|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Sintilimab versus docetaxel as second-line treatment in advanced or metastatic squamous non-small-cell lung cancer:an open-label,randomized controlled phase 3 trial(ORIENT-3)显示文摘Background:Treatment options for Chinese patients with locally advanced or metastatic squamous-cell non-small-cell lung cancer(sqNSCLC)after failure of first-line chemotherapy are limited.This study(ORIENT-3)aimed to evaluate the efficacy and safety of sintilimab versus docetaxel as second-line treatment in patients with locally advanced or metastatic sqNSCLC.Methods:ORIENT-3 was an open-label,multicenter,randomized controlled phase 3 trial that recruited patients with stage IIIB/IIIC/IV sqNSCLC after failure with first-line platinum-based chemotherapy.Patients were randomized in a 1:1 ratio to receive either 200 mg of sintilimab or 75 mg/m^(2) of docetaxel intravenously every 3 weeks,stratified by the Eastern Cooperative Oncology Group performance status.The primary endpoint was overall survival(OS)in the full analysis set(FAS).Secondary endpoints included progression-free survival(PFS),objective response rate(ORR),disease control rate(DCR),duration of response(DoR)and safety.Results:Between August 25,2017,and November 7,2018,290 patients were randomized.For FAS,10 patients fromthe docetaxel armwere excluded.Themedian OS was 11.79(n=145;95%confidence interval[CI],10.28-15.57)months with sintilimab versus 8.25(n=135;95%CI,6.47-9.82)months with docetaxel(hazard ratio[HR]:0.74;95%CI,0.56-0.96;P=0.025).Sintilimab treatment significantly prolonged PFS(median 4.30 vs.2.79 months;HR:0.52;95%CI,0.39-0.68;P<0.001)and showed higher ORR(25.50%vs.2.20%,P<0.001)and DCR(65.50%vs.37.80%,P<0.001)than the docetaxel arm.The median DoRwas 12.45(95%CI,4.86-25.33)months in the sintilimab arm and 4.14(95%CI,1.41-7.23)months in the docetaxel arm(P=0.045).Treatment-related adverse events of grade≥3were reported in 26(18.1%)patients in the sintilimab arm and 47(36.2%)patients in the docetaxel arm.Exploratory biomarker analysis showed potential predictive values of expression levels of two transcription factors,including OVOL2(HR:0.35;P<0.001)and CTCF(HR:3.50;P<0.001),for sintilimab treatment.Conclusions:Compared with docetaxel,sintilimab significantly improved the OS,PFS,and ORR of Chinese patients with previously treated locally advanced or metastatic sqNSCLC. | Yuankai Shi Lin Wu Xinmin Yu Puyuan Xing Yan Wang Jianying Zhou Airong Wang Jianhua Shi Yi Hu Ziping Wang Guangyu An Yong Fang Sanyuan Sun Caicun Zhou Changli Wang Feng Ye Xingya Li Junye Wang Mengzhao Wang Yunpeng Liu Yanqiu Zhao Ying Yuan Jifeng Feng Zhendong Chen Jindong Shi Tao Sun Gang Wu Yongqian Shu Qisen Guo Yi Zhang Yong Song Shucai Zhang Yuan Chen Wei Li Hongrui Niu Wenwei Hu Lijun Wang Jianan Huang Yang Zhang Ying Cheng Zhengdong Wu Bo Peng Jiya Sun Christoph Mancao Yanqi Wang Luyao Sun | 2022 | Cancer Communications2022，42，12： | 8 |
| 2 | Shenzhu Tiaopi granule combined with life style intervention therapy for impaired glucose tolerance:a randomized controlled trial显示文摘 | Fang Zhaohui Zhao Jindong Shi Guobing | 2014 | Complementary Therapies in Medicine2014，22，10： | 1 |
| 3 | MicroRNA-141 promotes the proliferation of non-small cell lung cancer cells by regulating expression of PHLPP1 and PHLPP2显示文摘 | Zhoufang Mei Yanchao He Jingjing Feng Jindong Shi Yong Du Ling Qian Qihui Huang Zhijun Jie | 2014 | FEBS Letters2014，，17： | 1 |
| 4 | Shenzhu Tiaopi Granule Combined with Lifestyle Intervention Ther- apy for Impaired Glucose Tolerance: a randomized con- trolled trial显示文摘 | Fang Zhaohui Zhao Jindong Shi Guobing | 2014 | Complementary Therapies in Medicine2014，22，10： | 1 |
| 5 | Loading experiment and thermal analysis for conduction cooled magnet of SMES system显示文摘China’s first 35 kJ high temperature superconducting magnetic energy storage(SMES)system with an experiment equipment was depicted.The dynamic heat analysis of the magnet of the SMES was conducted through the current load test on the directly cooled conduction magnet.The research results were as follows:when the converter charges and discharges the magnet for energy storage,the hysteresis loss is the main part of power loss,and contributes significantly to temperature rise;reducing the current frequency at the side of direct current is conducive to restraining temperature rise.The optimizing factors of the cool-guide structure were analyzed based on the heat stability theory,and it was found that the heat transfer of its key part(at the top of the magnet)must be strengthened to reduce the axial temperature difference of the magnet. | Gang WU Huiling WANG Jiangbo XIE Yan ZHAO Yuejin TANG Jindong LI Jing SHI | 2009 | Frontiers of Electrical and Electronic Engineering in China2009，4，2： | 0 |
| 6 | Modified Circumpolar Deep Water inflow to the Dotson-Getz Trough in the summers of 2020 and 2022显示文摘The melting of the West Antarctic Ice Shelf has increased since the 1990s,driven by the relatively warm Circumpolar Deep Water(CDW)that penetrates into the West Antarctic Ice Shelf cavities through submarine glacial troughs across the continental shelf.In this study,temperature,salinity,and current velocity data obtained by the Chinese National Antarctic Research Expedition in the Dotson-Getz Trough(DGT)shows clear differences in distribution of modified Circumpolar Deep Water(mCDW)in the summers of 2020 and 2022.Combined with contemporaneous wind data and additional temperature and salinity data from instrumented seals,the processes and mechanisms responsible for this variation are discussed.Compared with 2020,there is a significant increase in mCDW thickness in 2022,with a doubling of total heat content as the mCDW inflow path across the DGT shifts towards the eastern bank.We propose that a southward shift in the westerly winds in the summer of 2022 moved the upper oceanic divergence zone southward towards the continental slope,promoting the upwelling of mCDW above 500 m.Concurrently,stronger westerly winds over the continental slope strengthened the eastward undercurrent,increasing the transport of this mCDW and its associated heat content to the DGT through Ekman dynamics.These observations show there is strong interannual variability in the strength,path and extent of mCDW inflows to the DGT and that care must be taken when planning observation programs for long-term monitoring of the oceanic heat input to the ice shelves of this globally significant region. | XIE Chunhu SHI Jiuxin SUN Yongming JIANG Jindong Guy DWILLIAMS SHUAI Hongtao LIN Lijin XIAO Changhao CAO Yong WANG Kun | 2023 | Advances in Polar Science2023，34，2： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员