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| 1 | Endovascular stent-induced alterations in host artery mechanical environments and their roles in stent restenosis and late thrombosis显示文摘Cardiovascular stent restenosis remains a major challenge in interventional treatment of cardiovascular occlusive disease.Although the changes in arterial mechanical environment due to stent implantation are the main causes of the initiation of restenosis and thrombosis,the mechanisms that cause this initiation are still not fully understood.In this article,we reviewed the studies on the issue of stent-induced alterations in arterial mechanical environment and discussed their roles in stent restenosis and late thrombosis from three aspects:(i)the interaction of the stent with host blood vessel,involve the response of vascular wall,the mechanism of mechanical signal transmission,the process of re-endothelialization and late thrombosis;(ii)the changes of hemodynamics in the lumen of the vascular segment and(iii)the changes of mechanical microenvironment within the vascular segment wall due to stent implantation.This review has summarized and analyzed current work in order to better solve the two main problems after stent implantation,namely in stent restenosis and late thrombosis,meanwhile propose the deficiencies of current work for future reference. | Jinxuan Wang Xuepu Jin Yuhua Huang Xiaolin Ran Desha Luo Dongchuan Yang Dongyu Jia Kang Zhang Jianhua Tong Xiaoyan Deng Guixue Wang | 2018 | Regenerative Biomaterials2018，5，3： | 13 |
| 2 | Enhanced catalysis of ultrasmall Au-MoS_2 clusters against reactive oxygen species for radiation protection显示文摘Ionizing radiation produces excessive reactive oxygen species(ROS) which impose detrimental effects on biological systems. Thus, it is important to explore clinically safe and efficacious radioprotection agents to scavenge ROS and reduce the risks of radiotherapy. Recently, emerging catalytic nanomaterials such as sulfide nanomaterials have shown capability of clearing ROS in vivo by unique electron transfers between atoms, but their catalytic activities are yet suboptimal. As such, there is an unmet need to improve catalytic properties for stronger antioxidant activities and radiation protection. Herein, we prepared ultrasmall Au-MoS_2 clusters(~2.5 nm) and they showed enhanced catalytic properties via gold intercalation facilitating increased active sites and synergistic effects. Electrocatalysis results revealed that the catalytic activity of Au-MoS_2 towards H2O_2 was superior to ultrasmall MoS_2 without Au. As a result, we found that improving the electrocatalytic property of Au-MoS_2 can effectively enhance corresponding antioxidant activities and radioprotection effects in vivo. In addition, Au-MoS_2 also showed significant radioprotection in vitro and dramatically reduced the excess of radiation-induced adverse ROS. It also rescued radiation-induced DNA damages and protected the bone marrow hematopoietic system from ionizing radiation. | Peixian Bian Jinxuan Zhang Junying Wang Jiang Yang Jingya Wang Haile Liu Yuanming Sun Meixian Li Xiao-Dong Zhang | 2018 | Science Bulletin2018，63，14： | 2 |
| 3 | ROS-responsive biomimetic nanoparticles for potential application in targeted anti-atherosclerosis显示文摘The development of nanomedicines provides new opportunities for the treatment of atherosclerosis(AS)due to their great advantages such as the improved drug solubility,enhanced bioavailability and reduced side effects.Despite these advantages,nanomedicines are still facing some challenges.The problems remain in the short circulation life,lack of specific targeting and poor drug release controllability.In order to overcome the shortages of conventional nanomedicines,the combination of biomimetic strategy with smart nanoagents has been proposed.In light with the high reactive oxygen species(ROS)level in AS microenvironment and the fact that macrophages play a critical role in the