|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | A human circulating immune cell landscape in aging and COVID-19显示文摘Age-associated changes in immune cells have been linked to an increased risk for infection.However,a global and detailed characterization of the changes that human circulating immune cells undergo with age is lacking.Here,we combined scRNA-seq,mass cytometry and sCATAC-seq to compare immune cell types in peripheral blood collected from young and old subjects and patients with COVID-19.We found that the immune cell landscape was reprogrammed with age and was characterized by T cell polarization from naive and memory cells to effector,cytotoxic,exhausted and reg-ulatory cells,along with increased late natural killer cells,age-associated B cells,inflammatory monocytes and age-associated dendritic cells.In addition,the expression of genes,which were implicated in coron-avirus susceptibility,was upregulated in a cell subtype-specific manner with age.Notably,COVID-19 promoted age-induced immune cell polarization and gene expression related to inflammation and cellular senes-cence.Therefore,these findings suggest that a dysreg-ulated immune system and increased gene expression associated with SARS-CoV-2 susceptibility may at least partially account for COVID-19 vulnerability in the elderly. | Yingfeng Zheng Xiuxing Liu Wenqing Le Lihui Xie He Li Wen Wen Si Wang Shuai Ma Zhaohao Huang Jinguo Ye Wen Shi Yanxia Ye Zunpeng Liu Moshi Song Weiqi Zhang Jing-Dong J.Han Juan Carlos lzpisua Belmonte Chuanle Xiao Jing Qu Hongyang Wang Guang-Hui Liu Wenru Su | 2020 | Protein & Cell2020，11，10： | 10 |
| 2 | Vitamin C alleviates aging defects in a stem cell model for Werner syndrome显示文摘沃纳症候群(WS ) 是主要影响从中层导出的纸巾的早衰混乱。我们最近用 WRN 缺乏的人的间充质的干细胞(MSC ) 开发了一个新奇人的 WS 模型。这个模型概括 WS 的许多 phenotypic 特征。基于很多化学药品的一幅屏幕,这里,我们发现维生素 C 在出现在WRN缺乏的 MSC 的早衰为许多特征施加很有效的营救包括细胞生长拘捕,增加了反应的氧种层次, telomere 摩擦,煽动性的因素的过多的分泌物,象原子薄板和 heterochromatin 的组织的破坏一样。而且,维生素 C 在一个老鼠模型在 vivo 恢复 MSC 的生存能力。定序分析的 RNA 显示维生素 C 改变涉及染色质冷凝作用,房间周期规定, DNA 复制,和 DNA 损坏的一系列基因的表示在 WRN 缺乏的 MSC 的修理小径。我们的结果为 WS MSC 作为一个恢复因素识别维生素 C,它保持作为 WS 的处理的一种新奇类型被使用的潜力。 | Ying Li Weizhou Zhang Liang Chang Yan Han Liang Sun Xiaojun Gong Hong Tang Zunpeng Liu Huichao Deng Yanxia Ye Yu Wang Jian Li Jie Qiao Jing Qu Weiqi Zhang Guang-Hui Liu | 2016 | Protein & Cell2016，7，7： | 10 |
| 3 | Developing superior alleles of yield genes in rice by artificial mutagenesis using the CRISPR/Cas9 system显示文摘Rice yield is an important and complex agronomic trait controlled by multiple genes.In recent decades,dozens of yield-associated genes in rice have been cloned,many of which can increase production in the form of loss or degeneration of function.However,mutations occurring randomly under natural conditions have provided very limited genetic resources for yield increases.In this study,potentially yield-increasing alleles of two genes closely associated with yield were edited artificially.The recently developed CRISPR/Cas9system was used to edit two yield genes:Grain number 1a(Gn1a)and DENSE AND ERECT PANICLE1(DEP1).Several mutants were identified by a target sequence analysis.Phenotypic analysis confirmed one mutant allele of Gn1a and three of DEP1 conferring yield superior to that conferred by other natural high-yield alleles.Our results demonstrate that favorable alleles of the Gnla and DEP1 genes,which are considered key factors in rice yield increases,could be developed by artificial mutagenesis using genome editing technology. | Liyu Huang Ru Zhang Guangfu Huang Yanxia Li Getachew Melaku Shilai Zhang Haitao Chen Yanjuan Zhao Jing Zhang Yesheng Zhang Fengyi Hu | 2018 | The Crop Journal2018，6，5： | 8 |
