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| 1 | A huge oceanic-type UHP metamorphic belt in southwestern Tianshan, China: Peak metamorphic age and P-T path显示文摘Recent progress in the study of the UHP metamorphic belt in southwestern Tianshan,China,is summarized in this paper.This about 80-km-long and over 10-km-wide UHP belt has been recognized by the discovery of coesite,coesite pseudomorphs and other UHP minerals.It is the largest oceanic-type UHP metamorphic belt reported so far.It has formed due to northward subduction of the Tianshan Paleo-Ocean.U-Pb dating of metamorphic rims of zircons from a coesite-bearing garnet-phengite schist yields a peak UHP metamorphic ages of 320±3.7 Ma.Combined with ages of 233–226 Ma obtained from rims of zircons from retrograded eclogites,a long retrograde metamorphic evolution(>70 Ma)has been revealed.According to phase equilibria modeling,the P-T paths of both coesite-bearing eclogites and garnet-phengite schists are characterized by thermal relaxation,i.e.,the metamorphic temperature peak lags behind the pressure peak,indicating that the UHP rocks experienced slow and long heating and decompression during exhumation in the subduction channel.On the basis of the field observation that a small amount of eclogite lenses is wrapped in large volumes of metapelites,and the similar P-T paths of both rock types,we propose that the exhumation of the UHP eclogites from southwestern Tianshan,China,may have resulted from the exhumation of large volumes of low-density metapelites,which carried the denser eclogites to the Earth’s surface. | ZHANG LiFei DU JinXue Lü Zeng YANG Xin GOU LongLong XIA Bin CHEN ZhenYu WEI ChunJing SONG ShuGuang | 2013 | Chinese Science Bulletin2013，58，35： | 19 |
| 2 | A new type of plunge pool―Multi-horizontal submerged jets显示文摘Based on the understanding of the mechanism of energy dissipation,a new type of plunge pool is presented with the advantages of high rate of energy dissipation,low impact pressure,and small close-to-bed velocity on the soleplate of the plunge pool.The first advantage owes to enlarged shearing energy dissipation areas in the plunge pool,while the other two are caused by the jet that enters in a nearly horizontal level to keep the soleplate from being scoured directly.All of the above arrangements make this new type of energy dissipator distinct from the underflow energy dissipation.Through experiments on the physical model,the authors found that the water flow maintained stable and submerged in horizontal direction when the flow was narrow in horizontal but thick in vertical direction.However,the wide flat nappe was ready to submerge or float as the downstream water level rised or dropped.The entire flow fields of multi-horizontal submerged jets into plunge pool were also numerically simulated.The numerical results of water surface curve,close-to-bed velocity and floor pressure agree well with the experimental data.The flow pattern in the plunge pool was analyzed after combining the laboratory data and numerical simulation. | DENG Jun,XU WeiLin,ZHANG JianMing,QU JinXue & YANG YongQuan State Key Laboratory of Hydraulics and Mountain River Engineering,Sichuan University,Chengdu 610065,China | 2008 | Science China(Technological Sciences)2008，51，12： | 12 |
| 3 | A transgene-free method for rapid and efficient generation of precisely edited pigs without monoclonal selection显示文摘Gene-edited pigs for agricultural and biomedical applications are typically generated using somatic cell nuclear transfer(SCNT).However, SCNT requires the use of monoclonal cells as donors, and the time-consuming and laborious monoclonal selection process limits the production of large populations of gene-edited animals. Here, we developed a rapid and efficient method named RE-DSRNP(reporter RNA enriched dual-sg RNA/CRISPR-Cas9 ribonucleoproteins) for generating gene-edited donor cells. RE-DSRNP takes advantage of the precise