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| 1 | Neuroprotective effect of ischemic preconditioning in focal cerebral infarction: relationship with upregulation of vascular endothelial growth factor显示文摘Neuroprotection by ischemic preconditioning has been confirmed by many studies, but the precise mechanism remains unclear. In the present study, we performed cerebral ischemic preconditioning in rats by simulating a transient ischemic attack twice(each a 20-minute occlusion of the middle cerebral artery) before inducing focal cerebral infarction(2 hour occlusion-reperfusion in the same artery). We also explored the mechanism underlying the neuroprotective effect of ischemic preconditioning. Seven days after occlusion-reperfusion, tetrazolium chloride staining and immunohistochemistry revealed that the infarct volume was significantly smaller in the group that underwent preconditioning than in the model group. Furthermore, vascular endothelial growth factor immunoreactivity was considerably greater in the hippocampal CA3 region of preconditioned rats than model rats. Our results suggest that the protective effects of ischemic preconditioning on focal cerebral infarction are associated with upregulation of vascular endothelial growth factor. | Yong Liu Suiqiang Zhu Yunfu Wang Jingquan Hu Lili Xu Li Ding Guangjian Liu | 2014 | Neural Regeneration Research2014，9，11： | 15 |
| 2 | A flexible three-dimensional electrode mesh:An enabling technology for wireless brain-computer interface prostheses显示文摘The neural interface is a key component in wireless brain–computer prostheses.In this study,we demonstrate that a unique three-dimensional(3D)microneedle electrode on a flexible mesh substrate,which can be fabricated without complicated micromachining techniques,is conformal to the tissues with minimal invasiveness.Furthermore,we demonstrate that it can be applied to different functional layers in the nervous system without length limitation.The microneedle electrode is fabricated using drawing lithography technology from biocompatible materials.In this approach,the profile of a 3D microneedle electrode array is determined by the design of a two-dimensional(2D)pattern on the mask,which can be used to access different functional layers in different locations of the brain.Due to the sufficient stiffness of the electrode and the excellent flexibility of the mesh substrate,the electrode can penetrate into the tissue with its bottom layer fully conformal to the curved brain surface.Then,the exposed contact at the end of the microneedle electrode can successfully acquire neural signals from the brain. | Zhuolin Xiang Jingquan Liu Chengkuo Lee | 2016 | Microsystems & Nanoengineering2016，2，1： | 8 |
| 3 | Quantitative features of myoelectric signals in the orbicularis oculi muscle during different motion states显示文摘Artificial facial nerve prostheses are thought to restore eye-closed function in peripheral facial paralysis patients. At present,however,there is no adequate quantitative or qualitative information regarding myoelectric signal(MES) features for healthy orbicularis oculi muscle(OOM) . The present study analyzed MES features of normal OOM in rabbits during the natural continuous eye-opening(N1) state,natural continuous eye-closing(N2) state,natural blink(N3) state,and evoked eye-closing(E) state according to time domain and frequency domain analysis. Results showed that OOM electrical activities in N1 and N2 states,as well as myoelectric amplitude,were low and stable. Nevertheless,during N3 and E states,OOM electrical activities were significantly increased and amplitude was much higher in the E state than in the N3 state. In the time domain,differences in MES peak absolute potential were not significant between N1 and N2 states. In the frequency domain,differences in power spectral density peak frequency of electromyogram signals were significant between two sets of four OOM movement states. These results suggest that OOM significantly contracts and induces eyelid-closing action. In addition,OOM is diastolic during the N1 state. A N2 state does not require continuous intensive OOM contraction. Moreover,distinctions of quantitative information in time and frequency domain features of MES can be used as an OOM reference to identify muscle movement patterns. | Dongyue Xu Keyong Li Jingquan Liu Yujuan Wang Yuefeng Rui | 2010 | Neural Regeneration Research2010，5，24： | 6 |
