一个重要角色规定和 cytokines 分泌物。我们以前证实了熔化蛋白质 CTP-HBcAg 18-27-Tapasin 能便于骨头髓的成熟导出的树枝状的房间并且在 vitro 提高特定的 CTL 回答,它可能与 JAK/STAT 发信号的激活被联系小径。为了进一步探索 JAK/STAT 发信号小径是否参予了特定的有免疫力的回答,由我们压制了的 CTP-HBcAg 18-27-Tapasin, 调停了有在 vivo 的药理学禁止者(AG490 ) 的 JAK/STAT 小径。我们的研究证明 IFN-+-CD8+ T 房间的数字在被 AG490 堵住以后与另外的组相比显著地被减少。IFN-+-CD4+ T 房间和 IL-2-CD4 + T 房间的百分比也被减少。而且, Jak2, Tyk2, STAT1,和 STAT4 的更低的表示层次在 AG490 被检测组。另外,象 Th1 一样 cytokines 的分泌物层次被减少,更弱的特定的 T 房间回答在 AG490 组被观察。而且,在这条小径在 HBV 转基因的老鼠被禁止以后,在浆液的 HBV DNA 和 HBsAg 的层次和在肝纸巾的 HBsAg 和 HBcAg 的表示层次被提高。这些结果证明表明小径的 JAK/STAT 参予 CTP-HBcAg 18-27-Tapasin 导致的 Th1 面向的有免疫力的反应,这可能为 HBV 免疫疗法提供一个理论基础。 | Shanshan Wu Xiaohua Chen Yuyan Tang Yi Zhang Dan Li Jie Chen Jieling Wang Zhenghao Tang Guoqing Zang Yongsheng Yu | 2018 | Acta Biochimica et Biophysica Sinica2018，50，2： | 6 |
| 2 | Chemical probing reveals insights into the signaling mechanism of inflammasome activation显示文摘Caspase-1-mediated IL-1 尾生产被二条小径通常控制。像使用费的受体(TLR ) 认出导出病原体的产品并且导致 NF-魏 B 依赖者 pro-IL-1 尾抄写;像点头的受体(NLR ) 装配察觉到细菌的产品 / 危险信号的 caspase-1-activating inflammasome 建筑群。通过一幅指向的化学屏幕,我们识别 bromoxone,一个海洋的自然产品,一特定并且 caspase-1 小径的有势力禁止者。Bromoxone 在包括加 ATP/nigericin, cytosolic DNA, flagellin 和杆菌 anthracis 的 TLR ligands 的多样的煽动性的刺激上是有效的致命的毒素。Bromoxone 高效地也压制激活由细菌的感染的几种类型触发了的 caspase-1。在上游的 Bromoxone 行为或在以一种抄写无关的方式的 inflammasome 的水平。Bromoxone 也由在 TLR-NF-魏 B 小径指向 IKK 在上游的部件禁止 pro-IL-1 尾表示。bromoxone 的唯一的双活动被明确地堵住 Nalp3 inflammasome 激活的已知的 TAK1 禁止者分享。提示了从机械学并且 bromoxone 的药理学性质,我们进一步发现几个已知的 NF-魏 B 禁止者 IKK 在上游的那行为,然而并非下游地指向 IKK 或 IKK 的那些,是不同调停 NLRs 的 caspase-1 激活的有势力 blockers。我们的学习揭开可能的 non-transcriptional 在 NLR (Nalp3 ) 之间的分子的连接调停了 inflammasome 小径和 TLR-NF-魏 B 发信号,并且建议潜在的策略开发新反煽动性的药。 | Yi-Nan Gong Xiaoming Wang Jiayi Wang Zhenxiao Yang Shan Li Jieling Yang Liping Liu Xiaoguang Lei Feng Shao | 2010 | Cell Research2010，20，12： | 5 |
| 3 | Solving and Applying a Class of Block-diagonal Structured Large Linear Programming | SHENG Jie Department of Mathematics, Teachers College, Yangzhou University CHENG Jieling Departemt of Irrigation, Agriculture College, Yangzhou University CHEN Yixin Department of Computer Science, University of Science and Technology of China | 1998 | Systems Science and Systems Engineering1998，8，2： | 2 |
| 4 | High-temperature dielectric and microwave absorption performances of TiB2/Al2O3 ceramics prepared by spark plasma sintering显示文摘TiB_(2)/Al2O3 ceramics reinforced with Mg O are prepared by spark plasma sintering(SPS).The dielectric and microwave(MW)absorption properties are discussed.The results indicate that both the commercial TiB_(2)(C-TiB_(2))content and preparing temperature play important roles in the dielectric properties.Simultaneously,TiB_(2)/Al2O3 composite shows the best MW absorption property when the C-TiB_(2)content and preparing temperature are 9 wt%and 1400°C.To further improve the MW absorption properties,the composite containing 9 wt%synthesized TiB_(2)(S-TiB_(2))has been sintered at 1400°C.Its high-temperature complex permittivity is greater than that of TiB_(2)/Al2O3 composite with 9 wt%C-TiB_(2)sintered at 1400°C and is directly proportional to the temperature.Besides,TiB_(2)/Al2O3 composite with 9 wt%S-TiB_(2)possesses a better MW absorption at 25–500°C,its effective absorption bandwidth(RL<-5 dB)can reach 4.2 GHz at 25–500°C.And the minimum reflection loss(RLmin)value reaches-43.41 dB at the temperature of 800°C with a thickness of 1.45 mm for TiB_(2)/Al2O3 composite with 9 wt%C-TiB_(2).Consequently,the satisfying absorbing layer(d<1.75 mm),flexural strength,heat stability and considerable high-temperature MW absorption ability grant TiB_(2)/Al2O3 ceramics practical applications as high-temperature microwave absorption materials(MAMs). | LIU XiongZhang LUO Hui LI YinRui CHEN Fu LIU JieLing YANG WenTao WANG Xian GONG RongZhou | 2021 | Science China(Technological Sciences)2021，64，6： | 2 |
