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| 1 | Planning for a Healthy City: The Influence of Built Environment on Elderly's Body Mass Index显示文摘The influence of the built environment on human health has attracted increasing attention. Given that the elderly have been an integral part in China, the built environment not only influences their health, but also influences the life and work of their children, thus resulting in social problems. Based on questionnaire obtained data on the elderly people in Chongqing, an ordinal multi-categorical regression model is established to analyze the influence of built environment on the leisure and physical activities(especially walking) that the elderly participated in, and the influence on their Body Mass Index(BMI). The results show that, in addition to age and preference for high-calorie diet, whether there is convenient access to leisure and fitness places from where they live, and the corresponding distance in-between are significantly related to the BMI of the elderly. Particularly, the best distance range is less than 1,000 m, within which leisure and fitness places have significant impact on the BMI of the elderly and the influence shows distance decay. In the last section of this paper, according to the conclusion, proposals are put forward for the optimization of the built environment. | Chen Chun Chen Yong Yu Li Zhou Wei Liu Jinxin | 2018 | China City Planning Review2018，27，1： | 2 |
| 2 | Screening of Potential Biomarkers for Gastric Cancer with Diagnostic Value Using Label-free Global Proteome Analysis显示文摘Gastric cancer(GC)is known as a top malignant type of tumors worldwide.Despite the recent decrease in mortality rates,the prognosis remains poor.Therefore,it is necessary to find novel biomarkers with early diagnostic value for GC.In this study,we present a large-scale proteomic analysis of 30 GC tissues and 30 matched healthy tissues using label-free global proteome profiling.Our results identified 537 differentially expressed proteins,including 280 upregulated and 257 downregulated proteins.The ingenuity pathway analysis(IPA)results indicated that the sirtuin signaling pathway was the most activated pathway in GC tissues whereas oxidative phosphorylation was the most inhibited.Moreover,the most activated molecular function was cellular movement,including tissue invasion by tumor cell lines.Based on IPA results,15 hub proteins were screened.Using the receiver operating characteristic curve,most of hub proteins showed a high diagnostic power in distinguishing between tumors and healthy controls.A four-protein(ATP5B-ATP5O-NDUFB4-NDUFB8)diagnostic signature was built using a random forest model.The area under the curve(AUC)values of this model were 0.996 and 0.886 for the training and testing sets,respectively,suggesting that the four-protein signature has a high diagnostic power.This signature was further tested with independent datasets using plasma enzyme-linked immune sorbent assays,resulting in an AUC value of 0.778 for distinguishing GC tissues from healthy controls,and using immunohistochemical tissue microarray analysis,resulting in an AUC value of 0.805.In conclusion,this study identifies potential biomarkers and improves our understanding of the pathogenesis,providing novel therapeutic targets for GC. | Yongxi Song Jun Wang Jingxu Sun Xiaowan Chen Jinxin Shi Zhonghua Wu Dehao Yu Fei Zhang Zhenning Wang | 2020 | Genomics, Proteomics & Bioinformatics2020，18，6： | 1 |
| 3 | Highly in-plane anisotropy of thermal transport in suspended ternary chalcogenide Ta_(2)NiS_(5)显示文摘Energy dissipation has always been an attention-getting issue in modern electronics and the emerging low-symmetry two-dimensional(2D)materials are considered to have broad prospects in solving the energy dissipation problem.Herein the thermal transport of a typical 2D ternary chalcogenide Ta_(2)NiS_(5) is investigated.For the first time we have observed strongly anisotropic in-plane thermal conductivity towards armchair and zigzag axes of suspended few-layer Ta_(2)NiS_(5) flakes through Raman thermometry.For 7-nm-thick Ta_(2)NiS_(5) flakes,theκz i g z a g is 4.76 W·m^(−1)·K^(−1) andκa r m c h a i