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| 1 | Improving the performance of a thermoelectric power system using a flat-plate heat pipe显示文摘A gravitational flat-plate heat pipe is designed and fabricated in this paper to serve as a heat spreader to diffuse the local heat source to the hot side of the thermoelectric power module.Based on this, an experimental test for the thermoelectric power generation system is conducted to study the influences of the heat spreader on the temperature uniformity and power generation performance when exposing to a local heat source.In addition,the effects of the heating power, inclination angle, and local heat source size on the power generation performance of the thermoelectric power module using a flat-plate heat pipe as a heat spreader are examined and compared with that using a metal plate.The results indicate that the gravitational flat-plate heat pipe has considerable advantages over the metal plate in the temperature uniformity.The superiority of temperature uniformity in the improvement of power generation performance for the thermoelectric power system using a heat pipe is demonstrated.Particularly, the heat pipe shows good adaptability to placement mode and the local heat source size, which is beneficial to the application in the thermoelectric power generation. | Suchen Wu Yiwen Ding Chengbin Zhang Dehao Xu | 2019 | Chinese Journal of Chemical Engineering2019，27，1： | 6 |
| 2 | Melting heat transfer enhancement of a horizontal latent heat storage unit by fern-fractal fins显示文摘The latent heat storage(LHS)technique is of crucial importance in chemical energy engineering.Inspired by multi-bifurcated fern leaves,a mimic fern-fractal fin is designed to improve the thermal energy charging efficiency.This paper develops a transient melting model of a rectangular LHS unit using fern-fractal fins,and their melting behaviors are compared with the conventional fins.Besides,a parametric optimization of fernfractal fins is conducted for maximizing the thermal efficiency based on the response surface method(RSM).The results indicate that the temperature uniformity is more superior and the melting duration is shorter for the fern-fractal LHS unit when compared with the conventional one.Interestingly,the fern-fractal LHS device presents a slower heat storage rate during the initial conduction-dominated and early convection-dominated melting stages,while a prominent melting enhancement is achieved during the later melting stage.The shortest melting time is obtained based on the RSM technique when a fern-fractal fin with length ratio α=0.94 and branch angle θ=54.7°is utilized.Compared with a conventional fin,the averaged heat storage rate increases by 88.3%,and the total melting time is declined by 40.3%for an optimized fern-fractal fin. | Zilong Deng Suchen Wu Hao Xu Yongping Chen | 2020 | Chinese Journal of Chemical Engineering2020，28，11： | 3 |
| 3 | Histone H2B lysine 120 monoubiquitination is required for embryonic stem cell differentiation显示文摘 | SuChen JuanLi Da-LiangWang Fang-LinSun | 2012 | Cell Research2012，22，9： | 2 |
| 4 | Association Between IgE Antibody Against Soluble Egg Antigen and Resistance to Reinflection with Schistosoma aponicum 显示文摘 | Zhang Zhaosong Wu Haiwei Chen Suchen H | 1997 | Transaction of the Royal Society Tropical Medition and Hygiene1997，91，： | 1 |
| 5 | Iron-Catalyzed Aminomethyloxygenative Cyclization of Hydroxy-α-diazoesters with N,O-Aminals显示文摘Summary of main observation and conclusion A new and eficient cyclization reaction has bleen developed to synthesize cyclic a,a-disubstituted B-amino esters via iron-catalyzed intramolecular aminomethyloxygenative cyclization of diazo compounds with N,O-aminal under mild reaction condi-tions.A broad range of hydroxy-a diazoesters with different substituents and various N,O-aminals were compatible with this protocol,affording the corresponding a,a-disubstitutedβ-amino esters bearing a five-to eight-membered oxacycle in good yields. | Suchen Zou Tianze Zhang Siyuan Wang Hanmin Huang | 2020 | Chinese Journal of Chemistry2020，38，4： | 1 |
| 6 | Attachment of stem cells on porous ehitosan scaffold crosslinked by NasP3O10显示文摘 | LIN Hongru CHEN KeShao CHEN Suchen | 2007 | Materials Science and Engineering:C2007，27，2： | 1 |
| 7 | Production of lightweight aggregales from mining residues, heavy metal sludge, and incinerator fly ash 显示文摘 | HUANG Suchen CItANG Fangchih LO Shanglien | 2007 | Jorunal of tlazardoas Materials2007，144，12： | 1 |
