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| 1 | Understanding the medial ulnar collateral ligament of the elbow: Review of native ligament anatomy and function显示文摘The medial ulnar collateral ligament complex of the elbow, which is comprised of the anterior bundle [AB, more formally referred to as the medial ulnar collateral ligament(MUCL)], posterior(PB), and transverse ligament, is commonly injured in overhead throwing athletes. Attenuation or rupture of the ligament results in valgus instability with variable clinical presentations. The AB or MUCL is the strongest component of the ligamentous complex and the primary restraint to valgus stress. It is also composed of two separate bands(anterior and posterior) that provide reciprocal function with the anterior band tight in extension, and the posterior band tight in flexion. In individuals who fail co-mprehensive non-operative treatment, surgical repair or reconstruction of the MUCL is commonly required to restore elbow function and stability. A comprehensive understanding of the anatomy and biomechanical properties of the MUCL is imperative to optimize reconstructive efforts, and to enhance clinical and radiographic outcomes. Our understanding of the native anatomy and biomechanics of the MUCL has evolved over time. The precise locations of the origin and insertion footprint centers guide surgeons in proper graft placement with relation to bony anatomic landmarks. In recent studies, the ulnar insertion of the MUCL is described as larger than previously thought, with the center of the footprint at varying distances relative to the ulnar ridge, joint line, or sublime tubercle. The purpose of this review is to consolidate and summarize the existing literature regarding the native anatomy, biomechanical, and clinical significance of the entire medial ulnar collateral ligament complex, including the MUCL(AB), PB, and transverse ligament. | Joshua R Labott William R Aibinder Joshua S Dines Christopher L Camp | 2018 | World Journal of Orthopedics2018，9，6： | 4 |
| 2 | Heparin resistance in severe thermal injury:a prospective cohort study显示文摘Background:Low molecular-weight heparin(LMWH)is routinely administered to burn patients for thromboprophylaxis.Some studies have reported heparin resistance,yet the mechanism(s)and prevalence have not been systematically studied.We hypothesized that nucleosomes,composed of histone structures with associated DNA released from injured tissue and activated immune cells in the form of neutrophil extracellular traps(NETs or NETosis),neutralize LMWH resulting in suboptimal anticoagulation,assessed by reduction in anti-factor Xa activity.Methods:Blood was sampled from>15%total body surface area(TBSA)burn patients receiving LMWH on days 5,10 and 14.Peak anti-factor Xa(AFXa)activity,anti-thrombin(ATIII)activity,cellfree DNA(cfDNA)levels and nucleosome levels were measured.Mixed effects regression was adjusted for multiple confounders,including injury severity and ATIII activity,and was used to test the association between nucleosomes and AFXa.Results:A total of 30 patients with severe burns were included.Mean TBSA 43%(SD 17).Twentythree(77%)patients were affected by heparin resistance(defined by AFXa activity<0.2 IU/mL).Mean peak AFXa activity across samples was 0.18 IU/mL(SD 0.11).Mean ATIII was 81.9%activity(SD 20.4).Samples taken at higher LWMH doses were found to have significantly increased AFXa activity,though the effect was not observed at all doses,at 8000 IU no samples were heparin resistant.Nucleosome levels were negatively correlated with AFXa(r=−0.29,p=0.050)consistent with the hypothesis.The final model,with peak AFXa as the response variable,was adjusted for nucleosome levels(p=0.0453),ATIII activity(p=0.0053),LMWH dose pre-sample(p=0.0049),drug given(enoxaparin or tinzaparin)(p=0.03),and other confounders including severity of injury,age,gender,time point of sample.Conclusions:Heparin resistance is a prevalent issue in severe burns.Nucleosome levels were increased post-burn,and showed an inverse association with AFXa consistent with the hypothesis that they may interfere with the anticoagulant effect of heparin in vivo and contribute to heparin resistance.Accurate monitoring of AFXa activity with appropriate therapy escalation plans are recommended with dose adjustment following severe burn injury. | Liam D Cato Benjamin Bailiff Joshua Price Christos Ermogeneous Jon Hazeldine William Lester Gillian Lowe Christopher Wearn Jonathan RB Bishop Janet M Lord Naiem Moiemen Paul Harrison | 2021 | Burns & Trauma2021，9，1： | 3 |