and efficient editing features of dual-sg RNA and the high editing efficiency, low off-target effects, transgene-free nature, and low cytotoxic characteristics of reporter RNA enriched RNPs(CRISPR-Cas9ribonucleoproteins), thus eliminating the need for the selection of monoclonal cells and thereby greatly reducing the generation time of donor cells from 3–4 weeks to 1 week, while also reducing the extent of apoptosis and chromosomal aneuploidy of donor cells. We applied RE-DSRNP to produce cloned pigs bearing a deletion edit of the wild-type p53-induced phosphatase 1(WIP1)gene: among 32 weaned cloned pigs, 31(97%) carried WIP1 edits, and 15(47%) were homozygous for the designed fragment deletion, and no off-target event was detected. The WIP1 knockout(KO) pigs exhibited male reproductive disorders, illustrating the utility of RE-DSRNP for rapidly generating precisely edited animals for functional genomics and disease research. REDSRNP's strong editing performance in a large animal and its marked reduction in the required time for producing SCNT donor cells support its application prospects for rapidly generating populations of transgene-free cloned animals. | Kui Xu Xiuling Zhang Zhiguo Liu Jinxue Ruan Changjiang Xu Jingjing Che Ziyao Fan Yulian Mu Kui Li | 2022 | Science China(Life Sciences)2022，65，8： | 9 |
| 4 | GABAergic Abnormalities Associated with Sensorimotor Corticostriatal Community Structural Deficits in ErbB4 Knockout Mice and First-Episode Treatment-Naive Patients with Schizophrenia显示文摘The current study was designed to explore how disruption of specific molecular circuits in the cerebral cortex may cause sensorimotor cortico-striatal community structure deficits in both a mouse model and patients with schizophrenia.We used prepulse inhibition(PPI)and brain structural and diffusion MRI scans in 23 mice with conditional ErbB4 knockout in parvalbumin interneurons and 27 matched controls.Quantitative real-time PCR was used to assess the differential levels of GABA-related transcripts in brain regions.Concurrently,we measured structural and diffusion MRI and the cumulative contribution of risk alleles in the GABA pathway genes in firstepisode treatment-naı¨ve schizophrenic patients(n=117)and in age-and sex-matched healthy controls(n=86).We present the first evidence of gray and white matter impairment of right sensorimotor cortico-striatal networks and reproduced the sensorimotor gating deficit in a mouse model of schizophrenia.Significant correlations between gray matter volumes(GMVs)in the somatosensory cortex and PPI as well as glutamate decarboxylase 1 mRNA expression were found in controls but not in knockout mice.Furthermore,these findings were confirmed in a human sample in which we found significantly decreased gray and white matter in sensorimotor cortico-striatal networks in schizophrenic patients.The psychiatric risk alleles of the GABA pathway also displayed a significant negative correlation with the GMVs of the somatosensory cortex in patients.Our study identified that ErbB4 ablation in parvalbumin interneurons induced GABAergic dysregulation,providing valuable mechanistic insights into the sensorimotor cortico-striatal community structure deficits associated with schizophrenia. | Chengcheng Zhang Peiyan Ni Yikang Liu Yang Tian Jinxue Wei Bo Xiang Liansheng Zhao Xiaojing Li Xiaohong Ma Wei Deng Wanjun Guo Rongjun Ni Yamin Zhang Qiang Wang Hailiang Huang Nanyin Zhang Tao Li | 2020 | Neuroscience Bulletin2020，36，2： | 9 |
| 5 | Research on Pressure Tactile Sensing Technology Based on Fiber Bragg Grating Array显示文摘一个压力触觉的传感器基于纤维布拉格栅栏(FBG ) ,数组在这篇论文,和它的有弹性的身体的数字模拟被介绍被有限元素软件(ANSYS ) 实现。根据模拟,纤维布拉格栅栏绳在灵活硅酮被植入认识到传感器制造过程,并且一个严峻的系统被造。一系列刻度测试经由高精确被做通用出版社机器。触觉的传感器数组察觉了外部压力,它被纤维栅栏解调仪器使解调,并且三尺寸的图画被规划视觉上显示位置和尺寸。同时,传感器的一个动态接触实验为模仿在未知环境遇到另外的目标的机器人被进行。试验性的结果证明传感器有好线性,重覆性,并且有动态反应的好效果,并且它的压力敏感是 0.03 nm/N。另外,传感器也有反电磁的干扰的优点,好灵活性,简单结构,低等等花费,它被期望以后在便携人工的皮肤被过去常。 | Jinxue SONG Qi JIANG Yuanyang HUANG Yibin LI Yuxi JIA Xuewen RONG Rui SONG Hongbin LIU | 2015 | Photonic Sensors2015，5，3： | 8 |
