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57篇 您的检索式:作者名="Jingjing Meng"
    题名 作者 年代 出处 被引量
1The Antagonistic Action of Abscisic Acid and Cytokinin Signaling Mediates Drought Stress Response in Arabidopsis显示文摘Xiaozhen Huang Lingyan Hou Jingjing Meng Huiwen You Zhen Li Zhizhong Gong Shuhua Yang Yiting Shi 2018Molecular Plant2018,11,7:15
2Associations between individual and environmental factors and habitual physical activity among older Chinese adults:A social–ecological perspective显示文摘Purpose: To examine, within a social–ecological framework, associations between multifaceted individual and environmental factors and habitual physical activity(HPA) among older Chinese adults.Methods: Through a mix of qualitative and quantitative methods, a survey instrument assessing various factors underlying 3 social–ecological dimensions of intrapersonal, interpersonal, and community and environmental resources was developed. Using a cross-sectional design, older adults(n = 1580, aged 67 ± 7 years) recruited from 10 communities in Shandong province completed the social–ecological survey of HPA. Data were analyzed using Partial Least Squares Path Modeling.Results: Factors related to intrapersonal(medical knowledge, motivation, physical function, sport skills, socioeconomic status, and education),interpersonal(social support, social activity, and social norms), and community and physical environmental resources(safety, capacity, availability of and access to physical activity facilities) were found to be significantly associated with older adults' participation in HPA.Conclusion: The findings provide an initial validation of a social–ecological approach to the study of HPA in China, suggesting that strategies aimed at promoting physical activity in older adults should address multiple levels of factors that may contribute to the likelihood of older Chinese adults being physically active.Xiangren Yi Zachary Pope Zan Gao Shumei Wang Fang Pan Jingpeng Yan Meng Liu Peipei Wu Jingjing Xu Rui Wang 2016Journal of Sport and Health Science2016,5,3:11
3Techniques for detecting protein-protein interactions in living cells:principles, limitations, and recent progress显示文摘Detecting protein-protein interactions(PPIs) provides fundamental information for understanding biochemical processes such as the transduction of signals from one cellular location to another; however, traditional biochemical techniques cannot provide sufficient spatio-temporal information to elucidate these molecular interactions in living cells. Over the past decade, several new techniques have enabled the identification and characterization of PPIs. In this review, we summarize three main techniques for detecting PPIs in vivo, focusing on their basic principles and applications in biological studies. We place a special emphasis on their advantages and limitations, and, in particular, we introduced some uncommon new techniques, such as single-molecule FRET(smFRET), FRET-fluorescence lifetime imaging microscopy(FRET-FLIM), cytoskeleton-based assay for protein-protein interaction(CAPPI) and single-molecule protein proximity index(smPPI), highlighting recent improvements to the established techniques. We hope that this review will provide a valuable reference to enable researchers to select the most appropriate technique for detecting PPIs.Yaning Cui Xi Zhang Meng Yu Yingfang Zhu Jingjing Xing Jinxing Lin 2019Science China(Life Sciences)2019,62,5:9
4Single-Particle Tracking for the Quantification of Membrane Protein Dynamics in Living Plant Cells显示文摘The plasma membrane is a sophisticated,organized,and highly heterogeneous structure that compartmentalizes cellular processes.To decipher the biological processes involving membrane proteins,it is necessary to analyze their spatiotemporal dynamics.However,it is difficult to directly assess the dynamics and interactions of biomolecules in living cells using traditional biochemical methods.Singleparticle tracking (SPT)methods for imaging and tracking single particles conjugated with fluorescent probes offer an ideal approach to acquire valuable and complementary information about dynamic intracellular processes.SPT can be used to quantitatively monitor the diverse motions of individual particles in living cells.SPT also provides