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| 1 | Impact of simultaneous assay, the PCNA, cyclinDl, and DNA content with specimens before and after preoperative radiotherapy on prognosis of esophageal cancer-possible incorporation into clinical TNM staging system显示文摘AIM: The aim of the present study is to use immunohistochemical methods to investigate the clinical implications of tumor markers in esophageal squamous cell carcinoma and evaluate their impact on prognosis.METHODS: From November 1990 to December 1996, 47patients were treated with preoperative radiation followed by radical esophagectomy. All patients were confirmed pathologically as suffering from squamous cell carcinoma.Immunohistochemical stain was done for PCNA, cyclinD1 protein expression and DNA content analyzed by image cytometry. Kaplan-Meier method for single prognostic factor and log-rank test was used to test the significant difference. Cox stepwise regression model and prognosis index model were used for survival analysis with multiple prognostic factors.RESULTS: Radio-pathological change, T stage and N stage, as the traditional prognostic factors had statistical difference in 3-, 5- and 10-year survival rates. While, tumor cell proliferating marked PCNA, cyclinD1 and DNA content served as independent prognostic factors of esophageal carcinoma. There was definitely an identity between the single and multiple factor analyses. PI was more accurate to evaluate the prognosis of esophageal carcinoma.CONCLUSION: It is possible that tumor cell proliferating marked PCNA, cyclinD1 and DNA content would become the endpoints for evaluating the prognosis of esophageal carcinoma. | Shu-ChaiZhu RenLi Yu-XiangWang WeiFeng JuanLi RongQiu | 2005 | World Journal of Gastroenterology2005，11，25： | 17 |
| 2 | A New Sesquiterpene Lactone from Scorzonera austriaca显示文摘A new guaianolide was isolated from the roots of Scorzonera austriaca. The structure was elucidated on the basis of spectral methods including 2D NMR. | JuanLI QuanXiangwu YanPingSHI YingZHU | 2004 | Chinese Chemical Letters2004，15，11： | 7 |
| 3 | Diversity of methanotrophs in Zoige wetland soils under both anaerobic and aerobic conditions显示文摘Zoige wetland is one of the most important methane emission centers in China. The oxidation of methane in the wetland affects global warming, soil ecology and atmospheric chemistry. Despite their global significance, microorganisms that consume methane in Zoige wetland remain poorly characterized. In this study, we investigated methanotrophs diversity in soil samples from both anaerobic site and aerobic site in Zoige wetland using pmoA gene as a molecular marker. The cloning library was constructed according to the pmoA sequences detected. Four clusters of methanotrophs were detected. The phylogenetic tree showed that all four clusters detected were affiliated to type I methanotrophs. Two novel clusters (cluster 1, cluster 2) were found to relate to none of the recognized genera of methanotrophs. These clusters have no cultured representatives and reveal an ecological adaptation of particular uncultured methanotrophs in Zoige wetland. Two clusters were belonging to Methylobacter and Methylococcus separately. Denaturing gradient gel electrophoresis gel bands pattern retrieved from these two samples revealed that the community compositions of anaerobic soil and aerobic soil were different from each other while anaerobic soil showed a higher metanotrophs diversity. Real-time PCR assays of the two samples demonstrated that aerobic soil sample in Zoige wetland was 1.5 times as much copy numbers as anaerobic soil. These data illustrated that methanotrophs are a group of microorganisms influence the methane consumption in Zoige wetland. | Juanli Yun Anzhou Ma Yaoming Li Guoqiang Zhuang Yanfen Wang Hongxun Zhang | 2010 | Journal of Environmental Sciences2010，22，8： | 6 |
| 4 | Endothelial cells-targeted soluble human Delta-like 4 suppresses both physiological and pathological ocular angiogenesis显示文摘Due to its essential roles in angiogenesis, Notch pathway has emerged as an attractive target for the treatment of pathologic angiogenesis. Although both activation and blockage of Notch signal can impede angiogenesis, activation of Notch signal may be more promising because it was shown that long-term Notch signal blockage resulted in vessel neoplasm. However, an in vivo deliverable Notch ligand with highly efficient Notch-activating capacity has not been developed. Among all the Notch ligands, Delta-like4(Dll4) is specifically involved in angiogenesis. In this study, we generated a novel soluble Notch ligand h D4 R, which consists of the Delta-Serrate-Lag-2 fragment of human Dll4 and an arginine-glycine-aspartate(RGD) motif targeting endothelial cells(ECs). We demonstrated that h D4 R could bind