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| 1 | Endovascular stent-induced alterations in host artery mechanical environments and their roles in stent restenosis and late thrombosis显示文摘Cardiovascular stent restenosis remains a major challenge in interventional treatment of cardiovascular occlusive disease.Although the changes in arterial mechanical environment due to stent implantation are the main causes of the initiation of restenosis and thrombosis,the mechanisms that cause this initiation are still not fully understood.In this article,we reviewed the studies on the issue of stent-induced alterations in arterial mechanical environment and discussed their roles in stent restenosis and late thrombosis from three aspects:(i)the interaction of the stent with host blood vessel,involve the response of vascular wall,the mechanism of mechanical signal transmission,the process of re-endothelialization and late thrombosis;(ii)the changes of hemodynamics in the lumen of the vascular segment and(iii)the changes of mechanical microenvironment within the vascular segment wall due to stent implantation.This review has summarized and analyzed current work in order to better solve the two main problems after stent implantation,namely in stent restenosis and late thrombosis,meanwhile propose the deficiencies of current work for future reference. | Jinxuan Wang Xuepu Jin Yuhua Huang Xiaolin Ran Desha Luo Dongchuan Yang Dongyu Jia Kang Zhang Jianhua Tong Xiaoyan Deng Guixue Wang | 2018 | Regenerative Biomaterials2018，5，3： | 13 |
| 2 | Bioinspired Unidirectional Liquid Transport Micro-nano Structures:A Review显示文摘Unidirectional liquid transport without any need of external energy has drawn worldwide attention for its potential applications in various fields such as microfluidics,biomedicine and mechanical engineering.In nature,numerous creatures have evolved such extraordinary unidirectional liquid transport ability such as spider sik,Sarracenia's trichomes,and Nepenthes alata's peristome,etc.This review summarizes the current progresses of natural unidirectional liquid transport on 1-Dimensional(1D)linear structure and 2-Dimensional(2D)surface stucture.The driving force of unidirectional liquid transport which is determined by unique structure exist distinct differences in physics.The fundamental understanding of 1D and 2D unidirectionaliquid transport especially about hierarchical structural characteristics and their transport mechanism were concentrated,and various bioinspired fabrication methods are also introduced.The applications of bioinspired directional liquid transport are demonstrated especially in fields of microfluidies,biomedical devices and anti-icing surfaces.With newly developed smart materials,various liquid transport regulation strategies are also summarized for the control of transport speed,direction guiding,etc.Finally,we provide new insights and future perspectives of the directional transport materials. | Liwen Zhang Guang Liu Huawei Chen Xiaolin Liu Tong Ran Yi Zhang Yang Gan Deyuan Zhang | 2021 | Journal of Bionic Engineering2021，18，1： | 4 |
| 3 | Dose-effect analysis of treatment by modified Zhibaidihuang decoction on polycystic ovary syndrome hyperandrogenism显示文摘OBJECTIVE: To observe the efficacy and safety of different dosages of modified Zhibaidihuang decoction(MZBDD) on polycystic ovary syndrome(PCOS) hyperandrogenism(HA) patients.METHODS: Ninety PCOS HA patients and 30 infertile patients due to tubal factor were selected. Ninety PCOS HA patients were randomly divided into three groups: low dosage group(LDG), medium dosage group(MDG) and high dosage group(HDG) and infertile patients were selected as normal control group(NCG). PCOS HA patients were treated with different dosage of MZBDD for 4 weeks. For HA patients, serum total testosterone(T), estrodial(E2), follicle stimulating hormone(FSH), luteinizing