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| 1 | Current status, problems, and perspectives of non-alcoholic fatty liver disease research显示文摘Non-alcoholic fatty liver disease(NAFLD) is a major chronic liver disease that can lead to liver cirrhosis, liver cancer, and ultimately death. NAFLD is pathologically classified as non-alcoholic fatty liver(NAFL) or non-alcoholic steatohepatitis(NASH) based on the existence of ballooned hepatocytes,although the states have been known to transform into each other. Moreover,since the detection of ballooned hepatocytes may be difficult with limited biopsied specimens, its clinical significance needs reconsideration. Repeated liver biopsy to assess histological NAFLD activity for therapeutic response is also impractical, creating the need for body fluid biomarkers and less invasive imaging modalities. Recent longitudinal observational studies have emphasized the importance of advanced fibrosis as a determinant of NAFLD outcome. Thus,identifying predictors of fibrosis progression and developing better screening methods will enable clinicians to isolate high-risk NAFLD patients requiring early intensive intervention. Despite the considerable heterogeneity of NAFLD with regard to underlying disease, patient age, and fibrosis stage, several clinical trials are underway to develop a first-in-class drug. In this review, we summarize the present status and future direction of NAFLD/NASH research towards solving unmet medical needs. | Naoki Tanaka Takefumi Kimura Naoyuki Fujimori Tadanobu Nagaya Michiharu Komatsu Eiji Tanaka | 2019 | World Journal of Gastroenterology2019，25，2： | 29 |
| 2 | 空气弹簧在无气状态下铁道车辆仿真模型的建立显示文摘介绍了铁道车辆用空气弹簧在无气状态下的运行试验结果并建立了无气空气弹簧仿真模型。通过对比仿真结果与试验结果,验证了仿真模型的有效性。 | 周冬妍(译) 赵云生(校) | 2020 | 国外铁道车辆2020，57，5： | 2 |
| 3 | Bone regeneration with osteogenic matrix cell sheet and tricalcium phosphate:An experimental study in sheep显示文摘AIM To determine the effects of a cell sheet created from sheep bone marrow and tricalcium phosphate(TCP) on osteogenesis.METHODS Bone marrow cells were harvested from a sheep and cultured in a minimal essential medium(MEM) containing ascorbic acid phosphate(AscP) and dexamethasone(Dex). After 2 wk, the formed osteogenic matrix cell sheet was lifted from the culture dish using a scraper. Additionally, harvested bone marrow cells were cultured in MEM only as a negative control group, and in MEM with AscP, Dex, and β-glycerophosphate as a positive control group. For in vitro evaluation, we measured the alkaline phosphatase(ALP) activity and osteocalcin(OC) content in the media of the cultured cells from each group. For in vivo analysis, a porous TCP ceramic was used as a scaffold. We prepared an experimental group comprising TCP scaffolds wrapped with the osteogenic matrix cell sheets and a control group consisting of the TCP scaffold only. The constructs wereimplanted subcutaneously into athymic rats and the cell donor sheep, and bone formation was confirmed by histology after 4 wk.RESULTS In the in vitro part, the mean ALP activity was 0.39 ± 0.03 mg/well in the negative control group, 0.67 ± 0.04 mg/well in the sheet group, and 0.65 ± 0.07 mg/well in the positive control group. The mean OC levels were 1.46 ± 0.33 ng/well in the negative control group, 3.92 ± 0.16 ng/well in the sheet group, and 4.4 ± 0.47 ng/well in the positive control group, respectively. The ALP activity and OC levels were significantly higher in the cell sheet and positive control groups than in the negative control group(P < 0.05). There was no significant difference in ALP activity or OC levels between the cell sheet group and the positive control group(P > 0.05). TCP constructs wrapped with cell sheets prior to implantation showed bone formation, in contrast to TCP scaffolds alone, which exhibited poor bone formation when implanted, in the subcutaneous layer both in athymic rats and in the sheep. CONCLUSION This technique for preparing highly osteoinductive TCP may promote regeneration in large bone defects. | Tsutomu Kira Manabu Akahane Shohei Omokawa Takamasa Shimizu Kenji Kawate Tadanobu Onishi Yasuhito Tanaka | 2017 | World Journal of Orthopedics2017，8，10： | 2 |
| 4 | Purification and properties of leucine aminopeptidase Ⅰ from Aspergillus oryzae显示文摘 | Tadanobu N Seiichi N | 1973 | Agric Biol Chem1973，37，4： | 1 |
