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| 1 | Healthy function and high valued utilization of edible fungi显示文摘Edible fungi are large fungi with high added value that can be utilized as resources.They are rich in high-quality protein,carbohydrate,various vitamins,mineral elements and other nutrients,and are characterized by high protein,low sugar,low fat and low cholesterol.In addition,edible fungi contain a variety of bioactive substances,such as polysaccharides,dietary fiber,steroids,polyphenols,and most of these compounds have antioxidant,anti-tumor and other physiological functions.This review comprehensively discusses the bioactive components and functional characteristics of edible fungi(such as antioxidant,anti-aging,hypolipidemic activities,etc.).Then the recent developments and prospect in the high-valued utilization of edible fungi are discussed and summarized.The objective of this review is to improve the understanding of health-promoting properties of edible fungi,and provide reference for the industrial production of edible fungi-based health products. | Yanrong Zhang Dawei Wang Yuetong Chen Tingting Liu Shanshan Zhang Hongxiu Fan Hongcheng Liu Yu Li | 2021 | Food Science and Human Wellness2021，10，4： | 20 |
| 2 | Isolation,purification,structural characteristic and antioxidative property of polysaccharides from A.cepa L.var.agrogatum Don显示文摘Allium cepa L.var.agrogatum Don(ALAP)is commonly consumed in China as well as other regions and has various beneficial health effects.A novel acidic polysaccharide(named ALAP-21)was obtained from ALAP by ultrasonic and microwave-assisted extraction and purification using DEAE-52 anion exchange and Sephadex G-100 columns.The monosaccharide composition,structural and antioxidative properties of ALAP-21 were investigated by GC–MS chromatography,FT-IR and NMR spectroscopies and three antioxidative activity tests in vitro.The results showed that ALAP-21 was a heteropolysaccharide composed of glucose,galacturonic acid,mannose,galactose,arabinose,rhamnose,xylose,fructose and glucuronic acid with a relative molar ratio of 26.282:27.546:11.400:4.781:2.467:2.445:3.622:1.106:1.753,owning(1→4)-β-d-Glcp,(1→4)-β-d-GalAp6Me3OA,(1→4)-β-d-Galp6OMe,(1→2)-β-l-Rhap,(1→4)-β-d-Manp glycosidic linkages.(1→4)-β-d-Glcp and(1→4)-β-d-GalAp6Me3OA residues might be the main components of the sugar chain backbone of ALAP-21.Furthermore,ALAP-21 exhibited high potential for DPPH radicals(82.02%),hydroxyl radicals(53.33%)and superoxide anion radicals(50.28%).These results provide a reference for further research and rational development of ALAP polysaccharides. | Hongcheng Liu Hongxiu Fan Jing Zhang Shanshan Zhang Wenting Zhao Tingting Liu Dawei Wang | 2020 | Food Science and Human Wellness2020，9，1： | 10 |
| 3 | Non-noble metal single-atom catalysts prepared by wet chemical method and their applications in electrochemical water splitting显示文摘Water splitting by electrolysis is an appealing pathway for sustainable hydrogen production. The practical performance of water splitting is highly dependent on the efficiency of electrocatalysts, which can promote the anodic oxygen evolution reaction(OER) or cathodic hydrogen evolution reaction(HER). Downsizing the metal nanostructures to atomic level to construct single-atom catalysts(SACs) has attracted enormous attention due to its distinct advantages in maximizing the efficiency of metal atom utilization and enhancing activity over corresponding metal nanoparticles. Research on SACs towards electrochemical water splitting application is an emerging field and intensive investigations have been focused on their rational syntheses and applications in HER/OER. In this review, we focus on the wet chemical method developed to prepare non-noble metal based SACs with an emphasis on the synthetic strategies and structure-activity relationship between single metal atoms and catalytic activity. Finally, the challenges and future opportunities for application of single-atom catalysts in water splitting are briefly addressed. | Wei Liu Hongxiu Zhang Chuanming Li Xin Wang Jingquan Liu Xingwang Zhang | 2020 | Journal of Energy Chemistry2020，29，8： | 6 |