| 8 | Polymethoxy flavones are responsible for the anti-inflammatory activity of citrus fruit peel显示文摘 | HUANG Yungsheng HO Suchen | | 0，，03： | 1 |
| 9 | A biomimetic liver cancer on-a-chip reveals a critical role of LIPOCALIN-2 in promoting hepatocellular carcinoma progression显示文摘Hepatic stellate cells(HSCs)represent a significant component of hepatocellular carcinoma(HCC)microenvironments which play a critical role in tumor progression and drug resistance.Tumor-ona-chip technology has provided a powerful in vitro platform to investigate the crosstalk between activated HSCs and HCC cells by mimicking physiological architecture with precise spatiotemporal control.Here we developed a tri-cell culture microfluidic chip to evaluate the impact of HSCs on HCC progression.Onchip analysis revealed activated HSCs contributed to endothelial invasion,HCC drug resistance and natural killer(NK)cell exhaustion.Cytokine array and RNA sequencing analysis were combined to indicate the iron-binding protein LIPOCALIN-2(LCN-2)as a key factor in remodeling tumor microenvironments in the HCC-on-a-chip.LCN-2 targeted therapy demonstrated robust anti-tumor effects both in vitro 3D biomimetic chip and in vivo mouse model,including angiogenesis inhibition,sorafenib sensitivity promotion and NK-cell cytotoxicity enhancement.Taken together,the microfluidic platform exhibited obvious advantages in mimicking functional characteristics of tumor microenvironments and developing targeted therapies. | Peiliang Shen Yuanyuan Jia Weijia Zhou Weiwei Zheng Yueyao Wu Suchen Qu Shiyu Du Siliang Wang Huilian Shi Jia Sun Xin Han | 2023 | Acta Pharmaceutica Sinica B2023，13，11： | 0 |
| 10 | Application of biocompatible custom ceria nanoparticles in improving the quality of liver grafts for transplantation显示文摘Liver transplantation(LT),an ultimate and vital method for treating end-stage liver disease,is often accompanied by ischemiareperfusion injury(IRI)resulting from warm or cold ischemia of the donor liver.Organ protection techniques are used to improve the quality of liver grafts(from retrieval to implantation).Reactive oxygen species(ROS)cause oxidative stress,which is considered a crucial factor in IRI after LT.Nano antioxidants capable of scavenging ROS alleviate IRI in multiple types of organs and tissues.In this study,we synthesized ceria nanoparticles(NPs)with antioxidant properties using a pyrolysis method and covered them with phospholipid-polyethylene glycol to improve their biocompatibility in vivo.We investigated the potential organprotective effect of ceria NPs and the underlying mechanisms.Ceria NPs promoted liver function recovery after LT by attenuating IRI in liver grafts in vivo.The protective effect of ceria NPs on liver grafts was investigated by applying hypothermic oxygenated machine perfusion ex vivo.Ceria NPs attenuated hypoxia reoxygenation-or H_(2)O_(2)-induced hepatocyte injury by enhancing mitochondrial activity and ROS scavenging in vitro.These effects may be associated with the activation of the nuclear factor erythroid-derived 2-related factor 2(Nrf2)/Kelch-like ECH-associated protein 1(Keap1)/heme oxygenase 1(HO-1)signaling pathway.In conclusion,ceria NPs may serve as a promising antioxidant agent for the treatment of hepatic IRI after LT. | Yinbiao Qiao Jianhui Li Suchen Bian Chenyue Zhan Jia Luo Li Jiang Haoyu Li Hao Wu Cheng Zhang Shusen Zheng Haiyang Xie Penghong Song | 2023 | Nano Research2023，16，4： | 0 |
| 11 | Culture of patient-derived multicellular clusters in suspended hydrogel capsules for pre-clinical personalized drug screening显示文摘A personalized medication regimen provides precise treatment for an individual and can be guided by pre-clinical drug screening.The economical and high-efficiency simulation of the liver tumor microenvironment(TME)in a drug-screening model has high value yet challenging to accomplish.Herein,we propose a simulation of the liver TME with suspended alginate-gelatin hydrogel capsules encapsulating patient-derived liver tumor multicellular clusters,and the culture of patient-derived tumor organoids(PDTOs)for personalized pre-clinical drug screening.The hydrogel capsule offers a 3D matrix environment with mechanical and biological properties similar to those of the liver in vivo.As a result,18 of the 28 patient-derived multicellular clusters were successfully