| 4 | VO2·0.2H2O nanocuboids anchored onto graphene sheets as the cathode material for ultrahigh capacity aqueous zinc ion batteries显示文摘Aqueous Zinc-ion batteries(ZIBs),using zinc negative electrode and aqueous electrolyte,have attracted great attention in energy storage field due to the reliable safety and low-cost.A composite material comprised of VO2·0.2H2O nanocuboids anchored on graphene sheets(VOG)is synthesized through a facile and efficient microwave-assisted solvothermal strategy and is used as aqueous ZIBs cathode material.Owing to the synergistic effects between the high conductivity of graphene sheets and the desirable structural features of VO2·0.2H2O nanocuboids,the VOG electrode has excellent electronic and ionic transport ability,resulting in superior Zn ions storage performance.The Zn/VOG system delivers ultrahigh specific capacity of 423 mAh·g^−1 at 0.25 A·g^−1 and exhibits good cycling stability of up to 1,000 cycles at 8 A·g^−1 with 87%capacity retention.Systematical structural and elemental characterizations confirm that the interlayer space of VO2·0.2H2O nanocuboids can adapt to the reversible Zn ions insertion/extraction.The as-prepared VOG composite is a promising cathode material with remarkable electrochemical performance for low-cost and safe aqueous rechargeable ZIBs. | Dedong Jia Kun Zheng Ming Song Hua Tan Aitang Zhang Lihua Wang Lijun Yue Da Li Chenwei Li Jingquan Liu | 2020 | Nano Research2020，13，1： | 6 |
| 5 | Non-noble metal single-atom catalysts prepared by wet chemical method and their applications in electrochemical water splitting显示文摘Water splitting by electrolysis is an appealing pathway for sustainable hydrogen production. The practical performance of water splitting is highly dependent on the efficiency of electrocatalysts, which can promote the anodic oxygen evolution reaction(OER) or cathodic hydrogen evolution reaction(HER). Downsizing the metal nanostructures to atomic level to construct single-atom catalysts(SACs) has attracted enormous attention due to its distinct advantages in maximizing the efficiency of metal atom utilization and enhancing activity over corresponding metal nanoparticles. Research on SACs towards electrochemical water splitting application is an emerging field and intensive investigations have been focused on their rational syntheses and applications in HER/OER. In this review, we focus on the wet chemical method developed to prepare non-noble metal based SACs with an emphasis on the synthetic strategies and structure-activity relationship between single metal atoms and catalytic activity. Finally, the challenges and future opportunities for application of single-atom catalysts in water splitting are briefly addressed. | Wei Liu Hongxiu Zhang Chuanming Li Xin Wang Jingquan Liu Xingwang Zhang | 2020 | Journal of Energy Chemistry2020，29，8： | 6 |
| 6 | Hierarchical coral-like NiMoS nanohybrids as highly efficient bifunctional electrocatalysts for overall urea electrolysis显示文摘Ti 上的新奇层次像珊瑚的 Ni 瞬间硫化物协调(作为 HC-NiMoS/Ti 表示了) 没有任何模板,通过灵巧的热水、随后的硫化过程被综合。这些非宝贵的 HC-NiMoS/Ti 混血儿为切开的基于脲的全面的水作为 bifunctional 催化剂被探索,包括阳极的脲氧进化反应(UOR ) 和 cathodic 氢进化反应(她的) 。由于高度暴露的活跃地点,优秀费用转移能力,和从多部件反应的好 synergistic 效果, HC-NiMoS/Ti 混血儿展出了优异活动和高稳定性,吗并且 1.59 V 的仅仅房间电压被要求交付 10 妈( BTC ) MOF 在 ZnO/graphene 氧化物被合并(去) photocatalytic 系统由? | Xiaoxia Wang Jianmei Wang Xuping Sun Shuang Wei Liang Cui Wenrong Yang Jingquan Liu | 2018 | Nano Research2018，11，2： | 4 |
| 7 | Brassinosteroid signaling positively regulates abscisic acid biosynthesis in response to chilling stress in tomato显示文摘Brassinosteroids(BRs)and abscisic acid(ABA)are essential regulators of plant growth and stress tolerance.Although the antagonistic interaction of BRs and ABA is proposed to ensure the balance between growth and defense in model plants,the crosstalk between BRs and ABA in response to chilling in tomato(Solanum lycopersicum),a warmclimate horticultural crop,is unclear.Here,we determined that overexpression of the BR biosynthesis gene DWARF(DWF)or the key BR signaling gene BRASSINAZOLE-RESISTANT1(BZR1)increases ABA levels in response to chilling stress via positively regulating the expression of the ABA biosynthesis gene 9-CIS-EPOXYCAROTENOID DIOXYGENASE1(NCED1).BR-induced chilling tolerance was mostly dependent on ABA biosynthesis.Chilling stress or high BR levels decreased the abundance of BRASSINOSTEROID-INSENSITIVE2(BIN2),a negative regulator of BR signaling.Moreover,we observed that chilling stress increases BR levels and results in the accumulation of BZR1.BIN2negatively regulated both the accumulation of BZR1protein and chilling tolerance by suppressing ABA biosynthesis.Our results demonstrate that BR signaling positively regulates chilling tolerance via ABA biosynthesis in tomato.The study has implications in production of warm-climate crops in horticulture. | Shengmin An Yue Liu Kangqi Sang Ting Wang Jingquan Yu Yanhong Zhou Xiaojian Xia | 2023 | Journal of Integrative Plant Biology2023，65，1： | 4 |
