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| 1 | Molecular feature and therapeutic perspectives of immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome显示文摘Regulatory T(Treg) cells, a subtype of immunosuppressive CD4^+T cells, are vital for maintaining immune homeostasis in healthy people. Forkhead box protein P3(FOXP3), a member of the forkhead-wingedhelix family, is the pivotal transcriptional factor of Treg cells. The expression, post-translational modifications, and protein complex of FOXP3 present a great impact on the functional stability and immune plasticity of Treg cells in vivo. In particular, the mutation of FOXP3 can result in immune dysregulation,polyendocrinopathy, enteropathy, X-linked(IPEX) syndrome, which is a rare genetic disease mostly diagnosed in early childhood and can soon be fatal. IPEX syndrome is related to several manifestations,including dermatitis, enteropathy, type 1 diabetes, thyroiditis, and so on. Here, we summarize some recent findings on FOXP3 regulation and Treg cell function. We also review the current knowledge about the underlying mechanism of FOXP3 mutant-induced IPEX syndrome and some latest clinical prospects.At last, this review offers a novel insight into the role played by the FOXP3 complex in potential therapeutic applications in IPEX syndrome. | Qianru Huang Xu Liu Yujia Zhang Jingyao Huang Dan Li Bin Li | 2020 | Journal of Genetics and Genomics2020，47，1： | 8 |
| 2 | HMGB1-mediated autophagy promotes gefitinib resistance in human non-small cell lung cancer显示文摘Non-small cell lung cancer(NSCLC)ranks the first in incidence and mortality among malignant tumors in China.Molecular targeted therapies such as gefitinib,an oral inhibitor of the epidermal growth factor receptor tyrosine kinase,have shown significant benefits in patients with advanced NSCLC.However,most patients have unsatisfactory outcomes due to the development of drug resistance,and there is an urgent need to better understand the pathways involved in the resistance mechanisms.In this study,we found that HMGB1 is highly expressed in drug-resistant cells and confers to gefitinib resistance in NSCLC cells via activating autophagy process.Gefitinib upregulates HMGB1 expression in time-dependent and dose-dependent manners in human NSCLC cells.RNA interference-mediated knockdown of HMGB1 reduces PC9GR cell viability,induces apoptosis,and partially restores gefitinib sensitivity.Mechanistic analyses indicate that elevated HMGB1 expression contributes to gefitinib resistance by inducing autophagy.Thus,our results suggest that HMGB1 is an autophagy regulator and plays a key role in gefitinib resistance of NSCLC. | Tianyao Lei Jiali Huang Fei Xie Jingyao Gu Zhixiang Cheng Zhaoxia Wang | 2022 | Acta Biochimica et Biophysica Sinica2022，54，4： | 2 |
| 3 | ConceptualDesign and System Analysis of a Poly-Generation System forPower and Olefin Production from Natural Gas显示文摘 | Qian Yu Liu Jingyao Huang Zhixian | 2009 | ApplEnergy2009，86，10： | 1 |
| 4 | Robust Reconstruetion of Block Sparse Signals from Adaptively One-Bit Measurements显示文摘Though various theoretical results and algorithms have been proposed in one-bit Compressed sensing(l・bit CS),t here are few stu dies on more structured signals,such as block sparse signals.We address the problem of recovering block sparse signals from one-bit measurements.We first propose two recovery schemes,one based on second-order cone programming and the other based on hard thresholding,for common non-adaptively thresholded one-bit measurements.Note that the worst・case error in recovering sparse signals from non・adaptively thresholded one-bit measurements is bounded below by a polynomial of oversampling factor.To break the limit,we introduce a recursive strategy that allows the thresholds in quantization to be adaptive to previous measurements at each it eration.Using the scheme,we propose two iterative algorithms and show that corresponding recovery errors are both exponential functions of the oversampling factor.Several simulations are conducted to reveal the superiority of our methods to existing approaches. | HOU Jingyao WANG Jianjun ZHANG Feng HUANG Jianwen | 2020 | Chinese Journal of Electronics2020，29，5： | 1 |
