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| 1 | Sintilimab versus docetaxel as second-line treatment in advanced or metastatic squamous non-small-cell lung cancer:an open-label,randomized controlled phase 3 trial(ORIENT-3)显示文摘Background:Treatment options for Chinese patients with locally advanced or metastatic squamous-cell non-small-cell lung cancer(sqNSCLC)after failure of first-line chemotherapy are limited.This study(ORIENT-3)aimed to evaluate the efficacy and safety of sintilimab versus docetaxel as second-line treatment in patients with locally advanced or metastatic sqNSCLC.Methods:ORIENT-3 was an open-label,multicenter,randomized controlled phase 3 trial that recruited patients with stage IIIB/IIIC/IV sqNSCLC after failure with first-line platinum-based chemotherapy.Patients were randomized in a 1:1 ratio to receive either 200 mg of sintilimab or 75 mg/m^(2) of docetaxel intravenously every 3 weeks,stratified by the Eastern Cooperative Oncology Group performance status.The primary endpoint was overall survival(OS)in the full analysis set(FAS).Secondary endpoints included progression-free survival(PFS),objective response rate(ORR),disease control rate(DCR),duration of response(DoR)and safety.Results:Between August 25,2017,and November 7,2018,290 patients were randomized.For FAS,10 patients fromthe docetaxel armwere excluded.Themedian OS was 11.79(n=145;95%confidence interval[CI],10.28-15.57)months with sintilimab versus 8.25(n=135;95%CI,6.47-9.82)months with docetaxel(hazard ratio[HR]:0.74;95%CI,0.56-0.96;P=0.025).Sintilimab treatment significantly prolonged PFS(median 4.30 vs.2.79 months;HR:0.52;95%CI,0.39-0.68;P<0.001)and showed higher ORR(25.50%vs.2.20%,P<0.001)and DCR(65.50%vs.37.80%,P<0.001)than the docetaxel arm.The median DoRwas 12.45(95%CI,4.86-25.33)months in the sintilimab arm and 4.14(95%CI,1.41-7.23)months in the docetaxel arm(P=0.045).Treatment-related adverse events of grade≥3were reported in 26(18.1%)patients in the sintilimab arm and 47(36.2%)patients in the docetaxel arm.Exploratory biomarker analysis showed potential predictive values of expression levels of two transcription factors,including OVOL2(HR:0.35;P<0.001)and CTCF(HR:3.50;P<0.001),for sintilimab treatment.Conclusions:Compared with docetaxel,sintilimab significantly improved the OS,PFS,and ORR of Chinese patients with previously treated locally advanced or metastatic sqNSCLC. | Yuankai Shi Lin Wu Xinmin Yu Puyuan Xing Yan Wang Jianying Zhou Airong Wang Jianhua Shi Yi Hu Ziping Wang Guangyu An Yong Fang Sanyuan Sun Caicun Zhou Changli Wang Feng Ye Xingya Li Junye Wang Mengzhao Wang Yunpeng Liu Yanqiu Zhao Ying Yuan Jifeng Feng Zhendong Chen Jindong Shi Tao Sun Gang Wu Yongqian Shu Qisen Guo Yi Zhang Yong Song Shucai Zhang Yuan Chen Wei Li Hongrui Niu Wenwei Hu Lijun Wang Jianan Huang Yang Zhang Ying Cheng Zhengdong Wu Bo Peng Jiya Sun Christoph Mancao Yanqi Wang Luyao Sun | 2022 | Cancer Communications2022，42，12： | 8 |
| 2 | The Entire Small Intestine Mediates the Changes in Glucose Homeostasis After Intestinal Surgery in Goto-Kakizaki Rats显示文摘 | Shaozhuang Liu Guangyong Zhang Lei Wang Dong Sun Weijie Chen Zhibo Yan Yu Sun Sanyuan Hu | 2012 | Annals of Surgery2012，，6： | 2 |