| 8 | Flexible polyimide-based hybrid optoelectric neural interface with 16 channels of micro-LEDs and electrodes显示文摘In this paper,a polyimide-based flexible device that integrates 16 micro-LEDs and 16 IrO_(x)-modified microelectrodes for synchronous photostimulation and neural signal recording is presented.The 4×4 micro-LEDs(dimensions of 220×270×50μm^(3),700μm pitch)are fixed in the SU-8 fence structure on a polyimide substrate and connected to the leads via a wire-bonding method.The recording electrodes share a similar fabrication process on the polyimide with 16 microelectrode sites(200μm in diameter and 700μm in pitch)modified by iridium oxide(IrO_(x)).These two subparts can be aligned with alignment holes and glued back-to-back by epoxy,which ensures that the light from the LEDs passes through the corresponding holes that are evenly distributed around the recording sites.The long-term electrical and optical stabilities of the device are verified using a soaking test for 3 months,and the thermal property is specifically studied with different duty cycles,voltages,and frequencies.Additionally,the electrochemical results prove the reliability of the IrO_(x)-modified microelectrodes after repeated pressing or friction.To evaluate the tradeoff between flexibility and strength,two microelectrode arrays with thicknesses of 5 and 10μm are evaluated through simulation and experiment.The proposed device can be a useful mapping optogenetics tool for neuroscience studies in small(rats and mice)and large animal subjects and ultimately in nonhuman primates. | Bowen Ji Zhejun Guo Minghao Wang Bin Yang Xiaolin Wang Wen Li Jingquan Liu | 2018 | Microsystems & Nanoengineering2018，4，1： | 3 |
| 9 | Artificial facial nerve reflex restores eyelid closure following orbicularis oculi muscle denervation显示文摘To date,treatment of peripheral facial paralysis has focused on preservation of facial nerve integrity.However,with seriously damaged facial nerve cases,it is difficult to recover anatomical and functional integrity using present therapies.Therefore,the present study utilized artificial facial nerve reflex to obtain orbicularis oculi muscle(OOM) electromyography signals on the uninjured side through the use of implanted recording electrodes.The implanted electrical chips analyzed facial muscle motion on the uninjured side and triggered an electrical stimulator to emit current pulses,which resulted in stimulation of injured OOM contraction and maintained bilateral symmetry and consistency.Following signal recognition,extraction,and computer analysis,electromyography signals in the uninjured OOM resulted in complete eyelid closure,which was consistent with the voltage threshold for eye closure.These findings suggested that artificial facial nerve reflex through the use of implanted microelectronics in unilateral peripheral facial paralysis could restore eyelid closure following orbicularis oculi muscle denervation. | Yujuan Wang Keyong Li Jingquan Liu Dongyue Xu Yuefeng Rui Chunsheng Yang | 2010 | Neural Regeneration Research2010，5，22： | 3 |
| 10 | Recent advances in wireless epicortical and intracortical neuronal recording systems显示文摘An implantable brain-computer interface(BCI)has proven to be effective in the field of sensory and motor function restoration and in the treatment of neurological disorders.Using a BCI recording system,we can transform current methods of human interaction with machines and the environment,especially to help those with cognitive and mobility disabilities regain mobility and reintegrate into society.However,most reported work has focused on a simple aspect of the whole system,such as electrodes,circuits,or data transmission,and only a very small percentage of systems are wireless.A miniature,lightweight,wireless,implantable microsystem is key to realizing long-term,real-time,and stable monitoring on freely moving animals or humans in their natural conditions.Here,we summarize typical wireless recording systems,from recording electrodes,processing chips and controllers,wireless data transmission,and power supply to the system-level package for either epicortical electrocorticogram(ECoG)or intracortical local field potentials(LFPs)/spike acquisition,developed in recent years.Finally,we conclude with our vision of challenges in next-generation wireless neuronal recording systems for chronic and safe applications. | Bowen JI Zekai LIANG Xichen YUAN Honglai XU Minghao WANG Erwei YIN Zhejun GUO Longchun WANG Yuhao ZHOU Huicheng FENG Honglong CHANG Jingquan LIU | 2022 | Science China(Information Sciences)2022，65，4： | 2 |
| 11 | Frequencyspectrum characteristics of force in end milling with tool wear and eccentricity显示文摘 | Liu Can Wu Jingquan Li Guanghui | 2012 | The International Journal of Advanced Manufacturing Technology2012，23，3： | 1 |
| 12 | Fabrieation of a polymer micro needle array by mask-dragging X-ray li- thography and alignment X-ray lithography 显示文摘 | Li Yigui Yang Chunsheng Liu Jingquan | 2011 | Chin Phys Lett2011，28，03： | 1 |
| 13 | Assessing enter- prise micro -blogging marketing communication effec- tiveness and improvement suggestions 显示文摘 | Bing Wang Siying Li Jingquan Liu | 2014 | Journal of Chemical & Pharmaceutical Research2014，6，6： | 1 |
