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| 1 | Decreased fragile histidine triad expression in colorectal cancer and its association with apoptosis inhibition显示文摘AIM: To detect the expression of fragile histidine triad (FHIT) in normal colorectal tissue, colorectal adenoma and colorectal cancer (CRC) tissue, and to analyze its relationship with the clinicopathological features of CRC, and apoptosis-associated proteins (Bcl-2, Bax, survivin) and apoptosis in colorectal cancer. METHODS: FHIT mRNA analysis was performed by nested reverse transcription-polymerase chain reaction (RT-PCR) assay. Tissue microarray (TMA) was established to detect the expression of FHIT, Bcl-2, Bax and survivin genes in 80 CRC tissue specimens, 16 colorectal adenoma tissue specimens and 16 hemorrhoid (PPH) tissue specimens during the same period of time as the control. Citrate-microwave-SP was used as immunohistochemical method. The relationship between clinicopathological factors, such as differentiation grades and 5-year survival rate was observed. TUNEL assay was used to detect the apoptosis index in 80 CRC tissue specimens. RESULTS: Ten out of 26 (38.5%) CRC tissue specimens expressed aberrant FHIT transcripts, none of the aberrant FHIT transcripts was observed in the matchednormal tissue and colorectal adenoma tissue by nested RT-PCR assay. The positive rate of FHIT gene expression in normal colorectal tissue, colorectal adenoma and carcinoma tissue was 93.75%, 68.75% and 46.25%, respectively. Clinicopathological analysis of patients showed that the decreased FHIT gene expression was not associated with age, sex, serum CEA levels, tumor site and size, histological classification. However, the expression of FHIT was correlated with differentiation grades, pathological stages, lymph node metastases and 5-year survival rate after operation. The positive rate of apoptosis-associated proteins (Bax, Bcl-2 and survivin) in CRC tissue was 72.50%, 51.25% and 77.50%, respectively. The expression of these apoptosis- associated proteins in CRC tissue was correlated with the expression of FHIT. The mean apoptosis index in FHIT negative tumors was significantly lower than that in FHIT positive tumors (5.41 ± 0.23 vs 0.56 ± 0.10, P < 0.01). CONCLUSION: The FHIT gene plays an important role in the regulation of apoptosis and decreased FHIT expression plays a key role in the initiation and progression of colorectal carcinoma. | Jie Cao Xiao-Ping Chen Wang-Lin Li JieXia Hong Du Wei-Biao Tang Hui Wang Xi-Wen then Huan-Qing Xiao Yu-Yuan Li | 2007 | World Journal of Gastroenterology2007，13，7： | 12 |
| 2 | Equilibrator-based measurements of dissolved methane in the surface ocean using an integrated cavity output laser absorption spectrometer显示文摘A new off-axis integrated cavity output spectroscopy(ICOS) is coupled to Weiss equilibrator for continuous highresolution dissolved methane measurement in the surface ocean. The time constant for the equilibrator in freshwater at room temperature is determined via dis-equilibration and re-equilibration experiments. The constant for methane is about 40 min. The system is calibrated using a standard gas of 3.980×10–6, and the precision of the ICOS for methane is 0.07%. This system is equipped onboard to measure the spatial distribution in methane concentrations of South Yellow Sea(SYS) along the cruise track from Shanghai to Qingdao. Result shows that the methane concentration varies from 2.79 to 36.36 nmol/L, reveals a significant pattern of methane source in SYS, and a distinct decreasing trend from south to north. The peak value occurs at the coast area outside mouth of the Changjiang River, likely to be affected by the Changjiang diluted water mass dissolving a large amount of rich in methane. Moreover, all the surface waters are oversaturated, air-to-sea fluxes range from 98.59 to 5 485.35 μmol/(m2·d)(average value(1 169.74±1 398.46) μmol/(m2·d)), indicating a source region for methane to the atmosphere. Key words: methane, equilibrator, off-axis integrated cavity output spectroscopy(ICOS), South Yellow | LI Yuhong ZHAN Liyang ZHANG Jiexia CHEN Liqi | 2015 | Acta Oceanologica Sinica2015，34，6： | 4 |