| 6 | MEF2C mediates the activation induced cell death(AICD)of macrophages显示文摘有免疫力的房间的导致激活的房间死亡(AICD ) 广泛地被相信为有免疫力的回答的规定关键。尽管巨噬细胞 apoptosis 在许多病理学的条件下面被观察了,是否并且怎么有巨噬细胞的 AICD 的问题巨噬细胞寿命被调整很好没被探讨。在巨噬细胞的 AICD 要求二个信号。一个人是 LPS 或另外的细菌的部件触发的房间激活。其它是存在在的一个事件 AICD 易受影响(告知) 然而并非 unsusceptible (休息) 巨噬细胞。这里,我们证明当它与沙门氏菌 typhimurium,类型 5 侵入人体气管粘膜的病菌(Ad5 ) 或 IFN-gamma 被告知时,那个 RAW264.7 房间产生 LPS 刺激。我们发现抄写因素 MEF2C 的稳定性在告知的 RAW264.7 房间被增加。MEF2C 的一种主导的否定形式的 Transfection 保护告知的巨噬细胞免受 LPS 触发的房间死亡的伤害。我们的数据证明 MEF2C 蛋白质稳定性的增加是在巨噬细胞的 AICD 的一个关键因素。 | Wenxia Fu Jinxue Wei Jun Gu | 2006 | Cell Research2006，16，6： | 5 |
| 7 | Long-term,multidomain analyses to identify the breed and allelic effects in MSTN-edited pigs to overcome lameness and sustainably improve nutritional meat production显示文摘Beef and mutton production has been aided by breeding to integrate allelic diversity for myostatin(MSTN),but a lack of diversity in the MSTN germplasm has limited similar advances in pig farming.Moreover,insurmountable challenges with congenital lameness and a dearth of data about the impacts of feed conversion,reproduction,and meat quality in MSTN-edited pigs have also currently blocked progress.Here,in a largest-to-date evaluation of multiple MSTN-edited pig populations,we demonstrated a practical alternative edit-site-based solution that overcomes the major production obstacle of hindlimb weakness.We also provide long-term and multidomain datasets for multiple breeds that illustrate how MSTN-editing can sustainably increase the yields of breed-specific lean meat and the levels of desirable lipids without deleteriously affecting feed-conversion rates or litter size.Apart from establishing a new benchmark for the data scale and quality of genome-edited animal production,our study specifically illustrates how gene-editing site selection profoundly impacts the phenotypic outcomes in diverse genetic back-grounds. | Ziyao Fan Zhiguo Liu Kui Xu Tianwen Wu Jinxue Ruan Xinmin Zheng Shideng Bao Yulian Mu Tad Sonstegard Kui Li | 2022 | Science China(Life Sciences)2022，65，2： | 5 |
| 8 | Transportation Development Transition in China显示文摘Scientific development is an invaluable asset to a country.Policies and development modes should be carried out based on scientific findings not only in industry,but also in transportation infrastructure construction.Building an integrated transportation system,which is in line with the national requirements of China and supports sustainable socio-economic development,is a key strategic issue related to building a moderately prosperous society and achieving realistic goals of a medium-level developed country.Based on a systematic review of the advances in China's transportation infrastructure over the last 60 years,this paper explores the main drivers of transportation development,including national policy,transportation structure,investment efficiency,and technological innovation.Analysis shows that China's comprehensive transportation infrastructure construction since 1949 can be divided into five stages initiated by these drivers,which correspond to four transition modes:policy transition,structural transition,efficiency transition,and technology transition.The transition path of China's transportation development shows that the dominant factors have changed,and the interval for each transition has shortened.With the implementation of the '12th Five-Year Plan',China's transportation infrastructure construction is showing some new characteristics and facing a new development transition.Finally,this paper analyzes the trends in transportation development in China and concludes that technological innovation will be the main driving force to increase the transportation supply and service area in the future. | JIN Fengjun DING Jinxue WANG Jiao'e LIU Dong WANG Chengjin | 2012 | Chinese Geographical Science2012，22，3： | 4 |