| 5 | Tensor restricted isometry property analysis for a large class of random measurement ensembles显示文摘Dear editor,Low-rank tensor recovery(LRTR)[1]is a natural higherorder generalization of the compressed sensing(CS)[2]and the low-rank matrix recovery(LRMR)[3,4].It has been applied extensively in various fields of artificial intelligence,including computer vision,image processing and machine learning. | Feng ZHANG Wendong WANG Jingyao HOU Jianjun WANG Jianwen HUANG | 2021 | Science China(Information Sciences)2021，64，1： | 1 |
| 6 | Effectiveness and safety of tripterygium glycosides tablet(雷公藤多苷片)for lupus nephritis:a systematic review and Meta-analysis显示文摘OBJECTIVE:To investigate the effectiveness and safety of tripterygium glycosides(TG)tablet(雷公藤多苷片)for the treatment of Lupus nephritis(LN).METHODS:Several databases were systematically searched including Pub Med,Embase,Cochrane,Wiley,China National Knowledge Infrastructure Database,Sino Med and Wanfang Library till June 20,2020.Revman5.3 was utilized to analyze the data according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Statement.RESULTS:In total,8 randomized controlled trials involving 583 participants were identified.Meta-analyses showed that,compared with glucocorticoids(GC)alone,the combination with TG tablet provided a statistically significant improvement in total remission(TR)(RR=1.27,95%CI:1.08–1.50,P=0.004),complete remission(CR)(RR=1.61,95%CI:1.05–2.47,P=0.03)and C3 levels(WMD=0.27,95%CI:0.14–0.39,P<0.0001),C4 levels(WMD=0.12,95%CI:0.07–0.17,P<0.00001).No significant differences were seen in TR,CR,proteinuria,serum creatinine,C3 and C4(TR:RR=1.00,95%CI:0.87–1.16,P=0.95;CR:RR=1.10,95%CI:0.78–1.56,P=0.58;proteinuria levels:WMD=-0.06,95%CI:-0.13 to 0.01,P=0.10;serum creatinine levels:WMD=-0.01,95%CI:-7.36 to 7.35,P=1.00;C3 levels:WMD=0.01,95%CI:-0.06 to 0.07,P=0.84;C4 levels:WMD=-0.01,95%CI:-0.03 to 0.01,P=0.49)between azathioprine(AZA)/leflomit(LEF)+GC and TG tablet+GC.Adverse events(hepatic dysfunction,nausea,vomitting)showed no statistical differences between the TG tablet+GC group and the GC group.There were more new onset of irregular menstruation in the TG tablet+GC group than those in the AZA+GC(RR=3.57,95%CI:1.40–9.11,P=0.008)/LEF+GC(RR=6.69,95%CI:2.42-18.46,P=0.0002)group,but leucopenia lower than those in AZA+GC group(RR=0.38,95%CI:0.17-0.85,P=0.02)and alopecia(RR=0.14,95%CI:0.03-0.77,P=0.02)and rash(RR=0.09,95%CI:0.01-0.69,P=0.02)lower than those in LEF+GC group.Conclusions:This review indicates that TG tablet maybe effective in LN treatment.Nevertheless,adverse events cannot be ignored.Large sample,multi-center,highquality clinical studies are needed to verify the exact effects and safety of TG tablet in treatment of LN. | ZHOU Yingyan LIANG Huasheng YAN Jingyao HE Xiaohong PAN Lili LI Xue CHEN Xianghong CHEN Xiumin YANG Aicheng HUANG Qingchun | 2022 | Journal of Traditional Chinese Medicine2022，42，5： | 0 |
| 7 | Halide Anchors for Single-Cluster Electronics显示文摘Due to their unique electronic structure,well-defined metal clusters at the atomic level are promising materials for single-cluster electronics.However,coupling between the electrode and the cluster remains challenging mainly due to the coverage of bulky ligands on the noble clusters.Using the scanning tunneling microscopy break junction(STM-BJ)technique,we have developed a“direct contact”approach to fabrication and investigation of the charge transport through single-cluster junctions of AgCu bimetallic metal clusterswith different halide anchors.Wefound that the electrodes could make contact directly with the surface halides of the single-cluster junctions and experience different contact resistance from different halogen atoms.Experiments and calculations reveal that the halide anchors provided efficient coupling between the cluster and the electrode,and the enhanced coupling with various halide anchors promoted electron transport and improved transmission probability.Our work offers a“direct contact”strategy for interface design between clusters of noble metals and electrodes,an essential step in progress toward single-cluster electronics. | Caiyun Wei Jingyao Ye Yuming Su Jueting Zheng Siqiang Xiao Jiawei Chen Saisai Yuan Chengyang Zhang Jie Bai Han Xu Jia Shi Jiale Huang Wenjing Hong | 2023 | CCS Chemistry2023，5，7： | 0 |