pathogenesis of AS,we fabricated ROS-responsive biomimetic nanoparticles(NPs),which camouflaged macrophage membrane(MM)on ROS-responsive NPs loaded with rapamycin(RNPs)for potential application in AS therapy.The resulting ROSresponsive biomimetic NPs(MM/RNPs)exhibited favorable hydrodynamic size with negative surface charge,retained the functional proteins from MM,and showed ROS-responsive drug release.Because of the biomimetic camouflaging on surface,MM/RNPs could effectively escape from macrophages uptake and target to inflammatory endothelial cells.Meanwhile,MM/RNPs could inhibit the proliferation of macrophages and smooth muscle cells in vitro.Furthermore,the MM-coated NPs were found to be nontoxic in both cytotoxicity assay and in vivo toxicity evaluation.Consequently,these results demonstrated that MM/RNPs could be a potential candidate of drug delivery system for safe and effective anti-AS applications. | Dan Tang Yi Wang Andy Wijaya Boyan Liu Ali Maruf Jinxuan Wang Jianxiong Xu Xiaoling Liao Wei Wu Guixue Wang | 2021 | Regenerative Biomaterials2021，8，4： | 2 |
| 4 | Direct laser patterning of two-dimensional lateral transition metal disulfide-oxide-disulfide heterostructures for ultrasensitive sensors显示文摘Two-dimensional(2D)heterostructures based on the combination of transition metal dichalcogenides(TMDs)and transition metal oxides(TMOs)have aroused growing attention due to their integrated merits of both components and multiple functionalities.However,nondestructive approaches of constructing TMD-TMO heterostructures are still very limited.Here,we develop a novel type of lateral TMD-TMO heterostructure(NbS2-Nb2O5-NbS2)using a simple lithography-free,direct laser-patterning technique.The perfect contact of an ultrathin TMO channel(Nb2O5)with two metallic TMDs(NbS2)electrodes guarantee strong electrical signals in a two-terminal sensor.Distinct from sensing mechanisms in separate TMOs or TMDs,this sensor works based on the modulation of surface conduction of the ultrathin TMO(Nb2O5)channel through an adsorbed layer of water molecules.The sensor thus exhibits high selectivity and ultrahigh sensitivity for room-temperature detection of NH3(ΔR/R=80%at 50 ppm),superior to the reported NH3 sensors based on 2D materials,and a positive temperature coefficient of resistance as high as 15%–20%/℃.Bending-invariant performance and high reliability are also demonstrated in flexible versions of sensors.Our work provides a new strategy of lithography-free processing of novel TMD-TMO heterostructures towards high-performance sensors,showing great potential in the applications of future portable and wearable electronics. | Bolun Wang Hao Luo Xuewen Wang Enze Wang Yufei Sun Yu-Chien Tsai Jinxuan Dong Peng Liu Huanglong Li Yong Xu Sefaattin Tongay Kaili Jiang Shoushan Fan Kai Liu | 2020 | Nano Research2020，13，8： | 1 |
| 5 | trans-2-Enoyl-CoA Reductase Tecr-Driven Lipid Metabolism in Endothelial Cells Protects against Transcytosis to Maintain Blood-Brain Barrier Homeostasis显示文摘The transport and metabolism of lipids in cerebrovascular endothelial cells(ECs)have been hypothesized to regulate blood-brain barrier(BBB)maturation and homeostasis.Long-chain polyunsaturated fatty acids(LCPUFAs)as the important lipids components of cell membranes are essential for the development and function of BBB,but the direct links of lipid metabolism and ECs barrier function remain to be established.Here,we comprehensively characterize the transcriptomic phenotype of developmental cerebrovascular ECs in single-cell resolution and firstly find that trans-2-enoyl-CoA reductase(Tecr),a verylong-chain fatty acid synthesis,is highly expressed during barriergenesis and decreased after BBB maturation.EC-specific knockout of Tecr compromises angiogenesis due to delayed vascular sprouting.Importantly,EC-specific deletion of Tecr loss restrictive quality of vascular permeability from neonatal stages to adulthood,with high levels of transcytosis,but maintains