| 9 | The mechanism of nucleation of hydrogen blister in metals显示文摘The nucleating, growing and cracking of hydrogen blister have been investigated experimentally and theoretically. The results show that atomic hydrogen induces superabundant vacancies in metals. The superabundant vacancies and hydrogen aggregate into a hydrogen-vacancy cluster (microcavity). The hydrogen atoms in the microcavity become hydrogen molecules which can stabilize the cluster. And the hydrogen blister nucleates. With the entry of vacancies and hydrogen atoms, the blister nucleus grows and the pressure in the cavity increases. When the stress induced by hydrogen pressure on the blister is up to the cohesive strength, cracks will initiate from the wall of the blister. | REN XueChong ZHOU QingJun CHU WuYang LI JinXu SU YanJing QIAO LiJie | 2007 | Chinese Science Bulletin2007，52，14： | 4 |
| 10 | Interaction Between Variations in Dopamine D2 and Serotonin 2A Receptor is Associated with Short-Term Response to Antipsychotics in Schizophrenia显示文摘Dear Editor,Schizophrenia is a chronic and debilitating brain disorder,which has a strong genetic component with heritability ranging from 66%to 85%[1,2].Currently,antipsychotic drugs remain the most effective treatment for the psychotic symptoms of schizophrenia[3].Because of the severe sideeffects of first-generation antipsychotics(FGAs),secondgeneration antipsychotics(SGAs)have become more widely used in the treatment of schizophrenia. | Liansheng Zhao Huijuan Wang Yamin Zhang Jinxue Wei Peiyan Ni Hongyan Ren Gang Li Qiang Wang Gavin P Reynolds Weihua Yue Wei Deng Hao Yan Liwen Tan Qi Chen Guigang Yang Tianlan Lu Lifang Wang Fuquan Zhang Jianli Yang Keqing Li Luxian Lv Qingrong Tan Yinfei Li Hua Yu Hongyan Zhang Xin Ma Fude Yang Lingjiang Li Chuanyue Wang Huiyao Wang Xiaojing Li Wanjun Guo Xun Hu Yang Tian Xiaohong Ma Jeremy Coid Dai Zhang Chao Chen Tao Li Chinese Antipsychotics Pharmacogenomics Consortium | 2019 | Neuroscience Bulletin2019，35，6： | 3 |
| 11 | Antioxidative and immunological effects of Cyclocarya paliurus polysaccharides on the spleen injury of diabetic rats显示文摘OBJEVTIVE:To investigate the effects of Cyclocarya paliurus(C.paliurus)polysaccharides on the spleen injury of diabetic rats.METHODS:Animals were divided into 6 groups,including normal group,model group,control group,low-dose group of C.paliurus polysaccharides treatment,middle-dose group of C.paliurus polysaccharides treatment and high-dose group of C.paliurus polysaccharides treatment.Histological analysis of spleen was analyzed using hematoxilin and eosin.Levels of biological parameters and anti-oxidative enzymes were determined by spectrophotometry.Interleukin-7(IL-7)and IL-10 were measured by enzyme-linked immunosorbent assay.RESULTS:Compared with that of model group,superoxide dismutase,catalase,glutathione peroxidase,glutathione reductase level increased 78.63%(P<0.05),51.76%(P<0.05),2.95 times(P<0.01)and 41.11%(P<0.05)in the high-dose group of C.paliurus polysaccharides treatment,respectively.IL-7 and IL-10 increase 1.66(P<0.01)and 1.21 times(P<0.01)in the high-dose group of C.paliurus polysaccharides treatment,respectively.CONCLUSION:It is suggested that C.paliurus polysaccharides may play a protecting role for spleen injury of diabetic rats by enhancing the antioxidative ability and evaluating the immunity. | XIA Xichao LI Bin QIU Ju TIAN Gang CHEN Changdong LA Ming ZHANG Ke QI Jinxu LI Yanyan GAO Huashan SHAO Xiangyang SU Congying WANG Mengqi OUYANG Jingfeng | 2021 | Journal of Traditional Chinese Medicine2021，41，5： | 2 |