| 4 | Effects of AlN on the densification and mechanical properties of pressureless-sintered SiC ceramics显示文摘In the present work, Si C ceramics was fabricated with Al N using B_4 C and C as sintering aids by a solid-state pressureless-sintered method. The effects of Al N contents on the densification, mechanical properties, phase compositions, and microstructure evolutions of as-obtained Si C ceramics were thoroughly investigated. Al N was found to promote further densification of the Si C ceramics due to its evaporation over 1800 °C,transportation, and solidification in the pores resulted from Si C grain coarsening. The highest relative density of 99.65% was achieved for Si C sample with 15.0 wt% Al N by the pressureless-sintered method at 2130 °C for 1 h in Ar atmosphere. Furthermore, the fracture mechanism for Si C ceramics containing Al N tended to transfer from single transgranular fracture mode to both transgranular fracture and intergranular fracture modes when the sample with 30.0 wt% Al N sintered at 1900 °C for 1 h in Ar. Also, Si C ceramics with 30.0 wt% Al N exhibited the highest fracture toughness of 5.23 MPa m^(1/2) when sintered at 1900 °C. | Qisong Li Yujun Zhang Hongyu Gong Haibin Sun Yanxia Zhai Weiya Zhu Jie Jing | 2016 | Progress in Natural Science:Materials International2016，26，1： | 2 |
| 5 | Genetic algorithm for weld im- age edge detection显示文摘 | ZHANG Jing JIN Yanxia | 2010 | IEEE2010，，： | 1 |
| 6 | Anti-hyperalgesic effect of Ca MKII inhibitor is associated with downregulation of phosphorylated CREB in rat spinal cord显示文摘 | Yanxia W Xinzhi C Jing X | 2011 | J Anesth2011，25，1： | 1 |
| 7 | Dynamic Characteristics and Influencing Factors of Groundwater Level in Qianyang County显示文摘The dynamic characteristics and influencing factors of groundwater level in Qianyang County were analyzed.The results showed that in the south bank of the Qianhe River,the change of groundwater level was mainly affected by precipitation,and the response of the groundwater level to the change of precipitation was one year later.The groundwater level presented a downward trend on the whole.In the north bank of the Qianhe River,the supply source of the groundwater level included precipitation and hydrology,and the groundwater level showed a rising trend on the whole.In the plain area,there was a sudden change in the groundwater level under the control of human activities.In a word,the main factors influencing the groundwater level in various geological conditions were different,so there were great differences between various regions in the dynamic characteristics of the groundwater level in Qianyang County. | Zhao Dan Zhou Qi Jing Yanxia | 2016 | Meteorological and Environmental Research2016，7，4： | 1 |
| 8 | Genetic algorithm for weld im- age edge detection 显示文摘 | ZHANG Jing JIN Yanxia | 2010 | IEEE2010，，： | 1 |
| 9 | Effects of crystal structure on the activity of MnO2 nanorods oxidase mimics显示文摘The crystal structures would directly affect the physical and chemical properties of the surface of the material,and would thus influence the catalytic activity of the material.α-MnO2,β-MnO2 andγ-MnO2 nanorods with the same morphology yet different crystal structures were prepared and tested as oxidase mimics using 3,3’,5,5’-tetramethylbenzidine(TMB)as the substrate.β-MnO2 that exhibited the highest activity had a catalytic constant of 83.75μmol·m^−2·s^−1,2.7 and 19.0 times of those ofα-MnO2 andγ-MnO2(30.91 and 4.41μmol·m^−2·s^−1),respectively.The characterization results showed that there were more surface hydroxyls as well as more Mn4+on the surface of theβ-MnO2 nanorods.The surface hydroxyls were conducive to the oxidation reaction,while Mn4+was conducive to the regeneration of surface hydroxyls.The synergistic effect of the two factors significantly improved the activity ofβ-MnO2 oxidase mimic.Usingβ-MnO2,aβ-MnO2-TMB-GSH system was established to detect the content of glutathione(GSH)rapidly and sensitively by colorimetry.This method had a wide detection range(0.11-45μM)and a low detection limit(0.1μM),and had been successfully applied to GSH quantification in human serum samples. | Yanxia Meng Kunfeng Zhao Zhaokun Zhang Peng Gao Jing Yuan Ting Cai Qin Tong Gang Huang Dannong He | 2020 | Nano Research2020，13，3： | 1 |
| 10 | Role of tool- part interaction in consolidation of L- shaped laminates during autoclave process 显示文摘 | Sun Jing Gu Yizhuo Li Yanxia Li Min Zhang Zuoguang | 2012 | Applied Composite Materials2012，19，34： | 1 |
| 11 | Ecological Compensation for Natural Resource Utilization in China 显示文摘 | I-Shin Chang Jing Wu Yanxia Yang Mingmin Shi Xiaochun Li | 2014 | Journal of Environmental Planning and Management2014，57，2： | 1 |
