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| 1 | A new free-hand pedicle screw placement technique with reference to the supraspinal ligament显示文摘We sought to compare the safety and accuracy of a new free-hand pedicle screw placement technique to that of the conventional technique.One hundred fifty-three consecutive adult patients with simple fracture in the thoracic or/and lumbar spine were alternately assigned to either the new free-hand or the conventional group.In the new free-hand technique group,preoperative computerized tomography(CT) images were used to calculate the targeted medial-lateral angle of each pedicle trajectory and the pedicle screw was inserted perpendicular to the corresponding supraspinal ligament.In the conventional technique group,the medial-lateral and cranial-caudal angle of each pedicle trajectory was determined by intraoperatively under fluoroscopic guidance.The accuracy rate of pedicle screw placement,the time of intraoperative fluoroscopy,the operating time and the amount of blood loss during operation were respectively compared.All screws were analyzed by using intraoperative radiographs,intraoperative triggered electromyography(EMG) monitoring data,postoperative CT data and clinical outcomes.The accuracy rate of pedicle screw placement in the new free-hand technique group and the conventional technique group was 96.3% and 94.2%(P < 0.05),respectively.The intraoperative fluoroscopy time of the new technique group was less than that of the conventional technique group(5.37 seconds vs.8.79 seconds,P < 0.05).However,there was no statistical difference in the operating time and the amount of blood loss during operation(P > 0.05).Pedicle screw placement with the free-hand technique which keeps the screw perpendicular to the supraspinal ligament is an accurate,reliable and safe technique to treat simple fracture in the thoracic or lumbar spine. | Juming Li Hong Zhao Hao Xie Lipeng Yu Jifu Wei Min Zong Feng Chen Ziqiang Zhu Ning Zhang Xiaojian Cao | 2014 | The Journal of Biomedical Research2014，28，1： | 7 |
| 2 | Integrative genomic analyses on IL28RA, the common receptor of interferon-λ1,-λ2 and -λ3显示文摘 | Liming Yang Yuming Luo Jifu Wei Shaoheng He | 2010 | International Journal of Molecular Medicine2010，，5： | 1 |
| 3 | Regulatory T-Cell Generation and Kidney Allograft Tolerance Induced by Mesenchymal Stem Cells Associated With Indoleamine 2,3-Dioxygenase Expression显示文摘 | Wei Ge Jifu Jiang Jacqueline Arp Weihua Liu Bertha Garcia Hao Wang | 2010 | Transplantation2010，，12： | 1 |
| 4 | Ultrastretchable and wearable conductive multifilament enabled by buckled polypyrrole structure in parallel显示文摘Stretchable conductive fibers have attracted much attention due to their potential use in wearable electronics.However,the ultrahigh strain insensitive conductivity is hindered by mechanical mismatch in Young’s modulus and failure of stretchable structures under large deformation.This challenge is addressed with a conductive and elastic multifilament made of the polyurethane monofilaments that are surface-coated with buckled polypyrrole(PPy)of which flexibility is improved by sodium sulfosalicylate.Such parallel conductive monofilaments with PPy buckling on surface reduce the influence of cracks in the conductive coating on the overall conductivity,displaying an ultra-high strain insensitive behavior(quality factor Q=10.9).Remarkably,various complex forms of wearable electronic textiles made by this conductive multifilament maintain the strain-insensitive behavior of the original multifilament,even upon the large deformation of human joint.This multifilament with wrinkled PPy has attractive advantages in the application of super-stretched wearable electronic devices. | Yimeng Li Yaya Gao Lizhen Lan Qian Zhang Leqian Wei Mengqi Shan Lamei Guo Fujun Wang Jifu Mao Ze Zhang Lu Wang | 2022 | npj Flexible Electronics2022，6，1： | 1 |
| 5 | Plasma biomarkers and plaque strain predict long-term cardiovascular events in patients with acute coronary syndrome显示文摘To test whether circulating and intracoronary biomarkers and coronary plaque strain have additive values to Global Registry of Acute Coronary Events(GRACE) score for predicting long-term cardiovascular events in ACS patients. One hundred ACS patients were enrolled and the GRACE score and plasma levels and intracoronary gradients of a number of biomarkers were measured. Coronary plaque burden and morphology in non-critical stenotic plaques were determined by intravascular ultrasound(IVUS) technique, and the maximal shear strain(SSmax) and maximal area strain(ASmax) were determined by intravascular ultrasound elastography(IVUSE) technique. Patients were followed for cardiovascular events and the predictive values of clinical characteristics, plasma biomarkers and plaque parameters were compared with GRACE score, and the incremental values of these measurements to the GRACE score were assessed. GRACE score, plasma biomarkers and plaque strain were independent predictors of cardiovascular events. Combination of GRACE score, plasma biomarkers and plaque strains significantly improved the predictive value of the GRACE score alone with the receiver-operating characteristic area increased from0.457 to 0.667(P=0.014). The combination of circulating and intracoronary biomarkers, plaque strain and GRACE score provides a better predictive tool than GRACE score alone in patients with ACS. | Mingjun Xu Xiaobo Hu Lin Wang Wei Zhang Lindi Wu Jifu Li Yuguo Chen Pengfei Zhang Haijun Su Yaling Han Cheng Zhang Mei Zhang Yun Zhang | 2020 | Science China(Life Sciences)2020，63，2： | 1 |