| 12 | Small interfering RNA delivery to the neurons near the amyloid plaques for improved treatment of Alzheimer’s disease显示文摘Gene therapy represents a promising treatment for the Alzheimer’s disease(AD). However,gene delivery specific to brain lesions through systemic administration remains big challenge. In our previous work, we have developed an siRNA nanocomplex able to be specifically delivered to the amyloid plaques through surface modification with both CGN peptide for the blood–brain barrier(BBB)penetration and QSH peptide for β-amyloid binding. But, whether the as-designed nanocomplex could indeed improve the gene accumulation in the impaired neuron cells and ameliorate AD-associated symptoms remains further study. Herein, we prepared the nanocomplexes with an siRNA against β-site amyloid precursor protein-cleaving enzyme 1(BACE1), the rate-limiting enzyme of Aβ production, as the therapeutic siRNA of AD. The nanocomplexes exhibited high distribution in the Aβ deposits-enriched hippocampus, especially in the neurons near the amyloid plaques after intravenous administration. In APP/PS1 transgenic mice, the nanocomplexes down-regulated BACE1 in both mRNA and protein levels,as well as Aβ and amyloid plaques to the level of wild-type mice. Moreover, the nanocomplexes significantly increased the level of synaptophysin and rescued memory loss of the AD transgenic mice without hematological or histological toxicity. Taken together, this work presented direct evidences that the design of precise gene delivery to the AD lesions markedly improves the therapeutic outcome. | Qian Guo Xiaoyao Zheng Peng Yang Xiaoying Pang Kang Qian Pengzhen Wang Shuting Xu Dongyu Sheng Liuchang Wang Jinxu Cao Wei Lu Qizhi Zhang Xinguo Jiang | 2019 | Acta Pharmaceutica Sinica B2019，9，3： | 2 |
| 13 | The advancements,challenges,and future implications of the CRISPR/Cas9 system in swine research显示文摘Clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated protein 9(CRISPR/Cas9)genome editing technology has dramatically influenced swine research by enabling the production of high-quality disease-resistant pig breeds,thus improving yields.In addition,CRISPR/Cas9 has been used extensively in pigs as one of the tools in biomedical research.In this review,we present the advancements of the CRISPR/Cas9 system in swine research,such as animal breeding,vaccine development,xenotransplantation,and disease modeling.We also highlight the current challenges and some potential applications of the CRISPR/Cas9 technologies. | Jinfu Zhang Emmanuel M.Khazalwa Hussein M.Abkallo Yuan Zhou Xiongwei Nie Jinxue Ruan Changzhi Zhao Jieru Wang Jing Xu Xinyun Li Shuhong Zhao Erwei Zuo Lucilla Steinaa Shengsong Xie | 2021 | Journal of Genetics and Genomics2021，48，5： | 2 |
| 14 | Work Hardening Behavior of 1020 Steel During Cold-Beating Simulation显示文摘The present research of cold-beating formation mainly focused on roller design and manufacture, kinematics, constitutive relation, metal flow law, thermo-mechanical coupling, surface micro-topography and microstructure evolution. However, the research on surface quality and performance of workpieces in the process of cold-beating is rare. Cold-beating simulation experiment of 1020 steel is conducted at room temperature and strain rates ranging from 2000 to 4000 s^(-1) base on the law of plastic forming. According to the experimental data, the model of strain hardening of 1020 steel is established,Scanning Electron Microscopy(SEM) is conducted, the mechanism of the work hardening of 1020 steel is clarified by analyzing microstructure variation of 1020 steel. It is found that the strain rate hardening effect of 1020 steel is stronger than the softening effect induced by increasing temperatures, the process of simulation cold-beating cause the grain shape of 1020 steel significant change and microstructure elongate significantly to form a fibrous tissue parallel to the direction of deformation, the higher strain rate, the more obvious grain refinement and the more hardening effect. Additionally, the change law of the work hardening rate is investigated, the relationship between dislocation density and strain, the relationship between work hardening rate and dislocation density is obtained.Results show that the change trend