| 3 | Is There a Role for Endoscopic Therapy as a Definitive Treatment for Post-Laparoscopic Bile Duct Injuries?显示文摘 | Javairiah Fatima Joshua G. Barton Travis E. Grotz Zhimin Geng William S. Harmsen Marianne Huebner Todd H. Baron Michael L. Kendrick John H. Donohue Florencia G. Que David M. Nagorney Michael B. Farnell | 2010 | Journal of the American College of Surgeons2010，，4： | 2 |
| 4 | Efficacy of Neoadjuvant Chemoradiation, Followed by Liver Transplantation, for Perihilar Cholangiocarcinoma at 12 US Centers显示文摘 | Sarwa Darwish Murad W. Ray Kim Denise M. Harnois David D. Douglas James Burton Laura M. Kulik Jean F. Botha Joshua D. Mezrich William C. Chapman Jason J. Schwartz Johnny C. Hong Jean C. Emond Hoonbae Jeon Charles B. Rosen Gregory J. Gores Julie K. Heimbac | 2012 | Gastroenterology2012，，1： | 2 |
| 5 | Enhanced Effect of Combining Human Cardiac Stem Cells and Bone Marrow Mesenchymal Stem Cells to Reduce Infarct Size and to Restore Cardiac Function After Myocardial Infarction显示文摘 | Adam R. Williams Konstantinos E. Hatzistergos Benjamin Addicott Fred McCall Decio Carvalho Viky Suncion Azorides R. Morales Jose Da Silva Mark A. Sussman Alan W. Heldman Joshua M. Hare | 2013 | Circulation2013，，2： | 2 |
| 6 | Frequency of esophageal stenosis after simultaneous modulated accelerated radiation therapy and chemotherapy for head and neck cancer 显示文摘 | JOSHUA DL KRISTEN O WILLIAM G | 2008 | American Journal of Otolaryngology2008，29，1： | 1 |
| 7 | Mesenchymal Stem Cells: Biology, Pathophysiology, Translational Findings, and Therapeutic Implications for Cardiac Disease显示文摘 | Adam R. Williams Joshua M. Hare | 2011 | Circulation Research2011，，8： | 1 |
| 8 | Human intestinal fatty acid binding protein: Report of an assay with studies in normal volunteers and intestinal ischemia显示文摘 | Joshua M Lieberman James Sacchettini Christine Marks William H Marks | 1997 | Surgery1997，，3： | 1 |
| 9 | Strategy for combining heat treatment, cium infiltration, and biological control to reduce postharvest decay of' Gala' apple 显示文摘 | William S C Wojciech J J Joshua D K | 1999 | Hort Science1999，34，4： | 1 |
| 10 | Treating diabetes to accepted standards of care: A 10-year projection of the estimated economic and health impact in patients with type 1 and type 2 diabetes mellitus in the United States显示文摘 | Michael E. Minshall Stéphane Roze Andrew J. Palmer William J. Valentine Volker Foos Joshua Ray Claudia Graham | 2005 | Clinical Therapeutics2005，，6： | 1 |
| 11 | An Improved Technic for Vascular Isolation of the Liver: Experimental Study and Case Reports显示文摘 | John P. Heaney William K. Stanton David S. Halbert Joshua Seidel Tom Vice | 1966 | Annals Of Surgery1966，，： | 1 |
| 12 | Recouping fire and aspen recruit- ment after wolf reintroduction in Yellowstone National Park, USA 显示文摘 | Joshua S William J Robert L | 2008 | Forest Ecology and Management2008，256，5： | 1 |
| 13 | Anxiety in Personality显示文摘 | Joshua Wilt Katherine Oehlberg William Revelle | 2011 | Personality and Individual Differences2011，，50： | 1 |
| 14 | Insulin in the brain: There and back again显示文摘 | William A. Banks Joshua B. Owen Michelle A. Erickson | 2012 | Pharmacology and Therapeutics2012，，1： | 1 |
