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| 1 | Sintilimab versus docetaxel as second-line treatment in advanced or metastatic squamous non-small-cell lung cancer:an open-label,randomized controlled phase 3 trial(ORIENT-3)显示文摘Background:Treatment options for Chinese patients with locally advanced or metastatic squamous-cell non-small-cell lung cancer(sqNSCLC)after failure of first-line chemotherapy are limited.This study(ORIENT-3)aimed to evaluate the efficacy and safety of sintilimab versus docetaxel as second-line treatment in patients with locally advanced or metastatic sqNSCLC.Methods:ORIENT-3 was an open-label,multicenter,randomized controlled phase 3 trial that recruited patients with stage IIIB/IIIC/IV sqNSCLC after failure with first-line platinum-based chemotherapy.Patients were randomized in a 1:1 ratio to receive either 200 mg of sintilimab or 75 mg/m^(2) of docetaxel intravenously every 3 weeks,stratified by the Eastern Cooperative Oncology Group performance status.The primary endpoint was overall survival(OS)in the full analysis set(FAS).Secondary endpoints included progression-free survival(PFS),objective response rate(ORR),disease control rate(DCR),duration of response(DoR)and safety.Results:Between August 25,2017,and November 7,2018,290 patients were randomized.For FAS,10 patients fromthe docetaxel armwere excluded.Themedian OS was 11.79(n=145;95%confidence interval[CI],10.28-15.57)months with sintilimab versus 8.25(n=135;95%CI,6.47-9.82)months with docetaxel(hazard ratio[HR]:0.74;95%CI,0.56-0.96;P=0.025).Sintilimab treatment significantly prolonged PFS(median 4.30 vs.2.79 months;HR:0.52;95%CI,0.39-0.68;P<0.001)and showed higher ORR(25.50%vs.2.20%,P<0.001)and DCR(65.50%vs.37.80%,P<0.001)than the docetaxel arm.The median DoRwas 12.45(95%CI,4.86-25.33)months in the sintilimab arm and 4.14(95%CI,1.41-7.23)months in the docetaxel arm(P=0.045).Treatment-related adverse events of grade≥3were reported in 26(18.1%)patients in the sintilimab arm and 47(36.2%)patients in the docetaxel arm.Exploratory biomarker analysis showed potential predictive values of expression levels of two transcription factors,including OVOL2(HR:0.35;P<0.001)and CTCF(HR:3.50;P<0.001),for sintilimab treatment.Conclusions:Compared with docetaxel,sintilimab significantly improved the OS,PFS,and ORR of Chinese patients with previously treated locally advanced or metastatic sqNSCLC. | Yuankai Shi Lin Wu Xinmin Yu Puyuan Xing Yan Wang Jianying Zhou Airong Wang Jianhua Shi Yi Hu Ziping Wang Guangyu An Yong Fang Sanyuan Sun Caicun Zhou Changli Wang Feng Ye Xingya Li Junye Wang Mengzhao Wang Yunpeng Liu Yanqiu Zhao Ying Yuan Jifeng Feng Zhendong Chen Jindong Shi Tao Sun Gang Wu Yongqian Shu Qisen Guo Yi Zhang Yong Song Shucai Zhang Yuan Chen Wei Li Hongrui Niu Wenwei Hu Lijun Wang Jianan Huang Yang Zhang Ying Cheng Zhengdong Wu Bo Peng Jiya Sun Christoph Mancao Yanqi Wang Luyao Sun | 2022 | Cancer Communications2022，42，12： | 8 |
| 2 | Constructing confidence intervals of extreme rainfall quantiles using Bayesian,bootstrap,and profile likelihood approaches显示文摘Hydrological risk is highly dependent on the occurrence of extreme rainfalls.This fact has led to a wide range of studies on the estimation and uncertainty analysis of the extremes.In most cases,confidence intervals(CIs)are constructed to represent the uncertainty of the estimates.Since the accuracy of CIs depends on the asymptotic normality of the data and is questionable with limited observations in practice,a Bayesian highest posterior density(HPD)interval,bootstrap percentile interval,and profile likelihood(PL)interval have been introduced to analyze the uncertainty that does not depend on the normality assumption.However,comparison studies to investigate their performances in terms of the accuracy and uncertainty of the estimates are scarce.In addition,the strengths,weakness,and conditions necessary for performing each method also must be investigated.Accordingly,in this study,test experiments with simulations from varying parent distributions and different sample sizes were conducted.Then,applications to the annual maximum rainfall(AMR)time series data in South Korea were performed.Five districts with 38-year(1973–2010)AMR observations were fitted by the three aforementioned methods in the application.From