r is 7.79 W·m^(−1)·K^(−1),with a large anisotropic ratio(κa r m c h a i r/κz i g z a g)of 1.64 mainly ascribed to different phonon mean-free-paths along armchair and zigzag axes.Moreover,the thickness dependence of thermal anisotropy is also discussed.As the flake thickness increases,theκa r m c h a i r/κz i g z a g reduces sharply from 1.64 to 1.07.This could be attributed to the diversity in phonon boundary scattering,which decreases faster in zigzag direction than in armchair direction.Such anisotropic property enables heat flow manipulation in Ta_(2)NiS_(5) based devices to improve thermal management and device performance.Our work helps reveal the anisotropy physics of ternary transition metal chalcogenides,along with significant guidance to develop energy-efficient next generation nanodevices. | Yue Su Chuyun Deng Jinxin Liu Xiaoming Zheng Yuehua Wei Yangbo Chen Wei Yu Xiao Guo Weiwei Cai Gang Peng Han Huang Xueao Zhang | 2022 | Nano Research2022，15，7： | 1 |
| 4 | Association between the Apolipoprotein E4 and Postoperative Cognitive Dysfunction in Elderly Patients Undergoing Intravenous Anesthesia and Inhalation Anesthesia显示文摘 | Yingmin Cai Haitao Hu Pengbin Liu Gaifeng Feng Weijiang Dong Bing Yu Yulin Zhu Jinxin Song Minggang Zhao | 2012 | Anesthesiology2012，，1： | 1 |
| 5 | Construction 0D TiO_(2) nanoparticles/2D CoP nanosheets heterojunctions for enhanced photocatalytic H_(2) evolution activity显示文摘It is still of gigantic challenging to design and to optimize photocatalytic systems with cost-efficiency for photocatalytic hydrogen evolution from water splitting.Herein,noble-metal-free 2D CoP nanosheets were prepared by a phosphorization method using Co(OH)2 nanosheets as precursors,and then employed as photocatalytic cocatalyst and template to make 0D Ti O2 nanoparticles in-situ grow on the surface for construction of 0D/2D TiO_(2)/CoP hybrid by a simple hydrothermal method.The TiO2/CoP hybrid with the optimal ratio of CoP cocatalyst(1 wt.%)manifested significantly improved photocatalytic H_(2) evolution rate of 0.604 mmol g^(-1) h^(-1),which is tenfold in comparison to pure TiO2(0.06 mmol g^(-1) h^(-1).The mechanism of performance enhancement was fully investigated and supposed that 2D CoP nanosheets cocatalyst can enhance the photo-absorption and provide more active sites for water reduction reaction;furthermore,2D CoP nanosheets with smaller work function and high conductivity would form an Ohmicjunction with TiO_(2) nanoparticles,which can significantly accelerate the separation of photo-generated charge carriers and improve the exploitation of the photoexcited electrons in water redox reaction.This work is anticipated to impel more perspicacity into synthesizing innovative photocatalytic systems with 2D transition metal phosphides cocatalysts for attaining high photocatalytic H_(2) evolving pursuit. | Qinqin Liu Jinxin Huang Hua Tang Xiaohui Yu Jun Shen | 2020 | Journal of Materials Science & Technology2020，56，21： | 1 |
| 6 | Research Progress on Material Basis,Pharmacological Effect and Clinical Application of Danggui Shaoyao Powder显示文摘The research of modern pharmacology displays that main material basis of Danggui Shaoyao Powder exerting efficacy includes ligustilide,paeoniflorin,poria acid,ferulic acid,ligustrazine and so on,and its efficacy is mainly realized by regulating neural receptor-ligand interaction,cytokine release,and TNF-αinflammatory pathway.Systematic study of metabonomics,serum pharmacochemistry and network pharmacology of Danggui Shaoyao Powder sufficiently clarifies its potential pharmacodynamic mechanism,and it could provide scientific theoretical basis for its clinical application.In this paper,by systemically analyzing material basis of Danggui Shaoyao Powder,and exploring its complex pharmacological mechanism and clinical application in vivo,it could comprehensively understand the clinical value of Danggui Shaoyao Powder,so as to provide beneficial reference for further development of the material basis,quality control and classical prescription of Danggui Shaoyao Powder. | Lanqingqing ZHAO Na LI Zhe LI Jinxin LIU Yongzhou YU Haifeng PAN Zhenhua LIU Hui XIONG | 2021 | Medicinal Plant2021，12，5： | 1 |