| 5 | A new device for stress monitoring in continuously welded rails using bi-directional strain method显示文摘The technology of continuously welded rails(CWRs) is important in modern railway track structures.To measure rail stress, resistance strain gauges are preferred due to their good stability, sensitivity, and resistance to external interference. Based on the bi-directional strain method, we present a new method for measuring longitudinal rail stress using resistance strain gauges and develop a monitoring device for rail stress to realize long-term and multi-point measurement. Also relevant experimental verification and analysis are conducted. Results indicate that under various constraints the rail stress–strain values can be calculated just with the measured total longitudinal strain and total vertical strain. Considering the measurement error caused by sectional feature of sensors, we put forward a correction equation applicable to different stress conditions. Although the temperature values of the four full-bridge stress gauges can offset each other, the measurement error caused by rail flexural strain can also be eliminated to a certain extent at the same time, the nonuniform distribution of rail cross section temperature and unbalanced flexural strain still affect the measurement error. The experimental results also show that the developed rail-stress-monitoring sensor is suitable for measuring rail stress with reliable working performance. | Ganzhong Liu Hao Liu Anqi Wei Jieling Xiao Ping Wang Shaozheng Li | 2018 | Journal of Modern Transportation2018，26，3： | 1 |
| 6 | Ag/ZnO/graphene oxide he- terostructure for the removal of rhodamine B by the synergistic adsorption-degradation effects显示文摘 | Qin Jieling Li Rong Lu Chunyu | 2015 | Ceramics International2015，41，3： | 1 |
| 7 | Is Prehypertension Really Different from Normotension and Hypertension? A Case-Control Pilot Proteomic Study in Chinese显示文摘 | Zuoguang Wang Xiaoyun Peng Yanduo Tao Ya Liu Jieling Liu Xingjun Chen Shaojun Wen Zhaosu Wu | 2009 | Clinical and Experimental Hypertension2009，，4： | 1 |
| 8 | Prevalence of dry eye among adult Chinese in the Beijing eye study显示文摘 | Y Jiel L Xul YY Wul | 2009 | Eye2009，23，3： | 1 |
| 9 | Reevaluation of pathogens causing Valsa canker on apple in China显示文摘 | WANG Xuli WEI Jieling HUANG Lili KANG Zhensheng | 2011 | Mycologia2011，103，2： | 1 |
| 10 | A new membrane re-anchored protein originating from GPC3 against hepatomacells HepG2显示文摘 | Dongye Yang Junwen Yang Fanggen Lu Caihong Li Jingbo Yang Jieling Liang | 2011 | Molecular Medicine Reports2011，，6： | 1 |
| 11 | Tailoring the oxygen concentration in Ge-Sb-O alloys to enable femtojoule-level phase-change memory operations显示文摘Chalcogenide phase-change materials(PCMs),in particular,the flagship Ge2Sb2Te5(GST),are leading candidates for advanced memory applications.Yet,GST in conventional devices suffer from high power consumption,because the RESET operation requires melting of the crystalline GST phase.Recently,we have developed a conductive-bridge scheme for low-power phase-change application utilizing a self-decomposed Ge-Sb-O(GSO)alloy.In this work,we present thorough structural and electrical