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| 1 | Clinical risk score for invasive fungal diseases in patients with hematological malignancies undergoing chemotherapy:China Assessment of Antifungal Therapy in Hematological Diseases (CAESAR) study显示文摘Invasive fungal disease (IFD) is a major infectious complication in patients with hematological malignancies.In this study,we examined 4889 courses of chemotherapy in patients with hematological diseases to establish a training dataset (n=3500) by simple random sampling to develop a weighted risk score for proven or probable IFD through multivariate regression,which included the following variables: male patients,induction chemotherapy for newly diagnosed or relapsed disease,neutropenia,neutropenia longer than 10 days,hypoalbuminemia,central-venous catheter,and history of IFD.The patients were classified into three groups,which had low (0-10,~1.2%),intermediate (11-15,6.4%),and high risk (> 15,17.5%) of IFD.In the validation set (n=1389),the IFD incidences of the groups were ~1.4%,5.0%,and 21.4%.In addition,we demonstrated that antifungal prophylaxis offered no benefits in low-risk patients,whereas benefits were documented in intermediate (2.1% vs.6.6%,P=0.007) and high-risk patients (8.4% vs.23.3%,P=0.007).To make the risk score applicable for clinical settings,a pre-chemo risk score that deleted all unpredictable factors before chemotherapy was established,and it confirmed that anti-fungal prophylaxis was beneficial in patients with intermediate and high risk of IFD.In conclusion,an objective,weighted risk score for IFD was developed,and it may be useful in guiding antifungal prophylaxis. | Ling Wang Ying Wang Jiong Hu Yuqian Sun He Huang Jing Chen Jianyong Li Jun Ma Juan Li Yingmin Liang Jianmin Wang Yan Li Kang Yu Jianda Hu Jie Jin Chun Wang Depei Wu Yang Xiao Xiaojun Huang | 2019 | Frontiers of Medicine2019，13，3： | 10 |
| 2 | Neuroprotective effect of baicalin on focal cerebral ischemia in rats显示文摘Baicalin, a flavonoid compound from the root of the herb Scutellaria baicalensis Georgi, has been widely used to treat patients with inflammatory disease. The aim of this study was to assess the efficacy of baicalin in a rat model of focal cerebral ischemia. Adult male Sprague-Dawley rat models of cerebral artery occlusion were established and then randomly and equally divided into three groups: ischemia(cerebral ischemia and reperfusion), valproic acid(cerebral ischemia and reperfusion + three intraperitoneal injections of valproic acid; positive control), and baicalin(cerebral ischemia and reperfusion + intraperitoneal injection of baicalin for 21 days). Neurological deficits were assessed using the postural reflex test and forelimb placing test at 3, 7, 14, and 21 days after ischemia. Rat cerebral infarct volume was measured using 2,3,5-triphenyltetrazolium chloride(TTC) staining method. Pathological change of ischemic brain tissue was assessed using hematoxylin-eosin staining. In the baicalin group, rat neurological function was obviously improved, cerebral infarct volume was obviously reduced, and the pathological impairment of ischemic brain tissue was obviously alleviated compared to the ischemia group. Cerebral infarct volume was similar in the valproic acid and baicalin groups. These findings suggest that baicalin has a neuroprotective effect on cerebral ischemia. | Jiong Dai Yong-Ming Qiu Zheng-Wen Ma Guo-Feng Yan Jing Zhou Shan-Quan Li Hui Wu Yi-Chao Jin Xiao-Hua Zhang | 2018 | Neural Regeneration Research2018，13，12： | 7 |
| 3 | The study of perfectly matched layer absorbing boundaries for SH wave fields显示文摘当在无限的空间为波浪繁殖建模时,有马厩吸收边界有效地从截断边界消除假思考是必要的。嘘,为完美地匹配的层(PML ) 的波浪方程被推出,他们的 Crank-Nicolson 计划在这篇论文被介绍。我们使用第二 -- ,第六 -- ,并且计算空间衍生物的第十顺序的有限差别和伪 spectral 算法。有一个洞的二个数字模型,同类的各向同性的媒介和一个多层的模型,被设计调查吸收边界宽度和算法怎么决定 PML 效果。当吸收边界是薄的时,为 PML,低顺序的有限差别算法有相当好的吸收的数字结果表演完成,而,当边界是厚的时,高顺序的算法总是有好吸收。最后,我们讨论思考系数并且指出它的缺点,它是我们使用 SNR 到 PML 完成的份量上规模的原因。 | Liu Jiong Ma Jian-wei Yang Hui-zhu | 2009 | Applied Geophysics2009，6，3： | 5 |