| 3 | Differences in nitrous oxide distribution patterns between the Bering Sea basin and Indian Sector of the Southern Ocean显示文摘Nitrous oxide(N2O) distribution patterns in the Bering Sea basin(BSB) and Indian Sector of the Southern Ocean(ISSO) were described and compared. In both sites, the waters were divided into four layers: surface layer, subsurface layer, N2O maximum layer, and deep water. Simulations were made to find out the most important factors that regulate the N2O distribution patterns in different layers of both sites. The results showed that in the surface water, N2O was more understaturated in the ISSO than the BSB. This phenomenon in the surface water of ISSO may result from ice melt water intrusion and northeastward transport of the Antarctic surface water. Results of the rough estimation of air-sea fluxes during the expedition | CHEN Liqi ZHANG Jiexia ZHAN Liyang LI Yuhong SUN Heng | 2014 | Acta Oceanologica Sinica2014，33，6： | 2 |
| 4 | Multiple processes affecting surface seawater N_2O satura-tion anomalies in tropical oceans and Prydz Bay, Antarc-tica显示文摘We analyzed the N2O content of surface seawater sampled from Prydz Bay, Antarctica, on a cruise track between 30°S and 30°N during the twenty-second Chinese National Antarctic Research Expedition during austral summer, 2006. The surface water showed an average pN 2 O value of 311.9±7.6 nL·L -1 (14.1±0.4 nmol·L -1 ), which was slightly undersaturated. The air-sea N 2 O flux in the region was -0.3±0.8 μmol·m -2 ·d -1 ; however, N 2 O in the surface water was oversaturated in most stations along the cruise track. Saturation anomalies were greater than 10%, with a maximum of 54.7% being observed at the Equator, followed by 31% at 10°N in the Sulu Sea. The air-sea fluxes at these locations were 12.4 and 4 μmol·m -2 ·d -1 , respectively. Overall, the results indicated that surface water in Prydz Bay was near equilibrium with atmospheric N 2 O, and that ocean waters in lower latitudes acted as a N 2 O source. Physical processes such as stratification, ice-melt water dilution, and solar radiation dominate the factors leading to N 2 O saturation of surface water of Prydz Bay, while biological production and upwelling are primarily responsible for the N 2 O oversaturation of surface water observed in subtropical and tropical regions along the cruise track. | CHEN Liqi ZHAN Liyang XU Suqing ZHANG Jiexia ZHANG Yuanhui XU Guojie | 2012 | Advances in Polar Science2012，23，2： | 2 |
| 5 | Note: Low Genetic Variation of Penaeus chinensis as Revealed by Mitochondrial COI and 16S rRNA Gene Sequences显示文摘 | Jiexia Quan Xue-mei Lü Zhimeng Zhuang Jixun Dai Jingyao Deng Ya-ping Zhang | 2001 | Biochemical Genetics (-)2001，，7： | 1 |
| 6 | Rapid communication: three unique restriction fragment length polymorphisms of EeoRI, PvuⅡ, and ScaI digested mitochondrial DNA of Baetrian camels (Camelus baetrianus fetus) in China显示文摘 | Jianlin H Jiexia Q Zhenming M | 1999 | J Anim Sci1999，77，8： | 1 |
| 7 | Preparation and characterization of NaY type molecular sieve显示文摘 | Ouyang Jiexia Lang Wanzhong Guo Yajun | | 0，，： | 1 |
| 8 | Activation of Vascular Endothelial Growth Factor Receptor-3 in Macrophages Restrains TLR4-NF-κB Signaling and Protects against Endotoxin Shock显示文摘 | Yanbo Zhang Yao Lu Li Ma Xudong Cao Jun Xiao Jiexia Chen Shaozhuo Jiao Yunzhen Gao Chang Liu Zhaojun Duan Dangsheng Li Yulong He Bin Wei Hongyan Wang | 2014 | Immunity2014，，： | 1 |
| 9 | Anticancer effects of a plant lignan 7-hydroxymatairesinol on a prostate cancer model in vivo显示文摘 | BYLUND A SAAR/NEN N ZHANG Jiexia | 2005 | Experimental Biology and Medicine2005，230，3： | 1 |
| 10 | Nitrous oxide research progress in polar and sub-polar oceans显示文摘N2O gas depletes ozone and has a powerful greenhouse effect.Oceans are among the most important N2O sources and have been the subject of extensive studies.Polar oceans are important regions for deep water formation and global-scale thermohaline circulation.Therefore,these water bodies play an important role in the N2O budget,however,these regions were not well studied.This review of previously published studies and data on polar oceans,including both the Arctic Ocean and Southern Ocean,describes the distribution pattern of N2O and possible regulating mechanism of these distribution patterns and shows that the Arctic Ocean and Southern Ocean both represent source and sink regions,suggesting that the source/sink characteristics of the Arctic and Southern oceans and their strengths need further study.Questions related to N2O circulation in polar oceans were proposed,and future work is suggested. | ZHAN Liyang ZHANG Jiexia LI Yuhong&WU Man | 2020 | Advances in Polar Science2020，31，4： | 0 |