hormone(LH), prolatin(PRL), alanine aminotransferase(AST), aspartate amino transferase(AST) were determined before and after treatment, while acne scores(Rosenfield) were signed. Basal body temperatures(BBT) were asked to be measured every day. And for the else, T, E2,FSH, LH, PRL, AST, and AST were determined before treatment.RESULTS: Totally 111 patients completed the clinical research. There were no differences among the four groups on serum T before treatment(P =0.221). Serum T concentration of both MDG and HDG after treatment significantly were lower than that of before treatment(P = 0.039, P = 0.000),while there was no obvious difference in LDG(P =0.829). Serum T concentration of both MDG and HDG were significantly lower than that of LDG after treatment(P = 0.048, P = 0.006). To compared with before treatment, there were no differences in Serum FSH, LH, E2, P and PRL among the three groups(LDG, MDG, HDG)(as for FSH, P = 0.136, P = 0.503,P = 0.062; as for LH, P = 0.473, P = 0.513, P = 0.096;as for E2, P = 0.206, P = 0.927, P = 0.076; as for PRL,P = 0.120, P = 0.903, P = 0.407, as for P, P = 0.308, P =0.866, P = 0480). Acne scores of all the three groups were obviously lower than that of before treatment(P = 0.031; P = 0.033; P = 0.002). 39.5% of the patients had biphasic BBT, but there were no differences among the three groups(P = 0.510). There were no differences with ALT and AST between after and before treatment among the three groups(LDG, MDG, HDG)(as for ALT, P = 0.742, P = 0.383,P = 0.053; as for AST, P = 0.732, P = 0.519, P = 0.120).CONCLUSION: Different dosage of MZBDD has dose-effect relationship in treating PCOS HA. | Zhao Yiming Zheng Dongxue Cheng Ran Xu Xin Lian Fengmei Tong Xiaolin Liu Xinmin | 2018 | Journal of Traditional Chinese Medicine2018，38，2： | 4 |
| 4 | Utilizing vector hydrophones to achieve an active anechoic terminal in an acoustic tube显示文摘A new integrated active sound absorptive terminal using vector hydrophones is developed for the anechoic terminal of impedance tube,with which the reflected and the incident waves can be separated.The method overcomes the limitations imposed by the sensor spacing and measuring frequency range in the traditional two-hydrophone method,and can effectively expand low-frequency sound absorption band of the terminal.The effect of hydrophone sensitivity on the sound absorptive performance of the terminal is evaluated,a correction method is also provided for the reflection and transmission coefficient.The experimental results show that the absorption coefficient in the frequency band of 0.1-2 kHz is over 0.98,which agrees well with the theoretical results. | WANG Xiaolin LIU Bilong YANG Jun LIU Jingwei WANG Ran | 2019 | Chinese Journal of Acoustics2019，38，2： | 1 |
| 5 | Optimization of heat shield for single silicon crystal growth by using numerical simulation显示文摘In integrated circuit-grade single silicon Czochralski growth, the position and material of heat shield are main parameters affecting the heat exchange and crystal growth condition. By optimizing the above parameters, we attempted to increase the growth rate and crystal quality. Numerical simulation proved to verify the results before and after optimization. Through analyses of the temperature and microdefect distribution, it is found that the optimized heat shield can further increase the pulling rate and decrease the melt/crystal interface deflection, increase the average velocity of argon flow from ~2 to ~5 m·s^-1 , which is in favor of the transportation of SiO, and obtain the low defects concentration crystal and that the average temperature along the melt-free surface is 8 °C higher than before avoiding supercooled melt effectively. | TENG Ran ZHOU Qigang DAI Xiaolin WU Zhiqiang XU Wenting XIAO Qinghua WU Xiao GUO Xi | 2012 | Rare Metals2012，31，5： | 1 |