| 4 | Factors Controlling Hydrocarbon Accumulation in Jurassic Reservoirs in the Southwest Ordos Basin, NW China显示文摘The sedimentary, paleogeomorphological and reservoir characteristics of the Jurassic Yan’an Formation in the southwestern Ordos Basin, northwestern China, were studied by means of casting thin sections, scanning electron microscopy, inclusion analysis and identification of low-amplitude structures. A model for reservoir formation is established, and the controlling effects of sedimentary facies, paleotopography, low-amplitude structures and formation water on oil reservoirs are revealed. There are significant differences in the sedimentary characteristics, structural morphology and paleowater characteristics between the reservoirs above the Yan 10 Member and those in the Yan 9 to Yan 7 Members. The Yan 10 Member contains fluvial sediments, whereas the Yan 9 to Yan 7 members contain delta-plain anastomosing-river deposits. The distribution of high-permeability reservoir is controlled by pre-Jurassic paleogeomorphology and sedimentary facies. Some of these facies exhibit high porosity and high permeability in a lowpermeability background. The main hydrocarbon accumulation period was the late Early Cretaceous, filling was continuous, and the charging strength altered from weak to strong and then from strong to weak. The Yan 10 reservoir is mainly controlled by the paleogeomorphology: hydrocarbons migrated upward at a high speed through the unconformity surface, and accumulated in the favorable traps formed by paleogeomorphic structural units, such as gentle slopes or channel island. Furthermore, groundwater alternation in these areas was relatively stagnant, providing good reservoir preservation conditions. The reservoirs in the Yan 9 and higher members are controlled by the sedimentary facies, lowamplitude structure and paleowater characteristics. Hydrocarbons migrated through the three-dimensional delivery system, influenced by favorable sedimentary facies and high-salinity groundwater, then accumulated in the favorable low-amplitude structural traps that formed during the hydrocarbon production period. | LIU Xin WANG Feng LIU Baojun TIAN Jingchun SHANG Ting MA Jiong ZHANG Zhongyi ZHANG Xiaolei | 2020 | Acta Geologica Sinica(English Edition)2020，94，2： | 4 |
| 5 | Factors associated with upstaging in patients preoperatively diagnosed with ductal carcinoma in situ by core needle biopsy显示文摘Objective: Patients preoperatively diagnosed with ductal carcinoma in situ(DCIS) by core needle biopsy(CNB) exhibit a significant risk for upstaging on final pathology, which leads to major concerns of whether axillary staging is required at the primary operation. The present study aimed to identify clinicopathological factors associated with upstaging in patients preoperatively diagnosed with DCIS by CNB.Methods: The present study enrolled 604 patients(cN0 M0) with a preoperative diagnosis of pure DCIS by CNB, who underwent axillary staging between August 2006 and December 2015, at Fudan University Shanghai Cancer Center(Shanghai, China).Predictive factors of upstaging were analyzed retrospectively.Results: Of the 604 patients, 20.03%(n = 121) and 31.95%(n = 193) were upstaged to DCIS with microinvasion(DCISM) and invasive breast cancer(IBC) on final pathology, respectively. Larger tumor size on ultrasonography(> 2 cm) was independently associated with upstaging [odds ratio(OR) 1.558, P = 0.014]. Additionally, patients in lower breast imaging reporting and data system(BI-RADS) categories were less likely to be upstaged(4 B vs. 5: OR 0.435, P = 0.002;4 C vs. 5: OR 0.502, P = 0.001). Overall,axillary metastasis occurred in 6.79%(n = 41) of patients. Among patients with axillary metastasis, 1.38%(4/290), 3.31%(4/121)and 