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| 1 | miR-145 improves metabolic inflammatory disease through multiple pathways显示文摘Chronic inflammation plays a pivotal role in insulin resistance and type 2 diabetes,yet the mechanisms are not completely understood.Here,we demonstrated that serum LPS levels were significantly higher in newly diagnosed diabetic patients than in normal control.miR-145 level in peripheral blood mononuclear cells decreased in type 2 diabetics.LPS repressed the transcription of miR-143/145 cluster and decreased miR-145 levels.Attenuation of miR-145 activity by anti-miR-145 triggered liver inflammation and increased serum chemokines in C57BL/6 J mice.Conversely,lentivirus-mediated miR-145 overexpression inhibited macrophage infiltration,reduced body weight,and improved glucose metabolism in db/db mice.And miR-145 overexpression markedly reduced plaque size in the aorta in ApoE−/−mice.Both OPG and KLF5 were targets of miR-145.miR-145 repressed cell proliferation and induced apoptosis partially by targeting OPG and KLF5.miR-145 also suppressed NF-κB activation by targeting OPG and KLF5.Our findings provide an association of the environment with the progress of metabolic disorders.Increasing miR-145 may be a new potential therapeutic strategy in preventing and treating metabolic diseases such as type 2 diabetes and atherosclerosis. | Min He Nan Wu Man Cheong Leong Weiwei Zhang Zi Ye Rumei Li Jinyang Huang Zhaoyun Zhang Lianxi Li Xiao Yao Wenbai Zhou Naijia Liu Zhihong Yang Xuehong Dong Yintao Li Lili Chen Qin Li Xuanchun Wang Jie Wen Xiaolong Zhao Bin Lu Yehong Yang Qinghua Wang Renming Hu | 2020 | Journal of Molecular Cell Biology2020，12，2： | 7 |
| 2 | Single-shot compressed ultrafast photography: a review显示文摘Compressed ultrafast photography(CUP)is a burgeoning single-shot computational imaging technique that provides an imaging speed as high as 10 trillion frames per second and a sequence depth of up to a few hundred frames.This technique synergizes compressed sensing and the streak camera technique to capture nonrepeatable ultrafast transient events with a single shot.With recent unprecedented technical developments and extensions of this methodology,it has been widely used in ultrafast optical imaging and metrology,ultrafast electron diffraction and microscopy,and information security protection.We review the basic principles of CUP,its recent advances in data acquisition and image reconstruction,its fusions with other modalities,and its unique applications in multiple research fields. | Dalong Qi Shian Zhang Chengshuai Yang Yilin He Fengyan Cao Jiali Yao Pengpeng Ding Liang Gao Tianqing Jia Jinyang Liang Zhenrong Sun Lihong V.Wange | 2020 | Advanced Photonics2020，2，1： | 5 |
| 3 | Traditional Chinese Medicine etiology and pathogenesis of acquired immune deficiency syndrome in simian immunodeficiency virus-infected Chinese rhesus macaques显示文摘OBJECTIVE:To investigate the traditional Chinese Medicine(TCM) etiology and pathogenesis of acquired immune deficiency syndrome(AIDS) by 18-month observation of Chinese rhesus macaques infected with simian immunodeficiency virus(SIV) mac 239.METHODS:Thirty-five healthy Chinese rhesus macaques were divided into a model group(n=30) and a control group(n=5).The model was established by inoculating monkeys intravenously with SIVmac 239.Changes in TCM symptoms after SIV infection within 18 months were then observed and recorded.Routine blood tests,SIV viral load,T-lymphocyte subsets,plasma triiodothyronine(T3),tetraiodothyronine(T4),adrenocorticotropic hormone(ACTH) and cortisol(Cor) were tested periodically during the experiment.RESULTS:During the acute infection period of SIV,model monkeys temporarily showed clinical symptoms such as diarrhea,dysphoria and slight weight loss.Decrease percentages of CD4+ T-lymphocytes were observed but levels of T3,T4,Cor,and ACTH were relatively unchanged.Monkeys in the model group during the early and middle periods of infection showed no obvious symptoms,except few monkeys exhibited transient diarrhea and reduced food intake.All variables at this stage showed normal fluctuations.In the middle period model group monkeys showed chronic and persistent diarrhea,weight loss,reduced food intake and low levels of T3 and Cor.In the late period,symptoms including emaciation,weight loss,listlessness,crouching in corners and low levels of T3 appeared.CONCLUSION:The results suggest that the rhesus monkey SIV/SAIDS model can be applied to research on TCM etiology and pathogenesis of AIDS.According to this model,the etiology of disease is the SIV virus.The pathogenesis manifests as the invasion of SIV virus,incubation of the virus,balance between virus and healthy 'Qi',damage to spleen and kidney as the disease progressed,exhaustion of vitality and finally the failure of five zang and six fu organs. | Maoqing Li Linchun Fu Yinjie Hu Miaomiao Zhang Jinyang He Zhixi Chen Jinyan Chen | 2012 | Journal of Traditional Chinese Medicine2012，32，4： | 5 |