| 15 | Aurone derivatives as Vps34 inhibitors that modulate autophagy显示文摘We report in this study the identification of a natural product-like antagonist(1a) of Vps34 as a potent autophagy modulator via structure-based virtual screening. Aurone derivative 1a strongly inhibited Vps34 activity in cell-free and cell-based assays. Significantly, 1a prevents autophagy in human cells induced either by starvation or by an mT OR inhibitor. In silico modeling and kinetic data revealed that 1a could function as an ATP-competitive inhibitor of Vps34. Moreover, it suppressed autophagy in vivo and without inducing heart or liver damage in mice. 1a could be utilized as a new motif for more selective and efficacious antagonists of Vps34 for the potential treatment of autophagy-related human diseases. | Guodong Li Joshua William Boyle Chung-Nga Ko Wu Zeng Vincent Kam Wai Wong Jian-Bo Wan Philip Wai Hong Chan Dik-Lung Ma Chung-Hang Leung | 2019 | Acta Pharmaceutica Sinica B2019，9，3： | 1 |
| 16 | Serological profiling of Crohn’s disease and ulcerative colitis patients reveals anti-microbial antibody signatures显示文摘BACKGROUND The healthcare burden of inflammatory bowel disease(IBD)is rising globally and there are limited non-invasive biomarkers for accurate and early diagnosis.AIM To understand the important role that intestinal microbiota play in IBD pathogenesis and identify anti-microbial antibody signatures that benefit clinical management of IBD patients.METHODS We performed serological profiling of 100 Crohn’s disease(CD)patients,100 ulcerative colitis(UC)patients and 100 healthy controls against 1173 bacterial and 397 viral proteins from 50 bacteria and 33 viruses on protein microarrays.The study subjects were randomly divided into discovery(n=150)and validation(n=150)sets.Statistical analysis was performed using R packages.RESULTS Anti-bacterial antibody responses showed greater differential prevalence among the three subject groups than anti-viral antibody responses.We identified novel antibodies against the antigens of Bacteroidetes vulgatus(BVU_0562)and Streptococcus pneumoniae(SP_1992)showing higher prevalence in CD patients relative to healthy controls.We also identified antibodies against the antigen of Streptococcus pyogenes(SPy_2009)showing higher prevalence in healthy controls relative to UC patients.Using these novel antibodies,we built biomarker panels with area under the curve(AUC)of 0.81,0.87,and 0.82 distinguishing CD vs control,UC vs control,and CD vs UC,respectively.Subgroup analysis revealed that penetrating CD behavior,colonic CD location,CD patients with a history of surgery,and extensive UC exhibited highest antibody prevalence among all patients.We demonstrated that autoantibodies and anti-microbial antibodies in CD patients had minimal correlation.CONCLUSION We have identified antibody signatures for CD and UC using a comprehensive analysis of antimicrobial antibody response in IBD.These antibodies and the source microorganisms of their target antigens improve our understanding of the role of specific microorganisms in IBD pathogenesis and,after future validation,should aid early and accurate diagnosis of IBD. | Mahasish Shome Lusheng Song Stacy Williams Yunro Chung Vel Murugan Jin G Park William Faubion Shabana F Pasha Jonathan A Leighton Joshua LaBaer Ji Qiu | 2022 | World Journal of Gastroenterology2022，28，30： | 1 |
| 17 | Recouping fire and aspen recruit- ment after wolf reintroduction in Yellowstone National Park, USA 显示文摘 | Joshua S William J Robert L | 2008 | Forest Ecology and Management2008，256，5： | 1 |
| 18 | Comparison of robust input shapers显示文摘 | Joshua Vaughan Aika Yano William singhose | 2008 | Journal of Sound and Vibration2008，315，： | 1 |
| 19 | Neoadjuvant Bevacizumab, Oxaliplatin, 5-Fluorouracil, and Radiation for Rectal Cancer显示文摘 | Tom Dipetrillo Victor Pricolo Jorge Lagares-Garcia Matt Vrees Adam Klipfel Tom Cataldo William Sikov Brendan McNulty Joshua Shipley Elliot Anderson Humera Khurshid Brigid Oconnor Nicklas B.E. Oldenburg Kathy Radie-Keane Syed Husain Howard Safran | 2012 | International Journal of Radiation Oncology Biology Physics2012，，1： | 1 |
| 20 | The ruptured Achilles tendon:operative and non-opera- tive treatment options 显示文摘 | Joshua A Metzl Christopher S Ahmad William N | 2008 | Curt Rev Musculoskelet Med2008，1，2： | 1 |
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