| 12 | Single-nucleus transcriptomics reveals a gatekeeper role for FoxP1 in primate cardiac aging显示文摘Aging poses a major risk factor for cardiovascular diseases,the leading cause of death in the aged population.However,the cell type-specific changes underlying cardiac aging are far from being clear.Here,we performed single-nucleus RNA-sequencing analysis of left ventricles from young and aged cynomolgus monkeys to define cell composition changes and transcriptomic alterations across different cell types associated with age.We found that aged cardiomyocytes underwent a dramatic loss in cell numbers and profound fluctuations in transcriptional profles.Via transcription regulatory network analysis,we identified FOxP1,a core transcription factor in organ development,as a key downregulated factor in aged cardiomyocytes,concomitant with the dysregulation of FoxP1 target genes associated with heart function and cardiac diseases.Consistently,the deficiency of FOxP1 led to hypertrophic and senescent phenotypes in human embryonic stem cell-derived cardiomyocytes.Altogether,our findings depict the celiular and molecular landscape of ventricular aging at the single-cell resolution,and identify drivers for primate cardiac aging and potential targets for intervention against cardiac aging and associated diseases. | Yiyuan Zhang Yandong Zheng Si Wang Yanling Fan Yanxia Ye Yaobin Jing Zunpeng Liu Shanshan Yang Muzhao Xiong Kuan Yang Jinghao Hu Shanshan Che Qun Chu Moshi Song Guang-Hui Liu Weiqi Zhang Shuai Ma Jing Qu | 2023 | Protein & Cell2023，14，4： | 0 |
| 13 | Cultivation and Management Technologies for New Banana Cultivar ‘Refen 1’(Musa Spp. ABB,Pisang Awak Subgroup)显示文摘Banana is one of the most important crops in tropical and subtropical regions of China. Fenjiao( Musa Spp. ABB,Pisang Awak subgroup) has been grown by small scale famers because of its stable market price and better sugar-acid blend. However,the traditional Fenjiao variety is susceptible to banana Fusarium wilt,has a high plant height( over 5. 0 m),and farmers lack large-scale planting techniques.Based on the traditional Fenjiao variety,we selected‘Refen 1’variety through mutagenesis technology,which has low temperature resistance,suitable to marginal soils and relatively low plant height( 3. 2-4. 0 m). This paper mainly introduces the major techniques of propagation,cultivation,and post-harvest stages of‘Refen 1’banana,including the selection of explant materials,treatment,disinfection,initial culture,nursery hardening of in vitro-produced banana plants,and transplant of tissue culture seedlings. The major points of the cultivation technology include banana plantation selection and preparation,planting methods,irrigation and fertilizer management,pruning and retaining,and prevention and control of plant diseases and insect pests. | Fenling TANG Yanxia LI Fei LIN Yujia LI Jiashui WANG Anbang WANG Yi XU Dongmei HUANG Shun SONG Qing WEI Xiaoping ZANG Tao JING Jingyang LI | 2019 | Asian Agricultural Research2019，11，5： | 0 |
| 14 | Effects of Salt Stress on Stipa breviflora Seedlings and Antioxidant Isozymes显示文摘Stipa breviflora seeds,collected from Inner Mongolia,were sowed on MS medium containing 0,50,100,150,200 mmol/L NaC l,to investigate the effects of salt stress on the physiological phenotype and antioxidant enzyme activity of S.breviflora seedlings.The results showed the germination rate,root length and fresh weight of seedlings were all influenced by salinity.Germination rate,root length and fresh weight of seedlings were significantly inhibited by 100,150 and50 mmol/L NaC l,and were 62%,1.30 cm,0.299 g,respectively.With NaC l content increasing,the trend of superoxide dismutase( SOD) and peroxidase( POD) activity was rising at first and then falling,and the activity of SOD and POD reached the maximum at 150 and 100 mmol/L,48.6 and 6 766 U/g,respectively.The activity of catalase( CAT) continued to increase and reached the maximum at 150 mmol/L,299 U/g.The isozyme zymogram showed that SOD 2-4,POD 1-2,and CAT 1-2 were positively correlated with salinity tolerance of S.breviflora seedlings. | Jing WANG Hongzhou ZI Huangwei LI Yanxia NING Ling LUO | 2018 | Agricultural Biotechnology2018，7，6： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员