| 4 | Single-shot spectral-volumetric compressed ultrafast photography显示文摘In ultrafast optical imaging,it is critical to obtain the spatial structure,temporal evolution,and spectral composition of the object with snapshots in order to better observe and understand unrepeatable or irreversible dynamic scenes.However,so far,there are no ultrafast optical imaging techniques that can simultaneously capture the spatial–temporal–spectral five-dimensional(5D)information of dynamic scenes.To break the limitation of the existing techniques in imaging dimensions,we develop a spectral-volumetric compressed ultrafast photography(SV-CUP)technique.In our SV-CUP,the spatial resolutions in the x,y and z directions are,respectively,0.39,0.35,and 3 mm with an 8.8 mm×6.3 mm field of view,the temporal frame interval is 2 ps,and the spectral frame interval is 1.72 nm.To demonstrate the excellent performance of our SV-CUP in spatial–temporal–spectral 5D imaging,we successfully measure the spectrally resolved photoluminescent dynamics of a 3D mannequin coated with CdSe quantum dots.Our SV-CUP brings unprecedented detection capabilities to dynamic scenes,which has important application prospects in fundamental research and applied science. | Pengpeng Ding Yunhua Yao Dalong Qi Chengshuai Yang Fengyan Cao Yilin He Jiali Yao Chengzhi Jin Zhengqi Huang Li Deng Lianzhong Deng Tianqing Jia Jinyang Liang Zhenrong Sun Shian Zhang | 2021 | Advanced Photonics2021，3，4： | 3 |
| 5 | High-fidelity image reconstruction for compressed ultrafast photography via an augmented-Lagrangian and deep-learning hybrid algorithm显示文摘Compressed ultrafast photography(CUP) is the fastest single-shot passive ultrafast optical imaging technique,which has shown to be a powerful tool in recording self-luminous or non-repeatable ultrafast phenomena.However, the low fidelity of image reconstruction based on the conventional augmented-Lagrangian(AL)and two-step iterative shrinkage/thresholding(Tw IST) algorithms greatly prevents practical applications of CUP, especially for those ultrafast phenomena that need high spatial resolution. Here, we develop a novel AL and deep-learning(DL) hybrid(i.e., AL+DL) algorithm to realize high-fidelity image reconstruction for CUP. The AL+DL algorithm not only optimizes the sparse domain and relevant iteration parameters via learning the dataset but also simplifies the mathematical architecture, so it greatly improves the image reconstruction accuracy. Our theoretical simulation and experimental results validate the superior performance of the AL+DL algorithm in image fidelity over conventional AL and Tw IST algorithms, where the peak signalto-noise ratio and structural similarity index can be increased at least by 4 d B(9 d B) and 0.1(0.05) for a complex(simple) dynamic scene, respectively. This study can promote the applications of CUP in related fields, and it will also enable a new strategy for recovering high-dimensional signals from low-dimensional detection. | CHENGSHUAI YANG YUNHUA YAO CHENGZHI JIN DALONG QI FENGYAN CAO YILIN HE JIALI YAO PENGPENG DING LIANG GAO TIANQING JIA JINYANG LIANG ZHENRONG SUN SHIAN ZHANG | 2021 | Photonics Research2021，9，2： | 2 |
| 6 | IDH1突变体通过抑制JNK的激活减少生长因子缺失诱导的细胞凋亡显示文摘文章简介抵抗凋亡和能在血清营养因子缺乏的情况下生长是肿瘤细胞的两个主要特征。JNK的激活是血清饥饿诱导的细胞凋亡所必须的因素。目前研究表明IDH1突变体产生的致癌代谢物2-羟基戊二酸(2-HG)是突变的导致肿瘤形成的主要原因。 | Bin Jiang Jia Zhang Jinmei Xia Wentao Zhao Yanan Wu Minggang Shi Lianzhong Luo Huamin Zhou Ai Chen Huanhuan Ma Qingwen Zhao Muhammad Suleman Furong Lin Lin Zhou Jinyang Wang Yan Zhang Ying He Xiaotong Li Li-Man Hung Tak Wah Mak 李勤喜 | 2018 | 科学新闻2018，0，4： | 0 |
| 7 | Diamond Discovered in Dangqiong Ophiolite, Western Yarlung-Zangbu Suture Zone, Tibet显示文摘The first diamonds from ophiolite were found in peridotite of Luobusa ophiolite along Yarlung Zangbu suture zone in Tibet,China(IGCAGS,1981),and then more and more diamonds found in harzgurgite(Bai et al.,1993;Yang et al.,2007a;Robinson et al.,2014;Xu et al., | XIONG Fahui YANG Jingsui Robinson T.PAUL XU Xiangzhen BA Dengzhu LI Yuan LI Jinyang ZHANG Zhongming RONG He | 2015 | Acta Geologica Sinica(English Edition)2015，89，A02： | 0 |
| 8 | Lateral damage mechanism of the double-track tunnel in the mountainous layered soft rock and NPR anchor cable control显示文摘Due to complex geological formations,lateral damage often occurs during excavation in mountainous layered soft rock double-track tunnels.This paper discusses the stresses and the damage characteristics of the surrounding rock under overload in a mountainous layered soft rock double-track tunnel through indoor model experiments to provide a basis for the effective control of lateral damage.The experiments show that the conventional support method cannot effectively control the lateral damage due to interlayer sliding.Therefore,the negative Poisson’s ratio(NPR)anchor/cable control method is proposed.And the scientificity and feasibility of the NPR anchor/cable control technology are proved by the field application and monitoring data of the Minxian Tunnel and Changning Tunnel.It is further demonstrated that high preload is the most effective way to control the lateral damage in layered soft rock tunnels. | Qiru Sui Manchao He Tingting Shi Shihui Pang Jinyang Xiang Zhigang Tao Dingjun Qu | 2023 | Underground Space2023，，5： | 0 |
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