| 6 | Cytotoxic effects of docetaxel as a candidate drug of drug-eluting stent on human umbilical vein endothelial cells and the signaling pathway of cell migration inhibition,adhesion delay and shape change显示文摘Docetaxel(DTX),a paclitaxel analogue,can efficiently inhibit proliferation of vascular smooth muscle cells and has broadly been used as an antiangiogenesis drug.However,as a candidate drug of drug-eluting stent,the effects of DTX on human umbilical vein endothelial cells(HUVECs)are still not well understood.Herein,we investigated the effects of DTX on proliferation,apoptosis,adhesion,migration and morphology of HUVECs in vitro.We found that DTX had the cytostatic and cytotoxic effects at low and high concentrations,respectively.DTX could inhibit the proliferation and migration of HUVECs,induce HUVECs apoptosis,delay HUVECs adhesion and decrease spreading area and aspect ratio of individual cells.The signaling pathway that DTX led to the migration inhibition,adhesion delay and shape change of HUVECs is the VE-cadherin mediated integrin b1/FAK/ROCK signaling pathway.The study will provide a theoretical basis for the clinical application of DTX. | Tingzhang Hu Chun Yang Meiling Fu Jiali Yang Rolin Du Xiaolin Ran Tieying Yin Guixue Wang | 2017 | Regenerative Biomaterials2017，4，3： | 1 |
| 7 | Cryo-EM structures for the Mycobacterium tuberculosis iron-loaded siderophore transporter IrtAB显示文摘The adenosine 5'-triphosphate(ATP)-binding cassette(ABC)transporter,IrtAB,plays a vital role in the replication and viability of Mycobacterium tuberculosis(Mtb),where its function is to import iron-loaded siderophores.Unusually,it adopts the canonical type IV exporter fold.Herein,we report the structure of unliganded Mtb IrtAB and its structure in complex with ATP,ADP,or ATP analogue(AMP-PNP)at resolutions ranging from 2.8 to 3.5Å.The structure of IrtAB bound ATP-Mg2+shows a“head-to-tail”dimer of nucleotide-binding domains(NBDs),a closed amphipathic cavity within the transmembrane domains(TMDs),and a metal ion liganded to three histidine residues of IrtA in the cavity.Cryo-electron microscopy(Cryo-EM)structures and ATP hydrolysis assays show that the NBD of IrtA has a higher affinity for nucleotides and increased ATPase activity compared with IrtB.Moreover,the metal ion located in the TM region of IrtA is critical for the stabilization of the conformation of IrtAB during the transport cycle.This study provides a structural basis to explain the ATP-driven conformational changes that occur in IrtAB. | Shan Sun Yan Gao Xiaolin Yang Xiuna Yang Tianyu Hu Jingxi Liang Zhiqi Xiong Yuting Ran Pengxuan Ren Fang Bai Luke WGuddat Haitao Yang Zihe Rao Bing Zhang | 2023 | Protein & Cell2023，14，6： | 0 |
| 8 | Study on Pars Orbitalis Symmetry of UCLP Patients in Mixed Dentition Period显示文摘[Objectives] To analyze pars orbitalis symmetry of UCLP patients in mixed dentition period,and provide better theoretical basis for studying craniofacial shape and clinical treatment. [Methods]3 D reconstruction of CBCT images of 20 UCLP patients in mixed dentition period was conducted,and 13 mark points were selected from 3 D image for fixed-point measurement to analyze 3 D shape of pars orbitalis. [Results]( i) Horizontal symmetry of pars orbitalis. The width of pars orbitalis of UCLP patients at sites So,Lo,Oi,Or,So F,Z of fracture side was all equal to that at nonfracture side,and there was not statistical difference( P > 0. 05).( ii) Sagittal symmetry of pars orbitalis. Sagittal development of pars orbitalis of UCLP patients at sites So,Lo,Oi,Or,So F,Z of fracture side was equal to that at nonfracture side,and there was not statistical difference( P > 0. 05).( iii) Vertical symmetry of pars orbitalis. The height of pars orbitalis of UCLP patients at sites So,Lo,Oi,So F,Z of fracture side was higher than that at nonfracture side,and there was not obvious statistical difference( P > 0. 05).[Conclusions] There was not significant asymmetry in pars orbitalis of UCLP patients in mixed dentition period. | Ran LI Cunhui FAN Pinyi YAO Xinying HAN Xiaoxu FANG Zhonghui TIAN Xiaolin XU | 2018 | Medicinal Plant2018，9，1： | 0 |