| 4 | Dynamic microwave-assisted extraction combined with liquid phase microextraction based on the solidification of a floating drop for the analysis of organochlorine pesticides in grains followed by GC显示文摘A convenient,cost-effective and fast method using dynamic microwave-assisted extraction and liquid phase microextraction based on the solidification of a floating drop was proposed to analyze organochlorine pesticides in grains including rice,maize and millet.Twelve samples can be processed simultaneously in the method.During the extraction process,10%acetonitrile-water solutions containing 110μL of n-hexadecane were used to extract organochlorine pesticides.Subsequently,1.0 g sodium chloride was placed in the extract,and then centrifuged and cooled.The n-hexadecane drops containing the analytes were solidifi ed and transferred for determination by gas chromatography-electron capture detector without any further filtration or cleaning process.Limits of detection for organochlorine pesticides were 0.97–1.01μg/kg and the RSDs were in the range of 2.6%–8.5%.The developed technology has succeeded in analyzing six real grains samples and the recoveries of the organochlorine pesticides were 72.2%–94.3%.Compared with the published extraction methods,the developed method was used to analyze organochlorine pesticides in grains,being more environmentally friendly,which is suitable for the daily determination of organochlorine pesticides. | Guijie Li Xu Zhang Tingting Liu Hongxiu Fan Hongcheng Liu Shangyu Li Dawei Wang Lan Ding | 2021 | Food Science and Human Wellness2021，10，3： | 4 |
| 5 | Ursolic acid derivative FZU-03,010 inhibits STAT3 and induces cell cycle arrest and apoptosis in renal and breast cancer cells显示文摘 | Wei Li Hongxiu Zhang Mingxiu Nie Yanlei Tian Xu Chen Ceshi Chen Haijun Chen Rong Liu | 2017 | Acta Biochimica et Biophysica Sinica2017，49，4： | 2 |
| 6 | Mechanics performance of high-performance concrete with polypropylene fibers 显示文摘 | Hongxiu Du Yixiao Qin Wei Zhang | 2011 | Applied Mechanics and Materials2011，，99100： | 1 |
| 7 | Structure and Growth Mechanism of V/Ag Multilayers with Different Periodic Thickness Fabricated by Magnetron Sputtering Deposition显示文摘 | Hongxiu Zhang Feng Ren Mengqing Hong Xiangheng Xiao Guangxu Cai Changzhong Jiang | 2013 | Journal of Materials Science & Technology2013，，： | 1 |
| 8 | Structure and Growth Mechanism of V/Ag Multilayers with Different Periodic Thickness Fabricated by Magnetron Sputtering Deposition显示文摘V/Ag multilayers with different periodic thicknesses were fabricated by magnetron sputtering deposition.The columnar structure and the orientation relationship of the multilayers were investigated by transmission electron microscopy,high resolution transmission electron microscopy,selected-area electron diffraction and X-ray diffraction.It was found that the multilayered structure became flatter as increasing individual layer thickness from 2 to 6 nm,and then became waved as the individual layer thickness increases to 8 nm.At the beginning of the growth,the morphology of the multilayers with small periodic thickness was influenced mainly by thermodynamic instabilities,and the morphology of the multilayers with larger periodic thickness was mainly influenced mainly by the columnar growth of V.When the waved interfaces were formed,the continuum growth of the multilayers was also influenced by the shadowing effect and the finite atomic size effect.All of these factors resulted in the columnar structure of the multilayers.Multilayers with small periodic thickness presented strong orientation relationship.Nano-hardness tests indicated that multilayers with flat sublayer morphology and clear interfaces exhibited larger hardness. | Hongxiu Zhang Feng Ren Mengqing Hong Xiangheng Xiao Guangxu Cai Changzhong Jiang | 2014 | Journal of Materials Science & Technology2014，30，10： | 1 |
