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| 1 | Dual enzyme activated fluorescein based fluorescent probe显示文摘A simple dual analyte fluorescein-based probe(PF3-Glc)was synthesised containingβ-glucosidase(β-glc)and hydrogen peroxide(H2O2)trigger units.The presence ofβ-glc,resulted in fragmentation of the parent molecule releasing glucose and the slightly fluorescent mono-boronate fluorescein(PF3).Subsequently,in the presence of glucose oxidase(GOx),the released glucose was catalytically converted to D-glucono-δ-lactone,which produced H2O2 as a by-product.The GOx-produced H2O2,resulted in classic H2O2-mediated boronate oxidation and the release of the highly emissive fluorophore,fluorescein.This unique cascade reaction lead to an 80-fold increase in fluorescence intensity. | Maria L.Odyniec Jordan E.Gardiner Adam C.Sedgwick Xiao-Peng He Steven D.Bull Tony D.James | 2020 | Frontiers of Chemical Science and Engineering2020，14，1： | 1 |
| 2 | A general strategy for selective detection of hypochlorous acid based on triazolopyridine formation显示文摘Triazolopyridines are an important kind of fused-ring compounds.A HOCl-promoted triazolopyridine formation strategy is reported here for the first time in which hypochlorous acid(HOCl)mildly and efficiently promotes the formation of 1,2,4-triazolo[4,3-a]pyridines NT1-NT6 from various 2-pyridylhydrazones N1-N6.N6,a rhodol-pyridylhydrazone hybrid,was developed into a fluorescent probe for the selective detection of HOCl,and successfully applied to probe endogenous HOCl in living cells and zebrafish in situ and in real time.The present intramolecular cyclization reaction is selective and atom-economical,thereby not only providing an important approach for the convenient synthesis of triazolopyridines,but also offering a general strategy for sensitive,selective and biocompatible detection of endogenous HOCl in complex biosystems. | Yanhui Zhang Hao Teng Ying Gao Muhammad Wasim Afzal Jingye Tian Xi Chen Haoyang Tang Tony D.James Yuan Guo | 2020 | Chinese Chemical Letters2020，31，11： | 0 |
| 3 | A practical strategy to develop isoform-selective near-infrared fluorescent probes for human cytochrome P450 enzymes显示文摘Currently,the development of selective fluorescent probes toward targeted enzymes is still a great challenge,due to the existence of numerous isoenzymes that share similar catalytic capacity.Herein,a double-filtering strategy was established to effectively develop isoenzyme-specific fluorescent probe(s)for cytochrome P450(CYP)which are key enzymes involving in metabolism of endogenous substances and drugs.In the first-stage of our filtering approach,near-infrared(NIR)fluorophores with alkoxyl group were prepared for the screening of CYP-activated fluorescent substrates using a CYPs-dependent incubation system.In the second stage of our filtering approach,these candidates were further screened using reverse protein-ligand docking to effectively determine CYP isoenzyme-specific probe(s).Using our double-filtering approach,probes S9 and S10 were successfully developed for the real-time and selective detection of CYP2C9 and CYP2J2,respectively,to facilitate high-throughput screening and assessment of CYP2C9-mediated clinical drug interaction risks and CYP2J2-associated disease diagnosis.These observations suggest that our strategy could be used to develop the isoform-specific probes for CYPs. | Lei Feng Xiangge Tian Dahong Yao Zhenlong Yu Xiaokui Huo Zhenhao Tian Jing Ning Jingnan Cui Tony D.James Xiaochi Ma | 2022 | Acta Pharmaceutica Sinica B2022，12，4： | 0 |
| 4 | Special issue on “Fluorescent probes”显示文摘Fluorescent probes are intelligently designed molecules that transform the act of binding/reacting with a target analyte into an optical signal[1,2].Their high sensitivity and specificity coupled with high spatial and temporal resolution offers a non-invasive approach to observe a specific analyte within complex biological environments in real time with high precision[3].These'molecular tools'have the capability to interrogate the role of specific biomarkers that are associated with a particular disease state or can be used to improve our understanding of the role or certain species in a biological pathway[4,5]. | Adam C.Sedgwick Tony D.James | 2020 | Frontiers of Chemical Science and Engineering2020，14，1： | 0 |
