|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Diverse modes of clonal evolution in HBV-related hepatocellular carcinoma revealed by single-cell genome sequencing显示文摘Hepatocellular 癌(HCC ) 是癌症实质词法,基因并且 phenotypic 差异。然而,我们不理解在 intratumor 异质和肿瘤的联系词法 / 组织学的特征之间的关系。用介绍 96 个肿瘤房间(30-36 各个) 和 15 个正常的肝房间(5 各个) 的单个房间的整个染色体的定序,与联系 HBV 的 HCC 从三个男病人收集了,我们证实拷贝数字变化在 hepatocarcinogenesis 早发生,但是此后在整个肿瘤仍然保持相对稳定前进。重要地,我们证明特定的 HCC 能具有 monoclonal 或 polyclonal 起源。有汇合的 multinodular 形态学的肿瘤是典型 polyclonal 肿瘤并且显示最高的 intratumor 异质。除了 mutational 和拷贝数字侧面,我们把了用导出 HBV 的外国 genomic 标记的 HCC 的同种细胞的起源。在 monoclonal HCC,所有肿瘤单身者房间展出一样的 HBV 集成,显示 HBV 集成是一个早司机事件并且在肿瘤前进期间仍然保持极其稳定。另外,我们的结果显示那两个都转移,迟了的传播并且早播种当模特儿,在 HCC 有一个角色前进。尤其是,开始的克隆传播的早 intrahepatic 导致同步 multifocal 肿瘤的形成。同时,我们在 HCC 识别了潜在的司机基因 ZNF717,它展出变化的高频率在单个房间并且人口铺平,,通过调整 IL-6/STAT3 小径行动的肿瘤 suppressor。这些调查结果热点多重不同肿瘤在 HCC 的进化机制,它为特定的处理策略建议需要。 | Meng Duan, Shu Zhang, Zhichao Wang, Jieyi Shi, Longzi Liu, Xiaoying Wang, Aiwu Ke, Jian Zhou, Jia Fan, Qiang Gao Junfeng Hao, Chong Li Sijia Cui Daniel L Worthley Ya Cao Ruibin Xi Xiaoming Zhang Jian Zhou, Jia Fan Qiang Gao | 2018 | Cell Research2018，28，3： | 21 |
| 2 | A pan-cancer blueprint of the heterogeneous tumor microenvironment revealed by single-cell profiling显示文摘The stromal compartment of the tumor microenvironment consists of a heterogeneous set of tissue-resident and tumor-infiltrating cells,which are profoundly moulded by cancer cells.An outstanding question is to what extent this heterogeneity is similar between cancers affecting different organs.Here,we profile 233,591 single cells from patients with lung,colorectal,ovary and breast cancer(n=36)and construct a pan-cancer blueprint of stromal cell heterogeneity using different single-cell RNA and protein-based technologies.We identify 68 stromal cell populations,of which 46 are shared between cancer types and 22 are unique.We also characterise each population phenotypically by highlighting its marker genes,transcription factors,metabolic activities and tissue-specific expression differences.Resident cell types are characterised by substantial tissue specificity,while tumor-infiltrating cell types are largely shared across cancer types.Finally,by applying the blueprint to melanoma tumors treated with checkpoint immunotherapy and identifying a naive CD4+T-cell phenotype predictive of response to checkpoint immunotherapy,we illustrate how it can serve as a guide to interpret scRNA-seq data.In conclusion,by providing a comprehensive blueprint through an interactive web server,we generate the first panoramic view on the shared complexity of stromal cells in different cancers. | Junbin Qian Siel Olbrecht Bram Boeckx Hanne Vos Damya Laoui Emre Etlioglu Els Wauters Valentina Pomella Sara Verbandt Pieter Busschaert Ayse Bassez Amelie Franken Marlies Vanden Bempt Jieyi Xiong Birgit Weynand Yannick van Herck Asier Antoranz Francesca Maria Bosisio Bernard Thienpont Giuseppe Floris Ignace Vergote Ann Smeets Sabine Tejpar Diether Lambrechts | 2020 | Cell Research2020，30，9： | 11 |
| 3 | Chitosan nanoparticles as non-viral gene delivery vehicles based on atomic force microscopy study显示文摘Chitosan (CS ) , biocompatible 和可被细菌破坏的材料,能与低毒性充当非病毒的交货车辆。在这研究, plasmid DNA (pDNA ) 和 siRNA 在 CS nanoparticles (NP ) 被包含准备 CSDNA,用建筑群的 CSsiRNA NP 聚处理。CSDNA 粒子尺寸在 pH 从 0 ~ 18 mV 在有表面费用的 180370 nm 的范围以内正在 5.5。在 CSDNA 的 pDNA 的稳定性被 pDNA 版本学习和 DNase 调查我保护试金。从 NP 的 pDNA 的版本在 pH 被学习 7.4 缓冲磷酸盐在 37 挠昭獯 ? 盐 ??瑅 吗?? | Yujing Yuan | 2009 | Acta Biochimica et Biophysica Sinica2009，41，6： | 7 |