of the work hardening rate of 1020 steel is divided into two stages, the work hardening rate decreases dramatically in the first stage and slowly decreases in the second stage, finally tending toward zero. Dislocation density increases with increasing strain and strain rate, work hardening rate decreases with increasing dislocation density. The research results provide the basis for solving the problem of improving the surface quality and performance of workpieces under cold-beating formation of 1020 steel. | Fengkui CUI Yuanfei LING Jinxue XUE Jia LIU Yuhui LIU Yan LI | 2017 | Chinese Journal of Mechanical Engineering2017，30，2： | 2 |
| 15 | Characterization of the archaeal community fouling a membrane bioreactor显示文摘Biofilm formation, one of the primary causes of biofouling, results in reduced membrane flux or increased transmembrane pressure and thus represents a major impediment to the wider implementation of membrane bioreactor(MBR) technologies for water purification. Most studies have focused on the role of bacteria in membrane fouling as they are the most dominant and best studied organisms present in the MBR. In contrast, there is limited information on the role of the archaeal community in biofilm formation in MBRs. This study investigated the composition of the archaeal community during the process of biofouling in an MBR. The archaeal community was observed to have lower richness and diversity in the biofilm than the sludge during the establishment of biofilms at low transmembrane pressure(TMP). Clustering of the communities based on the Bray–Curtis similarity matrix indicated that a subset of the sludge archaeal community formed the initial biofilms. The archaeal community in the biofilm was mainly composed of Thermoprotei, Thermoplasmata,Thermococci, Methanopyri, Methanomicrobia and Halobacteria. Among them, the Thermoprotei and Thermoplasmata were present at higher relative proportions in the biofilms than they were in the sludge. Additionally, the Thermoprotei, Thermoplasmata and Thermococci were the dominant organisms detected in the initial biofilms at low TMP, while as the TMP increased, the Methanopyri, Methanomicrobia, Aciduliprofundum and Halobacteria were present at higher abundances in the biofilms at high TMP. | Jinxue Luo Jinsong Zhang Xiaohui Tan Diane McDougald Guoqiang Zhuang Anthony G.Fane Staffan Kjelleberg Yehuda Cohen Scott A.Rice | 2015 | Journal of Environmental Sciences2015，27，3： | 2 |
| 16 | Investigating the bacterial community and amoebae population in rural domestic wastewater reclamation for irrigation显示文摘Reclamation of domestic wastewater for agricultural irrigation is viewed as a sustainable option to create an alternative water source and address water scarcity. Free-living amoebae(FLA), which are amphizoic protozoa, are widely distributed in various environmental sources. The FLA could cause considerable environmental and health risks. However, little information is available on the risk of these protozoa. In this study, we evaluated the feasibility using rural domestic wastewater for agricultural irrigation, and analyzed dynamic changes of the microbial community structure and FLA populations in raw and treated wastewater, as well as the phyllosphere and rhizosphere of lettuce production sites that were irrigated with different water sources. The bacterial community dynamics were analyzed by terminal restriction fragment length polymorphism(T-RFLP). The bacterial community structures in the influent were similar to that in the effluent, while in some cases relative abundances varied significantly. The populations of Acanthamoeba spp. and Hartmannella vermiformis in the anaerobically treated wastewater were significantly higher than in the raw wastewater. The vegetables could harbor diverse amoebae, and the abundances of Acanthamoeba spp. and H. vermiformis in the rhizosphere were significantly higher than in the phyllosphere. Accordingly, our studies show insight into the distribution and dissemination of amoebae in wastewater treatment and irrigation practices. | Bingjian Cui Jinxue Luo Decai Jin Bo Jin Xuliang Zhuang Zhihui Bai | 2018 | Journal of Environmental Sciences2018，30，8： | 2 |