to ECs through its RGD motif and effectively triggered Notch signaling in ECs. Further, we confirmed that h D4 R could suppress angiogenesis in vitro as manifested by network formation assay and sprouting assay. More importantly, h D4 R efficiently repressed neonatal retinal angiogenesis and laser-induced choroidal neovascularization(CNV) as well in vivo. In conclusion, we have developed an in vivo deliverable Notch ligand h D4 R, which suppresses angiogenesis both in vitro and in vivo, thus providing a new approach to tackle excessive angiogenesis relevant disease such as CNV. | YAN XianChun YANG ZiYan CHEN Yan LI Na WANG Li DOU GuoRui LIU Yuan DUAN JuanLi FENG Lei DENG SanMing HAN Hua ZHANG Ping | 2015 | Science China(Life Sciences)2015，58，5： | 5 |
| 5 | Application of high-throughput first-principles calculations in ceramic innovation显示文摘Recent technical progress in the industry has led to an urgent requirement on new materials with enhanced multi-properties.To meet this multi-property requirement,the materials consisting of three and more elements have attracted increasing attention.However,facing to the nearly unknown huge multi-component materials system,the traditional trial and error method cannot provide sufficient data efficiently.Therefore,an efficient material innovation strategy is significant.The first-principles calculation based on the density functional theory is a powerful tool for both the accurate prediction of material properties and the identification of its underlying thermodynamics and dynamics.At the same time,the advances of computational methods and computer calculation abilities that are orders of magnitude faster than before make the high throughput first-principles calculations popular.At present,the simulation-assisted material design has become a main branch in the material research field and a great many successes have been made.In this article,the advances of the high throughput first-principles calculations are reviewed to show the achievements of the first-principles calculations and guide the future directions of its applications in ceramics. | Bin Liu Juanli Zhao Yuchen Liu Jianqi Xi Qian Li Huimin Xiang Yanchun Zhou | 2021 | Journal of Materials Science & Technology2021，，29： | 4 |
| 6 | Arthroscopic Patelloplasty and Circumpatellar Denervation for the Treatment of Patellofemoral Osteoarthritis显示文摘 | Gang Zhao Yujie Liu Bangtuo Yuan Xuezhen Shen Feng Qu Jiangtao Wang Wei Qi Juanli Zhu Yang Liu | 2015 | Chinese Medical Journal2015，，1： | 3 |
| 7 | Mechanical tests on the reconstructed anterior cruciate ligament fixed with allogenetic cortical bone cross-pin on the femoral side显示文摘 | Liu Chang Liu Yujie Zhang Yingze Qu Feng Li Shuyuan Wang Junliang Qi Wei Wang Aiyuan Wang Xin Liang Jianjun Liang Dongqi Zhu Juanli Liu Yang | 2014 | Chinese Medical Journal2014，，15： | 3 |
| 8 | An operation optimization method of a fully mechanized coal mining face based on semi-physical virtual simulation显示文摘A mathematical hydraulic support self-tracking model for three-machine cooperative mining is proposed to address low efficiency and difficulties in strategy evaluation of a fully mechanized coal face.The proposed model uses the coordinates and traction speed of the shearer to calculate the frequency of the circular hydraulic support and realize the coordinated operation of the three-machine mining technology.A unity3d hardware-in-the-loop simulation experimental hearer and hydraulic support platform was used to validate the model of autonomous follow-up.The results indicate that collaborative control of coal mining allowed for an efficiency 3.76%higher than under automatic operation mode and 46.03%higher than under manual control;thus,The mathematical model provided an improved production efficiency of the fully mechanized mining face.The mathematical model also provides a more intelligent and reliable security support,and improves the intelligent level of hydraulic support follow-up control. | Hengbo Shi Jiacheng Xie Xuewen Wang Juanli Li Xing Ge | 2020 | International Journal of Coal Science & Technology2020，7，1： | 3 |
| 9 | Can we early diagnose metabolic syndrome using brachial-ankle pulse wave velocity in community population?显示文摘 | Li Xin Zheng Liang Wu Juanli Ma Yunsheng Masanori Munakata Oleski Jessica Zhang Lijuan Wo Da Wang Jingsong Jiang Qiaoyu Zou Liling Liu Xuebo Li Jue | 2014 | Chinese Medical Journal2014，，17： | 3 |