| 5 | A simple,azulene-based colorimetric probe for the detection of nitrite in water显示文摘We describe the synthesis and evaluation of an azulene-based chemodosimeter for nitrite.The probe was found to undergo two distinct color changes upon introduction of aqueous nitrite ion.A near-instant formation of a grey color provides a qualitative indication of the presence of nitrite,followed by the formation of a deep-yellow/orange color,the endpoint from which quantitative data can be derived.The azulene probe exhibits 1:1 stoichiometry of reaction with nitrite in water,and is selective for nitrite over other anions.The azulene probe was applied to determine nitrite content in cured meat,and compared with the British Standard testing procedure(Griess test).The value obtained from the azulene-based probe agreed closely with the standard test.Our procedure only requires the preparation of one standard solution,instead of the three required for the standard Griess test. | Lloyd C.Murfin Carlos M.Lopez-Alled Adam C.Sedgwick Jannis Wenk Tony D.James Simon E.Lewis | 2020 | Frontiers of Chemical Science and Engineering2020，14，1： | 0 |
| 6 | A boronic acid-based fluorescent hydrogel for monosaccharide detection显示文摘A boronic acid-based anthracene fluorescent probe was functionalised with an acrylamide unit to incorporate into a hydrogel system for monosaccharide detection.In solution,the fluorescent probe displayed a strong fluorescence turn-on response upon exposure to fructose,and an expected trend in apparent binding constants,as judged by a fluorescence response where D-fructose>D-galactose>D-mannose>D-glucose.The hydrogel incorporating the boronic acid monomer demonstrated the ability to detect monosaccharides by fluorescence with the same overall trend as the monomer in solution with the addition of D-fructose resulting in a 10-fold enhancement(≤0.25 mol/L). | Suying Xu Adam C.Sedgwick Souad A.Elfeky Wenbo Chen Ashley S.Jones George T.Williams A.Toby A.Jenkins Steven D.Bull John S.Fossey Tony D.James | 2020 | Frontiers of Chemical Science and Engineering2020，14，1： | 0 |
| 7 | Fluorescent probes and functional materials for biomedical applications显示文摘Due to their simplicity in preparation,sensitivity and selectivity,fluorescent probes have become the analytical tool of choice in a wide range of research and industrial fields,facilitating the rapid detection of chemical substances of interest as well as the study of important physiological and pathological processes at the cellular level.In addition,many long-wavelength fluorescent probes developed have also proven applicable for in vivo biomedical applications including fluorescenceguided disease diagnosis and theranostics(e.g.,fluorogenic prodrugs).Impressive progresses have been made in the development of sensing agents and materials for the detection of ions,organic small molecules,and biomacromolecules including enzymes,DNAs/RNAs,lipids,and carbohydrates that play crucial roles in biological and disease-relevant events.Here,we highlight examples of fluorescent probes and functional materials for biological applications selected from the special issues“Fluorescent Probes”and“Molecular Sensors and Logic Gates”recently published in this journal,offering insights into the future development of powerful fluorescence-based chemical tools for basic biological studies and clinical translation. | Xi-Le Hu Hui-Qi Gan Fan-De Meng Hai-Hao Han De-Tai Shi Shu Zhang Lei Zou Xiao-Peng He Tony D.James | 2022 | Frontiers of Chemical Science and Engineering2022，16，10： | 0 |
| 8 | Special issue on “Molecular Sensors and Molecular Logic Gates”显示文摘This issue of Frontiers of Chemical Science and Engineering highlights recent progress toward fluorescent probes that was originally conceived to coincide with 7th Conference on Molecular Sensors and Molecular Logic Gates(MSMLG 2020)to celebrate the career of Seiji Shinkai and hosted by Anthony Czarnik at the University of Nevada in Reno.Sadly,that meeting was cancelled due to the pandemic associated with COVID-19.However,this collection of research and review papers will now serve as an introduction to MSMLG 2022 which will be in Dublin,Ireland on 7–10 June 2022,where Thorfinnur Gunnlaugsson will be the local host.The collection of papers contained in this special issue covers in vitro and in vivo applications and illustrates the potential for practical sensing and imaging of disease-related species. | Luling Wu Tony D.James | 2022 | Frontiers of Chemical Science and Engineering2022，16，1： | 0 |
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