characterizations of GSO thin films by tailoring the concentration of oxygen in the phase-separating GSO system.We elucidate a two-step process in the as-deposited amorphous film upon the introduction of oxygen:with increasing oxygen doping level,germanium oxides form first,followed by antimony oxides.To enable the conductive-bridge switching mode for femtojoule-level RESET energy,the oxygen content should be sufficiently low to keep the antimony-rich domains easily crystallized under external electrical stimulus.Our work serves as a useful example to exploit alloy decomposition that develops heterogeneous PCMs,minimizing the active switching volume for low-power electronics. | Jiang-Jing Wang Xiaozhe Wang Yudong Cheng Jieling Tan Chao Nie Zhe Yang Ming Xu Xiangshui Miao Wei Zhang En Ma | 2022 | Materials Futures2022，1，4： | 1 |
| 12 | Clinical Study on the Anti-Aging Effect of a Cream Containing Ginseng Root Extract and L-Carnosine显示文摘The anti-aging effects of a cream containing L-carnosine and ginseng root extract to provide a reference for the evaluation and development of anti-aging cosmetics were tested. Sixty healthy females, aged 35-60,were grouped into test sample and placebo groups. Skin elasticity, gloss, and wrinkles of the participants were analyzed before use and after use for 8 weeks. Instrument measurement results showed that after 8 weeks,skin elasticity, gloss, and wrinkles in the members of the test sample group obviously improved relative to those of the placebo group. Clinical effect assessment results showed that subjects did not experience adverse skin reactions, and their skin gloss showed obvious improvement. Self-assessment results showed that 87%subjects are satisfied with the test sample. Cream containing L-carnosine and ginseng root extract has a certain anti-aging effect. | Sun Hongmei Dai Jieling Yang Qiongli Li Yingyi Liu Fengsong | 2018 | China Detergent & Cosmetics2018，3，3： | 1 |
| 13 | Reconstitution of Motor Proteins through Molecular Assembly显示文摘What is the most favorite and original chemistry developed in your research group?The most favorite and original chemistry developed in my research group is about the reconstitution of motor proteins in artificially designed and assembled units.It is based on the molecular assembly technique,but the method is different from the conventional approach. | Yi Jia Mingjun Xuan Xiyun Feng Li Duan Jieling Li Junbai Li | 2020 | Chinese Journal of Chemistry2020，38，2： | 1 |
| 14 | Key frame extraction based on visual attention model显示文摘 | Lai Jieling Yi Yang | 2012 | Journal of Visual Commu- nication and Image Representation2012，23，1： | 1 |
| 15 | High sulfur loading and shuttle inhibition of advanced sulfur cathode enabled by graphene network skin and N,P,F-doped mesoporous carbon interfaces for ultra-stable lithium sulfur battery显示文摘Achieving high loading of active sulfur yet rational regulating the shuttle effect of lithium polysulfide(LiPS)is of great significance in pursuit of high-performance lithium-sulfur(Li-S)battery.Herein,we develop a free-standing graphene nitrogen(N),phosphorus(P)and fluorine(F)co-doped mesoporous carbon-sulfur(G-NPFMC-S)film,which was used as a binder-free cathode in Li-S battery.The developed mesoporous carbon(MC)achieved a high specific surface area of 921 m^(2)·g^(-1)with a uniform pore size distribution of 15 nm.The inserted graphene network inside G-NPFMC-S cathode can effectively improve its electrical conductivity and simultaneously restrict the shuttle of LiPS.A