the vascular tight junctions.Moreover,lipidomic analysis shows that the expression of Tecr in ECs is associated with the containing of omega-3 fatty acids,which directly suppresses caveolae vesicles formation.These results reveal a protective role for Tecr in BBB integrity and suggest that Tecr as a novel therapeutic target in the central nervous system(CNS)diseases associated with BBB dysfunction. | Jinxuan Wang Jianxiong Xu Guangchao Zang Tao Zhang Qi Wu Hongping Zhang Yidan Chen Yi Wang Weixi Qin Shuang Zhao Erdai Qin Juhui Qiu Xiaojuan Zhang Lin Wen Yeqi Wang Guixue Wang | 2022 | Research2022，，3： | 1 |
| 6 | Experimental study of interactions between multi-directional focused wave and vertical circular cylinder, Part I: Wave run-up显示文摘 | Jinxuan Li Zhanhang Wang Shuxue Liu | 2012 | Coastal Engineering2012，，： | 1 |
| 7 | 3D-printed cell-free PCL-MECM scaffold with biomimetic micro-structure and micro-environment to enhance in situ meniscus regeneration显示文摘Despite intensive effort was made to regenerate injured meniscus by cell-free strategies through recruiting endogenous stem/progenitor cells,meniscus regeneration remains a great challenge in clinic.In this study,we found decellularized meniscal extracellular matrix(MECM)preserved native meniscal collagen and glycosaminoglycans which could be a good endogenous regeneration guider for stem cells.Moreover,MECM significantly promoted meniscal fibrochondrocytes viability and proliferation,increased the expression of type II collagen and proteoglycans in vitro.Meanwhile,we designed 3D-printed polycaprolactone(PCL)scaffolds which mimic the circumferential and radial collagen orientation in native meniscus.Taken these two advantages together,a micro-structure and micro-environment dually biomimetic cell-free scaffold was manipulated.This cell-free PCL-MECM scaffold displayed superior biocompatibility and yielded favorable biomechanical capacities closely to native meniscus.Strikingly,neo-menisci were regenerated within PCL-MECM scaffolds which were transplanted into knee joints underwent medial meniscectomy in rabbits and sheep models.Histological staining confirmed neo-menisci showed meniscus-like heterogeneous staining.Mankin scores showed PCL-MECM scaffold could protect articular cartilage well,and knee X-ray examination revealed same results.Knee magnetic resonance imaging(MRI)scanning also showed some neo-menisci in PCL-MECM scaffold group.In conclusion,PCL-MECM scaffold appears to optimize meniscus regeneration.This could represent a promising approach worthy of further investigation in preclinical applications. | Weimin Guo Mingxue Chen Zhenyong Wang Yue Tian Jinxuan Zheng Shuang Gao Yangyang Li Yufeng Zheng Xu Li Jingxiang Huang Wei Niu Shuangpeng Jiang Chunxiang Hao Zhiguo Yuan Yu Zhang Mingjie Wang Zehao Wang Jiang Peng Aiyuan Wang Yu Wang Xiang Sui Wenjing Xu Libo Hao Xifu Zheng Shuyun Liu Quanyi Guo | 2021 | Bioactive Materials2021，6，10： | 1 |
| 8 | Charactering the spoilage mechanism of'three sticks'of Jinhua ham显示文摘To investigate the spoilage characteristics of Jinhua ham,sensory scores,volatile compounds,biogenic amine,physicochemical parameters and microbial counts were evaluated between normal and spoiled hams.The results showed that off-odors of spoiled hams were dominated by rancid,sour,sulfide and ammonia odors derived from these compounds including butanoic acid,methanethiol and dimethyl disulfide.Total content of biogenic amine in spoiled hams was significantly higher(more than 10-fold)compared with normal hams,and putrescine,cadaverine and histamine were the key components of biogenic amine of spoiled hams.Lower salt content,and higher moisture,TVB-N and thiobarbituric acid reactive substances(TBARS)values were observed in spoiled hams compared with normal hams.The populations of Enterobacteriaceae and Enterococcus of spoiled hams were obviously higher than that of normal hams.High moisture and low salt content caused the abnormal growth of Enterobacteriaceae and Enterococcus in spoiled hams,which contributed to the spoilage of Jinhua ham. | Changyu Zhou Guang Zhan Daodong Pan Guanghong Zhou Ying Wang Jun He Jinxuan Cao | 2022 | Food Science and Human Wellness2022，11，5： | 1 |