cultured as PDTOs.These PDTOs,along with hepatocyte growth factor(HGF)of non-cellular components,preserve stromal cells,including cancer-associated fibroblasts(CAFs)and vascular endothelial cells(VECs).They also maintain stable expression of molecular markers and tumor heterogeneity similar to those of the original liver tumors.Drugs,including cabazitaxel,oxaliplatin,and sorafenib,were tested in PDTOs.The sensitivity of PDTOs to these drugs differs between individuals.The sensitivity of one PDTO to oxaliplatin was validated using magnetic resonance imaging(MRI)and biochemical tests after oxaliplatin clinical treatment of the corresponding patient.Therefore,this approach is promising for economical,accurate,and high-throughput drug screening for personalized treatment. | Haijiang Dong Zequn Li Suchen Bian Guangyuan Song Wenfeng Song Mingqi Zhang Haiyang Xie Shusen Zheng Xuxu Yang Tiefeng Li Penghong Song | 2022 | Bioactive Materials2022，7，12： | 0 |
| 12 | SERPINE2 promotes liver cancer metastasis by inhibiting c-Cbl-mediated EGFR ubiquitination and degradation显示文摘Background:Liver cancer is a malignancy with high morbidity and mortality rates.Serpin family E member 2(SERPINE2)has been reported to play a key role in the metastasis of many tumors.In this study,we aimed to investigate the potential mechanism of SERPINE2 in liver cancer metastasis.Methods:The Cancer Genome Atlas database(TCGA),including DNA methy-lation and transcriptome sequencing data,was utilized to identify the crucial oncogene associated with DNA methylation and cancer progression in liver can-cer.Data from the TCGA and RNA sequencing for 94 pairs of liver cancer tissues were used to explore the correlation between SERPINE2 expression and clin-ical parameters of patients.DNA methylation sequencing was used to detect the DNA methylation levels in liver cancer tissues and cells.RNA sequencing,cytokine assays,immunoprecipitation(IP)and mass spectrometry(MS)assays,protein stability assays,and ubiquitination assays were performed to explore the regulatory mechanism of SERPINE2 in liver cancer metastasis.Patient-derived xenografts and tumor organoid models were established to determine the role of SERPINE2 in the treatment of liver cancer using sorafenib.Results:Based on the public database screening,SERPINE2 was identified as a tumor promoter regulated by DNA methylation.SERPINE2 expression was significantly higher in liver cancer tissues and was associated with the dismal prognosis in patients with liver cancer.SERPINE2 promoted liver cancer metas-tasis by enhancing cell pseudopodia formation,cell adhesion,cancer-associated fibroblast activation,extracellular matrix remodeling,and angiogenesis.IP/MS assays confirmed that SERPINE2 activated epidermal growth factor receptor(EGFR)and its downstream signaling pathways by interacting with EGFR.Mechanistically,SERPINE2 inhibited EGFR ubiquitination and maintained its protein stability by competing with the E3 ubiquitin ligase,c-Cbl.Additionally,EGFR was activated in liver cancer cells after sorafenib treatment,and SER-PINE2 knockdown-induced EGFR downregulation significantly enhanced the therapeutic efficacy of sorafenib against liver cancer.Furthermore,we found that SERPINE2 knockdown also had a sensitizing effect on lenvatinib treatment.Conclusions:SERPINE2 promoted liver cancer metastasis by preventing EGFR degradation via c-Cbl-mediated ubiquitination,suggesting that inhibition of the SERPINE2-EGFR axis may be a potential target for liver cancer treatment. | Shiyu Zhang Xing Jia Haojiang Dai Xingxin Zhu Wenfeng Song Suchen Bian Hao Wu Shinuo Chen Yangbo Tang Junran Chen Cheng Jin Mengqiao Zhou Haiyang Xie Shusen Zheng Penghong Song | 2024 | Cancer Communications2024，44，3： | 0 |
| 13 | 缓激肽、胰蛋白酶、钙载体A_(23187)对血管内皮细胞释放前列环素的影响显示文摘本实验用6-酮-前列腺素F1α放射免疫分析法观测缓激肽、钙载体A_(23187)、胰蛋白酶及花生四烯酸对牛、猪血管内皮细胞释放前列环素(PGI_2)的影响。结果表明以上4种药物均可显著刺激猪、牛血管内皮细胞释放PGI_2(P<0.01,n=8),并且在本实验条件下,各药对猪血管内皮细胞的活性作用明显大于对牛血管内皮细胞的作用,提示猪、牛血管内皮细胞对各药的反应性存在程度不同的差异。 | 程锦轩 Suchen L.Hong | 1992 | 中国医学科学院学报1992，14，5： | 0 |
| 14 | CREATION OF OPTIMAL MOVEMENT STRATEGY OF PLURAL MOVING OB-JECTS BY GA显示文摘CREATIONOFOPTIMALMOVEMENTSTRATEGYOFPLURALMOVINGOB-JECTSBYGACREATIONOFOPTIMALMOVEMENTSTRATEGYOFPLURALMOVINGOB-JECTSBYGASuSuche... | Su Suchen Tsuchiya Kiichi( Waseda University, Japan) | 1995 | Chinese Journal of Mechanical Engineering1995，8，2： | 0 |
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