| 7 | Prevalence and significance of Hepatitis B reverse transcriptase mutants in different disease stages of untreated patients显示文摘 | Jinxin Zheng Zheng Zeng Duyi Zhang Yanyan Yu Fang Wang Calvin Q. Pan | 2012 | Liver Int2012，，10： | 1 |
| 8 | Molecular basis of Spns2-facilitated sphingosine-1-phosphate transport显示文摘Dear Editor,As one of the critical sphingolipid metabolites in eukaryotes,sphingosine-1-phosphate(S1P)acts as a bioactive lipid mediator in the immune and vascular systems.S1P prompts its physiological roles through two mechanisms,binding to its intracellular targets or extracellular secretion.Intracellular S1P promotes cellular proliferation,whereas plasma S1P facilitates immune cell trafficking,regulates angiogenesis,and helps to maintain vascular integrity.1 Due to the amphipathic property,S1P cannot diffuse freely but has to be transported across the cell membrane through active transport.1 In the past two decades,several S1P transporters have been identified,including two major facilitator superfamily(MFS)members:Spinster homolog 2(Spns2)and Mfsd2b,and some ATP-binding cassette family transporters.Among these transporters,Spns2 is the first identified and the most extensively studied.2 Here,we reported two cryo-electron microscopy(EM)structures of human Spns2 in inward-open conformations bound to S1P or inhibitor 16d. | Bin Pang Leiye Yu Tong Li Haizhan Jiao Xiaomei Wu Jinxin Wang Ruiping He Yurou Zhang Juan Wang Hongli Hu Wei Dai Li Chen Ruobing Ren | 2024 | Cell Research2024，34，2： | 0 |
| 9 | The impact of market coordination on urban green total factor productivity:An analysis of the mediating effect of factor misallocation显示文摘Promoting market coordination and enhancing the efficiency of green growth is a necessity for China’s effective economic development.Using panel data from 2007 to 2020,this paper conducts a comprehensive study on 226 cities at the prefecture-level and above,combining theoretical analysis and empirical tests to systematically explore the impact of market cohesion on urban green total factor productivity(GTPF)and the mediating role of factor mismatch.Findings demonstrate that market coordination maximizes urban GTPF.At the mechanism level,factor mismatch plays a mediating role,and market coordination can enhance GTPF by addressing capital and labor mismatch.In terms of heterogeneity analysis,market coordination significantly promotes GTPF positively in the east-central region and negatively in the western region.In terms of technological progress and technical efficiency,the eastern region shows a larger significance than the central and western regions combined.In view of the above,the concept of market coordination development has been implemented to promote GTFP in cities. | Yafei Wang Jinxin Yu Zihan Zhao Huanhuan Huang Xi Wang Yuhang Zheng Jun He | 2023 | Chinese Journal of Population,Resources and Environment2023，21，3： | 0 |
| 10 | The Trend of Logistics Development in China显示文摘 | Gang Li Yu Liu Jinxin Zhang | 2004 | China-USA Business Review2004，3，7： | 0 |
| 11 | CRISPR/Cas9-edited Pax6-GFP reporter system facilitates the generation of mouse neural progenitor cells during differentiation显示文摘Embryonic stem cells(ESCs)obtained from blastocysts can self-renew and potentially differentiate into three germ layers,thus acting as a promising platform in cell-replacement therapies and developmental research(Evans and Kaufman,1981;Thomson et al.,1998).Neural specification of ESCs has been extensively studied due to their superior value as a cellular resource in studying neurodegenerative diseases(Tao | Yanni Li Xu Li Haisong Wang Qian Gao Jinxin Zhang Wenhao Zhang Zhisong Zhang Luyuan Li Yang Yu Ling Shuai | 2018 | Journal of Genetics and Genomics2018，45，5： | 0 |