super-spatiotemporal resolution that allows early-stage or rapid response information to be obtained for a better understanding of molecular basis of associated signal transduction processes.More importantly,SPT can be used to detect the motion paths of individual biomolecules in vivo and in situ,thus unveiling the dynamic behavior of the biomolecules that support developmental processes in living cells.In this review,we give an overview of SPT methods,from image acquisition to the detection of single particles,as well as tracking and data analysis.We also discuss recent applications of SPT methods in the field ofplant biology to reveal the complex biological functions of membrane proteins.Yaning Cui Meng Yu Xiaomin Yao Jingjing Xing Jinxing Lin Xiaojuan Li 2018Molecular Plant2018,11,11:5
5Non-coding RNAs and Their Roles in Stress Response in Plants显示文摘Eukaryotic genomes encode thousands of non-coding RNAs(ncRNAs), which play crucial roles in transcriptional and post-transcriptional regulation of gene expression. Accumulating evidence indicates that ncRNAs, especially micro RNAs(miRNAs) and long ncRNAs(lncRNAs),have emerged as key regulatory molecules in plant stress responses. In this review, we have summarized the current progress on the understanding of plant miRNA and lncRNA identification,characteristics, bioinformatics tools, and resources, and provided examples of mechanisms of miRNA-and lncRNA-mediated plant stress tolerance.jingjing wang xianwen meng oxana b.dobrovolskaya yuriy l.orlov ming chen 2017Genomics, Proteomics & Bioinformatics2017,15,5:5
6miR395-regulated sulfate metabolism exploits pathogen sensitivity to sulfate to boost immunity in rice显示文摘MicroRNAs (miRNAs) play important roles in plant physiological activities. However, their roles and molecular mechanisms in boosting plant immunity, especially through the modulation of macronutrient metabolism in response to pathogens, are largely unknown. Here, we report that an evolutionarily conserved miRNA, miR395, promotes resistance to Xanthomonas oryzae pv. oryzae (Xoo) and X. oryzae pv. oryzicola (Xoc), two destructive bacterial pathogens, by regulating sulfate accumulation and distribution in rice. Specifically, miR395 targets and suppresses the expression of the ATP sulfurylase gene OsAPS1, which functions in sulfate assimilation, and two sulfate transporter genes, OsSULTR2;1 and OsSULTR2;2, which function in sulfate translocation, to promote sulfate accumulation, resulting in broad-spectrum resistance to bacterial pathogens in miR395-overexpressing plants. Genetic analysis revealed that miR395-triggered resistance is involved in both pathogen-associated molecular pattern-triggered immunity and R gene-mediated resistance. Moreover, we found that accumulated sulfate but not S-metabolites inhibits proliferation of pathogenic bacteria, revealing a sulfate-mediated antibacterial defense mechanism that differs from sulfur-induced resistance. Furthermore, compared with other bacteria, Xoo and Xoc, which lack the sulfate transporter CysZ, are sensitive to high levels of extracellular sulfate. Accordingly, miR395-regulated sulfate accumulation impaired the virulence of Xoo and Xoc by decreasing extracellular polysaccharide production and biofilm formation. Taken together, these results suggest that rice miR395 modulates sulfate metabolism to exploit pathogen sensitivity to sulfate and thereby promotes broad-spectrum resistance.Zeyu Yang Shugang Hui Yan Lv Miaojing Zhang Dan Chen Jingjing Tian Haitao Zhang Hongbo Liu Jianbo Cao Wenya Xie Changyin Wu Shiping Wang Meng Yuan 2022Molecular Plant2022,15,4:3
7Plant multiscale networks:charting plant connectivity by multi-level analysis and imaging techniques显示文摘In multicellular and even single-celled organisms,individual components are interconnected at multiscale levels to produce enormously complex biological networks that help these systems maintain homeostasis for development and environmental adaptation.Systems biology studies initially adopted network analysis to explore how relationships between individual components give rise to complex biological processes.Network analysis has been applied to dissect the complex connectivity of mammalian brains across different scales in time and space in The Human Brain