| 9 | CuS/RGO hybrid by one-pot hydrothermal method for efficient electrochemical sensing of hydrogen peroxide显示文摘In this study,a non-enzymatic hydrogen peroxide sensor was successfully fabricated on the basis of copper sulfide nanoparticles/reduced graphene oxide(CuS/RGO) electrocatalyst.Using thiourea as reducing agent and sulfur donor,CuS/RGO hybrid was synthesized through a facile one-pot hydrothermal method,where the reduction of GO and deposition of CuS nanoparticles on RGO occur simultaneously.The results confirmed that the CuS/RGO hybrid helps to prevent the aggregation of CuS nanoparticles.Electrochemical investigation showed that the as-prepared hydrogen peroxide sensor exhibited a low detection limit of 0.18μmol/L(S/N = 3),a good reproducibility(relative standard deviation(RSD) of4.21%),a wide linear range(from 3 to 1215 μmol/L) with a sensitivity of 216.9 μA L/mmol/cm^2 under the optimal conditions.Moreover,the as-prepared sensor also showed excellent selectivity and stability for hydrogen peroxide detection.The excellent performance of CuS/RGO hybrid,especially the lower detection limit than certain enzymes and noble metal nanomaterials ever reported,makes it a promising candidate for non-enzymatic H_2O_2 sensors. | Wei Liu Chaojun Lei Hongxiu Zhang Xiaolin Wu Qing Jia Denghong He Bin Yang Zhongjian Li Yang Hou Lecheng Lei Xingwang Zhang | 2017 | Chinese Chemical Letters2017，28，6： | 1 |
| 10 | Transgenic silkworms (Bombyx mori) produce recombinant spider dragline silk in eoeoons 显示文摘 | WEN Hongxiu LAN Xiqian ZHANG Yuansong | 2010 | Mol Biol Rep2010，37，4： | 1 |
| 11 | Review on plant-derived bioactive peptides:biological activities,mechanism of action and utilizations in food development显示文摘Plant proteins are good alternative to animal sources in bioactive peptide production due to their safety,low-cost,rich resources and easy for large scale production.The bioactivities of the peptides derived from plant proteins including antihypertensive,hypocholesterolemic,immunomodulatory,antioxidant,antimicrobial,anti-diabetic,opiate and hepatoprotective effect are being increasingly recognized with regards to health promoting and disease prevention.In addition to bioactivities,the plant-derived bioactive peptides possess various functional properties including emulsifying and foaming properties,and water and oil retention capacities owning to the hydrophilic/lipophilic property,conformational flexibility and chain length of peptides.Hence,the plant-derived bioactive peptides are promising ingredients for the development of health-care and functional products.This review provides the research progress on the biological activities and functional properties of plant derived peptides.The mechanism of action and structure-activity relationships of the bioactive peptide were also described,when known.Furthermore,recent developments,major challenges and prospect in the application of the plant-derive bioactive peptides in the development of functional products are discussed and summarized.The objective of this review is to improve the understanding of plant-derive bioactive peptides,and provide some constructive inspirations for further research and industrial application in the food and medicine industry. | Hongxiu Fan Hongcheng Liu Yanrong Zhang Shanshan Zhang Tingting Liu Dawei Wang | 2022 | Journal of Future Foods2022，2，2： | 0 |
| 12 | SIRT5 is important for bacterial infection by regulating insulin secretion and glucose homeostasis显示文摘Dear Editor,Recent studies indicate that cellular metabolism plays a key role in supporting immune cell development,maintenance and function(Norata et al.,2015).For example,sensing of microbial ligands by macrophages triggers increased glucose metabolism,which delivers energy to support antimicrobial inflammation and the production of cytokines.This effect further enhances the generation of mitochondrial reactive oxygen species(ROS)to fight infections. | Cuiping Zhang Ke Wang Zuojian Hu Lujie Yang Bin Wei Shan Li Xue Qin Pengyuan Yang Hongxiu Yu | 2020 | Protein & Cell2020，11，11： | 0 |
| 13 | Use of nerve conduits for peripheral nerve injury repair:A Web of Science-based literature analysis显示文摘OBJECTIVE: To identify global research trends in the use of nerve conduits for peripheral nerve injury repair. DATA RETRIEVAL: Numerous basic and clinical studies on nerve conduits for peripheral nerve injury repair were performed between 2002-2011. We performed a bibliometric analysis of the institutions, authors, and hot topics in the field, from the Web of Science, using the key words peripheral nerve and conduit or tube. SELECTION CRITERIA: Inclusion criteria: peer-reviewed published articles on nerve conduits for peripheral nerve injury repair, indexed in the Web of Science; original research articles, reviews, meeting abstracts, proceedings papers, book