| 11 | Transcriptome profiling reveals the association of multiple genes and pathways contributing to hormonal control in celery leaves显示文摘Celery is a vital vegetable belonging to the Apiaceae family.The leaves of celery are its main edible part with high nutritional value.Hormone signaling plays diverse and critical roles in controlling plant growth and development.However,the molecular mechanism of hormone regulating growth and development in celery leaves has not been investigated.Here,we aimed to understand the molecular functions of genes related to hormone metabolism in celery leaf growth and development.A total of 77 hormone-related differentially expressed genes(DEGs)were identified from the transcriptome of celery leaves at three development stages.The roles and interactions of DEGs in the growth and development of celery leaves were discussed.The contents of multiple hormones(IAA,ZR,ABA,BR,GA3,and MeJA)in celery leaf development were also detected.The changes of endogenous hormone level during the development of celery leaves could be regulated by the expressions of hormone-related genes.Our results indicated that the plant hormones had a complex regulatory mechanism for the growth of celery leaves.Our current findings will provide potential valuable references for the future research on celery leaf development. | Jiexia Liu Kai Feng Xilin Hou Hui Li Guanglong Wang Zhisheng Xu Aisheng Xiong | 2019 | Acta Biochimica et Biophysica Sinica2019，51，5： | 0 |
| 12 | Concentration maxima of methane in the bottom waters over the Chukchi Sea shelf:implication of its biogenic source显示文摘Knowledge about the distribution of CH_(4)remains insufficient due to the scarcity of data in the Arctic shelves.We conducted shipboard observations over the Chukchi Sea shelf(CSS)in the western Arctic Ocean in September 2012 to obtain the distribution and source characteristics of dissolved CH_(4)in seawater.The oceanographic data indicated that a salinity gradient generated a pronounced pycnocline at depths of 20-30 m.The vertical diffusion of biogenic elements was restricted,and these elements were trapped in the bottom waters.Furthermore,high CH_(4)concentrations were measured below the pycnocline,and low CH_(4)concentrations were observed in the surface waters.The maximum concentrations of nutrients simultaneously occurred in the dense and cold bottom waters,and significant correlations were observed between CH_(4)and SiO_(3)^(2-),PO_(4)^(3-),NO_(2)^(-),and NH_(4)^(+)(p<0.01,n=44).These results suggest that the production of CH_(4)in the CSS has a similar trend as that of nutrient regeneration and is probably associated with the degradation of organic matter.The high primary productivity and high concentration of organic matter support the formation of biogenic CH_(4)in the CSS and the subsequent release of CH_(4)to the water column. | LI Yuhong ZHANG Jiexia YE Wangwang JIN Haiyan ZHUANG Yanpei ZHAN Liyang | 2022 | Advances in Polar Science2022，33，3： | 0 |
| 13 | Analysis of nutrient content and assessment of economic value for major salt-tolerant plants in coastal areas:a case study of Dongying City, Shandong Province显示文摘Salinization of soil is a worldwide problem concerning resources and ecology,especially serious in coastal areas.Testing of 26 sorts of data or parameters are carried out on leaves of 22 plant species(in 24 plant variety) of existing main salt-tolerant plant of the Yellow River Delta region.Data or parameters include the following ele-ments:contents of K+,Na+,Ca2+,Mg2+ and Cl-,contents of protein,fat,total energy,ash and contents of 17 amino acids.The results show that these tested plants have economic values.For example,according to their uses,they can be divided into edible plants,forage plants,medicine or health plants,and some of them can be used for multipurposes.These plants have played important roles in the sustainable utilization of plant resources in coastal areas.This paper has taken evaluations on the economic uses of salt-tolerant plants and given suggestions for saline soil improvement and resource utilization in coastal areas.Based on the results of investigation and experiments,we suppose that the salt-tolerant plants in coastal areas can be grouped into 9 main groups according to their economic value:pioneer plants for saline land improvement,medicine,edible and forage plants,industry material,forestation,breeding material,energy plants and eco-tourism resources. | Weng Senhong Li Weijiong Zhang Jiexia Xi Qingguo | 2008 | Ecological Economy2008，4，4： | 0 |
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