| 8 | THE BROAD-BAND CCD PHOTOMETRY AND DUST PRODUCTION RATES OF COMET HALE-BOPP显示文摘Based upon broad-band CCD observation data of comet Hale-Bopp obtained by a 60cm telescope at Xinglong Station of Beijing Astronomical Observatory during March-August, 1996, the photometric results of comet Hale-Bopp are reported. Using the photometric results, the dust production rate, radius and mass of nucleus of comet Hale-Bopp are estimated as follows: dM/dt~1.5×10 5 kgs -1, R n~35.5km, and M n~5.65×10 16kg. | Huang Keliang 1 Hu Jingyao 2 Zhou Hongnan 1 (1. Department of Physics, Nanjing Normal University, Nanjing 210097) (2. Beijing Observatory, Chinese Academy of Sciences, Beijing 100080) | 2000 | 中国科学院上海天文台年刊2000，，S1： | 0 |
| 9 | Sub-nanometer supramolecular rectifier based on the symmetric building block with destructive σ-interference显示文摘Molecular rectifier, as a basic function of molecular electronic devices, has attracted extensive attention for the opportunity in constructing sub-nanometer electronic devices. However, tunneling leakage current has a significant contribution as electronic devices shrink in size, which leads to a challenge in fabricating molecular rectifiers at the sub-nanometer scale. Here, we experimentally demonstrate a sub-nanometer molecular rectifier based on the supramolecular junction assembled between water and 1,4-diazabicyclo[2.2.2]octane (DABCO) molecule. The charge transport through DABCO and corresponding supramolecular junctions exhibits destructive σ-interference, ensuring a sharp conductance variation for transmission modulation. The supramolecular interaction between DABCO and water readily introduces the asymmetric electrode-molecule interaction, which combines with the destructive σ-interference to support the sub-nanometer rectification. | Longfeng Huang Yu Zhou Yaorong Chen Jingyao Ye Junyang Liu Zongyuan Xiao Chun Tang Haiping Xia Wenjing Hong | 2021 | Science China Chemistry2021，64，8： | 0 |
| 10 | JARID2 coordinates with the NuRD complex to facilitate breast tumorigenesis through response to adipocyte-derived leptin显示文摘Background Proteins containing the Jumonji C(JmjC)domain participated in tumorigenesis and cancer progression.However,the mechanisms underlying this effect are still poorly understood.Our objective was to investigate the role of Jumonji and the AT-rich interaction domain-containing 2(JARID2)—a JmjC family protein—in breast cancer,as well as its latent association with obesity.Methods Immunohistochemistry,The Cancer Genome Atlas,Gene Expression Omnibus,and other databases were used to analyze the expression of JARID2 in breast cancer cells.Growth curve,5-ethynyl-2-deoxyuridine(EdU),colony formation,and cell invasion experiments were used to detect whether JARID2 affected breast cancer cell proliferation and invasion.Spheroidization-based experiments and xenotumor transplantation in NOD/SCID mice were used to examine the association between JARID2 and breast cancer stemness.RNA-sequencing,Kyoto Encyclopedia of Genes and Genomes,and Gene Set Enrichment Analysis were used to identify the cell processes in which JARID2 participates.Immunoaffinity purification and silver staining mass spectrometry were conducted to search for proteins that might interact with JARID2.The results were further verified using co-immunoprecipitation and glutathione S-transferase(GST)pull-down experiments.Using chromatin immunoprecipitation(ChIP)sequencing,we sought the target genes that JARID2 and metastasis-associated protein 1(MTA1)jointly regulated;the results were validated by ChIP-PCR,quantitative ChIP(qChIP)and ChIP-reChIP assays.A coculture experiment was used to explore the interactions between breast cancer cells and adipocytes.Results In this study,we found that JARID2 was highly expressed in multiple types of cancer including breast cancer.JARID2 promoted glycolysis,lipid metabolism,proliferation,invasion,and stemness of breast cancer cells.Furthermore,JARID2 physically interacted with the nucleosome