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| 1 | Multicenter study of endoscopic preoperative biliary drainage for malignant distal biliary obstruction显示文摘AIM: To determine the optimal method of endoscopic preoperative biliary drainage for malignant distal biliary obstruction.METHODS: Multicenter retrospective study was conducted in patients who underwent plastic stent(PS) or nasobiliary catheter(NBC) placement for resectable malignant distal biliary obstruction followed by surgery between January 2010 and March 2012. Procedurerelated adverse events, stent/catheter dysfunction(occlusion or migration of PS/NBC, developmentof cholangitis, or other conditions that required repeat endoscopic biliary intervention), and jaundice resolution(bilirubin level < 3.0 mg/d L) were evaluated. Cumulative incidence of jaundice resolution and dysfunction of PS/NBC were estimated using competing risk analysis. Patient characteristics and preoperative biliary drainage were also evaluated for association with the time to jaundice resolution and PS/NBC dysfunction using competing risk regression analysis.RESULTS: In total, 419 patients were included in the study(PS, 253 and NBC, 166). Primary cancers included pancreatic cancer in 194 patients(46%), bile duct cancer in 172(41%), gallbladder cancer in three(1%), and ampullary cancer in 50(12%). The median serum total bilirubin was 7.8 mg/d L and 324 patients(77%) had ≥ 3.0 mg/d L. During the median time to surgery of 29 d [interquartile range(IQR), 30-39 d]. PS/NBC dysfunction rate was 35% for PS and 18% for NBC [Subdistribution hazard ratio(SHR) = 4.76; 95%CI: 2.44-10.0, P < 0.001]; the pig-tailed tip was a risk factor for PS dysfunction. Jaundice resolution was achieved in 85% of patients and did not depend on the drainage method(PS or NBC).CONCLUSION: PS has insufficient patency for preoperative biliary drainage. Given the drawbacks of external drainage via NBC, an alternative method of internal drainage should be explored. | Naoki Sasahira Tsuyoshi Hamada Osamu Togawa Ryuichi Yamamoto Tomohisa Iwai Kiichi Tamada Yoshiaki Kawaguchi Kenji Shimura Takero Koike Yu Yoshida Kazuya Sugimori Shomei Ryozawa Toshiharu Kakimoto Ko Nishikawa Katsuya Kitamura Tsunao Imamura Masafumi Mizuide Nobuo Toda Iruru Maetani Yuji Sakai Takao Itoi Masatsugu Nagahama Yousuke Nakai Hiroyuki Isayama | 2016 | World Journal of Gastroenterology2016，22，14： | 18 |
| 2 | A minimally invasive multiple percutaneous drainage technique for acute necrotizing pancreatitis显示文摘BACKGROUND: In approximately 20% of patients, necrotizing pancreatitis is complicated with severe acute pancreatitis, with high morbidity and mortality rates. Minimally invasive step-up approach is both safe and effective, but sometimes requires multiple access sites.METHODS: A 62-year-old woman was admitted with diabetic ketoacidosis, and initial computed tomography(CT) revealed no evidence of acute pancreatitis. She was clinically improved with insulin therapy, fl uid administration, and electrolyte replacement. However, on the 14 th day of admission, she developed a high-grade fever, and CT demonstrated evidence of acute necrotizing pancreatitis with a large collection of peripancreatic fl uid. Percutaneous transgastric drainage was performed and a 14 French gauge(Fr) pigtail catheter was placed 1 week later, which drained copious pus. Because of persistent high-grade fever and poor clinical improvement, multiple 8 and 10 Fr pigtail catheters were placed via the initial drainage route, allowing the safe and effective drainage of the extensive necrotic tissue that was occupying the bilateral anterior pararenal space.RESULTS: After drainage, the patient recovered well and the last catheter was removed on day 123 of admission.CONCLUSIONS: Multiple percutaneous drainage requires both careful judgment and specialist skills. The perforation of the colon and small bowel as well as the injury of the kidney and major vessels can occur. The current technique appears to be safe and minimally invasive compared with other drainage methods in patients with extended, infected necrotic pancreatic pseudocysts. | Takero Terayama Toru Hifumi Nobuaki Kiriu Hiroshi Kato Yuichi Koido Yoshiaki Ichinose Kohei Morimoto Kuroda Yasuhiro | 2014 | World Journal of Emergency Medicine2014，5，4： | 7 |
