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| 1 | 胃癌:诊断和治疗方案的选择显示文摘胃癌是消化系统最常见的恶性肿瘤之一,是世界上第四高发肿瘤,也是我国目前第二高发肿瘤。据统计,在2013年全球胃癌新增的952000例患者中,中国占47%,其发病率远高于欧美等国家。广泛的癌细胞转移使我国每年有352300人死于胃癌,死亡率位居第三。由于早期症状不典型且胃镜常规检查未普及,我国60%~80%的胃癌患者就诊时已到晚期。加上现有治疗手段获益有限,预后差,晚期胃癌患者5年生存率不超过20%。因此,如何及早发现胃癌,进而预防和治疗胃癌是广大医师关注的热点问题。为使广大医师对胃癌有深入了解,本期“专题研究”栏目对胃癌转移的机制进行了分析,发现锌指蛋白139(ZNF139)可调控胃癌肿瘤细胞凋亡、随肿瘤转移而表达增强,成为导致肿瘤进展的可能因素之一。同时,为使广大医师及时了解胃癌治疗的新动向,本期又从胃癌根治术中纳米炭淋巴示踪剂的作用以及胃癌微创治疗进展方面进行了探讨与论述,为临床今后胃癌治疗的研究提供了理论依据和方向。 | John C. Layke Peter P. Lopez | 2015 | 中国全科医学2015，18，3： | 56 |
| 2 | Disassembly of the fruit cell wall by the ripening-associated polygalacturonase and expansin influences tomato cracking显示文摘Fruit cracking is an important problem in horticultural crop production.Polygalacturonase(SlPG)and expansin(SlEXP1)proteins cooperatively disassemble the polysaccharide network of tomato fruit cell walls during ripening and thereby,enable softening.A Golden 2-like(GLK2)transcription factor,SlGLK2 regulates unripe fruit chloroplast development and results in elevated soluble solids and carotenoids in ripe fruit.To determine whether SlPG,SlEXP1,or SlGLK2 influence the rate of tomato fruit cracking,the incidence of fruit epidermal cracking was compared between wild-type,Ailsa Craig(WT)and fruit with suppressed SlPG and SlEXP1 expression(pg/exp)or expressing a truncated nonfunctional Slglk2(glk2).Treating plants with exogenous ABA increases xylemic flow into fruit.Our results showed that ABA treatment of tomato plants greatly increased cracking of fruit from WT and glk2 mutant,but not from pg/exp genotypes.The pg/exp fruit were firmer,had higher total soluble solids,denser cell walls and thicker cuticles than fruit of the other genotypes.Fruit from the ABA treated pg/exp fruit had cell walls with less water-soluble and more ionically and covalently-bound pectins than fruit from the other lines,demonstrating that ripening-related disassembly of the fruit cell wall,but not elimination of SlGLK2,influences cracking.Cracking incidence was significantly correlated with cell wall and wax thickness,and the content of cell wall protopectin and cellulose,but not with Ca^(2+)content. | Fangling Jiang Alfonso Lopez Shinjae Jeon Sergio Tonetto de Freitas Qinghui Yu Zhen Wu John M.Labavitch Shengke Tian Ann L.T.Powell Elizabeth Mitcham | 2019 | Horticulture Research2019，6，1： | 13 |
| 3 | Current systematic reviews and meta-analyses of COVID-19显示文摘BACKGROUND Coronavirus disease 2019(COVID-19)has left a significant impact on the world's health,economic and political systems;as of November 20,2020,more than 57 million people have been infected worldwide,with over 1.3 million deaths.While the global spotlight is currently focused on combating this pandemic through means ranging from finding a treatment among existing therapeutic agents to inventing a vaccine that can aid in halting the further loss of life.AIM To collect all systematic reviews and meta-analyses published related to COVID-19 to better identify available evidence,highlight gaps in knowledge,and elucidate further meta-analyses and umbrella reviews that are yet to be performed.METHODS We explored studies based on systematic reviews and meta-analyses with the keyterms,including severe acute respiratory syndrome(SARS),SARS virus,coronavirus disease,COVID-19,and SARS coronavirus-2.The included studies were extracted from Embase,Medline,and Cochrane databases.The publication timeframe of included studies ranged between January 01,2020,to October 30,2020.Studies that were published in languages other than English were not considered for this systematic review.The finalized full-text articles are freely accessible in the public domain.RESULTS Searching Embase,Medline,and Cochrane databases resulted in 1906,669,and 19 results,respectively,that comprised 2594 studies.515 duplicates were subsequently removed,leaving 2079 studies.The inclusion criteria were systematic reviews or meta-analyses.860 results were excluded for being a review article,scope review,rapid