17.10%(33/193) were in the DCIS, DCISM, and IBC groups, respectively.Conclusions: For patients initially diagnosed with DCIS by CNB, larger tumor size on ultrasonography(> 2 cm) and higher BIRADS category were independent predictive factors of upstaging on final pathology. Thus, axillary staging in patients with smaller tumor sizes and lower BI-RADS category may be omitted, with little downstream risk for upstaging. | Jing Si Benlong Yang Rong Guo Naisi Huang Chenlian Quan Linxiaoxi Ma Bingqiu Xiu Yun Cao Yue Tang Linxiao Shen Jiajian Chen Jiong Wu | 2019 | Cancer Biology & Medicine2019，16，2： | 3 |
| 6 | Prospective, naturalistic study of open-label OROS methylphenidate treatment in Chinese school-aged children with attention-deficit/hyperactivity disorder显示文摘背景注意赤字活动过度混乱( ADHD )在童年期间是最普通的心理混乱之一,由活动过度, impulsivity 和疏忽的核心症状描绘了并且自己把大负担放在孩子上,他们的家庭和 society.Osmotic 释放口头的系统 methylphenidate (OROS哩/时)开发克服一些限制的一次每日的控制版本明确的表达与立即版本的 methylphenidate (红外哩/时)被联系 .It | ZHENG Yi WANG Yu-feng QIN Jiong WANG Li-wen ZOU Li-ping J IN Xing-ming XU Tong WANG Yi OI Yuan-li GONG Mei-en YIN Qing-yun MAI Jian-ning JING Jin LUO Xiang-yang MA Hong-wei LI Hai-bo XIE Ling LIYan Kuang Gui-fang YI Ming-ji WANG Feng ZHU Xiao-hua YAO Yan-bin | 2011 | Chinese Medical Journal2011，，20： | 2 |
| 7 | Triphenyltin biodegradation and intracellular material release by Brevibacillus brevis显示文摘 | Jinshao Ye Hangjian Zhao Hua Yin Hui Peng Litao Tang Jiong Gao Yujia Ma | 2013 | Chemosphere2013，，： | 2 |
| 8 | Characterization of DNA damage response deficiency in pancreatic cancer patients from China显示文摘To the editor,Pancreatic ductal adenocarcinoma(PDAC)has the worst prognosis among all common malignant solid tumors,with a 5-year overall survival(OS)rate of less than 10%[1].Few effective targets for anticancer ther-apy have been confirmed in pancreatic cancer.Recently,it was substantiated that pancreatic cancer patients carry-ing deleterious mutations of the DNA damage response(DDR)genes are more likely to benefit from platinum-based chemotherapy[2]and poly(adenosine diphosphate-ribose)polymerase(PARP)inhibitor[3]. | Xiaofei Zhang Tiebo Mao Bei Zhang Haiyan Xu Jiujie Cui Feng Jiao Dongqin Chen Yu Wang Jiong Hu Qing Xia Shumin Li Ming Yue Jingyu Ma Jiayu Yao Yongchao Wang Xiao Zhang Shiqing Chen Yuezong Bai Yuexiang Wang Xuebin Zhang Qiang Liu Yongwei Sun Deliang Fu Yingbin Liu Lei Xiong Liwei Wang | 2022 | Cancer Communications2022，42，1： | 2 |
| 9 | XAFS study of Cu^(2+) in aqueous solution of CuBr_2显示文摘Copper ion is the essential microelement to many organisms. In this paper, the local structure of Cu2+ in CuBr2 aqueous solutions with different concentrations are investigated by using X-ray absorption fine structure (XAFS) technique. XANES (X-ray Absorption Near Edge Structure) spectra indicate that charge transfer from Br- to Cu2+ decreases with the solution concentration, which lead to a shift of the absorption edge. The shoulder appearing at the rising edge proves to be characteristic of a tetragonal distortion. The Fourier transform magnitudes of EXAFS (Extended X-ray absorption fine structure) data of Cu species suggest that more Cu-Br bonds may exist in high concentrations. A fivefold coordination configuration like a pyramid is used as the fitting parameters. From the analysis of the coordination numbers, the proportion of Cu-O and Cu-Br is 4:1 in the saturated solution. The Br atom is on the equatorial plane of the model. The fitting results agree well with the experiment data. | DAI Binbin WANG Qian MA Jingyuan LI Jiong ZHANG Shuo HUANG Yuying HUANG Wei WU Guozhong ZOU Yang JIANG Zheng XU Hongjie | 2012 | Nuclear Science and Techniques2012，23，3： | 2 |