| 9 | The phase separation of SGS3 regulates antiviral immunity and fertility in Arabidopsis显示文摘Dear Editor,As a conserved mechanism among eukaryotic organisms,RNA silencing is vital for suppressing gene expression at the transcriptional or posttranscriptional level to regulate multiple biological processes.Small interfering RNAs(si RNAs)generated by Dicer proteins integrate with Argonaute(AGO)to form an RNA-induced silencing complex(RISC),in which RNA/DNA could be degraded/methylated through a sequence-specific manner(Ding et al.,2004). | Yujie Han Xiaolin Zhang Ran Du Xiaoyi Shan Daoxin Xie | 2023 | Science China(Life Sciences)2023，66，8： | 0 |
| 10 | Critical Value Aware Data Acquisition Strategy in Wireless Sensor Networks显示文摘To monitor the physical world, Equi-Frequency Sampling (EFS) methods are widely applied for data acquisition in sensor networks.Due to the noise and inherent uncertainty of the environment,EFS based data acquisition may result in misconception to the physical world, and high frequency scheme produces massive sensed data, which consumes substantial cost for transmission. This paper proposes a novel sensed data model. Based on maximum likelihood estimation, the model can minimize measurement error. It is proved that the proposed model is asymptotic unbiased. Furthermore, this paper proposes Model based Adaptive Data Collection (MADC) Algorithm and designs a distributed lightweight computation algorithm named Distributed Adaptive Data Collection Algorithm (DADC). Based on the error of prediction, both algorithms can adaptively adjust the cycle of data collection. Performance evaluation verifies that the proposed algorithms have high performance in terms of accuracy and effectiveness. | Ran Bi Guozhen Tan Xiaolin Fang | 2017 | 国际计算机前沿大会会议论文集2017，，2： | 0 |
| 11 | The water-soluble bicyclic 2-pyridone-based fluorescent probe for fast and selective detection of hypochlorite显示文摘As a strong oxidizer,hypochlorite(Cl O^(-))are widely employed as bleaching agents and disinfectants.Determination of ClO^(-)is required to ensure bactericidal effects and avoid hazards caused by excessive residual chlorine.Herein,the derivative bicyclic 2-pyridone,namely DHIP-Py,was prepared successfully to establish a new ClO^(-)-quantitative method.The probe exhibits excellent Cl O^(-)selectivity over other ROS and anions/cations,high sensitivity(LOD=1.32μmol/L),fast response(<5 s),and wide-p H tolerance(pH4~10).Benefit from its good water solubility,DHIP-Py is well suited for water sample analysis and has been successfully applied to detect Cl O^(-)in real-world food and environmental samples,including tap water,bottled water and river water.The detection results were essentially identical to that of obtained from traditional DPD method.Moreover,visual detection of Cl O^(-)via filter paper-based solid sensor and imaging of ClO^(-)in Escherichia coli were also achieved by DHIP-Py.These satisfactory results demonstrate that this bicyclic 2-pyridone-based hypochlorite probe is a promising free chlorine chemosensor with great potential for analytical applications. | Qian Zhou Shanqiang Wang Xiaoyun Ran Linzhi Shen Xiaolin Luo Gui Wang Hui Yang Zhouyu Wang Xiaoqi Yu | 2023 | Chinese Chemical Letters2023，34，6： | 0 |
| 12 | Tetrazole tethered polymers for alkaline anion exchange membranes显示文摘(2,6-dimethyl-1,4-phenylene 氧化物) Poly 通过一个第四级的铵连接与 1,5-disubstituted tetrazole 被拴住。在产生聚合物的一个 tetrazole 离子网络的形成被发现通过 Grotthus 类型机制支持氢氧化物离子运输。 | Erigene Bakangura Yubin He Xiaolin Ge Yuan Zhu Liang Wu Jin Ran Congliang Cheng Kamana Emmanuel Zhengjin Yang Tongwen Xu | 2018 | Frontiers of Chemical Science and Engineering2018，12，2： | 0 |
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