both the experimental and application results,the Bayesian method is found to provide the lowest uncertainty of the design level while the PL estimates generally have the highest accuracy but also the largest uncertainty.The bootstrap estimates are usually inferior to the other two methods,but can perform adequately when the distribution model is not heavy-tailed and the sample size is large.The distribution tail behavior and the sample size are clearly found to affect the estimation accuracy and uncertainty.This study presents a comparative result,which can help researchers make decisions in the context of assessing extreme rainfall uncertainties. | CHEN Si LI YaXing SHIN JiYae KIM TaeWoong | 2016 | Science China(Technological Sciences)2016，59，4： | 4 |
| 3 | Polyurethane real-size models used in planning complex spinal surgery显示文摘 | Van Dijk M Smit TH Jiya TU | 2001 | Spine2001，26，17： | 1 |
| 4 | Polyurethane real-size models used in planning complex spinal surgery 显示文摘 | van Dijk M Smit TH Jiya TU | 2001 | Spine2001，26，： | 1 |
| 5 | Polyurethane real-size models used in planning complex spinal surgery 显示文摘 | van Dijk M Smit TH Jiya TU | 2001 | Spine2001，17，： | 1 |
| 6 | Posterior lumbar interbody fusion using nonresorbable poly-ether-ethe-ketone versus resorbable ply-L-lactide-co-D,L-Lactide fusion devices:a prospective,randomized study to assess fusion and clinical outcome显示文摘 | Jiya T Smit T Deddens J | | 0，，1976： | 1 |
| 7 | Polyurethane real-size models used in planning complex spinal surgery显示文摘 | van Dijk M Smit TH Jiya TU et a l | | 0，，1976： | 1 |
| 8 | Sequential interactions of silver-silica nanocomposite (Ag-SiO2 NC) with cell wall, metabolism and genetic stability of Pseudomonas aeruginosa, multiple antibiotic-resistant bacterium显示文摘 | Anas A Jiya J Rameez MJ | 2013 | Lett Appl Mierobiol2013，56，1： | 1 |
| 9 | Abiotrophia defectiva infection of a total hip arthroplasty diagnosed by 16S rRNA gene sequencing显示文摘 | Rozemeijer W Jiya TU Rijnsburger M | 2011 | Diagn Microbiol Infect Dis2011，70，1： | 1 |
| 10 | Polyurethane real-size models used in planning complex spinal surgery 显示文摘 | Van Dijk M Smit TH Jiya TU | 2001 | Spine2001，26，17： | 1 |
| 11 | Posterior lumbar interbody fusion using nonresorbable poly-ether-ether-ketone versus resorbable poly-L-lactide-co-D,L-lactide fusion devices:a prospective,randomized study to assess fusion and clinical outcome显示文摘 | Jiya T Smit T Deddens J | | 0，，1976： | 1 |
| 12 | Posterior lumbar interbody fusion using nonresorbable poly-ether-ether-ketone versus resorbable poly-L-lactide-co-D,L-lactide fusion devices:a prospective,randomized study to assess fusion and clinical outcome显示文摘 | Jiya T Smit T Deddens J | 2009 | Spine(Phila Pa 1976)2009，3，： | 1 |
| 13 | Polyurethane real-size models used in planning complex spinal surgery 显示文摘 | Van Dijk M Smit TH Jiya TU | 2001 | Spine2001，26，17： | 1 |
| 14 | Posterior lumbar interbody fusion using nonresorbable poly-ether-ether-ketone versus resorbable poly-L-lactide-co-D, L-lactide fusion devices a prospective, randomized study to assess fusion and clinical outcome显示文摘 | Jiya T Smit T Deddens J | 2009 | Spine (Phila Pa 1976)2009，34，3： | 1 |
| 15 | Jayaraman, A, Laboratory corrosion studies of refinery overhead distillation units显示文摘 | Saxena R C Nand Jiya | 2000 | Corrosion Prevention and Control2000，47，2： | 1 |
| 16 | Event reconstruction by dig- ital filtering显示文摘 | Ayodeji O O Jiya J Y Hale J M | 2013 | Advances in Signal Processing2013，1，3： | 1 |
| 17 | Posterior lumbar interbody fusion using nonresorbable poly-ether-ether-ketone versus resorbable poly-L-lactide-co-D, L-lactide fusion devices: A prospective, randomized study to assess fusion and clinical outcome 显示文摘 | JIYA T SMIT T DEDDENS J | 2009 | Spine2009，34，： | 1 |
| 18 | Neonatal septicaemia in II orin: bacterial pathogens and antibiotic sensitivity pattern 显示文摘 | Mokuolu AO Jiya N Adesiyun OO | 2002 | Afr JMed Sci2002，31，2： | 1 |
| 19 | Polyurethane real-size models used in planning complex spinal surgery 显示文摘 | van Dijk M Smit TH Jiya TU | 2001 | Spine2001，26，17： | 1 |
| 20 | Antioxidant vitamin levels among preschool children with uncomplicated Plasmodi-um falciparum malaria in Sokoto,Nigeria显示文摘 | Aghedo FI Shehu RA Jiya MN | | 0，，： | 1 |
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