| 12 | Revealing an initiation inhibition of RCA and its application in nucleic acid detection显示文摘Rolling circle amplification is a widely used biosensing technique.Although various secondary structures have been employed in RCA,their effects on RCA efficiency have seldom been reported.Here,we find that stems in circular templates can strongly inhibit RCA,and the primer-stem distance is responsible for the inhibition.Based on the results,we propose an initiation inhibition mechanism and present a design principle for a general RCA assay.Inspired by this mechanism,we further propose a new nucleic acid detection method.The results verify that this method can increase RCA detection sensitivity according to the target recycling principle.Besides DNA detection,it can also achieve single mismatch discrimination of miRNA detection after optimization.This method also shows convenient visualization detection.The initiation inhibition of RCA could be helpful for RCA applications as promising detection techniques. | Qian Zhuang Meiqiong Ge Xiaodong Yu Jing Chai Lu Zhang Suming Tang Hua Wei Jinxin Zhang Guojie Zhao | 2023 | Acta Biochimica et Biophysica Sinica2023，55，4： | 0 |
| 13 | Vaspin alleviates pathological cardiac hypertrophy by regulating autophagy-dependent myocardial senescence显示文摘Background:Visceral adipose tissue-derived serine protease inhibitor(vaspin),a secretory adipokine,protects against insulin resistance.Recent studies have demonstrated that serum vaspin levels are decreased in patients with coronary artery disease and that vaspin protects against myocardial ischemia-reperfusion injury and atherosclerosis.However,it remains unclear whether vaspin exerts specific effects on pathological cardiac hypertrophy.Methods:An in vivo study was conducted using a cardiac hypertrophy model established by subcutaneous injection of isoproterenol(ISO)in C57BL/6 and vaspin-ko mice.Rapamycin was administered intraperitoneally to mice,for further study.H9c2 cells and neonatal rat ventricular myocytes(NRVMs)were treated with ISO to induce hypertrophy.Human vaspin fusion protein,the proteasome inhibitor MG132,and chloroquine diphosphate were used for further mechanistic studies.Results:Here,we provide the first evidence that vaspin knockdown results in markedly exaggerated cardiac hypertrophy,fibrosis,and cardiomyocyte senescence in mice treated with ISO.Conversely,the administration of exogenous recombinant human vaspin protected NRVMs in vitro against ISO-induced hypertrophy and senescence.Furthermore,vaspin significantly potentiated the ISO-induced decrease in autophagy.Both rapamycin and chloroquine diphosphate regulated autophagy in vivo and in vitro,respectively,and participated in vaspin-mediated cardioprotection.Moreover,the PI3K-AKT-mTOR pathway plays a critical role in vaspin-mediated autophagy in cardiac tissues and NRVMs.Our data showed that vaspin downregulated the p85 and p110 subunits of PI3K by linking p85 and p110 to NEDD4L-mediated ubiquitination degradation.Conclusion:Our results show,for the first time,that vaspin functions as a critical regulator that alleviates pathological cardiac hypertrophy by regulating autophagy-dependent myocardial senescence,providing potential preventive and therapeutic targets for pathological cardiac hypertrophy. | Haiying Rui Huaxiang Yu Dan Zou Kai Chi Ping Xu Xiaoshuai Song Lulu Liu Xuting Wu Jinxin Wang Li Xue | 2024 | Emergency and Critical Care Medicine2024，4，1： | 0 |
| 14 | Self-Assembly of Schiff Base Organogelator with Enhanced Fluorescence Emission显示文摘A new organogelator based on Schiff base derivative has been designed and synthesized.It can be employed as building blocks to fabricate organic nano-or micro-structures.It shows excellent self-assembling properties.It could form stable gels with nanofiber structures in various organic solvents,such as n-butanol,benzyl alcohol,ethyl acetate,acetone,aniline.The gelation properties,structural characteristics and fluorescence of the gels were studied.Compared with the solution,the gel showed significantly enhanced emission.This organogel system can be used as a thermally driven fluorescence molecular switch. | Jinxin Han Jiefang Song Zhenfang Hao Haitao Yu Jianrong Han | 2015 | Chinese Journal of Chemistry2015，33，1： | 0 |
| 15 | The Research on the Life Cycle of Merger & Acquisition显示文摘 | Tieming Yu Jinxin Zhang XueWang | 2004 | Chinese Business Review2004，3，8： | 0 |