review,panel review,or guideline that produced a total of 1219 studies.After screening articles were categorized,the included articles were put into main groups of clinical presentation,epi-demiology,screening and diagnosis,severity assessment,special populations,and treatment.Subsequently,there was a second subclassification into the following groups:gastrointestinal,cardiovascular,neurological,stroke,thrombosis,anosmia and dysgeusia,ocular manifestations,nephrology,cutaneous manifestations,D-dimer,lymphocyte,anticoagulation,antivirals,convalescent plasma,immunosuppressants,corticosteroids,hydroxychloroquine,renin-angiotensin-aldosterone system,technology,diabetes mellitus,obesity,pregnancy,children,mental health,smoking,cancer,and transplant.CONCLUSION Among the included articles,it is clear that further research is needed regarding treatment options and vaccines.With more studies,data will be less heterogeneous,and statistical analysis can be better applied to provide more robust clinical evidence.This study was not designed to give recommendations regarding the management of COVID-19. | Mahmoud Nassar Nso Nso Mostafa Alfishawy Anastasia Novikov Salim Yaghi Luis Medina Bahtiyar Toz Sofia Lakhdar Zarwa Idrees Yungmin Kim Dawa Ongyal Gurung Raheel S Siddiqui David Zheng Mariam Agladze Vikram Sumbly Jasmine Sandhu Francisco Cuevas Castillo Nadya Chowdhury Ravali Kondaveeti Sakil Bhuiyan Laura Guzman Perez Riki Ranat Carlos Gonzalez Harangad Bhangoo John Williams Alaa Eldin Osman Joyce Kong Jonathan Ariyaratnam Mahmoud Mohamed Ismail Omran Mariely Lopez Akwe Nyabera Ian Landry Saba Iqbal Anoosh Zafar Gondal Sameen Hassan Ahmed Daoud Bahaaeldin Baraka Theo Trandafirescu Vincent Rizzo | 2021 | World Journal of Virology2021，10，4： | 2 |
| 4 | Two-dimensional current percolation in nanocrystalline vana- dium dioxide films 显示文摘 | Rozen John Lopez Rene Haglund R F | 2006 | Applied Physics Letters2006，88，08： | 1 |
| 5 | Retroperitoneal lipoblastoma: A discussion of current management显示文摘 | Daniela Burchhardt Sara C. Fallon Monica E. Lopez Eugene S. Kim John Hicks Mary L. Brandt | 2012 | Journal of Pediatric Surgery2012，，10： | 1 |
| 6 | Endothelial dysfunction:implication for therapy of cardiovascular diseases显示文摘 | Bell DM Johns TE Lopez LM | 1998 | Ann Pharmacother1998，32，4： | 1 |
| 7 | The major genetic determinants of HIV-1control affect HLA class I peptide presentation显示文摘 | International HIV Controllers Study Pereyra F Jia X McLaren P J Telenti A de Bakker P I Walker B D Ripke S Brumme C J Pulit S L Carrington M Kadie C M Carlson J M Heckerman D Graham R R Plenge R M Deeks S G Gianniny L Crawford G Sullivan J Gonzalez E Davies L Camargo A Moore JM Beattie N Gupta S Crenshaw A Burtt N P Guiducci C Gupta N Gao X Qi Y Yuki Y Piechocka-Trocha A Cutrell E Rosenberg R Moss K L Lemay P O'Leary J Schaefer T Verma P Toth I Block B Baker B Rothchild A Lian J Proudfoot J Alvino D M Vine S Addo M M Allen T M Altfeld M Henn M R Le Gall S Streeck H Haas D W Kuritzkes D R Robbins G K Shafer R W Gulick R M Shikuma C M Haubrich R Riddler S Sax P E Daar E S Ribaudo H J Agan B Agarwal S Ahern R L Allen B L Altidor S Altschuler E L Ambardar S Anastos K Anderson B Anderson V Andrady U Antoniskis D Bangsberg D Barbaro D Barrie W Bartczak J Barton S Basden P Basgoz N Bazner S Bellos N C Benson A M Berger J Bernard N F Bernard A M Birch C Bodner S J Bolan R K Boudreaux E T Bradley M Braun J F Brndjar J E Brown S J Brown K Brown S T Burack J Bush LM Cafaro V Campbell O Campbell J Carlson R H Carmichael J K Casey K K Cavacuiti C Celestin G Chambers S T Chez N Chirch L M Cimoch P J Cohen D Cohn LE Conway B Cooper D A Cornelson B Cox D T Cristofano M V Cuchural G Jr Czartoski J L Dahman J M Daly J S Davis B T Davis K Davod S M DeJesus E Dietz C A Dunham E Dunn M E Ellerin T B Eron J J Fangman J J Farel C E Ferlazzo H Fidler S Fleenor-Ford A Frankel R Freedberg K A French N K Fuchs JD Fuller J D Gaberman J Gallant J E Gandhi R T Garcia E Garmon D Gathe J C Jr Gaultier C R Gebre W Gilman F