| 4 | Differential efficiencies to neutralize the novel mutants B.1.1.7 and 501Y.V2 by collected sera from convalescent COVID-19 patients and RBD nanoparticle-vaccinated rhesus macaques显示文摘New strains of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)with several dominant mutations in the spike protein have been identified recently,and crucial issues associated with the possible reinfection of recovered patients and the efficiencies of vaccines designed based on epidemic strains in early 2020. | Rong Li Xiancai Ma Jieyi Deng Qier Chen Weiwei Liu Zhilin Peng Yidan Qiao Yingtong Lin Xin He Hui Zhang | 2021 | Cellular & Molecular Immunology2021，18，4： | 4 |
| 5 | Emergency response facility location in transportation networks: A literature review显示文摘Emergency response activity relies on transportation networks. Emergency facility location interacts with transportation networks clearly. This review is aimed to provide a combined framework for emergency facility location in transportation networks. The article reveals emergency response activities research clusters, issues, and objectives according to keywords co-occurrence analysis. Four classes of spatial separation models in transportation networks, including distance, routing, accessibility, and travel time are introduced. The stochastic and time-dependent characteristics of travel time are described. Travel time estimation and prediction method, travel time under emergency vehicle preemption,transportation network equilibrium method, and travel time in degradable networks are demonstrated. The emergency facilities location models interact with transportation networks, involving location-routing model, location models embedded with accessibility,location models embedded with travel time, and location models employing mathematical program with equilibrium constraints are reviewed. We then point out the-state-of-art challenges: ilities-oriented, evolution landscape and sequential decision modelling, datadriven optimization approach, and machine learning-based algorithms. | Yang Liu Yun Yuan Jieyi Shen Wei Gao | 2021 | Journal of Traffic and Transportation Engineering(English Edition)2021，8，2： | 4 |
| 6 | Relationship between Indian Ocean dipole and ENSO and their connection with the onset of South China Sea summer monsoon显示文摘用雷纳兹和史密斯 1950 ~ 1998 重建了与华南海夏季风(SCSSM ) 的发作讨论在 ENSO 和印度洋偶极子(IOD ) 和他们的可能的连接之间的关系的每月平均数的 SST,结果如下被获得:大多数 IOD 事件在夏天和秋天有一种密切积极的关系到同时的 ENSO 事件。在秋天(成熟阶段) 的 IOD 事件也是仔细与在冬季(成熟阶段) 的 ENSO 事件有关。当这些二种事件发生在阶段时,我。e。, positive (negative ) IODevents 被结合 El Nino (拉·尼娜) 事件,他们总是被跟随由迟了(或早) SCSSM 的发作。相反,当这些二种事件从阶段发生时,我。e。positive (negative ) IOD 事件被结合拉·尼娜(El Nino ) 事件,他们被 SCSSM 的正常发作跟随。另外,单个 IOD 事件或单个 ENSO 事件不能对应于很好 SCSSM 的反常发作。 | LIANG Zhaoning WEN Zhiping LIANG Jieyi WU Liji WU Naigeng | 2006 | Acta Oceanologica Sinica2006，25，6： | 3 |
| 7 | The influence of ^(18)F-fluorodeoxyglucose positron emission tomography/computed tomography on the N-and M-staging and subsequent clinical management of intrahepatic cholangiocarcinoma显示文摘Background:Intrahepatic cholangiocarcinoma(ICC)is a highly metastatic cancer.^(18)F-fluorodeoxyglucose positron emission tomography/computed tomography(^(18)F-FDG PET/CT)enables sensitive tumor and metastasis detection.Our aim is to evaluate the influence of pre-treatment PET/CT on the N-and M-staging and subsequent clinical management in ICC patients.Methods:Between August 2010 and August 2018,660 consecutive ICC patients,without prior anti-tumor treatments nor other malignancies,were enrolled.The diagnostic performance of PET/CT on the N-and M-staging was compared with conventional imaging,and the preoperative staging accuracy and treatment re-allocation by PET/CT were retrospectively calculated.Survival difference was compared between patients receiving PET/CT or not after propensity score matching.Results:Patients were divided into group A(n=291)and group B(n=369)according to whether PET/CT was performed.Among 291 patients with both PET/CT and