| 9 | Immunogenic-cell-killing and immunosuppression-inhibiting nanomedicine显示文摘Combining chemo-therapeutics with immune checkpoint inhibitors facilitates killing cancer cells and activating the immune system through inhibiting immune escape.However,their treatment effects remain limited due to the compromised accumulation of both drugs and inhibitors in certain tumor tissues.Herein,a new poly(acrylamide-co-acrylonitrile-co-vinylimidazole-co-bis(2-methacryloyl)oxyethyl disulfide)(PAAVB)polymer-based intelligent platform with controllable upper critical solution temperature(UCST)was used for the simultaneous delivery of paclitaxel(PTX)and curcumin(CUR).Additionally,a hyaluronic acid(HA)layer was coated on the surface of PAAVB NPs to target the CD44-overexpressed tumor cells.The proposed nanomedicine demonstrated a gratifying accumulation in tumor tissue and uptake by cancer cells.Then,the acidic microenvironment and high level of glutathione(GSH)in cancer cells could spontaneously decrease the UCST of polymer,leading to the disassembly of the NPs and rapid drug release at body temperature without extra-stimuli.Significantly,the released PTX and CUR could induce the immunogenic cell death(ICD)to promote adaptive anti-tumor immunogenicity and inhibit immunosuppression through suppressing the activity of indoleamine 2,3-dioxygenase 1(IDO1)enzyme respectively.Therefore,the synergism of this intelligent nanomedicine can suppress primary breast tumor growth and inhibit their lung metastasis. | Ying Wang Di Gao Yan Liu Xiaoqing Guo Shuojia Chen Li Zeng Jinxuan Ma Xingcai Zhang Zhongmin Tian Zhe Yang | 2021 | Bioactive Materials2021，6，6： | 0 |
| 10 | Unidirectional acoustic metamaterials based on nonadiabatic holonomic quantum transformations显示文摘Nonadiabatic holonomic quantum transformations(NHQTs)have attracted wide attention and have been applied in many aspects of quantum computation,whereas related research is usually limited to the field of quantum physics.Here we bring NHQTs into constructing a unidirectional acoustic metamaterial(UDAM)for shaping classical beams.The UDAM is made up of an array of three-waveguide couplers,where the propagation of acoustic waves mimics the evolution of NHQTs.The excellent agreement among analytical predictions,numerical simulations,and experimental measurements confirms the great applicability of NHQTs in acoustic metamaterial engineering.The present work extends research on NHQTs from quantum physics to the field of classical waves for designing metamaterials with simple structures and may pave a new way to design UDAMs that would be of potential applications in acoustic isolation,communication,and stealth. | JinLei Wu Shuai Tang Yan Wang XiaoSai Wang JinXuan Han Cheng Lü Jie Song ShiLei Su Yan Xia YongYuan Jiang | 2022 | Science China(Physics,Mechanics & Astronomy)2022，65，2： | 0 |
| 11 | Direct infection of SARS-CoV-2 in human iPSC-derived 3D cardiac organoids recapitulates COVID-19 myocarditis显示文摘Dear editor,The pandemic of coronavirus disease-19(COVID-19)has lasted for more than three years,causing lots of extra death and posing a serious threat to public health.This pandemic swept the last global safety island in a matter of months,coinciding with the switch of zero-COVID policy of China.The causative agent,SARS-CoV-2,spreads globally and then lurks in the population with sporadic outbreaks in local areas.Meanwhile,the sequelae of convalescent COVID-19 patients receded slowly.The pantissue tropism of SARS-CoV-2 results in a wide range of symptoms in patients,including cardiovascular disorders.Cardiac complications occur in 20%–44%of hospitalized patients,which is an independent risk factor for COVID-19 mortality(Ma et al.,2022;Patone et al.,2022).Survivors of acute COVID-19 also have a substantial risk of cardiovascular disease burden lasting up to one year(Xie et al.,2022). | Weijie Wang Jinxuan Yang Pinfang Kang Jinsong Bai Xiaoli Feng Liuqi Huang Yiming Zhang Yuechun Wu Bi Tang Hongju Wang JianJie Jiang Minghua Li Bing Zhao Xinglou Yang | 2023 | Virologica Sinica2023，38，6： | 0 |