| 16 | The role of cAMP-dependent protein kinase A in the formation of long-term memory in Bactrocera dorsalis显示文摘The cAMP-dependent protein kinase A(PKA)signaling pathway has long been considered critical for long-term memory(LTM)formation.Previous studies have mostly focused on the role of PKA signaling in LTM induction by multiple spaced conditioning with less attention to LTM induction by a single conditioning.Here,we conducted behavioral-pharmacology,enzyme immunoassay and RNA interference experiments to study the role of the PKA signaling pathway in LTM formation in the agricultural pest Bactrocera dorsalis,which has a strong memory capacity allowing it to form a two-day memory even from a single conditioning trial.We found that either blocking or activating PKA prior to conditioning pretreatment affected multiple spaced LTM,and conversely,they did not affect LTM formed by single conditioning.This was further confirmed by enzyme-linked immunosorbent assay(ELISA)and silencing of the protein kinase regulatory subunit 2 and catalytic subunit 1.Taken together,these results suggest that activating PKA during memory acquisition helps to induce the LTM formed by multiple spaced conditioning but not by a single conditioning.Our findings challenge the conserved role of PKA signaling in LTM,which provides a basis for the greater diversity of molecular mechanisms underlying LTM formation across species,as well as possible functional and evolutionary implications. | Jinxin Yu Yanmin Hui Jiayi He Yinghao Yu Zhengbing Wang Siquan Ling Wei Wang Xinnian Zeng Jiali Liu | 2024 | Journal of Integrative Agriculture2024，23，2： | 0 |
| 17 | Research on Multi-Objective Optimization Model of Industrial Microgrid Considering Demand Response Technology and User Satisfaction显示文摘In the process of wind power,coal power,and energy storage equipment participating in the operation of industrial microgrids,the stable operation of wind-storage industrial microgrids is guaranteed by considering demand response technology and user satisfaction.This paper firstly sorts out the status quo of microgrid operation optimization,and determines themain requirements for user satisfaction considering three types of load characteristics,demand response technology,power consumption benefit loss,user balance power purchase price and wind power consumption evaluation indicators in the system.Secondly,the operation architecture of the windstorage industrialmicrogrid is designed,and themulti-objective optimizationmodel of the wind-storage industrial microgrid is established with the comprehensive operating cost and user satisfaction as the target variables,and the corresponding solution method is mentioned.Finally,a typical wind-storage industrial microgrid is selected for simulation analysis,and the results showthat,(1)Considering the demand response technology,the comprehensive operating cost of the wind-storage industrial microgrid per day is 5292.63 yuan,the user satisfaction index is 0.953,and the wind power consumption rate reaches 100%.(2)By setting four scenarios,it highlights that the grid-connected operation mode is superior to the off-grid operation mode.Considering the demand response technology,the load curve can be optimized,and the time-of-use electricity price can be fully used to coordinate the operation of each unit,which enhances the wind power consumption capacity.The compromise solution of the system comprehensive operating cost and user satisfaction under the confidence level of 0.95 is obtained,namely(5343.22,0.94).(3)The frontier curve shows that in the process of model solving,it is impossible to optimize any sub-objective by changing the control variables,which proves that there is a close relationship between the comprehensive operating cost of the system and the confidence level,which can provide effective guidance for the optimal operation of industrial microgrids. | Junhui Li Jinxin Zhong Kailiang Wang Yu Luo Qian Han Jieren Tan | 2023 | Energy Engineering2023，120，4： | 0 |