| 3 | Endoscopic ultrasonography can diagnose distal biliary strictures without a mass on computed tomography显示文摘AIM:To assess the diagnostic ability of endoscopic ultrasonography(EUS)for evaluating causes of dista biliary strictures shown on endoscopic retrograde chol angiopancreatography(ERCP)or magnetic resonance cholangiopancreatography(MRCP),even without iden tifiable mass on computed tomography(CT). METHODS:The diagnostic ability of EUS was retro spectively analyzed and compared with that of routine cytology(RC)and tumor markers in 34 patients with distal biliary strictures detected by ERCP or MRCP a Dokkyo Medical School Hospital from December 2005 to December 2008,without any adjacent mass or ec centric thickening of the bile duct on CT that could cause biliary strictures.Findings considered as benign strictures on EUS included preservation of the normasonographic layers of the bile duct wall,irrespective of the presence of a mass lesion.Other strictures were considered malignant.Final diagnosis of underlying diseases was made by pathological examination in 18 cases after surgical removal of the samples,and by clinical follow-up for>10 mo in 16 cases. RESULTS:Seventeen patients(50%)were finally di- agnosed with benign conditions,including 6'normal' subjects,while 17 patients(50%)were diagnosed with malignant disease.In terms of diagnostic ability,EUS showed 94.1%sensitivity,82.3%specificity,84.2% positive predictive value,93.3%negative predictive value(NPV)and 88.2%accuracy for identifying ma- lignant and benign strictures.EUS was more sensi- tive than RC(94.1%vs 62.5%,P=0.039).NPV was also better for EUS than for RC(93.3%vs 57.5%,P= 0.035).In addition,EUS provided significantly higher sensitivity than tumor markers using 100 U/mL as the cutoff level of carbohydrate antigen 19-9(94.1%vs 53%,P=0.017).On EUS,biliary stricture that was fi- nally diagnosed as malignant showed as a hypoechoic, irregular mass,with obstruction of the biliary duct and invasion to surrounding tissues. CONCLUSION:EUS can diagnose biliary strictures caused by malignant tumors that are undetectable on CT.Earlier detection by EUS would provide more therapeutic options for patients with early-stage pancreaticobiliary cancer. | Yasuyuki Saifuku Michiko Yamagata Takero Koike Genyo Hitomi Kazunari Kanke Hidetaka Watanabe Toshimitsu Murohisa Masaya Tamano Makoto Iijima Keiichi Kubota Hideyuki Hiraishi | 2010 | World Journal of Gastroenterology2010，16，2： | 5 |
| 4 | Heat coma as an indicator of resistance to environmental stress and its relationship to ocean dynamics in the sea skaters, Halobates (Heteroptera: Gerridae)显示文摘到温度增加的忍耐为在西方的热带太平洋在二巡航期间收集的 Halobates 个人被测试(MR-06-05-Leg 3, 12 月 21 日, 2006January 12, 2007, 0 搠浥湡吗? | Tetsuo Harada Shiho Takenaka Takero Sekimoto Mitsuru Nakajyo Takao Inoue Takamasa Ishibashi Chihiro Katagiri | 2011 | Insect Science2011，18，6： | 2 |
| 5 | Non-invasive blood glucose measurement by Fourier transform infrared spectroscopic analysis through the mucous membrane of the lip:application of a chalcogenide optical fiber system显示文摘 | Takero Uemura Kenro Nishida Michiharu Sakakida Kenshi Ichinose Seiya Shimoda Motoaki Shichiri | 1999 | Frontiers of medical and biological engineering1999，9，2： | 1 |
| 6 | New chiral diphosphine ligands designed to have a narrow dihedral angle in the biaryl backbone显示文摘 | Takao Saito Tohru Yokozawa Takero Ishizaki | 2001 | Adv Synth Catal2001，343，： | 1 |
| 7 | Enteral versus Parenteral Nutrition after Gastrointestinal Surgery: A Systematic Review and Meta-Analysis of Randomized Controlled Trials in the English Literature 显示文摘 | Takero Mazaki Kiyoko Ebisawa | 2008 | J Gastrointest Surg2008，12，： | 1 |