| 10 | Low levels of neutralizing antibodies against XBB Omicron subvariants after BA.5 infection显示文摘The COVID-19 response strategies in Chinese mainland were recently adjusted due to the reduced pathogenicity and enhanced infectivity of Omicron subvariants.In Chengdu,China,an infection wave was predominantly induced by the BA.5 subvariant.It is crucial to determine whether the hybrid anti-SARS-CoV-2 immunity following BA.5 infection. | Jingyun Yang Weiqi Hong Hong Lei Cai He Wenwen Lei Yanan Zhou Tingmei Zhao Aqu Alu Xuelei Ma Jiong Li Li Yang Zhenling Wang Wei Wang Guangwen Lu Guobo Shen Shuaiyao Lu Guizhen Wu Huashan Shi Xiawei Wei | 2023 | Signal Transduction and Targeted Therapy2023，8，7： | 1 |
| 11 | EXPRESSION OF p16 AND p53 IN GASTRIC CARCINOMA显示文摘Objective:To investigate the clinical significance of p53 and p16 expression in gastric carcinoma with special reference to the prognosis.Methods:One hundred and fifty-two patients with gastric carcinoma undergoing operation in our hospital between 1991 and 1998 were evaluated for expression of p53 and p16 in formalin-fixed and paraffin-embedded tumor tissue utilizing Avidin-Biotin immunohistochemistry techniques. Statistical correlations with stage, histological type, differentiation degree, location, size, and overall survival were done. The Cox proportional hazard model was also performed to evaluate which factors had an independent prognostic value.Results:In 152 cases of resected gastric cancer, 110 (72.4%) were p16 positive and 49 (32.2%) showed p53 overexpression. Differences were observed in the frequency of p16 positivity with respect to age, gender and tumor size. The frequency of p53 positivity cells in well-differentiated tumors was significantly higher than that in poorly differentiated tumors (41.9% vs. 25.6%; P = 0.034). In a multivariate analysis, tumor TNM stage, perioperation chemotherapy and the expression of p16 were independent prognostic factors in gastric cancer.Conclusions:The results of the current study suggest that expression of p16 may be a useful prognostic factor for patients with gastric carcinoma, but the expression of p53 as detected by immunohistochemistry were of no value in predicting the prognosis of patients with gastric carcinoma independently. | Ma Yu, Gao Liping 1, Song Yifeng, Jing Jiong, Wang ChunjiangFirst Department of Surgery,Shengzhou People’s Hospital, Shengzhou 312400 | 2003 | 中国现代医学杂志2003，13，1： | 1 |
| 12 | Mussel-inspired fabrication of structurally stable chitosan/polyaerylonitrile composite membrane for pervaporation dehydration显示文摘 | Ma Jing Zhang Minhua Wu Hong Yin Xin Chen Jing Jiong Zhongyi | 2010 | Journal of Membrane Science2010，348，： | 1 |
| 13 | SCN1A, SCN1B, and GABRG2 gene mutation analysis in Chinese families with generalized epilepsy with febrile seizures plus显示文摘 | Huihui Sun Yuehua Zhang Jianmin Liang Xiaoyan Liu Xiuwei Ma Husheng Wu Keming Xu Jiong Qin Yu Qi Xiru Wu | 2008 | Journal of Human Genetics2008，，8： | 1 |
| 14 | Conflict detection and resolution for authorization policies in workflow systems显示文摘The specification of authorization policies in access control models proposed so far cannot satisfy the requirements in workflow management systems(WFMSs).Furthermore,existing approaches have not provided effective conflict detection and resolution methods to maintain the consistency of authorization polices in WFMSs.To address these concerns,we propose the definition of authorization policies in which context constraints are considered and the complicated requirements in WFMSs can be satisfied.Based on the definition,we put forward static and dynamic conflict detection methods for authorization policies.By defining two new concepts,the precedence establishment rule and the conflict resolution policy,we provide a flexible approach to resolving conflicts. | Chen-hua MA Guo-dong LU Jiong QIU | 2009 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2009，10，8： | 1 |
| 15 | Light-controlled self-assembly and conductance: from nanoribbons to nanospheres显示文摘 | MA Lulu JIA Jiong YANG Tieying | 2012 | Rsc Adv2012，2，7： | 1 |