| 18 | Origins,timing and introgression of domestic geese revealed by whole genome data显示文摘Background Geese are among the most important poultry species in the world.The current generally accepted hypothesis is that the European domestic geese originated from greylag geese(Anser anser),and Chinese domestic geese have two origins,most of which originated from swan geese(Anser cygnoides),and the Yili goose originated from greylag geese.To explain the origin and demographic history of geese,we selected 14 goose breeds from Europe and China and wild populations of swan and greylag geese,and whole genome sequencing data were obtained for 74 samples.Results Population structure analysis and phylogenetic trees showed that the wild ancestor of Chinese domestic geese,except for Yili,is the swan geese,and the wild ancestor of Chinese Yili and European domestic geese is greylag geese.Analysis of the demographic history suggests that the domestication of Chinese geese occurred~3499 years ago and that of the European geese occurred~7552 years ago.Furthermore,gene flow was observed between domestic geese and their wild ancestors.Analysis of introgression showed that Yili geese had been introgressed by Chinese domestic geese,and the body size of Yili geese may be influenced by introgression events of some growthrelated genes,including IGF-1.Conclusions Our study provides evidence for the origin of geese at the genome-wide level and advances the understanding of the history of goose domestication and the traits affected by introgression events. | Junhui Wen Haiying Li Huie Wang Jincheng Yu Tao Zhu Jinxin Zhang Xinghua Li Zhihua Jiang Zhonghua Ning Lujiang Qu | 2023 | Journal of Animal Science and Biotechnology2023，14，3： | 0 |
| 19 | A Retrospective Modeling Study of the Targeted Non-Pharmaceutical Interventions During the Xinfadi Outbreak in the Early Stage of the COVID-19 Pandemic — Beijing, China, 2020显示文摘Summary What is already known about this topic?China has repeatedly contained multiple severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)outbreaks through a comprehensive set of targeted nonpharmaceutical interventions(NPIs).However,the effectiveness of such NPIs has not been systematically assessed. | Yan Wang Kaiyuan Sun Yang Pan Lan Yi Da Huo Yanpeng Wu Shuaibing Dong Jinxin Guo Xiangfeng Dou Wei Wang Shuangsheng Wu Xufang Bai Hongjie Yu Quanyi Wang | 2023 | China CDC weekly2023，5，5： | 0 |
| 20 | Investigation of anisotropic strength criteria for layered rock mass显示文摘Layered rock mass is a type of engineering rock mass with sound mechanical anisotropy,which is generally unfavorable to the stability of underground works.To investigate the strength anisotropy of layered rock,the Mohr-Coulomb and Hoek-Brown criteria are introduced to establish the two transverse isotropic strength criteria based on Jaeger's single weak plane theory and maximum axial strain theory,and parameter determination methods.Furthermore,the sensitivity of strength parameters(K 1,K 2,and K 3)that are used to characterize the anisotropy strength of non-sliding failure involved in the strength criteria and confining pressure are investigated.The results demonstrate that strength parameters K 1 and K 2 affect the strength of layered rock samples at all bedding angles except for the bedding angle of 90°and the angle range that can cause the shear sliding failure along the bedding plane.The strength of samples at any bedding angle decreases with increasing K 1,whereas the opposite is for K 2.Except for bedding angles of 0°and 90°and the bedding angle range that can cause the shear sliding along the bedding plane,K 3 has an impact on the strength of rock samples with other bedding angles that the specimens'strength increases with increase of K 3.In addition,the strength of the rock sample increases as confining pressure rises.Furthermore,the uniaxial and triaxial tests of chlorite schist samples were carried out to verify and evaluate the strength criteria proposed in the paper.It shows that the predicted strength is in good agreement with the experimental results.To test the applicability of the strength criterion,the strength data of several types of rock in the literature are compared.Finally,a comparison is made between the fitting effects of the two strength criteria and other available criteria for layered rocks. | Shuling Huang Jinxin Zhang Xiuli Ding Chuanqing Zhang Gang Han Guoqi Yu Lulu Qu | 2024 | Journal of Rock Mechanics and Geotechnical Engineering2024，16，4： | 0 |
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