D Gilson I Goepfert P A Gottlieb M S Goulston C Groger R K Gurley T D Haber S Hardwicke R Hardy W D Harrigan P R Hawkins T N Heath S Hecht F M Henry W K Hladek M Hoffman R P Horton J M Hsu R K Huhn G D Hunt P Hupert M J Illeman M L Jaeger H Jellinger R M John M Johnson J A Johnson K L Johnson H Johnson K Joly J Jordan W C Kauffman C A Khanlou H Killian R K Kim A Y Kim D D Kinder C A Kirchner J T Kogelman L Kojic E M Korthuis P T Kurisu W Kwon D S LaMar M Lampiris H Lanzafame M Lederman M M Lee D M Lee J M Lee M J Lee E T Lemoine J Levy J A Llibre J M Liguori M A Little S J Liu A Y Lopez A J Loutfy M R Loy D Mohammed D Y Man A Mansour M K Marconi V C Markowitz M Marques R Martin J N Martin H L Jr Mayer K H McElrath M J McGhee T A McGovern B H McGowan K McIntyre D Mcleod GX Menezes P Mesa G Metroka CE Meyer-Olson D Miller A O Montgomery K Mounzer K C Nagami E H Nagin I Nahass R G Nelson M O Nielsen C Norene D L O'Connor D H Ojikutu B O Okulicz J Oladehin O O Oldfield E C Olender S A Ostrowski M Owen WF Jr Pae E Parsonnet J Pavlatos A M Perlmutter A M Pierce M N Pincus J M Pisani L Price L J Proia L Prokesch R C Pujet H C Ramgopal M Rathod A Rausch M Ravishankar J Rhame F S Richards C S Richman D D Rodes B Rodriguez M Rose R C 3rd Rosenberg E S Rosenthal D Ross P E Rubin D S Rumbaugh E Saenz L Salvaggio M R Sanchez WC Sanjana V M Santiago S Schmidt W Schuitemaker H Sestak P M Shalit P Shay W Shirvani V N Silebi V I Sizemore J M Jr Skolnik P R Sokol-Anderson M Sosman J M Stabile P Stapleton J T Starrett S Stein F Stellbrink H J Sterman FL Stone V E Stone D R Tambussi G Taplitz R A Tedaldi E M Telenti A Theisen W Torres R Tosiello L Tremblay C Tribble M A Trinh P D Tsao A Ueda P Vaccaro A Valadas E Vanig T J Vecino I Vega V M Veikley W Wade B H Walworth C Wanidworanun C Ward D J Warner D A Weber R D Webster D Weis S Wheeler D A White D J Wilkins E Winston A Wlodaver C G van't Wout A Wright D P Yang O O Yurdin D L Zabukovic B W Zachary K C Zeeman B Zhao M | 2010 | Science2010，330，6010： | 1 |
| 8 | Monoclonal Antibody-Mediated Targeting of CD123, IL-3 Receptor α Chain, Eliminates Human Acute Myeloid Leukemic Stem Cells显示文摘 | Liqing Jin Erwin M. Lee Hayley S. Ramshaw Samantha J. Busfield Armando G. Peoppl Lucy Wilkinson Mark A. Guthridge Daniel Thomas Emma F. Barry Andrew Boyd David P. Gearing Gino Vairo Angel F. Lopez John E. Dick Richard B. Lock | 2009 | Cell Stem Cell2009，，1： | 1 |
| 9 | Utility of urgent colonoscopy in acute lower gastro-intestinal bleeding:a single-center experience显示文摘Background.The role of urgent colonoscopy in lower gastro-intestinal bleeding(LGIB)remains controversial.Over the last two decades,a number of studies have indicated that urgent colonoscopy may facilitate the identification and treatment of bleeding lesions;however,studies comparing this approach to elective colonoscopy for LGIB are limited.Aims.To determine the utility and assess the outcome of urgent colonoscopy as the initial test for patients admitted to the intensive care unit(ICU)with acute LGIB.Methods.Consecutive patients who underwent colonoscopy at our institution for the initial evaluation of acute LGIB between January 2011 and January 2012 were analysed retrospectively.Patients were grouped into urgent vs.elective colonoscopy,depending on the timing of colonoscopy after admission to the ICU.Urgent colonoscopy was defined as being performed within 24 hours of admission and those performed later than 24 hours were considered elective.Outcomes included length of hospital stay,early re-bleeding rates,and the need for additional diagnostic or therapeutic interventions.Multivariable logistic regression analysis was performed to identify factors associated with increased transfusion requirements.Results.Fifty-seven patients underwent colonoscopy for the evaluation of suspected LGIB,24 of which were urgent.There was no significant difference in patient demographics,co-morbidities,or medications between the two groups.Patients who underwent urgent colonoscopy were more likely to