| 10 | Coordinated transcription of ANRIL and P16 genes is silenced by P16 DNA methylation显示文摘Objective: To investigate the relationship between the transcription of ANRIL, P15, P14 and P16 at the same locus and the regulation mechanism of ANRIL.Methods: Publicly available database of Cancer Cell Line Encyclopedia(CCLE) was used in bioinformatic analyses. Methylation of Cp G islands was detected by denaturing high performance liquid chromatography(DHPLC). Gene transcript levels were determined using quantitative real-time polymerase chain reaction(q RTPCR) assays. An engineered P16-specific transcription factor and DNA methyltransferase were used to induce P16-specific DNA demethylation and methylation.Results: The expression level of ANRIL was positively and significantly correlated with that of P16 but not with that of P15 in the CCLE database. This was confirmed in human cell lines and patient colon tissue samples. In addition, ANRIL was significantly upregulated in colon cancer tissues. Transcription of ANRIL and P16 was observed only in cell lines in which the P16 alleles were unmethylated and not in cell lines with fully methylated P16 alleles.Notably, P16-specific methylation significantly decreased transcription of P16 and ANRIL in BGC823 and GES1 cells. In contrast, P16-specific demethylation re-activated transcription of ANRIL and P16 in H1299 cells(P<0.001).Alteration of ANRIL expression was not induced by P16 expression changes.Conclusions: ANRIL and P16 are coordinately transcribed in human cells and regulated by the methylation status of the P16 Cp G islands around the transcription start site. | Ying Gan Wanru Ma Xiuhong Wang Juanli Qiao Baozhen Zhang Chenghua Cui Zhaojun Liu Dajun Deng | 2018 | Chinese Journal of Cancer Research2018，30，1： | 2 |
| 11 | Borate-Modified,Flame-Retardant Paper Packaging Materials for Archive Conservation显示文摘Paper packaging materials like cardboards are widely used to protect archives which are a major kind of cultural relics.Unfortunately,paper is a combustible material,and thus exploring environment-friendly flame retardant for paper-based archive packaging material plays an important role.Herein,boric acid,borax and disodium octaborate are used to modify the craft paper-based packaging materials for archive conservation to improve fire safety.The modified craft paper exhibits much higher flame retardancy than the pristine one dose based on vertical burning tests,without much influence on mechanical properties such as tensile strength and elongation at break.Thermogravimetric analysis(TGA),scanning electron microscope(SEM),and X-ray photoelectron spectroscopy(XPS)reveal that porous glass structure is formed during the combustion,because thermal decomposition of boric acid,borax and disodium octaborate will produce porous glassy matter as B_(2)O_(3).The porous glass covers the paper surface as an insulating layer which retards the further pyrolysis and combustion,resulting in a denser carbon layer.Our study provides a robust way to reduce the fire hazard of the archive packaging material by applying environment-friendly boron-based fire retardants. | Juanli Wang Ming Cao Jiaxin Li Kaiyuan Li Xiaolian Chao Bingjie Mai Yuhu Li Jing Cao | 2022 | Journal of Renewable Materials2022，10，4： | 2 |
| 12 | Native point defects and oxygen migration of rare earth zirconate and stannate pyrochlores显示文摘Various excellent properties of rare earth zirconate and stannate pyrochlores are close related with their native point defects.First-principles calculations are performed to systematically investigate the point defect mechanism and the oxygen diffusion behavior of A_(2)B_(2)O_(7)(A=La,Ce,Pr,Nd,Pm,Sm,Eu,Gd;B=Zr,Sn).The possible defect complexes and their associated reactions under stoichiometric and nonstoichiometric conditions are explored.The O Frenkel pairs are the most stable defect structure in stoichiometric zirconates,whereas the cation antisite defects are the predominant one in stoichiometric stannates.In the case of BO_(2) excess zirconates and stannates,the BA cation antisite defect with the A vacancy and/or the oxygen interstitial is energetically favorable,whereas the ABantisite defect together with the oxygen vacancy and/or the A interstitial is preferable under the A_(2)O_(3) excess condition.Meanwhile,the maximum point defect concentrations of zirconates are much higher than those of stannates.Furthermore,the oxygen migration barriers are similar in these compounds,ranging in 0.68 eV–0.80 eV.The predicted point defects and oxygen diffusion mechanisms play the critical role in their engineering applications and are expected to guide the future property improvement of pyrochlores through the control of point defects and/or composition. | Juanli Zhao Yuchen Liu Yun Fan Wei Zhang Chengguan Zhang Guang Yang Hongfei Chen Bin Liu | 2021 | Journal of Materials Science & Technology2021，，14： | 2 |
| 13 | Histone H2B lysine 120 monoubiquitination is required for embryonic stem cell differentiation显示文摘 | SuChen JuanLi Da-LiangWang Fang-LinSun | 2012 | Cell Research2012，22，9： | 2 |