Project.In plant science,network analysis has similarly been applied to study the connectivity of plant components at the molecular,subcellular,cellular,organic,and organism levels.Analysis of these multiscale networks contributes to our understanding of how genotype determines phenotype.In this review,we summarized the theoretical framework of plant multiscale networks and introduced studies investigating plant networks by various experimental and computational modalities.We next discussed the currently available analytic methodologies and multi-level imaging techniques used to map multiscale networks in plants.Finally,we highlighted some of the technical challenges and key questions remaining to be addressed in this emerging field.Xi Zhang Yi Man Xiaohong Zhuang Jinbo Shen Yi Zhang Yaning Cui Meng Yu Jingjing Xing Guangchao Wang Na Lian Zijian Hu Lingyu Ma Weiwei Shen Shunyao Yang Huimin Xu Jiahui Bian Yanping Jing Xiaojuan Li Ruili Li Tonglin Mao Yuling Jiao Sodmergen Haiyun Ren Jinxing Lin 2021Science China(Life Sciences)2021,64,9:3
8紊乱的肺部菌群通过分泌外膜囊泡调控白介素-17B的产生促进肺纤维化显示文摘文章简介粘膜微生态一直是当前免疫学领域的研究热点,它已经被证明广泛参与多种粘膜组织免疫稳态的维持以及相关疾病的发生。该团队多年来围绕粘膜微生态与白介素-17家族细胞因子做了一系列研究工作,一方面肠癌发生过程中紊乱的微生态菌群可以通过调控IL-17C的产生促进肠癌的发生,另一方面肠道中微生态菌群也可以通过调控IL-17A的分泌促进肠道损伤修复。尽管如此,目前我们对肺组织中微生态的功能尚知之甚少。杨大平 Xi Chen Jingjing Wang Qi Lou Yunwei Lou Li Li Honglin Wang Jiangye Chen Meng Wu Xinyang Song 钱友存 2020科学新闻2020,,2:3
9Ecology of industrial pollution in China显示文摘Industrial development has brought China both opportunities and challenges since the reform and opening up in 1978.Spatial and temporal analysis showed that rapid industrialization has made eastern China under a more serious pollution stress.The most serious effects of industrial pollution were reflected in aquatic and soil ecosystem degradation,and damage can be observed from species,population,and community to ecosystem level.Public consciousness about contaminated sites rose from 2004 leading to greater efforts in ecological remediation,monitoring,and risk governance.Considerable efforts are still needed in expanding the extent and breadth of monitoring to explore where the greatest ecological risks lie and how to control them.Ecology of industrial pollution has become a popular discipline in China and will be further developed to help achieve the Sustainable Development Goals.Future research for a better ecological risk management should be focused on multi-media transfer and effects of mixed pollutants,mechanisms for clean energy and material flow,and integration of ecological risk with human health risk.Jingjing Yuan Yonglong Lu Chenchen Wang Xianghui Cao Chunci Chen Haotian Cui Meng Zhang Cong Wang Xiaoqian Li Andrew C.Johnson Andrew J.Sweetman Di Du 2020Ecosystem Health and Sustainability2020,6,1:2
10C.elegans-based screen identifies lysosome-damaging alkaloids that induce STAT3-dependent lysosomal cell death显示文摘Lysosomes are degradation and signaling centers within the cell,and their dysfunction impairs a wide variety of cellular processes.To understand the cellular effect of lysosome damage,we screened natural smallmolecule compounds that induce iysosomal abnormality using Caenorhabditis elegans (C.elegans)as a model system.A group of vobasinyl-ibogan type bisindole alkaloids (ervachinines A-D)were identified that caused lysosome enlargement in C.elegans macrophage-like cells.Intriguingly,these compounds triggered cell death in the germ line independently of the canonical apoptosis pathway.In mammalian cells, ervachinines A-D induced lysosomal enlargement and damage,leading to leakage of cathepsin proteases, inhibition of autophagosome degradation and necrotic cell death.Further analysis revealed that this ervachinine-induced lysosome damage and lysosomal cell death depended on STAT3 signaling,but not RIP1 or RIP3 signaling.These findings suggest that lysosomedamaging compounds are promising reagents for dissecting signaling mechanisms underlying lysosome homeostasis and lysosome-related human disorders.Yang Li Yu Zhang Qiwen Gan Meng Xu Xiao Ding Guihua Tang Jingjing Liang Kai Liu Xuezhao Liu Xin Wang Lingli Guo Zhiyang Gao Xiaojiang Hao Chonglin Yang 2018Protein & Cell2018,9,12:2