conventional imaging for staging in group A,PET/CT showed significantly higher sensitivity(83.0%vs.70.5%,P=0.001),specificity(88.3%vs.74.9%,P<0.001)and accuracy(86.3%vs.73.2%,P<0.001)than conventional imaging in diagnosing regional lymph node metastasis,as well as higher sensitivity(87.8%vs.67.6%,P<0.001)and accuracy(93.5%vs.89.3%,P=0.023)in diagnosing distant metastasis.Overall,PET/CT improved the accuracy of preoperative staging from 60.1%to 71.8%(P<0.001),and modified clinical treatment strategy in 5.8%(17/291)of ICC patients,with unique roles in different tumor-node-metastasis(TNM)stages.High tumor-to-non-tumor ratio(TNR)predicted poor overall survival[hazard ratio(HR)=2.17;95%confidence interval(CI):1.49-3.15;P<0.001].Furthermore,patients performing PET/CT had longer overall survival compared with those without PET/CT(HR=0.74;95%CI:0.58-0.93;P=0.011)after propensity score matching.Conclusions:PET/CT was valuable for diagnosing regional lymph node metastasis and distant metastasis in ICC patients,and facilitated accurate tumor staging and optimal treatment allocation. | Youpei Lin Huanhuan Chong Guohe Song Chenhao Zhang Liangqing Dong Ling Aye Fei Liang Shuaixi Yang Mengsu Zeng Guangyu Ding Shu Zhang Jieyi Shi Aiwu Ke Xiaoying Wang Jian Zhou Jia Fan Qiang Gao | 2022 | Hepatobiliary Surgery and Nutrition2022，11，5： | 3 |
| 8 | Interface evolution in the platelet-like SiC@C and SiC@ SiO2 monocrystal nanocapsules显示文摘有六角形的像血小板的形态学的碳涂的 SiC@C nanocapsules (NC ) 被简单直接水流(DC ) 制作弧分泌物血浆方法。SiC@C NC 是 monocrystalline,在尺寸的 120-150 nm,和约 50 nm 厚。同样准备的 SiC@C NC 的形成包括了成核截断八面原文如此种子和进在充满碳的气氛的六角形的 nanoplatelets 的种子的随后的各向异性的生长。SiC@C NC 上的混乱的碳层被热处理在 650 楴湯挠浯潰湵獤猠潨敷 ? 牤浡瑡捩污祬映獡整 ? 牤杵爠汥慥敳椠 ? 潭敤慲整祬愠楣楤? 潳畬楴湯琠慨 ? 湩渠略牴污挠湯楤楴湯 ? 湡 ? 硥楨楢整 ? 湥慨据摥琠敨慲数瑵捩攠晦 ' 太 B 愠慧湩瑳琠湥洠摯汥挠湡散 ? 变换成 SiC@SiO 2 NC 的 SiO 2 壳散汬挠汵畴敲 ? 湩愠搠獯 ? 敤数摮湥 ? | Jian Gao Jieyi Yu Lei Zhou Javid Muhammad Xinglong Dong Yinong Wang Hongtao Yu Xie Quan Shaojie Li Youngguan Jung | 2017 | Nano Research2017，10，8： | 3 |
| 9 | Back-scattering from rough sea surface with foams显示文摘By using iterative method to solve the vector radiative transfer equation of discrete scatterers with randomly rough under-boundary, the back-scattering coefficient is derived, and is applied to the two-scale model of sea surface with foam scatterers driven by strong wind. By employing the modified probability density function of Cox and Munk’s, and Pierson’s sea spectrum, numerical results of polarized back-scatter ing are calculated. The functional dependence on wind speed and direction, observation angle, polarization and other parameters are discussed, and theoretical results are favorably matched with experimental data. | Jin Yaqiu, Huang Xingzhong and Yin Jieyi Department of Electronic Engineering, Fudan University, Shanghai 200433, China Department of Electronic Science, China East Normal University, Shanghai 200062, China | 1993 | Acta Oceanologica Sinica1993，12，4： | 3 |
| 10 | Hydraulic characteristics of stepped spillway dropshafts显示文摘Nowadays, 'Sponge Cities' are being built to provide a valid solution to the glaring drainage problems in the urban areas of China. The hydraulics of a dropshaft, especially discharge capacity, energy dissipation and cavitation damage control, evidently affect its safety and the city's underground tunnel system, due to the high dropshaft and large discharge. The hydraulic characteristics of stepped spillway dropshafts are experimentally investigated for the variable step rotation angles and end sill heights. Flow regimes inside the dropshafts are classified under the different approach flow discharges. The results illustrate that there is high energy dissipation in the present dropshafts with the stepped spillway and the cavitation damage could be effectively avoided thanks to the effect of the air entrainment to the flow. | SHEN JieYi WU JianHua MA Fei | 2019 | Science China(Technological Sciences)2019，62，5： | 3 |