chapters, editorial material, and news items. Exclusion criteria: articles requiring manual searching or telephone access; documents not published in the public domain; and several corrected papers. MAIN OUTCOME MEASURES: (a) Annual publication output; (b) publication type; (c) publication by research field; (d) publication by journal; (e) publication by funding agency; (f) publication by author; (g) publication by country and institution; (h) publications by institution in China; (i) most-cited papers. RESULTS: A total of 793 publications on the use of nerve conduits for peripheral nerve injury repair were retrieved from the Web of Science between 2002-2011. The number of publications gradually increased over the 10-year study period. Articles constituted the main type of publication. The most prolific journals were Biomaterials, Microsurgery, and Journal of Biomedical Materials Research Part A. The National Natural Science Foundation of China supported 27 papers, more than any other funding agency. Of the 793 publications, almost half came from American and Chinese authors and institutions. CONCLUSION: Nerve conduits have been studied extensively for peripheral nerve regeneration; however, many problems remain in this field, which are difficult for researchers to reach a consensus. | Jinniang Nan Xuguang Hu Hongxiu Li Xiaonong Zhang Renjing Piao | 2012 | Neural Regeneration Research2012，7，35： | 0 |
| 14 | Total Synthesis of Stemarene and Betaerene Diterpenoids:Divergent Ring-Formation Strategy and Late-Stage C–H Functionalization显示文摘A unified protecting group-free approach to two stemarene and two betaerene diterpenoids through a bioinspired two-phase strategy has been developed,and three of them were obtained for the first time via chemical synthesis.Starting from a common intermediate,two distinct tetracyclic frameworks containing diastereoisomeric bridged bicycles were constructed by a divergent ring reorganization strategy.Late-stage C–H functionalization through a xanthylation-oxygenation protocol furnished the corresponding oxygenated stereocenters or oxo functionality in high regio-and diastereoselective fashion within a complex hydrocarbon system.The stereochemical puzzles in(–)-2-acetoxybetaer13(17)-ene and(+)-7-acetoxybetaer-13(17)-ene were first predicted by the comparison of density functional theory(DFT)-nuclear magnetic resonance(NMR)data with the reported data and then unambiguously addressed through the total syntheses of natural products and three diastereomers. | Renzhi Chen Feng Zhang Yuhui Hua Dong Shi Xin Lei Hongxiu Xiao Yinong Wang Shihao Ding Yang Shen Yandong Zhang | 2022 | CCS Chemistry2022，4，3： | 0 |
| 15 | Effect of Tremella fuciformis polysaccharide on the stalling and flavor of tteok during storage显示文摘The effect of Tremella fuciformis polysaccharide(TFP)on the retrogradation property and aroma profile changes of tteok during storage was investigated.Results indicated that addition of TFP significantly increased the stability to thermal and mechanical shearing of starch,decreased short-term retrogradation,the hardness and the retrogradation enthalpy(ΔH)of tteok during storage,but had no significant effect on the amylopectin chain length of tteok.The possible mechanism for the retarding staling effect of TFP is related to the interaction between TFP and starch chains that interferes with the alignment of starch chains.Electronic nose and g as chromatography-mass spectrum(GC-MS)analysis results showed that the difference in the concentrations of volatile compounds and fatty acids of tteoks at different storage time gradually increased with the advancement of storage period.The addition of TFP to tteok inhibited the development of unpleasant volatile compounds,probably by delaying the oxidation and decomposition of lipids and preserving the antioxidant phenolic compounds in tteok,thus slowing down the flavor deterioration of tteok and contributing to flavor maintainace.Overall,this study could help food manufacturers to choose a high-effective and natural polysaccharide to control the retrogradation rate and flavor loss of tteok. | Hongxiu Fan Hongcheng Liu Wenyi Li Wenjing Su Dawei Wang Shanshan Zhang Tingting Liu Yanrong Zhang | 2023 | Food Science and Human Wellness2023，12，1： | 0 |
