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| 1 | A super pan-genomic landscape of rice显示文摘Pan-genomes from large natural populations can capture genetic diversity and reveal genomic complexity.Using de novo longread assembly,we generated a graph-based super pan-genome of rice consisting of a 251-accession panel comprising both cultivated and wild species of Asian and African rice.Our pan-genome reveals extensive structural variations(SVs)and gene presence/absence variations.Additionally,our pan-genome enables the accurate identification of nucleotide-binding leucine-rich repeat genes and characterization of their inter-and intraspecific diversity.Moreover,we uncovered grain weight-associated SVs which specify traits by affecting the expression of their nearby genes.We characterized genetic variants associated with submergence tolerance,seed shattering and plant architecture and found independent selection for a common set of genes that drove adaptation and domestication in Asian and African rice.This super pan-genome facilitates pinpointing of lineage-specific haplotypes for trait-associated genes and provides insights into the evolutionary events that have shaped the genomic architecture of various rice species. | Lianguang Shang Xiaoxia Li Huiying He Qiaoling Yuan Yanni Song Zhaoran Wei Hai Lin Min Hu Fengli Zhao Chao Zhang Yuhua Li Hongsheng Gao Tianyi Wang Xiangpei Liu Hong Zhang Ya Zhang Shuaimin Cao Xiaoman Yu Bintao Zhang Yong Zhang Yiqing Tan Mao Qin Cheng Ai Yingxue Yang Bin Zhang Zhiqiang Hu Hongru Wang Yang Lv Yuexing Wang Jie Ma Quan Wang Hongwei Lu Zhe Wu Shanlin Liu Zongyi Sun Hongliang Zhang Longbiao Guo Zichao Li Yongfeng Zhou Jiayang Li Zuofeng Zhu Guosheng Xiong Jue Ruan Qian Qian | 2022 | Cell Research2022，32，10： | 3 |
| 2 | Identification of Risk Pathways and Functional Modules for Coronary Artery Disease Based on Genome-wide SNP Data显示文摘Coronary artery disease(CAD) is a complex human disease, involving multiple genes and their nonlinear interactions, which often act in a modular fashion. Genome-wide single nucleotide polymorphism(SNP) profiling provides an effective technique to unravel these underlying genetic interplays or their functional involvements for CAD. This study aimed to identify the susceptible pathways and modules for CAD based on SNP omics. First, the Wellcome Trust Case Control Consortium(WTCCC) SNP datasets of CAD and control samples were used to assess the jointeffect of multiple genetic variants at the pathway level, using logistic kernel machine regression model. Then, an expanded genetic network was constructed by integrating statistical gene–gene interactions involved in these susceptible pathways with their protein–protein interaction(PPI)knowledge. Finally, risk functional modules were identified by decomposition of the network. Of 276 KEGG pathways analyzed, 6 pathways were found to have a significant effect on CAD. Other than glycerolipid metabolism, glycosaminoglycan biosynthesis, and cardiac muscle contraction pathways, three pathways related to other diseases were also revealed, including Alzheimer's disease, non-alcoholic fatty liver disease, and Huntington's disease. A genetic epistatic network of 95 genes was further constructed using the abovementioned integrative approach. Of 10 functional modules derived from the network, 6 have been annotated to phospholipase C activity and cell adhesion molecule binding, which also have known functional involvement in Alzheimer's disease.These findings indicate an overlap of the underlying molecular mechanisms between CAD and Alzheimer's disease, thus providing new insights into the molecular basis for CAD and its molecular relationships with other diseases. | Xiang Zhao Yi-Zhao Luan Xiaoyu Zuo Ye-Da Chen Jiheng Qin Lv Jin Yiqing Tan Meihua Lin Naizun Zhang Yan Liang Shao-Qi Rao | 2016 | Genomics, Proteomics & Bioinformatics2016，14，6： | 3 |