high sulfur loading of 86%was achieved due to the excellent porous structures of graphene-NPFMC(G-NPFMC)composite.When implemented as a freestanding cathode in Li-S battery,this G-NPFMC-S achieved a high specific capacity(1,356 mAh·g^(-1)),favorable rate capability,and long-term cycling stability up to 500 cycles with a minimum capacity fading rate of 0.025%per cycle,outperforming the corresponding performances of NPFMC-sulfur(NPFMC-S)and MC-sulfur(MC-S).These promising results can be ascribed to the featured structures that formed inside G-NPFMC-S film,as that highly porous NPFMC can provide sufficient storage space for the loading of sulfur,while,the N,P,F-doped carbonic interface and the inserted graphene network help hinder the shuttle of LiPS via chemical adsorption and physical barrier effect.This proposed unique structure can provide a bright prospect in that high mass loading of active sulfur and restriction the shuttle of LiPS can be simultaneously achieved for Li-S battery. | Haotian Liu Fan Liu Zehua Qu Jieling Chen Hui Liu Yiqing Tan Jiabao Guo Yan Yan Shuang Zhao Xinsheng Zhao Xinming Nie Xin Ma Zengxia Pei Mingkai Liu | 2023 | Nano Research Energy2023，2，1： | 1 |
| 16 | Efficient BAD equalizer in two-ray multipath fading channels 显示文摘 | Wang Jieling Yang Hong Yi Kechu | 2009 | IEEE Communications Letters2009，13，11： | 1 |
| 17 | A Class Effect Network Meta-analysis of Lipid Modulation in Non-alcoholic Steatohepatitis for Dyslipidemia显示文摘Background and Aims:Pharmaceutical therapy for NASH is associated with lipid modulation,but the consensus on drug treatment is limited and lacks comparative analysis of effectiveness.A network meta-analysis was conducted to compare NASH drug classes in lipid modulation.Methods:Online databases were searched for randomized controlled trails(RCTs)evaluating NASH treatments in biopsy-proven NASH patients.Treatments were classified into four groups:(1)inflammation,(2)energy,(3)bile acids,and(4)fibro-sis based on the mechanism of action.A Bayesian network analysis was conducted with outcome measured by mean difference(MD)with credible intervals(Crl)and surface un-der the cumulative ranking curve(SUCRA).Results:Forty-four RCTs were included in the analysis.Bile acid modulat-ing treatments(MD:0.05,Crl:0.03-0.07)were the best treatment for improvement in high-density lipid(HDL)cho-lesterol,followed by treatments modulating energy(MD:0.03,Crl:0.02-0.04)and fibrosis(MD:0.01,Crl:−0.12 to 0.14)compared with placebo.The top three treatments for reduction in triglycerides were treatments modulating energy(MD:−0.46,Crl:−0.49 to−0.43),bile acids(MD:−0.22,Crl:−0.35 to−0.09),and inflammation(MD:−0.08,Crl:−0.13 to−0.03)compared with placebo.SUCRA found treatment modulating fibrosis(MD:−1.27,Crl:−1.76 to−0.79)was the best treatment for reduction in low-density lipid(LDL)cholesterol followed by treatment modulating in-flammation(MD:−1.03,Crl:−1.09 to−0.97)and energy(MD:−0.37,Crl:−0.39 to−0.34)compared with placebo,but LDL cholesterol was worsened by treatments modulat-ing bile acids.Conclusions:Network analysis comparing the class effects of dyslipidemia modulation in NASH found that treatment targets can include optimization of athero-genic dyslipidemia.Future studies are required to evaluate the cardiovascular outcomes. | Jieling Xiao Cheng-Han Ng Yip-Han Chin Darren Jun Hao Tan Wen-Hui Lim Grace Lim Jingxuan Quek Ansel Shao Pin Tang Kai-En Chan Rou-Yi Soong Nicholas Chew Benjamin Tay Daniel Q.Huang Nobuharu Tamaki Roger Foo Mark Y.Chan Mazen Noureddin Mohammad Shadab Siddiqui Arun J.Sanyaland Mark D.Muthiah | 2022 | Journal of Clinical and Translational Hepatology2022，10，6： | 0 |