| 14 | Discovery of ABO_(4)scheelites with the extra low thermal conductivity through high-throughput calculations显示文摘Searching for new materials with extra low thermal conductivities is significant in numerous fields like thermal barrier coatings and thermoelectric devices.Traditional multiple-component design has successfully reduced the thermal conductivity,but it also dramatically increases the complexity of manufactural technologies and the risk of material failures.In this work,a specific category known as ABO_(4) scheelites that with both simple crystal structure and the structural signature of the low lattice thermal conductivity is explored.High-throughput calculations are employed to screen for the materials with the targeted performance by multi-dimensional mechanical/thermal property criteria and a database of 46 stable scheelites is constructed.Seven scheelites with both ultra-low thermal conductivities(<1.2 W/(m∙K))and quasi-ductility are predicted to be novel thermal insulation materials.Low thermal conductivities prefer the scheelites with large valence disparity between“A”and“B”cations and/or small ionic radius ratio.The adopted strategy starting from the structural fingerprint and the data-driven material selection is expected to be a reference of future structural and functional ceramics design. | Yuchen Liu Dechang Jia Yu Zhou Yanchun Zhou Juanli Zhao Qian Li Bin Liu | 2020 | Journal of Materiomics2020，6，4： | 2 |
| 15 | Prevalence and correlates of depressive symptoms in Chinese older adults: a population‐based study显示文摘 | JingYu JuanLi PimCuijpers ShengtaoWu ZhenyunWu | 2012 | Int J Geriatr Psychiatry2012，，3： | 2 |
| 16 | Corrosion resistance of non-stoichiometric gadolinium zirconate fabricated by laser-enhanced chemical vapor deposition显示文摘Gadolinium zirconate (GZ) is a promising candidate for next-generation thermal barrier coating (TBC) materials.Its corrosion resistance against calcium-magnesium-alumino-silicate(CMAS) needs to be further increased for enhancing its in-service life.As the Gd element plays an important role in the CMAS resistance,three GZ coatings (GZ-0.75,GZ-1.0,and GZ-1.2) with different Gd/Zr atomic ratios are designed and deposited by laser enhanced chemical vapor deposition(LCVD) in this work.It is found that the generated Gd-apatite in GZ-1.2 would block micro-cracks inside the column structure and the inter-columnar gap more efficiently.Thus,the CMAS penetration rate (5.2 μm/h) of GZ-1.2 decreases over 27% comparing with GZ-1.0 and GZ-0.75,which is even lower than the Gd_(2)Zr_(2)O_(7) coatings fabricated by electron-beam physical vapor depositions (EB-PVDs).This work provides a feasible way to adjust the coating's corrosion resistance and may guide the development of future coating for long in-service life. | Chengguan ZHANG Yun FAN Juanli ZHAO Guang YANG Hongfei CHEN Liangmiao ZHANG Yanfeng GAO Bin LIU | 2021 | Journal of Advanced Ceramics2021，10，3： | 2 |
| 17 | Entropy-Based Approach to Remove Redundant Monitoring Wells from Regional-Scale Groundwater Network显示文摘An entropy based approach is applied to identify redundant wells in the network. In the process of this research, groundwater monitoring network is considered as a communication system with a capability to transfer information, and monitoring wells are taken as information receivers. The concepts of entropy and mutual information are then applied to measure the information content of individual monitoring well and information relationship between monitoring well pairs. The efficiency of information transfer among monitoring wells is the basis to judge the redundancy in the network. And the capacity of the monitoring wells to provide information on groundwater is the point of evaluation to identify redundant monitoring wells. This approach is demonstrated using the data from a regional scale groundwater network in Hebei plain, China. The result shows that the entropy based method is recommendable in optimizing groundwater networks, especially for those within media of higher heterogeneities and anisotropies. | Chen Zhihua Engineering Faculty, China University of Geosciences, Wuhan 430074 Jing Juanli Graduate School, China University of Geosciences, Wuhan 430074 Chen Gang Engineering Faculty, China University of Geosciences, Wuhan 430074 | 2002 | Journal of China University of Geosciences2002，13，3： | 1 |
| 18 | The transformation mechanism from suspension to green body and the development of colloidal forming显示文摘 | Juanli Yu Jinlong Yang Yong Huang | 2011 | Ceramics International2011，，5： | 1 |
| 19 | Color Space Conversion Model from CMYK to LAB Based on Prism显示文摘 | Hu Juanli Deng Jiabin | 2007 | IEEE2007，8，2： | 1 |
| 20 | Relational mechanisms, formal contracts, and local knowledge acquisition by international subsidiaries显示文摘 | Julie JuanLi LauraPoppo Kevin ZhengZhou | 2010 | Strat. Mgmt. J2010，，4： | 1 |
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