| 8 | Up-regulation of TFF1(pS2)expression by TNF-a in gastric Epithelial cells显示文摘 | Takero Koike Tadahito Shimada Yoichiro Fujii | | 0，，06： | 1 |
| 9 | Japanese government debt and sustainability of fiscal policy 显示文摘 | Doi Takero Takeo Hoshi Tatsuyoshi Okimoto | 2011 | Journal of the Japanese and International Economies2011，，4： | 1 |
| 10 | Enteral versus Parenteral Nutrition after Gastrointestinal Surgery: A Systematic Review and Meta-Analysis of Randomized Controlled Trials in the English Literature显示文摘 | Takero Mazaki Kiyoko Ebisawa | 2008 | Journal of Gastrointestinal Surgery2008，，： | 1 |
| 11 | Enteral versus parenteral nutrition after gastrointestinal surgery: a systematic review and meta-analysis of randomized controlled trials in the English literature显示文摘 | Takero Mazaki Kiyoko Ebisawa | 2008 | J Gastrointest Surg2008，12，： | 1 |
| 12 | Oxygen separation properties of bisphen01 fluorene-based cardo polymer membranes 显示文摘 | Shingo K Takero T Kenji H | 2005 | High Performance Polymers2005，17，1： | 1 |
| 13 | Herd Behavior of Japanese economists显示文摘 | Masahiro Ashiya Takero Doi | 2001 | Journal of Economic Behavior & Organization2001，46，： | 1 |
| 14 | Prophylactic pancreatic stent placement and post-ERCP pancreatitis: an updated meta-analysis显示文摘 | Takero Mazaki Kazunari Mado Hideki Masuda Motomi Shiono | | Journal of Gastroenterology0，，2： | 1 |
| 15 | Down-regulation of SREBP-1c is associated with the development of burned-out NASH显示文摘 | Tadanobu Nagaya Naoki Tanaka Takefumi Suzuki Kenji Sano Akira Horiuchi Michiharu Komatsu Takero Nakajima Tomoko Nishizawa Satoru Joshita Takeji Umemura Tetsuya Ichijo Akihiro Matsumoto Kaname Yoshizawa Jun Nakayama Eiji Tanaka Toshifumi Aoyama | 2010 | Journal of Hepatology2010，，4： | 1 |
| 16 | Japanese government debt and sustainability of fiscal policy显示文摘 | Takero Doi Takeo Hoshi Tatsuyoshi Okimoto | 2011 | Journal of The Japanese and International Economies2011，，4： | 1 |
| 17 | Simulation Analysis of Policies to Ensure Japan' s Fiscal Sustainability 显示文摘 | DOI TAKERO H | 2008 | Mita Journal of Eco- nomics2008，，4： | 1 |
| 18 | Mechanisms of Steatosis-Derived Hepatocarcinogenesis:Lessons from HCV Core Gene Transgenic Mice显示文摘Hepatitis C virus(HCV)is a major cause of chronic hepatitis,liver cirrhosis,and hepatocellular carcinoma(HCC)worldwide.Among the structural proteins of HCV,the HCV core protein has the ability to regulate gene transcription,lipid metabolism,cell proliferation,apoptosis,and autophagy,all of which are closely related to the development of HCC.Transgenic mice carrying the HCV core gene exhibited age-dependent insulin resistance,hepatic steatosis,and HCC that resembled the clinical characteristics of chronic hepatitis C patients.Several dietary modifications,including calorie restriction and diets rich in saturated fatty acids,trans fatty acids,or cholesterol,were found to influence hepatic steatogenesis and tumorigenesis in HCV core gene transgenic mice.These strategies modulated hepatocellular stress and proliferation,in addition to hepatic fibrotic processes and the microenvironment,thereby corroborating a close interconnection between dietary habits and steatosis-related hepatocarcinogenesis.In this review,we summarize the findings obtained from mouse models transgenic for the HCV genome,with a special focus on HCV core gene transgenic mice,and discuss the mechanisms of steatogenesis and hepatocarcinogenesis induced by the HCV core protein and the impact of dietary habits on steatosis-derived HCC development. | Pan Diao Fangping Jia Xiaojing Wang Xiao Hu Takefumi Kimura Takero Nakajima Toshifumi Aoyama Kyoji Moriya Kazuhiko Koike Naoki Tanaka | 2021 | Engineering2021，7，12： | 0 |
| 19 | Plant Dynamics Evaluation of a MONJU Ex-vessel Fuel Storage System during a Station Blackout显示文摘 | Takero Mori Masutake Sotsu Kei Honda Satoshi Suzuki Hiroaki Ohira | 2013 | Journal of Energy and Power Engineering2013，7，9： | 0 |
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