present with hemodynamic instability(P=0.019)and require blood transfusions(P=0.003).No significant differences in length of hospital stay,re-bleeding rates,or the need for additional diagnostic or therapeutic interventions were found.Patients requiring blood transfusions(n=27)were more likely to be female(P=0.016)and diabetics(P=0.015).Fourteen patients re-bled at a median of 2 days after index colonoscopy.Those with hemodynamic instability were more likely to re-bleed[HR 3.8(CI 1.06–13.7)],undergo angiography[HR 9.8(CI 1.8–54.1)],require surgery[HR 13.5(CI 3.2–56.5)],and had an increased length of hospital stay[HR 1.1(1.05–1.2)].Conclusion:The use of urgent colonoscopy,as an initial approach to investigate acute LGIB,did not result in significant differences in length of ICU stay,re-bleeding rates,the need for additional diagnostic or therapeutic interventions,or 30-day mortality compared with elective colonoscopy.In a pre-specified subgroup analysis,patients with hemodynamic instability were more likely to re-bleed after index colonoscopy,to require additional interventions(angiography or surgery)and had increased length of hospital stay. | Mazen Albeldawi Duc Ha Paresh Mehta Rocio Lopez Sunguk Jang Madhusudhan R.Sanaka John J.Vargo | 2014 | Gastroenterology Report2014，2，4： | 1 |
| 10 | Apoptotic Cells Promote Their Own Clearance and Immune Tolerance through Activation of the Nuclear Receptor LXR显示文摘 | Noelia A-Gonzalez Steven J. Bensinger Cynthia Hong Susana Beceiro Michelle N. Bradley Noam Zelcer Jose Deniz Cristina Ramirez Mercedes Díaz German Gallardo Carlos Ruiz de Galarreta Jon Salazar Felix Lopez Peter Edwards John Parks Miguel Andujar Peter Tont | 2009 | Immunity2009，，2： | 1 |
| 11 | Bisoprolol: is this just another beta-blocker for hypertension or angina? 显示文摘 | Johns TE Lopez LM | 1995 | Ann Pharmacother1995，29，： | 1 |
| 12 | Interpretational appli- cations of spectral decomposition in reservoir characterization显示文摘 | Greg Partyka James Gridley John Lopez | 1999 | The Leading Edge1999，18，3： | 1 |
| 13 | Endothelial dysfunction: implications for therapy of cardiovascular diseases显示文摘 | Bell DM Johns TE Lopez Lm | 1998 | Arm Pharmacother1998，32，4： | 1 |
| 14 | Acute liver failure in children: The first 348 patients in the pediatric acute liver failure study group显示文摘 | Robert H. Squires Benjamin L. Shneider John Bucuvalas Estella Alonso Ronald J. Sokol Michael R. Narkewicz Anil Dhawan Philip Rosenthal Norberto Rodriguez-Baez Karen F. Murray Simon Horslen Martin G. Martin M. James Lopez Humberto Soriano Brendan M. McGuir | 2006 | The Journal of Pediatrics2006，，5： | 1 |
| 15 | Synthesis of ZrO2 nano- metric using controlled precipitation 显示文摘 | Cabrera Lopez John Jairo Luis Narvaez Jose Ro- driguez Paez Jorge Enrique | 2009 | Revista Fac-ultad De Ingeneria-Universided de Antioquia2009，47，3： | 1 |
| 16 | Comprehensive molecular diagnosis of 179 Leber congenital amaurosis and juvenile retinitis pigmentosa patients by targeted next generation sequencing显示文摘 | Xia Wang Hui Wang Vincent Sun Han-Fang Tuan Vafa Keser Keqing Wang Huanan Ren Irma Lopez Jacques E Zaneveld Sorath Siddiqui Stephanie Bowles Ayesha Khan Jason Salvo Samuel G Jacobson Alessandro Iannaccone Feng Wang David Birch John R Heckenlively Gerald A | 2013 | Journal of Medical Genetics2013，，10： | 1 |
| 17 | Interpretational applications of spectral decomposition in reservoir characterization显示文摘 | James Gridly John Lopez | 1999 | The Leading Edge1999，18，3： | 1 |
| 18 | Interpre- tational applications of spectral decomposition in res- ervoir characterization显示文摘 | Greg Partyka James Gridley John Lopez | 1999 | The Leading Edge1999，18，3： | 1 |
| 19 | Interpretational application of spectral decomposition in reservoir eharacterization 显示文摘 | Greg Partyka James Gridley John Lopez | 1999 | The Leading Edge1999，18，3： | 1 |
| 20 | Does this child have a urinary tract infection? 显示文摘 | Nader Shaikh Natalia Morone John Lopez | 2007 | JAMA2007，298，24： | 1 |
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