11Targeted chemotherapy for subcutaneous and orthotopic non-small cell lung tumors with cyclic RGD-functionalized and disulfide-crosslinked polymersomal doxorubicin显示文摘Lung cancer, with its high mortality and increasing morbidity, has become one of the most lethal malignancies worldwide. Here, we developed cyclic RGD peptide-directed and disulfide-crosslinked polymersomal doxorubicin (cRGD-PS-Dox) as a targeted chemotherapy for human non-small cell lung cancer (NSCLC). Notably, cRGD-PS-Dox exhibited a high Dox loading (15.2 wt.%), small hydrodynamic diameter (96 nm), superb stability, prominent targetability to αvβ3 integrin overexpressing A549 human lung cancer cells, and rapid release of the drug into nuclei, leading to a significantly improved antitumor activity compared with the control groups, i.e., PS-Dox and Lipo-Dox (a liposome injection employed in clinical settings). The pharmacokinetic and biodistribution results for cRGD-PS-Dox revealed similar elimination half-lives but two-fold enhanced tumor accumulation compared with PS-Dox and Lipo-Dox. Intriguingly, cRGD-PS-Dox effectively suppressed the growth of A549 lung tumors in both subcutaneous and orthotopic models with minimal adverse effects at a Dox dose of 12 mg/kg, leading to significant survival benefits compared with PS-Dox and Lipo-Dox. This αvβ3 integrin-targeting multifunctional polymersomal doxorubicin is highly promising for targeted chemotherapy of human NSCLC.Yan Zou Jingjing Wei Yifeng Xia Fenghua Meng Jiandong Yuan Zhiyuan Zhong 2018Signal Transduction and Targeted Therapy2018,3,1:2
12Effectiveness of Chinese herbal medicine for primary Raynaud's phenomenon:a systematic review and Meta-analysis of randomized controlled trials显示文摘OBJECTIVE:To evaluate the effectiveness of Chinese herbal medicine for primary Raynaud's phenomenon(PRP).METHODS:The Cochrane Central Register of Controlled Trials,PubMed,Chinese Biomedical Literature Database,China National Knowledge Infrastructure,China Science and Technology Journal Database,and Wanfang Database were searched up to February 13,2018.Randomized controlled trials(RCTs)on treatment of PRP with Chinese herbal medicine compared with placebo,blank control,lifestyle changes,or calcium antagonists were identified and reviewed.The quality of included trials was assessed using a risk of bias tool.RESULTS:Eight RCTs involving 674 participants were included.The methodological quality of the included trials was generally poor.Meta-analysis of two trials showed that Buyang Huanwu Tang plus Danggui Sini Tang produced greater improvement in global symptoms than nifedipine.One trial showed that Danggui Sini Tang and a self-composed Chinese herbal medicine decoction,respectively,produced greater improvement in global symptoms than nifedipine alone.In one trial,modified Danggui Sini Tang showed greater improvement in global symptoms and arterial peak systolic velocity compared with nifedipine.One trial showed that Jiejing Tongmi Tang produced greater improvement in global symptoms,plasma endothelin,and plasma nitric oxide than cinepazide maleate injection.However,Jiejing Tongmi Tang did not produce a significant difference in skin temperature and peripheral artery blood stream drawing after cold pressor testing compared with cinepazide maleate injection.None of the trials reported frequency of attacks,duration of attacks,participant preference scores,or adverse events.CONCLUSION:Chinese herbal medicine may have a positive effective on PRP.However,owing to weak methodology,the benefits of Chinese herbal medicine for PRP are inconclusive.More rigorously designed studies are needed to confirm these findings.Zhang Jinchao Hu Jing He Xiujuan Meng Yujiao Chen Guangkun Chen Zhaoxia Lu Jingjing Li Ping 2020Journal of Traditional Chinese Medicine2020,40,4:2