| 16 | Modeling photobleached optical polymer waveguides 显示文摘 | Jiong Ma Sihan Lin Wei Feng | 1995 | Appl Opt1995，34，24： | 1 |
| 17 | Detection of PCC functional connectivity characteristics in resting-state fMRI in mild Alzheimer’s disease显示文摘 | Hong-Ying Zhang Shi-Jie Wang Jiong Xing Bin Liu Zhan-Long Ma Ming Yang Zhi-Jun Zhang Gao-Jun Teng | 2008 | Behavioural Brain Research2008，，1： | 1 |
| 18 | Spatial Working Memory Impairment in Subclinical Hypothyroidism: An fMRI Study显示文摘 | Yin Jing-jing Liao Ling-min Luo Dong-xue Xu Ke Ma Shu-hua Wang Zhao-xin Le Hong-bo Huang Ran-ran Cai Ze-long Zhang Jiong | 2013 | Neuroendocrinology2013，，3： | 1 |
| 19 | Long-Term Trend Analysis of Major Human Helminth Infections — Guangdong Province, China, 1988–2021显示文摘Introduction:Although helminth infections threaten millions of people worldwide,the spatiotemporal characteristics remain unclear across China.This study systematically describes the spatiotemporal changes of major human helminth infections and their epidemiological characteristics from 1988 to 2021 in Guangdong Province,China.Methods:The survey data in Guangdong Province were primarily obtained from 3 national surveys implemented during 1988–1992,2001–2004,and 2014–2016,respectively,and from the China Information System for Disease Control and Prevention during 2019–2021.A modified Kato-Katz technique was used to detect parasite eggs in collected fecal samples.Results:The overall standardized infection rates(SIRs)of any soil-transmitted helminths(STH)and Clonorchis sinensis decreased from 65.27%during 1988–1992 to 4.23%during 2019–2021.In particular,the SIRs of STH had even more of a decrease,from 64.41%during 1988–1992 to 0.31%during 2019–2021.The SIRs of Clonorchis sinensis in the 4 surveys were 2.40%,12.17%,5.20%,and 3.93%,respectively.This study observed different permutations of gender,age,occupation,and education level on the SIRs of helminths.Conclusions:The infection rate of STH has substantially decreased.However,the infection rate of Clonorchis sinensis has had fewer changes,and it has become the dominant helminth. | Yueyi Fang Jiong Wang Guanhao He Qiming Zhang Jianpeng Xiao Jianxiong Hu Zuhua Rong Lihua Yin Fangfang Zeng Pan Yang Xiaomei Dong Dan Liu Xiaofeng Liang Zhuohui Deng Tao Liu Wenjun Ma | 2022 | China CDC weekly2022，4，41： | 1 |
| 20 | AgInS_(2)/ZnS quantum dots for noninvasive cervical cancer screening with intracellular pH sensing using fluorescence lifetime imaging microscopy显示文摘Intracellular pH plays a critical role in biological functions,and abnormal pH values are related to various diseases.Here,we report on an intracellular pH sensor AgInS_(2)(AIS)/ZnS quantum dots(QDs)that show long fluorescence lifetimes of hundreds of nanoseconds and low toxicity.Fluorescence lifetime imaging microscopy(FLIM)combined with AIS/ZnS QDs is used for the imaging of live cells in different pH buffers and different cell lines.The FLIM images of AIS/ZnS QDs in live cells demonstrate different intracellular pH values in different regions,such as in lysosomes or cytoplasm.This method can also distinguish cancer cells from normal cells,and the fluorescence lifetime difference of the AIS/ZnS QDs between the two types of cells is 100±7 ns.Most importantly,the exfoliated cervical cells from 20 patients are investigated using FLIM combined with AIS/ZnS QDs.The lifetime difference value between the normal and cervical cancer(CC)groups is 115±9 ns,and the difference between the normal and the precancerous lesion group is 64±9 ns.For the first time,the noninvasive method has been used for cervical cancer screening,and it has shown great improvement in sensitivity compared with a clinical conventional cytology examination. | Wenhua Su Dan Yang Yulan Wang Yawei Kong Wanlu Zhang Jing Wang Yiyan Fei Ruiqian Guo Jiong Ma Lan Mi | 2022 | Nano Research2022，15，6： | 0 |
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