| 12 | Comprehensive evaluation factor of optoelectronic properties for transparent conductive metallic mesh films显示文摘Finding the optimal optoelectronic properties(zero-order optical transmittance,shielding effectiveness,and stray light uniformity)of metallic mesh is significant for its application in electromagnetic interference shielding areas.However,there are few relevant studies at present.Based on optoelectronic properties,we propose a comprehensive evaluation factor Q,which is simple in form and can be used to evaluate the mesh with different parameters in a simple and efficient way.The effectivity of Q is verified by comparing the trend of Q values with the evaluation results of the technique for order preference by similarity to ideal solution(TOPSIS).The evaluation factor Q can also be extended to evaluate the optoelectronic properties of different kinds of metallic meshes,which makes it extremely favorable for metallic mesh design and application. | Yilei ZHANG Jinxuan CAO Zhengang LU Heyan WANG Jiubin TAN | 2021 | Frontiers of Information Technology & Electronic Engineering2021，22，11： | 0 |
| 13 | Recent advances of natural and bioengineered extracellular vesicles and their application in vascular regeneration显示文摘The progression of cardiovascular diseases such as atherosclerosis and myocardial infarction leads to serious vascular injury,highlighting the urgent need for targeted regenerative therapy.Extracellular vesicles(EVs)composed of a lipid bilayer containing nuclear and cytosolic materials are relevant to the progression of cardiovascular diseases.Moreover,EVs can deliver bioactive cargo in pathological cardiovascular and regulate the biological function of recipient cells,such as inflammation,proliferation,angiogenesis and polarization.However,because the targeting and bioactivity of natural EVs are subject to several limitations,bioengineered EVs have achieved wide advancements in biomedicine.Bioengineered EVs involve three main ways to acquire including(i)modification of the EVs after isolation;(ii)modification of producer cells before EVs’isolation;(iii)synthesize EVs using natural or modified cell membranes,and encapsulating drugs or bioactive molecules into EVs.In this review,we first summarize the cardiovascular injury-related disease and describe the role of different cells and EVs in vascular regeneration.We also discuss the application of bioengineered EVs from different producer cells to cardiovascular diseases.Finally,we summarize the surface modification on EVs which can specifically target abnormal cells in injured vascular. | Jianxiong Xu Jinxuan Wang Yidan Chen Yuanfang Hou Jianjun Hu Guixue Wang | 2022 | Regenerative Biomaterials2022，9，1： | 0 |
| 14 | Enhanced carrier mobility in MoSe_(2) by pressure modulation显示文摘Two-dimensional(2D)materials hold great potential for the development of next-generation integrated circuits(ICs)at the atomic limit.However,it is still very challenging to build high performance devices.One of the main factors that limit the incorporation of 2D materials into IC technology is their relatively low carrier mobility.Thus,the engineering strategies that focus on optimizing performance continue to emerge.Herein,using a spatiotemporal resolved pump-probe setup,the carrier transport performance and relaxation process of few-layer and bulk MoSe_(2) under pressure were investigated nondestructively and simultaneously.Our results show that pressure can tune the transport performance effectively.In particular,under pressure regulation,the carrier mobility of the bulk MoSe_(2) increases by~4 times;meanwhile,the carrier