| 5 | InAsSb thick epilayers applied to long wavelength photoconductors显示文摘InAs0.052Sb0.948 epilayers with cutoff wavelengths longer than 8 μm were successfully grown on InAs substrates using melt epitaxy (ME). Scanning electron microscopy observations show that the interface between the epilayers and substrates is flat, indicating the good quality of the epilayers, and the thickness of the epilayers is 40 μm. Photoconductors were fabricated using InAs 0.052Sb0.948 thick epilayers grown by ME. Ge optical lenses were set on the photoconductors. At room temperature, the photoresponse wavelength range was 2-10 μm. The peak detectivity D*λp reached 5.4 × 109 cm·Hz 1/2 ·W-1 for the immersed detectors. The detectivity D*was 9.3 × 108 and 1.3 × 108 cm·Hz 1/2 ·W-1 at the wavelength of 8 and 9 μm, respectively. The good performance of the uncooled InAsSb detectors was experimentally validated. | Yu-zhu Gao Xiu-ying Gong Guang-hui Wu Yan-bin Feng Takamitsu Makino Hirofumi Kan Tadanobu Koyama Yasuhiro Hayakawa | 2013 | International Journal of Minerals,Metallurgy and Materials2013，20，4： | 1 |
| 6 | Purification and properties of leucine aminopeptidase Ⅱ and Ⅲ from Aspergillus oryzae显示文摘 | Tadanobu N Seiichi N | 1973 | Agric Biol Chem1973，37，4： | 1 |
| 7 | Shear-lag simulation of the progress of interracial debonding in unidirectional composites 显示文摘 | Ocial S Tadanobu H M | 1999 | Composites Science and Technology1999，59，1： | 1 |
| 8 | Comparison of Alzheimer’s disease with vascular dementia and non-dementia using specific voxel-based Z score maps显示文摘 | Shirou Ishii Fumio Shishido Masayuki Miyajima Koutarou Sakuma Takeshi Shigihara Tadanobu Tameta Makoto Miyazaki Hiroshi Kuroda | 2009 | Annals of Nuclear Medicine2009，，1： | 1 |
| 9 | Real time robust identification algorithm for structural systems with time varying dynamic characteristics显示文摘 | Tadanobu S Kenji T | 1997 | SPIE1997，3039，： | 1 |
| 10 | A practical numerical method for large strain liquefaction analysis of saturated soils显示文摘 | YUAN Di TADANOBU SATO | 2004 | Soil Dynamics and Earthquake Engineering2004，24，： | 1 |
| 11 | Accurate and simple method for quantification of hepatic fat content using magnetic resonance imaging: a prospective study in biopsy-proven nonalcoholic fatty liver disease显示文摘 | Tomoko Hatta Yasunari Fujinaga Masumi Kadoya Hitoshi Ueda Hiroaki Murayama Masahiro Kurozumi Kazuhiko Ueda Michiharu Komatsu Tadanobu Nagaya Satoru Joshita Ryo Kodama Eiji Tanaka Tsuyoshi Uehara Kenji Sano Naoki Tanaka | 2010 | Journal of Gastroenterology2010，，12： | 1 |
| 12 | Effects of a parathyroidectomy on the immune system and nutritional condition in chronic dialysis patients with secondary hyperparathyroidism显示文摘 | Chikao Yasunaga Masahiko Nakamoto Kenzo Matsuo Gakusen Nishihara Tetsuhiko Yoshida Tadanobu Goya | 1999 | The American Journal of Surgery1999，，4： | 1 |
| 13 | Oviposition stimulants for the tropical swallowtail butterfly, Papilio polytes, feeding on a rutaceous plant, Toddalia asiatica 显示文摘 | Tadanobu N Keiichi H Nanao H | 2003 | JChem Ecol2003，29，7： | 1 |
| 14 | Quantitative determination of the fatty acid composition of human serum lipids by high- performance liquid chromatography 显示文摘 | Yoshiharu S Satoru S Tadanobu T | 1986 | Journal of Chromatography A1986，383，2： | 1 |
| 15 | Purification and properties of Leucine aminopeptidase Ⅰ from Aspergillu soryzae显示文摘 | Tadanobu Nakadai Seiichi Nasuno | 1973 | Agri Biol Chem1973，37，4： | 1 |
| 16 | Purification and properties of Leucine aminopeptidase Ⅱ and Ⅲ from Aspergillus oryzae显示文摘 | Tadanobu Nakadai Seiichi Nasuno | 1973 | Agri Biol Chem1973，37，4： | 1 |
| 17 | Study on the Initial Stage of Emulsion Polymerization of Vinyl Acetate Using Poly(Vinyl Alcohol)as a Protective Colloid显示文摘 | Atsushi S Makoto Y Tadanobu S | 2003 | Colloid Polym Sct2003，281，4： | 1 |
| 18 | Analysis of User Relations and Reading Activity in Weblogs显示文摘 | Tadanobu Furukawa Tomofumi Matsuzawa Yutaka Matsuo Koki Uchiyama Masayuki Takeda | 2006 | Electronics and Communications in Japan (Part I:Communications)2006，，12： | 1 |
| 19 | Growth and structure of graphitic tubules and polyhedral particles in arcdischarge显示文摘 | Yahachi Saito Tadanobu Yoshikawa | 1993 | Chem Phys Lett1993，204，： | 1 |
| 20 | Chronic Gastritis in the Setting of Autoimmune Pancreatitis显示文摘 | Takeshi Uehara Hideaki Hamano Shigeyuki Kawa Kenji Sano Keiko Oki Yukihiro Kobayashi Tadanobu Nagaya Taiji Akamatsu Masahiro Kurozumi Yasunori Fujinaga Eiji Tanaka Takayuki Honda Hiroyoshi Ota | 2010 | The American Journal of Surgical Pathology2010，，9： | 1 |
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