13Chronic heat stress induces the disorder of gut transport and immune function associated with endoplasmic reticulum stress in growing pigs显示文摘Although high temperatures influence gut health,data on underlying mechanisms remains scant.Using a pig model,this study performed a global analysis on how chronic heat stress affects the transport and immune function of the gut through transcriptome,proteome,microbial diversity and flow cytometry.A total of 27 pigs with similar body weights were assigned into 3 groups,control(Con)group(23℃),chronic heat stressed(HS)group(33°C),and pair-fed(PF)group,in a controlled environment for 21 days.Our results showed that pigs in the HS group had reduced growth performance and diminished height of ileal villi(P<0.01).Transcriptome and proteome analyses demonstrated notable modification of expression of nutrients and ion transport-related transporters and gut mechanical barrier-related genes by chronic heart stress(P<0.05),suggesting damage of transport functions and the gut barrier.Chronic heat stress-induced endoplasmic reticulum stress also increased the synthesis of misfolded proteins,leading to upregulation of misfolded protein degradation and synthesis,as well as vesicle transport disorder(P<0.05).Energy supply processes were enhanced in the mitochondrion(P<0.05)to maintain biological processes with high energy demands.Furthermore,chronic heat stress activated complement cascade response-related genes and proteins in the gut mucosa(P<0.05).Our flow cytometry assays showed that the proportion of gut lymphocytes(CD4^(+)T cells,T cells,B cells in Peyer’s patch lymphocytes and CD4^(+)CD25^(+)T cells in intraepithelial lymphocytes)were significantly altered in the HS group pigs(P<0.05).In addition,the occurrence of gut microbial dysbiosis in the HS group pigs was characterized by increased potential pathogens(e.g.,Asteroleplasma,Shuttleworthia,Mycoplasma)and suppression of beneficial bacteria(e.g.,Coprococcus and Aeriscardovia),which are associated with gut immune function.Altogether,our data demonstrated that chronic heat stress induced gut transport and immune function disorder associated with endoplasmic reticulum stress in growing pigs.Shanlong Tang Jingjing Xie Wei Fang Xiaobin Wen Chang Yin Qingshi Meng Ruqing Zhong Liang Chen Hongfu Zhang 2022Animal Nutrition2022,,4:2
14Ammonia in urban atmosphere can be substantially reduced by vehicle emission control:A case study in Shanghai, China显示文摘To investigate the impact of emission controls on ammonia(NH_(3)) pollution in urban atmosphere, observation on NH_(3)(1 hr interval) was performed in Shanghai before, during and after the 2019 China International Import Expo (CIIE) event, along with measurements on inorganic ions, organic tracers and stable nitrogen isotope compositions of ammonium in PM_(2.5). NH_(3)during the CIIE period was 6.5±1.0μg/m^(3), which is 41% and 32% lower than that before and after the event, respectively. Such a decrease was largely ascribed to the emission controls in nonagricultural sources, of which contribution for measured NH_(3)in control phase abated by ~20% compared to that during uncontrol period. Molecular compositions of PAHs and hopanes further suggested a dominant role of the reduced vehicle emissions in the urban NH_(3)abatement during the CIIE period. Our results revealed that vehicle exhaust emission control is an effective way to mitigate NH_(3)pollution and improve air quality in Chinese urban areas.Can Wu Shaojun Lv Fanglin Wang Xiaodi Liu Jin Li Lang Liu Si Zhang Wei Du Shijie Liu Fan Zhang Jianjun Li Jingjing Meng Gehui Wang 2023Journal of Environmental Sciences2023,,4:1
15Hg 2+ reduction and re-emission from simulated wet flue gas desulfurization liquors显示文摘Jingjing Wo Meng Zhang Xiaoya Cheng Xiaohang Zhong Jiang Xu Xinhua Xu 2009Journal of Hazardous Materials2009,,2:1
16Fotemustine-based therapy in combination with rituximab as a first-line induction chemotherapy followed by WBRT for newly diagnosed primary central nervous system lymphoma: a prospective phase II trial显示文摘Objective:This study aimed to evaluate the safety,efficacy,and feasibility of the rituximab,fotemustine,pemetrexed,and dexamethasone(R-FPD)regimen followed by whole-brain radiotherapy(WBRT)for patients with primary central nervous system lymphoma(PCNSL).Methods:A prospective,single-center phase II clinical trial was conducted.Patients with PCNSL newly diagnosed at the First Affiliated Hospital of Zhengzhou University between July 2018 and July 2020 were studied.The R-FPD regimen consisted of rituximab(375 mg/m2 i.v.on D0),fotemustine(100 mg/m2 i.v.on D1),pemetrexed(600 mg/m2 i.v.on D1),and dexamethasone(40 mg i.v.on D1-5).Patients 60 years or younger who showed a complete response(CR)were treated with 23.4 Gy of WBRT after the end of chemotherapy;those older than 60 years with CR were treated with