| 14 | An ionic liquid-modified graphene based molecular imprinting electrochemical sensor for sensitive detection of bovine hemoglobin显示文摘 | Zonghua Wang Feng Li Jianfei Xia Lin Xia Feifei Zhang Sai Bi Guoyu Shi Yanzhi Xia Jingquan Liu Yanhui Li Linhua Xia | 2014 | Biosensors and Bioelectronics2014，，： | 1 |
| 15 | Stretchable Parylene-C electrodes enabled by serpentine structures on arbitrary elastomers by silicone rubber adhesive显示文摘The delicate serpentine structures are widely used in high-performance stretchable electronics over the past decade.The metal interconnects encapsulated in biocompatible polymer Parylene-C film is a superior choice for long-term implantation in vivo,especially as neural interface to acquire electrophysiological signals or apply electrical stimulation.To avoid the physical contact damages from the neural tissues such as the brain or peripheral nerves,serpentine interconnects are utilized as stretchable electrodes and usually bonded to the soft elastomer substrate.The adhesion strength between the serpentine interconnects and the elastomer substrate becomes a considerable issue to ensure reliability and structural integrity.In this paper,the stretchable Parylene-C electrodes can be transfer printed onto arbitrary elastomer substrates by a thin layer of silicone rubber adhesive with low modulus for electrocorticogram(ECoG)recording.Mechanical simulation of serpentine structures consisting of same periodic arcs and different straight segments is investigated by uniaxial stretching.Then,the elastic stretchability of serpentine electrodes is further studied by simulation and experiments.After 5000 repetitive stretching cycles,the electrochemical impedance of microelectrodes remains in steady states.These results prove that the silicone rubber adhesive facilitates the interfacial bonding in the structure of stretchable electrodes as the compliant and reliable neural interface. | Bowen Ji Zhaoqian Xie Wen Hong Chunpeng Jiang Zhejun Guo Longchun Wang Xiaolin Wang Bin Yang Jingquan Liu | 2020 | Journal of Materiomics2020，6，2： | 1 |
| 16 | Fabrication and performance of MEMS-based piezoe- lectric power generator for vibration energy harvesting 显示文摘 | FANG Huabin LIU Jingquan XU Zhengyi | 2006 | Microelectronies Journal2006，37，11： | 1 |
| 17 | Development of high performance piezoelectric d33 mode MEMS vibration energy har- vester based on PMN-PT single crystal thick film 显示文摘 | Tang Gang Yang Bin Liu Jingquan | 2014 | Sensors and Actuators A2014，205，： | 1 |
| 18 | A flexible neural implant with ultrathin substrate for low-invasive brain–computer interface applications显示文摘Implantable brain–computer interface(BCI)devices are an effective tool to decipher fundamental brain mechanisms and treat neural diseases.However,traditional neural implants with rigid or bulky cross-sections cause trauma and decrease the quality of the neuronal signal.Here,we propose a MEMS-fabricated flexible interface device for BCI applications.The microdevice with a thin film substrate can be readily reduced to submicron scale for low-invasive implantation.An elaborate silicon shuttle with an improved structure is designed to reliably implant the flexible device into brain tissue.The flexible substrate is temporarily bonded to the silicon shuttle by polyethylene glycol.On the flexible substrate,eight electrodes with different diameters are distributed evenly for local field potential and neural spike recording,both of which are modified by Pt-black to enhance the charge storage capacity and reduce the impedance.The mechanical and electrochemical characteristics of this interface were investigated in vitro.In vivo,the small cross-section of the device promises reduced trauma,and the neuronal signals can still be recorded one month after implantation,demonstrating the promise of this kind of flexible BCI device as a low-invasive tool for brain–computer communication. | Zhejun Guo Fang Wang Longchun Wang Kejun Tu Chunpeng Jiang Ye Xi Wen Hong Qingda Xu Xiaolin Wang Bin Yang Bomin Sun Zude Lin Jingquan Liu | 2022 | Microsystems & Nanoengineering2022，8，6： | 1 |
| 19 | Glucose-regulated protein 78 may play a crucial role in promoting the pulmonary microvascular remodeling in a rat model of hepatopulmonary syndrome显示文摘 | Huiying Zhang Minli Lv Zhongfu Zhao Jiantao Jia Lili Zhang Peng Xiao Limin Wang Chen Li Jingquan Ji Xiaoxia Tian Xujiong Li Yimin Fan Lina Lai Yan Liu Baohong Li Cuiying Zhang Mingshe Liu Jianhong Guo Dewu Han Cheng Ji | 2014 | Gene2014，，1： | 1 |
| 20 | In situ formation of protein-polymer conjugates through reversible addition fragmentation chain transfer polymerization 显示文摘 | Liu Jingquan Bulmus V Herlambang D L | 2007 | Angewandte Chemie International Edition2007，46，17： | 1 |
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