remodeling and deacetylase(NuRD)complex,transcriptionally repressing a series of tumor suppressor genes such as BRCA2 DNA repair associated(BRCA2),RB transcriptional corepressor 1(RB1),and inositol polyphosphate-4-phosphatase type II B(INPP4B).Additionally,JARID2 expression was regulated by the obesity-associated adipokine leptin via Janus kinase 2/signal transducer and activator of transcription 3(JAK2/STAT3)pathway in the breast cancer microenvironment.Analysis of various online databases also indicated that JARID2/MTA1 was associated with a poor prognosis of breast cancer.Conclusion Our data indicated that JARID2 promoted breast tumorigenesis and development,confirming JARID2 as a target for cancer treatment. | Wei Liu Yi Zeng Xinhui Hao Xin Wang Jiaxiang Liu Tianyang Gao Mengdi Wang Jingyao Zhang Miaomiao Huo Ting Hu Tianyu Ma Die Zhang Xu Teng Hefen Yu Min Zhang Baowen Yuan Wei Huang Yunkai Yang Yan Wang | 2023 | Cancer Communications2023，43，10： | 0 |
| 11 | 重庆·明斯克州文化旅游日活动精彩纷呈显示文摘特色陶艺、手工腰带、精美木雕……3月21日,重庆·明斯克州文化旅游日在重庆国泰艺术中心举行。明斯克州民间工艺品展、“明斯克州——白俄罗斯的心脏”摄影展与重庆印象图片展,充分展示了丰富多彩的白俄罗斯传统文化,明斯克州文化旅游资源和医疗教育,以及重庆城市风貌、人文自然风情。 | 刘丁睿 唐安冰(图) Huang Jingyao(Translator) | 2019 | 重庆与世界2019，0，4： | 0 |
| 12 | Ultrafast photoexcitation dynamics behavior of hydrogen-bonded polyfluorenol显示文摘Exciton behavior is crucial to the exploitation of light-emitting conjugated polymer(LCPs)for optoelectronic devices.Singlet excitons are easily trapped by the intrinsically defect structures.Herein,we set a polyfluorenol(PPFOH)as an example to systematically investigate its photophysical behavior to check the role of defect structures in LCPs.According to time-resolved photoluminescence analysis,the feature emission peaks from individual chain of PPFOH in diluted DMF solution is effectively avoided the influence of fluorenone formation,but the residual green-band emission at 550nm is easily observed in the PL spectra of PPFOH dilute toluene solution obtained delay 1.5 ns,confirmed the formation of“guest”physical aggregation-induced defect structure.Remarkably,efficient and ultrafast energy transfer from individual chain to defect structure is observed in PPFOH films.Interestingly,the efficient energy transfer happened for the film obtained from DMF solution(200 ps)than those of toluene ones(600 ps).Meanwhile,compared to relatively stable green-band emission in PPFOH film from toluene solution,red-shifted emission peak(11 nm)of PPFOH film from DMF solutions exposed to saturated DNT vapor also confirmed their different aggregation-induced green-band emission.Therefore,this aggregation defect structures are influenced on the photophysical property of LCPs in solid states. | Man Xu Chuanxin Wei Yunlong Zhang Hao Li Jingyao Ma Jinyi Lin Shengjie Wang Wei Xue Qi Wei Linghai Xie Wei Huang | 2024 | Chinese Chemical Letters2024，35，1： | 0 |
| 13 | α/Sulfono-γ-AA peptide hybrids agonist of GLP-1R with prolonged action both in vitro and in vivo显示文摘Peptides are increasingly important resources for biological and therapeutic development,however,their intrinsic susceptibility to proteolytic degradation represents a big hurdle.As a natural agonist for GLP-1R,glucagon-like peptide 1(GLP-1)is of significant clinical interest for the treatment of type-2 diabetes mellitus,but its in vivo instability and short half-life have largely prevented its therapeutic application.Here,we describe the rational design of a series of a/sulfono-γ-AA peptide hybrid analogues of GLP-1 as the GLP-1R agonists.Certain GLP-1 hybrid analogues exhibited enhanced stability(t_(1/2)>14 days)compared to t_(1/2)(<1 day)of GLP-1 in the blood plasma and in vivo.These newly developed peptide hybrids may be viable alternative of semaglutide for type-2 diabetes treatment.Additionally,our findings suggest that sulfono-γ-AA residues could be adopted to substitute canonical amino acids residues to improve the pharmacological activity of peptide-based drugs. | Yan Shi Candy Lee Peng Sang Zaid Amso David Huang Weixia Zhong Meng Gu Lulu Wei Vân T.B.Nguyen-Tran Jingyao Zhang Weijun Shen Jianfeng Cai | 2023 | Acta Pharmaceutica Sinica B2023，13，4： | 0 |
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