lifetimes of the samples become shorter.Although the processes almost return to their initial state after the pressure release,it is still surprising to see that the carrier mobilities of fewlayer and bulk MoSe2 are still~1.5 and 2 times enhanced,and carrier lifetimes are still shorter than the initial state.Combined with the Raman spectra under pressure,we consider that it is caused by the enhanced layer coupling and lattice compression.The combination of enhanced mobility and shortened lifetime in MoSe_(2) under pressure holds great potential for optoelectronic applications under the deep ocean and deep earth. | Zhiying Bai He Zhang Jiaqi He Dawei He Jiarong Wang Guili Li Jinxuan Bai Kun Zhao Xiaohui Yu Yongsheng Wang Xiaoxian Zhang | 2023 | Nano Research2023，16，11： | 0 |
| 15 | Enhanced exciton diffusion from interlayer charge-transfer transitions in PtSe2/MoSe_(2) van der Waals heterojunction显示文摘Artificial van der Waals(vdWs)heterostructures offer unprecedented opportunities to explore and reveal novel synergistic electronic and optical phenomena,which are beneficial for the development of novel optoelectronic devices at atomic limits.However,due to the damage caused by the device fabrication process,their inherent properties such as carrier mobility are obscured,which hinders the improvement of device performance and the incorporation of vdWs materials into next-generation integrated circuits.Herein,combining pump-probe spectroscopic and scanning probe microscopic techniques,the intrinsic optoelectronic properties of PtSe_(2)/MoSe_(2)heterojunction were nondestructively and systematically investigated.The heterojunction exhibits a broad-spectrum optical response and maintains ultrafast carrier dynamics(interfacial charge transfer~0.8 ps and carrier lifetime~38.2 ps)simultaneously.The in-plane exciton diffusion coefficient of the heterojunction was extracted(19.4±7.6 cm^(2)∙s^(−1)),and its exciton mobility as high as 756.8 cm^(2)∙V−1∙s^(−1)was deduced,exceeding the value of its components.This enhancement was attributed to the formation of an n-type Schottky junction between PtSe_(2)and MoSe_(2),and its built-in electric field assisted the ultrafast transfer of photogenerated carriers from MoSe_(2)to PtSe_(2),enhancing the in-plane exciton diffusion of the heterojunction.Our results demonstrate that PtSe_(2)/MoSe_(2)is suitable for the development of broadspectrum and sensitive optoelectronic devices.Meanwhile,the results contribute to a fundamental understanding of the performance of various optoelectronic devices based on such PtSe_(2)two-dimensional(2D)heterostructures. | Jiarong Wang Dawei He Zhiying Bai Guili Li Jinxuan Bai Keqin Liu Fangying Ren Xiaojing Liu Jiaqi He Weiya Zhou Jianlin Sun Yongsheng Wang Xiaoxian Zhang Yuchao Yang | 2023 | Nano Research2023，16，11： | 0 |
| 16 | Quality assessment of systematic reviews assessing the effects of traditional Chinese exercises in the control of diabetes mellitus显示文摘Objective:To assess the quality of systematic reviews assessing the effects of traditional Chinese exercises on controlling blood indices,anthropometric indices,psychological indices,and quality of life in patients with diabetes.Methods:Systematic studies/meta-analyses of intervention with traditional Chinese exercises on diabetes mellitus were searched in the Pub Med,Web of Science,the China National Knowledge Infrastructure Databases(CNKI),Wan Fang Database,and Chinese Scientific Journal Database(VIP).Two researchers independently screened the studies and extracted the data.The methodology and quality of evidence of the included studies were assessed using A Measurement Tool to Assess Systematic Reviews2(AMSTAR-2)and Grading of Recommendations Assessment,Development and Evaluation(GRADE)criteria,respectively.Results:A total of 32 systematic reviews/meta-analyses were included in the present study.Of them,the methodological quality of 4 studies was graded as low,while that of the other 28 was