| 16 | Activation of the 5-hydroxytryptamine 4 receptor ameliorates tight junction barrier dysfunction in the colon of type 1 diabetic mice显示文摘Hyperglycemia drives dysfunction of the intestinal barrier.5-Hydroxytryptaine 4 receptor(5-HT4R)agonists have been considered therapeutics for constipation in clnic.However,the roles of 5-HT4R activation in mucosa should be fully realized.Here,we investigate the effects of 5-HT4R activation on diabetes-induced disruption of the tight junction(TJ)barrier in the colon.Not surprisingly,the TJ barrier in diabetic mice with or without 5-HT4R is tremendously destroyed,as indicated by increased serum fluorescein isothiocyanate(FITC)-dextran and decreased transepithelial electrical resistance(TER).Simultaneously,decreased expressions of TJ proteins are shown in both wild-type(WT)and 5-HT4R knockout(KO)mice with diabetes.Notably,chronic treatment with intraperitoneal injection of a 5-HT4R agonist in WT mice with diabetes repairs the TJ barrier and promotes TJ protein expressions,including occludin,claudin-1 and ZO-1,in the colon,whereas a 5-HT4R agonist does not improve TJ barrier function or TJ protein expressions in 5-HT4R KO mice with diabetes.Furthermore,stimulation of 5-HT4R inhibits diabetesinduced upregulation of myosin light chain kinase(MLCK),Rho-associated coiled coil protein kinase 1(ROCK1),and phosphorylated myosin light chain(p-MLC),which are key molecules that regulate TJ integrity,in the colonic mucosa of WT mice.However,such action induced by a 5-HT4R agonist is not observed in 5-HT4R KO mice with diabetes.These findings indicate that 5-HT4R activation may restore TJ integrity by inhibiting the expressions of MLCK,ROCK1 and p-MLC,improving epithelial barrier function in diabetes. | Shasha Hu Yueting Kou Xiaochen Liu Weifang Rong Hongxiu Han Guohua Zhang | 2023 | Acta Biochimica et Biophysica Sinica2023，55，12： | 0 |
| 17 | Metastasis-related genes in hepatocellular carcinoma cell-lines are clustered on chromosome territories predicted by transcriptome and proteome显示文摘Recently,we have analyzed expressional transcriptome and proteome for a number of cancer cell lines,including 8hepatocellular carcinoma(HCC)ones[1,2].These 8 HCC cell lines consist of 6 metastatic(all with mutant p53)and 2non-metastatic(with a mutant and a lost p53)ones,being all HBV traceable for relatively close genetic-backgrounds.We have analyzed the related dataset and obtained transcriptome(16353 genes)and proteome(7861 proteins)of these 8HCC cell lines,and explored a group of up-regulated | Li Feng Hong Li Yang Zhang Huali Shen Hongxiu Yu Fan Zhong Lunxiu Qin Fuchu He Pengyuan Yang Zhaoyou Tang | 2016 | Science China Chemistry2016，59，3： | 0 |
| 18 | Identification of a Novel OsCYP2 Allele that Was Involved in Rice Response to Low Temperature Stress显示文摘Cyclophilin(CYP)plays an important role in plant response to stress,and OsCYP2,one gene of cyclophlilin family,is involved in auxin signal transduction and stress signaling in rice.However,the mechanism that OsCYP2 is involved in rice response to low temperature is still unclear.We identified a new OsCYP2 allelic mutant,lrl3,with fewer lateral roots,and the differences in shoot height,primary root length and adventitious root length increased with the growth process compared to the wild-type plant.Auxin signaling pathway was also affected and became insensitive to gravity.The transgenic rice plants with over-expression of OsCYP2 were more tolerant to low temperature than the wild-type plants,suggesting that OsCYP2 was involved in the low temperature response in rice.In addition,OsCYP2 negatively regulated the expression of OsTPS38,a terpene synthase gene,and was dependent on the OsCDPK7-mediated pathway in response to low temperature stress.OsTPS38-overexpressed transgenic line ox-2 was more sensitive to low temperature.Therefore,OsCYP2 may negatively regulate OsTPS38 through an OsCDPK7-dependent pathway to mediate the response to low temperature in rice.These results provide a new basis for auxin signaling genes to regulate rice response to low temperature stress. | Hongxiu Gao Lin Zhu Tianqi Liu Xueyu Leng Zhenxing Zhu Wei Xie Haitao Lv Zhengxun Jin Ping Wu Zhongchen Zhang | 2023 | Phyton-International Journal of Experimental Botany2023，92，6： | 0 |
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