a wait-and-see approach;and those who did not show CR after the 4th cycle of chemotherapy were given salvage WBRT 30 Gy+local tumor field irradiation up to 45 Gy,regardless of age.Results:A total of 30 patients were included.After 2 cycles,the objective response rate(ORR)was 96.5%(28/29,1 CR,27 PR,0 SD,and 1 PD).After 4 cycles,the ORR was 73.1%(19/26,11 CR,8 PR,4 SD,and 3 PD).After WBRT,the ORR was 90.9%(10/11,7 CR,3 PR,and 1 SD).The grade III and IV toxicity responses were mainly leukopenia(20.0%),thrombocytopenia(23.3%),and anemia(10.0%).Conclusions:Fotemustine-based therapy in combination with rituximab chemotherapy followed by WBRT can improve outcomes,providing ORR benefits and favorable tolerability in patients newly diagnosed with PCNSL.Jingjing Wu Fenghua Gao Wenhua Wang Xudong Zhang Meng Dong Lei Zhang Xin Li Ling Li Zhenchang Sun Xinhua Wang Xiaorui Fu Linan Zhu Mengjie Ding Songtao Niu Zhaoming Li Yu Chang Feifei Nan Jiaqian Yan Hui Yu Xiaolong Wu Zhiyuan Zhou Jieming Zhang Mingzhi Zhang 2022Cancer Biology & Medicine2022,19,7:1
17Significant coal combustion contribution to water-soluble brown carbon during winter in Xingtai, China: Optical properties and sources显示文摘To understand the characteristics of atmospheric brown carbon(BrC),daily PM2.5 samples in Xingtai,a small city in North China Plain(NCP),during the four seasons of 2018-2019,were collected and analyzed for optical properties and chemical compositions.The light absorption at 365 nm(abs λ=365 nm)displayed a strong seasonal variation with the highest value in winter(29.0±14.3 M/m),which was 3.2∼5.4-fold of that in other seasons.A strong correlation of abs λ=365 nm with benzo(b)fluoranthene(BbF)was only observed in winter,indicating that coal combustion was the major source for BrC in the season due to the enhanced domestic heating.The mass absorbing efficiency of BrC also exhibited a similar seasonal pattern,and was found to correlate linearly with the aerosol pH,suggesting a positive effect of aerosol acidity on the optical properties and formation of BrC in the city.Positive matrix factorization(PMF)analysis further showed that on a yearly basis the major source for BrC was biomass burning,which accounted for 34% of the total BrC,followed by secondary formation(26.7%),coal combustion(21.3%)and fugitive dust(18%).However,the contribution from coal combustionwas remarkably enhanced in winter,accounting for∼40%of the total.Our work revealed that more efforts of“shifting coal to clean energy”are necessary in rural areas and small cities in NCP in order to further mitigate PM2.5 pollution in China.Dapeng Li Can Wu Si Zhang Yali Lei Shaojun Lv Wei Du Shijie Liu Fan Zhang Xiaodi Liu Lang Liu Jingjing Meng Yuesi Wang Jian Gao Gehui Wang 2023Journal of Environmental Sciences2023,,2:1
18Precise Editing Enables Crop Broad-Spectrum Resistance显示文摘Loss of resistance to fast-adapted pathogens urgently calls for a sustainable and broad-spectrum strategy to meet the requirement of crop yield and safety for the increasing world population.Pyramidization of resistance genes,such as nucleotide-binding leucine-rich repeat proteins,from diverse cultivars,landraces,and domesticated or wild germplasm accessions offers the most direct practice for this purpose.Nevertheless,the facts of a narrow resistance spectrum and limited number or even shortage of such resistance genes to many specific pathogens leave an immediate question to be resolved in such a situation.In light of the evidence that all compatible pathogens trigger a conserved and wide range of host genes,namely susceptibility genes for their proliferation,management of those genes are of equal importance and promising for improvement in crop disease resistance(Zaidi et al.,2018).Jingjing Tian Guoyong Xu Meng Yuan 2019Molecular Plant2019,12,12:1
19Research on the infuluence that stop position of carpet tufting machine to yarn tension and the method of eliminating stop mark 显示文摘Meng zhuo Sun Jingjing zhou tingze etal 2008Key Engineering Materials2008,,:1
20Research on the influence that stop position of carpet tufting machine to yarn tension and the method ofeliminating stop markt显示文摘MENG Zhuo SUN Jingjing ZHOU Tingze 2008Key Engineering Materials2008,,375376:1
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