| 3 | OsWR2 recruits HDA704 to regulate the deacetylation of H4K8ac in the promoter of OsABI5 in response to drought stress显示文摘Drought stress is a major environmental factor that limits the growth, development, and yield of rice(Oryza sativa L.). Histone deacetylases(HDACs) are involved in the regulation of drought stress responses. HDA704 is an RPD3/HDA1 class HDAC that mediates the deacetylation of H4K8(lysine 8of histone H4) for drought tolerance in rice. In this study, we show that plants overexpressing HDA704(HDA704-OE) are resistant to drought stress and sensitive to abscisic acid(ABA), whereas HDA704 knockout mutant(hda704) plants displayed decreased drought tolerance and ABA sensitivity.Transcriptome analysis revealed that HDA704 regulates the expression of ABA-related genes in response to drought stress. Moreover, HDA704 was recruited by a drought-resistant transcription factor,WAX SYNTHESIS REGULATORY 2(Os WR2), and co-regulated the expression of the ABA biosynthesis genes NINE-CIS-EPOXYCAROTENOID DIOXYGENASE 3(NCED3), NCED4, and NCED5 under drought stress. HDA704 also repressed the expression of ABA-INSENSITIVE 5(Os ABI5) and DWARF AND SMALL SEED 1(Os DSS1) by regulating H4K8ac levels in the promoter regions in response to polyethylene glycol 6000 treatment. In agreement, the loss of Os ABI5 function increased resistance to dehydration stress in rice. Our results demonstrate that HDA704 is a positive regulator of the drought stress response and offers avenues for improving drought resistance in rice. | Yalu Guo Yiqing Tan Minghao Qu Kai Hong Longjun Zeng Lei Wang Chuxiong Zhuang Qian Qian Jiang Hu Guosheng Xiong | 2023 | Journal of Integrative Plant Biology2023，65，7： | 1 |
| 4 | Inactivation of Bacillus subtilis Spores Using Various Combinations of Ultraviolet Treatment with Addition of Hydrogen Peroxide显示文摘 | Yiqing Zhang Lingling Zhou Yongji Zhang Chaoqun Tan | 2014 | Photochem Photobiol2014，，3： | 1 |
| 5 | Resistin and insulin resistance in hepatocytes: Resistin disturbs glycogen metabolism at the protein level显示文摘 | Yang Yang Meifang Xiao Yiqing Mao Hui Li Shuyong Zhao Yi Gu Rong Wang Jianqiang Yu Xuemei Zhang David M. Irwin Gang Niu Huanran Tan | 2008 | Biomedicine & Pharmacotherapy2008，，5： | 1 |
| 6 | High sulfur loading and shuttle inhibition of advanced sulfur cathode enabled by graphene network skin and N,P,F-doped mesoporous carbon interfaces for ultra-stable lithium sulfur battery显示文摘Achieving high loading of active sulfur yet rational regulating the shuttle effect of lithium polysulfide(LiPS)is of great significance in pursuit of high-performance lithium-sulfur(Li-S)battery.Herein,we develop a free-standing graphene nitrogen(N),phosphorus(P)and fluorine(F)co-doped mesoporous carbon-sulfur(G-NPFMC-S)film,which was used as a binder-free cathode in Li-S battery.The developed mesoporous carbon(MC)achieved a high specific surface area of 921 m^(2)·g^(-1)with a uniform pore size distribution of 15 nm.The inserted graphene network inside G-NPFMC-S cathode can effectively improve its electrical conductivity and simultaneously restrict the shuttle of LiPS.A high sulfur loading of 86%was achieved due to the excellent porous structures of graphene-NPFMC(G-NPFMC)composite.When implemented as a freestanding cathode in Li-S battery,this G-NPFMC-S achieved a high specific capacity(1,356 mAh·g^(-1)),favorable rate capability,and long-term cycling stability up to 500 cycles with a minimum capacity fading rate of 0.025%per cycle,outperforming the corresponding performances of NPFMC-sulfur(NPFMC-S)and MC-sulfur(MC-S).These promising results can be ascribed to the featured structures that formed inside G-NPFMC-S film,as that highly porous NPFMC can provide sufficient storage space for the loading of sulfur,while,the N,P,F-doped carbonic interface and the inserted graphene network help hinder the shuttle of LiPS via chemical adsorption and physical barrier effect.This proposed unique structure can provide a bright prospect in that high mass loading of active sulfur and restriction the shuttle of LiPS can be simultaneously achieved for Li-S battery. | Haotian Liu Fan Liu Zehua Qu Jieling Chen Hui Liu Yiqing Tan Jiabao Guo Yan Yan Shuang Zhao Xinsheng Zhao Xinming Nie Xin Ma Zengxia Pei Mingkai Liu | 2023 | Nano Research Energy2023，2，1： | 1 |