| 11 | Enhancement and mapping of tolerance to salt stress and 5-fluorocytosine in synthetic yeast strains via SCRaMbLE显示文摘Varied environmental stress can affect cell growth and activity of the cellular catalyst.Traditional path of adaptive evolution generally takes a long time to achieve a tolerance phenotype,meanwhile,it is a challenge to dissect the underlying genetic mechanism.Here,using SCRaMbLE,a genome scale tool to generate random structural variations,a total of 222 evolved yeast strains with enhanced environmental tolerances were obtained in haploid or diploid yeasts containing six synthetic chromosomes.Whole genome sequencing of the evolved strains revealed that these strains generated different structural variants.Notably,by phenotypic-genotypic analysis of the SCRaMbLEd strains,we find that a deletion of gene YFR009W(GCN20)can improve salt tolerance of Saccharomyces cerevisiae,and a deletion of gene YER056C can improve 5-flucytosine tolerance of Saccharomyces cerevisiae.This study shows applications of SCRaMbLE to accelerate phenotypic evolution for varied environmental stress and to explore relationships between structural variations and evolved phenotypes. | Jianping Kang Jieyi Li Zhou Guo Sijie Zhou Shuxin Su Wenhai Xiao Yi Wu Yingjin Yuan | 2022 | Synthetic and Systems Biotechnology2022，7，3： | 2 |
| 12 | QoS routing based on genetic algorithm显示文摘 | Xiang F Junzhou L Jieyi W | 1999 | Computer Communications1999，22，1516： | 2 |
| 13 | QoS Routing Based on Genetic Algorithm显示文摘 | Xiang F Junzhou L Jieyi W | 1999 | Computer Communications1999，22，15： | 1 |
| 14 | QoS routing based on genetic algorithm显示文摘 | Junzhou L Jieyi W | 1999 | Computer Communications1999，22，： | 1 |
| 15 | QoS Routlng Based on Cenetic Algorithm显示文摘 | Xiang F Junzhou L Jieyi W | 1999 | Computer Communications1999，2，15： | 1 |
| 16 | QoS Routing based on genetic algorithm 显示文摘 | F Xiang L Junzhou W Jieyi G Guanqun | 1999 | Computer Communications1999，22，9： | 1 |
| 17 | Qos Routing Based on Genetic Algorithm显示文摘 | F Xiang L Junahou W Jieyi G Guangqun | 1999 | Computer Communication1999，22，9： | 1 |
| 18 | QoS routing based on genetic algorithm 显示文摘 | XIANG Fei LUO Junzhou WU Jieyi | 1999 | Computer Communications1999，22，1516： | 1 |
| 19 | QoS Routing Based on Genetic Algorithm显示文摘 | Xiang F Junzhou L Jieyi W | 1999 | Computer Communications1999，22，1516： | 1 |
| 20 | Experimental and theoretical study on N-hydroxyphthalimide and its derivatives catalyzed aerobic oxidation of cyclohexylbenzene显示文摘The liquid phase oxidation of cyclohexylbenzene(CHB)is a new green synthetic approach to cyclohexylbenzene-1-hydroperoxide(CHBHP),a key intermediate for preparing phenol and cyclohexanone.In this work,aryl-substituted(Cl and Br)derivatives of N-hydroxyphthalimide(NHPI)were synthesized and their catalytic performances for CHB oxidation were studied.In addition,geometric optimization and transition state search were performed using DFT calculations.Both experimental and theoretical studies have proven that chloro-substitution on NHPI can significantly improve its catalytic effects on the oxidation of CHB by oxygen.Compared with NHPI,CHB conversion and selectivity of CHBHP over Cl;NHPI were increased by 10.47%and 13.24%.The strategy of aryl-substituting NHPI with halogen atoms proposed in this study would provide a potential way to the development of new NHPI-based catalysts for aerobic oxidation reactions. | Yufei Yang Jieyi Ma Junyan Wu Weixia Zhu Yadong Zhang | 2022 | Chinese Journal of Chemical Engineering2022，35，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员