| 6 | Conductive fibers for biomedical applications显示文摘Bioelectricity has been stated as a key factor in regulating cell activity and tissue function in electroactive tissues.Thus,various biomedical electronic constructs have been developed to interfere with cell behaviors to promote tissue regeneration,or to interface with cells or tissue/organ surfaces to acquire physiological status via electrical signals.Benefiting from the outstanding advantages of flexibility,structural diversity,customizable mechanical properties,and tunable distribution of conductive components,conductive fibers are able to avoid the damage-inducing mechanical mismatch between the construct and the biological environment,in return to ensure stable functioning of such constructs during physiological deformation.Herein,this review starts by presenting current fabrication technologies of conductive fibers including wet spinning,microfluidic spinning,electrospinning and 3D printing as well as surface modification on fibers and fiber assemblies.To provide an update on the biomedical applications of conductive fibers and fiber assemblies,we further elaborate conductive fibrous constructs utilized in tissue engineering and regeneration,implantable healthcare bioelectronics,and wearable healthcare bioelectronics.To conclude,current challenges and future perspectives of biomedical electronic constructs built by conductive fibers are discussed. | Leqian Wei Shasha Wang Mengqi Shan Yimeng Li Yongliang Wang Fujun Wang Lu Wang Jifu Mao | 2023 | Bioactive Materials2023，，4： | 1 |
| 7 | Scavenging of hydrogen peroxide and inhibition of ultraviolet light-induced oxidative dna damage by aqueousextracts from green and black teas显示文摘 | Wei Huachen Zhang Xueshu Jifu Zhao | 1999 | Free Radical Biology & Medicine1999，26，1112： | 1 |
| 8 | Ultrasensitive detection of IgE levels based on magnetic nanocapturer linked immunosensor assay for early diagnosis of cancer显示文摘Rapid and accurate detection of immunoglobulin E(Ig E) in serum and reduction of serum dosage are of great significance for clinical detection. Herein, we described a rapid magnetic separation of Ig E from patient serum based on Fe3 O4@Si O2-NTA@026 sdab as the capture probe and multiple horseradish peroxidase(HRP)-labeled antibodies linked gold nanoparticles(Au NPs) as chemiluminescence(CL) signal amplifier for ultrasensitive detection of total Ig E. Results showed that the limit of detection of our immunosensor system in serum samples was 0.03 k U/L, which is lowest in comparison with current methods, and far lower than that of Immuno CAP for Ig E detection(0.1 k U/L). Furthermore, our immunosensor possessed satisfied repeatability and accuracy, as well as good stability. In comparison with the Immuno CAP for the quantitative detection of Ig E, highly consistent results were achieved in 20 serum samples. Specially, this method was also successfully utilized for assessing the Ig E traces in breast cancer patients,which provides a new idea for the diagnosis of early cancer. Therefore, we believe that such versatile immunosensor will offer an alternative method for the on-site monitoring and determination of various Ig E-related diseases. | Yongxin Liu Mengda Cao Zhongxi Huang Changmin Yu Naidi Yang Qiong Wu Liang Shi Wenjie Duan Yi Zhu Jifu Wei Lin Li Wei Huang | 2022 | Chinese Chemical Letters2022，33，4： | 0 |
| 9 | Plant-derived nanovesicles: Further exploration of biomedical function and application potential显示文摘Extracellular vesicles(EVs)are phospholipid bilayer vesicles actively secreted by cells,that contain a variety of functional nucleic acids,proteins,and lipids,and are important mediums of intercellular communication.Based on their natural properties,EVs can not only retain the pharmacological effects of their source cells but also serve as natural delivery carriers.Among them,plant-derived nanovesicles(PNVs)are characterized as natural disease therapeutics with many advantages such as simplicity,safety,eco-friendliness,low cost,and low toxicity due to their abundant resources,large yield,and low risk of immunogenicity in vivo.This review systematically introduces the biogenesis,isolation methods,physical characterization,and components of PNVs,and describes their administration and cellular uptake as therapeutic agents.We highlight the therapeutic potential of PNVs as therapeutic agents and drug delivery carriers,including anti-inflammatory,anticancer,wound healing,regeneration,and antiaging properties as well as their potential use in the treatment of liver disease and COVID-19.Finally,the toxicity and immunogenicity,the current clinical application,and the possible challenges in the future development of PNVs were analyzed.We expect the functions of PNVs to be further explored to promote clinical translation,thereby facilitating the development of a new framework for the treatment of human diseases. | Aixue Li Dan Li Yongwei Gu Rongmei Liu Xiaomeng Tang Yunan Zhao Fu Qi Jifu Wei Jiyong Liu | 2023 | Acta Pharmaceutica Sinica B2023，13，8： | 0 |
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