| 7 | Comparative study on consumption behaviors in private car markets between large and medium-small cities in China显示文摘With the economic development and the acceleration of motorization in China,the number of private cars increases rapidly in urban areas.However,the limit of urban resources and the contradiction between traffic supply and demand are increasingly prominent in large cities,while private car consumption has been a new 'light' in medium and small cities.Consumers' behaviors differ from region to region.Aiming at the above problems,we formulate structural equation modeling and carry out empirical research.In this paper,a comparative study about the main influential factors that affect the consumption of private cars in large and small cities in China is made,and it is hoped that some guidance for policy recommendations can be obtained. | Deqing Tan Yiqing Tang Ning Lu | 2016 | Chinese Journal of Population,Resources and Environment2016，16，2： | 0 |
| 8 | Comparison of Drying Rate and Energy Consumption between Vacuum and Ambient Pressure Drying for Chinese Fir显示文摘In this work, Chinese fir samples with a size of 400 mm (L) by 50 mm (W) 30 mm (H) weretaken as specimens, and drying rate and energy consumption were compared under the conditions, inwhich the absolute pressure was 0.02 , 0.04 , 0.06 and 0.10 MPa, respectively, and the temperature was80 oC. The results showed that, when the moisture content (MC) of the samples was above fibersaturation point (FSP), the vacuum drying rate was 0.96-1.24 times as high as the ambient pressuredrying rate. However, when it was below FSP, the vacuum drying rate was 1.26-1.32 times as high as theambient pressure drying rate. At the same time, when the MC was above FSP, the energy consumptionof vacuum drying was 81.1%-95.9% of that of ambient pressure drying; when the MC was below FSP,the energy consumption of vacuum drying was 62.40%-69.40% of that of ambient pressure drying.Therefore, the vacuum drying was superior to the ambient pressure drying in terms of drying rate andenergy consumption. | PENG Yiqing LI Fan TAN Hui YI Songlin | 2011 | Chinese Forestry Science and Technology2011，10，Z1： | 0 |
| 9 | Exploring the psychological impact of the 2022 SARS-CoV-2 Omicron variant outbreak in China显示文摘To the editor:The impact of the coronavirus disease 2019(COVID-19)pandemic in 2020 on mental health was substantialin Chinai2and various other countries.34 Beyond the direct consequences of COVID-19,the pandemic created an environment in which many determinants of mental health were affected.Issues associated with the pandemic,such as loss of livelihood,limited access to medical services,reduced social interactions,and economic downturn,could potentially have adverse effects on the population's mental well-being.5 In November 2021,the World Health Organization(WHO)designated the new variant of the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),variant B.1.1.529,as a variant of concern and named it Omicron;its rapid mutation and spread raised a new global health concern. | Gangbin Han Guirong Cheng Feifei Hu Chunli Li Dan Liu Juan Zhou Jing Liu Linya Huang Xiaochang Liu Qianqian Nie Dan Song Deyang Zeng Lang Xu Jinquan Li Yushan Chen Zhen Wei Qiong Wu Xiaoming He Qingming Wu Wei Tan Yufei Mei Xingxing Chen Yangming Ou Jingjing ZhangYafu Yu Mengliu Yang Pengfei Lian Fukai Zhou Renjia Fan Hong Wan Chenlu Hu Yidi Fu Shiyue Li Junyi Wang Cheng Cai Mengdie Pei Yuyang Cui Wanying Cai Yiqing Li Shiyao Pan Chang Chen Yan He Zhaoxia Wu Liu Hu Liang Tao Hongyan Xiao Xinyan Xie Yan Zeng | 2023 | General Psychiatry2023，36，6： | 0 |
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