| 17 | Analysis of transportation carbon emissions and its potential for reduction in China显示文摘The transportation industry is an essential sector for carbon emissions mitigation.This paper firstly used the LMDI(Logarithmic Mean Divisia Index)decomposition method to establish factors decomposition model on China's transportation carbon emission.Then,a quantitative analysis was performed to study the factors influencing China's transportation carbon emissions from 1991 to 2008,which are identified as transportation energy efficiency,transportation structure and transportation development.The results showed that:(1)The impact of transportation development on transportation carbon emissions showed pulling function.Its contribution value to carbon emissions remained at high growth since 1991 and showed an exponential growth trend.(2)The impact of transportation structure on transportation carbon emissions showed promoting function in general,but its role in promoting carbon emissions decreased year by year.And with the continuous optimization of transportation structure,the promoting effect decreased gradually and showed the inversed'U'trend.(3)The impact of transportation energy efficiency on transportation carbon emissions showed a function of inhibition before pulling.In order to predict the potential of carbon emission reduction,three scenarios were set.Analysis of the scenarios showed that if greater intensity emission reduction measures are taken,the carbon emissions will reduce by 31.01 million tons by 2015 and by 48.81 million tons by 2020. | Jinxue Ding Fengjun Jin Yuejiao Li Jiao'e Wang | 2013 | Chinese Journal of Population,Resources and Environment2013，11，1： | 2 |
| 18 | Evaluation and optimization of the spatial organization of the petrochemical industry in China显示文摘中国石油化学的工业的空间组织根据采用线性编程和 ArcGIS 的工业的开发的地位被优化空间分析工具。我们首先识别了石油化学的工业的空间组织的索引并且建立了包括四个主要范畴和 11 指示物的一个全面评估索引系统。每个索引的重量然后被分析层次过程决定。后来,作为基本单位花 337 中国人府级的政府并且科学地评估城市的潜在的全面布局系数, 151 个府级的行政单位与一个线性编程模型一起作为优化地点的选择的基础被选择。用 151 个府级的行政单位和最大范围的模型,第二,最佳的数字和精炼厂的空间分发为 100, 200 和 300 km 的服务半径被识别。就瓷器精炼厂的实际分发而言,第三,将军为精炼厂布局点和目的数字裁定价值被总结,并且 52 个精炼厂布局点为中国被选择。与 ArcGIS 空间分析工具,最后, 52 个最佳的精炼厂布局点的空间效果分别地为服务范围和社会经济的因素被模仿,并且为每个精炼厂布局点的 GDP 和人口数据然后在服务范围以内被提取。在这个基础上并且与粗略油的消费的紧张的评价,最后的结果为精制能力和乙烯生产能力的汉语的最佳的空间组织被获得。 | LIU He JIN Fengjun LIU Yi DING Jinxue XU Xu | 2013 | Journal of Geographical Sciences2013，23，1： | 2 |
| 19 | Glial U87 cells protect neuronal SH-SY5Y cells from indirect effect of radiation by reducing oxidative stress and apoptosis显示文摘最近的研究在 neurodegeneration 表明了放射的间接效果的角色。然而,在对放射的间接效果的 neuroprotection 的 glial 房间的角色仍然不是清楚的,尽管他们被知道在中央神经系统在压力条件下面保护神经原。我们的学习证明放射的那间接效果增加了进一步提高关键 apoptotic 蛋白质的表示并且导致 neuronal 房间死亡的氧化压力。我们也在一个 transwell 合作文化系统面对 glial 房间在 neuronal 房间上调查了放射的间接效果,当我们的分析集中于 neuronal 房间时。当间接放射和 neuroprotective 效果的来源被各种各样的端点分析,照耀的调节房间的中等 ICCM 被使用。导致 ICCM 的反应氧化种类水平显著地在与 glial U87 房间 co 有教养的 SH-SY5Y 房间被减少,这被观察,它可能帮助维持 mitochondrial 膜潜力的正直。抗氧化剂酶 superoxide dismutase 和抗氧化剂谷胱甘肽的增加的层次在与 glial U87 房间 co 有教养的 SH-SY5Y 房间被观察。而且,有 glial 房间的合作文化禁止导致 ICCM 的 apoptotic 蛋白质的表示,这也被观察,即在 SH-SY5Y 房间的 Bax,细胞色素 c,和 caspase-3。因此,在合作文化系统 glial,房间可以由减少导致 ICCM 的氧化压力和 apoptotic 死亡保护 neuronal SH-SY5Y 房间,这能被推测。 | Yasmeen Saeed Bingjie Xie JinXu Abdur Rehman Ma Hong Qing Hong Yulin Deng | 2015 | Acta Biochimica et Biophysica Sinica2015，47，4： | 2 |
| 20 | Rapid separation and idention cation of multiple constituents in traditional Chi- nese medicine formula Shenqi Fuzheng Injection by ultra-fast liquid chromatography combined with quadrupole-time-ogight mass speetrometry显示文摘 | Liu Menghua Tong Xin Wang Jinxu | 2013 | J Pharm Biomed Anal2013，74，： | 1 |
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