graded as extremely low.The most common quality flaws in key items included a lack of preliminary proposals for systematic reviews,failure to explain the reasons for the inclusion criteria,failure to provide a list of excluded studies and reasons for exclusion,failure to report potential conflicts of interest,and inadequate assessment of publication bias.The quality of evidence for most of the 18 outcomes was subsequently graded as medium or low.Overall,the results of these studies indicated that Tai Chi,health qigong,and other traditional Chinese exercises lowered fasting blood glucose(FBG),2-h postprandial blood glucose(2hPBG),hemoglobin A_(1c)(HbA_(1c)),and body mass index,and relieved anxiety and depression in patients with diabetes.Conclusion:Our findings indicate that the methodological quality of systematic reviews related to traditional Chinese exercises in the diabetic population is generally low,and the quality of evidence is also relatively poor.Therefore,we suggest that the quality of systematic reviews and meta-analyses on traditional Chinese exercises for controlling diabetes mellitus needs to be improved.In the future,researchers should conduct higher-quality clinical studies with reference to the AMSTAR2 checklist and GRADE system. | Huifeng Wang Jinxuan Wang Mei Han Xin Niu | 2023 | Journal of Traditional Chinese Medical Sciences2023，10，3： | 0 |
| 17 | The recent advances and future perspectives of genetic compensation studies in the zebrafish model显示文摘Genetic compensation is a remarkable biological concept to explain the genetic robustness in an organism to maintain its fitness and viability if there is a disruption occurred in the genetic variation by mutation.However,the underlying mechanism in genetic compensation remain unsolvable.The initial concept of genetic compensation has been studied in model organisms when there was a discrepancy between knockout-mediated and knockdown-mediated phenotypes.In the zebrafish model,several studies have reported that zebrafish mutants did not exhibit severe phenotype as shown in zebrafish morphants for the same genes.This phenomenon in zebrafish mutants but not morphants is due to the response of genetic compensation.In 2019,two amazing works partially uncovered genetic compensation could be triggered by the upregulation of compensating genes through regulating NMD and/or PTC-bearing mRNA in collaboration with epigenetic machinery in mutant zebrafish.In this review,we would like to update the recent advances and future perspectives of genetic compensation studies,which including the hypothesis of time-dependent involvement and addressing the discrepancy between knockout-mediated and knockdown-mediated to study gene function in the zebrafish model.At last,the study of genetic compensation could be a potential therapeutic strategy to treat human genetic disorder related diseases. | Muhammad Abdul Rouf Lin Wen Yoga Mahendra Jinxuan Wang Kun Zhang Shuang Liang Yuming Wang Zhenggong Li Yeqi Wang Guixue Wang | 2023 | Genes & Diseases2023，10，2： | 0 |
| 18 | Thermodynamic equilibrium theory-guided design and synthesis of Mg-doped LiFe_(0.4)Mn_(0.6)PO_(4)/C cathode for lithium-ion batteries显示文摘Mn-rich LiFe_(1-x)Mn_(x)PO_(4)(x>0.5),which combines the high operation voltage of LiMnPO_(4)with excellent rate performa nce of LiFePO4,is hindered by its sluggish kinetic properties.Herein,thermodynamic equilibrium analysis of Mn^(2+)-Fe^(2+)-Mg^(2+)-C_(2)O_(4)^(2-)-H_(2)O system is used to guide the design and preparation of insitu Mg-doped(Fe_(0.4)Mn_(0.6))_(1-x)Mg_(x)C_(2)O_(4)intermediate,which is then employed as an innovative precursor to synthesize high-performance Mg-doped LiFe_(0.4)Mn_(0.6)PO_(4).It indicates that the metal ions with a high precipitation efficiency and the stoichiometric precursors with uniform element distribution can be achieved under the optimized thermodynamic conditions.Meanwhile,accelerated Li+diffusivity and reduced charge transfer resistance originating from Mg doping are verified by various kinetic characterizations.Benefiting from the contributions of inherited homogeneous element distribution,small particle size,uniform carbon layer coating,enhanced Li+migration ability and structural stability induced by Mg doping,the Li(Fe_(0.4)Mn_(0.6))_(0.97)Mg_(0.03)PO_(4)/C exhibits splendid electrochemical performance. | Wei Lyu Wenlong Cai Tuan Wang Xiaobo Sun Enhao Xu Jinxuan Chen Kaipeng Wu Yun Zhang | 2024 | Journal of Energy Chemistry2024，91，4： | 0 |