| 3 | Undulated 2D Covalent Organic Frameworks Based on Bowl-Shaped Cyclotricatechylene显示文摘Two 2D wavy hexagonal hexahydroxyl cyclotricatechylene (CTC) based COFs, CTC-COF-2 and CTC-COF-3were synthesized through solvothermal reaction. The bowl-shaped conformation caused CTC skeletons packed in acolumnar manner with the same oriented units, thus forming an undulated structure. The gas adsorption propertiesof CTC-COFs were investigated, which show the potential application abilities in hydrogen storage of CTC-COFs.The introduction of pyrene into CTC-COF-3 makes it a potential semiconducting π-conjugated material. | Jingru Zhen Sanyuan Ding Wei Wang Junmin Liu Junliang Sun Zhitang Huang Qiyu Zheng | 2016 | Chinese Journal of Chemistry2016，34，8： | 2 |
| 4 | Duodenal-Jejunal Bypass Surgery Suppresses Hepatic De Novo Lipogenesis and Alleviates Liver Fat Accumulation in a Diabetic Rat Model显示文摘 | Haifeng Han Chunxiao Hu Lei Wang Guangyong Zhang Shaozhuang Liu Feng Li Dong Sun Sanyuan Hu | 2014 | Obesity Surgery2014，，12： | 1 |
| 5 | 显示文摘 | Chen Sanyuan Sun Chialiang | 2001 | J Appl Phys2001，90，6： | 1 |
| 6 | The better effect of Roux-en-Y gastrointestinal reconstruction on blood glucose of nonobese type 2 diabetes mellitus patients显示文摘 | Weijie Chen Zhibo Yan Shaozhuang Liu Guangyong Zhang Dong Sun Sanyuan Hu | 2014 | The American Journal of Surgery2014，，6： | 1 |
| 7 | Sub-sleeve gastrectomy achieves good diabetes control without weight loss in a non-obese diabetic rat model显示文摘 | Dong Sun Shaozhuang Liu Guangyong Zhang Punsiri Colonne Chunxiao Hu Haifeng Han Mingxia Li Sanyuan Hu | 2014 | Surgical Endoscopy2014，，3： | 1 |
| 8 | Genome-wide CRISPR screening reveals key genes and pathways associated with 20-hydroxyecdysone signal transduction in the silkworm(Bombyx mori)显示文摘Metamorphosis is a complex developmental process involving multiple pathways and a large number of genes that are regulated by juvenile hormone(JH)and 20-hydroxyecdysone(20E).Despite important progress in understanding various aspects of silkworm biology,the hormone signaling pathway in the silkworm remains poorly understood.Genome-wide screening using clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated protein 9(Cas9)-based libraries has recently emerged as a novel method for analyzing genome function,enabling further research into essential genes,drug targets,and virus-host interaction.Previously,we constructed a genome-wide CRISPR/Cas9-based library of the silkworm(Bombyx mori)and successfully revealed the genes involved in biotic or abiotic stress factor responses.In this study,we used our silkworm CRISPR library and large-scale genome-wide screening to analyze the key genes in the silkworm 20E signaling pathway and their mechanisms of action.Functional annotation showed that 20E regulates key proteins in processes that mainly occur in the cytoplasm and nucleus.Pathway enrichment analysis showed that 20E can activate phosphorylation and may affect innate immunity,interfere with intracellular nutrition and energy metabolism,and eventually cause cell apoptosis.The screening results were experimentally validated by generating cells with knockout alleles of the relevant genes,which had increased tolerance to 20E.Our findings provide a panoramic overview of signaling in response to 20E in the silkworm,underscoring the utility of genome-wide CRISPR mutant libraries in deciphering hormone signaling pathways and the mechanisms that regulate metamorphosis in insects. | Hao Sun Jingya Chen Ruolin Wang Dan Liu Na Zhang Tong Zhang Ling Jia Sanyuan Ma Qingyou Xia | 2024 | Insect Science2024，31，1： | 0 |
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