| 18 | Computation model and improved ACO algorithm for p//T显示文摘Scheduling jobs on parallel machines to minimize the total tardiness(p//T) is proved to be NP hard.A new ant colony algorithm to deal with p//T(p//T ACO) is addressed, and the computing model of mapping p//T to the ant colony optimization environment is designed.Besides, based on the academic researches on p//T, some new properties used in the evolutionary computation are analyzed and proved.The theoretical analysis and comparative experiments demonstrate that p//T ACO has much better performance and can be used to solve practical large scale problems efficiently. | Yi Yang Lai Jieling | 2009 | Journal of Systems Engineering and Electronics2009，20，6： | 0 |
| 19 | Average life expectancy of the Chinese population in 1949-2019: trends, contributors and prospects显示文摘This paper provided an overview of literature on life expectancy of Chinese popu-lation,elaborated the characteristics of the significant increase in the average life expectancy(ALE)of Chinese population over the past 70 years since the founding of PRC,analyzed the major factors contributing to the improvement in the ALE,and highlight the needs to put greater emphasize to increase average healthy life expectancy(AHLE),to narrow the regional differences in AHLE,to advocate and promote healthy lifestyles,and to prevent and control pollution persistently and effectively. | Shixun Gui Jieling Chen | 2020 | China Population and Development Studies2020，3，1： | 0 |
| 20 | Necroptosis-elicited host immunity:GOx-loaded MoS_(2) nanocatalysts for self-amplified chemodynamic immunotherapy显示文摘Nanoparticles induced potent antitumor immunotherapy plays a significant role for enhancing conventional therapeutic effectiveness.However,revealing the pathway of how nanoagents themselves trigger the host immunity or how to maximize the immunotherapy efficacy still needs further exploration.Herein,rose-like MoS2 nanoflowers modified with 2-deoxy-D-glucose(2-DG)and glucose oxidase(GOx)(MPGGFs)have been successfully fabricated via a one-pot hydrothermal reaction and following one-by-one surface modification as a multifunctional nanocatalyst for photothermal therapy enhanced self-amplified chemodynamic immunotherapy(PTT-co-CDT).By introducing GOx,the obtained MPGGFs exhibited self-amplified chemodynamic therapeutic efficacy under hypoxia tumor microenvironment(TME)because of the raised intracellular H2O2 level via enzyme-catalysis of oxygen.Furthermore,combined with the intrinsic excellent photothermal conversion efficiency of MoS2 nanoflowers,PTT-co-CDT performances by MPGGFs could effectively induce the necroptosis of tumor cells both in vitro and in vivo.Then the induced necroptosis via PTT-co-CDT by MPGGFs could directly trigger host immunity by activating the antigen-specific T-cells(CD4^(+) and CD8^(+)).Finally,the excellent in vivo safety of MPGGFs makes us believe that the successful construction of rose-like multifunctional nanocatalyst not only has great potentials for self-amplified chemodynamic immunotherapy,but also provides a paradigm for exploring necroptosis triggered host immunity for cancer treatment. | Wensheng Xie Jingsong Lu Zhenhu Guo Xiaoxiao Guo Yongjiu Chi Jieling Ye Junxin Zhang Wanling Xu Lingyun Zhao Yen Wei | 2022 | Nano Research2022，15，3： | 0 |
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