| 19 | Effects of potassium lactate on sensory attributes,bacterial community succession and biogenic amines formation in Rugao ham显示文摘To deepen the understanding in the effect of potassium lactate on the sensory quality and safety of Rugao ham,sensory attributes,physicochemical parameters,total volatile basic nitrogen(TVBN),microorganism community and biogenic amines of Rugao ham manufactured with different potassium lactate levels(0%,0.5%,1%,2%)were investigated;the relationship between microbial community and the formation of TVBN and biogenic amines was further evaluated.With the increase of potassium lactate from 0%to 2%,the increased sensory scores and the decreased total aerobic bacterial count and TVBN were observed;the abundance of Staphylococcus increased,while the content of Halomonas decreased.LDA effect size(LEf Se)and correlations analysis showed that Staphylococcus equorum and Lactobacillus fermentum could be the key species to improve sensory scores and decrease biogenic amines and TVBN.Metabolic pathway analysis further showed that amino acids metabolism and nitrogen metabolism were mainly involved in decreasing TVBN and biogenic amines in the treatment of 2%potassium lactate. | Renyong Liao Ying Wang Qiang Xia Changyu Zhou Fang Geng Daodong Pan Jinxuan Cao | 2024 | Food Science and Human Wellness2024，13，1： | 0 |
| 20 | The effects of deformation parameters and cooling rates on the aging behavior of AZ80+0.4%Ce显示文摘The extruded AZ80+0.4%Ce magnesium alloy was twisted in the temperature range of 300-380℃by using a Gleeble 3500 thermal simulation test machine with a torsion unit.The deformed cylindrical specimens were cooled at a cooling rate of 10℃/s or 0.1℃/s,respectively,and aged at 170℃.The microstructure analysis results showed that the grain size decreased with increasing specimen radial position from center(SRPC),and that the strong initial basal texture of the extruded magnesium alloy was weakened.Both continuous and discontinuous dynamic recrystallization mechanisms were involved in contributing to the grain refinement for all specimens investigated.And a novel extension twinning induced dynamic recrystallization mechanism was proposed for specimen deformed at 300℃.For the specimens deformed at 300℃and 340℃followed by a slow cooling rate(0.1℃/s),precipitates of various shapes(β-Mg_(17)Al_(12)),with the dominant precipitates being on the grains boundaries,appeared on the surface section.For specimen deformed at 380℃,lamellar precipitates(LPS)in the interiors of the grains were predominant.After aging,the LPS still dominated for specimens twisted at 380℃;however,the LPS gradually decreased with decreasing deformation temperatures from 380℃to 300℃.Dynamically precipitatedβ,especially those decorating the grain boundaries,changed the competition pictures for the LPS and precipitates of other shapes after aging.Interestingly,LPS dominated the areas for the center section of the specimens after aging regardless of deformation temperatures.Low temperature deformation with high SRPC followed by rapid cooling rate increased the micro hardness of the alloy after aging due to refined grain,reduced precipitates size,decreased lamellar spacing as well as strain hardening. | Yongbiao Yang Jinxuan Guo Cuiying Wang Ting Yan Zhang Wenxuan Jiang Zhimin Zhang Qiang Wang Guojun Li Jun Wang | 2024 | Journal of Magnesium and Alloys2024，12，2： | 0 |
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