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| 1 | Is rectal indomethacin effective in preventing of post-endoscopic retrograde cholangiopancreatography pancreatitis?显示文摘AIM:To investigate the effectiveness of rectally administered indomethacin in the prophylaxis of post-endoscopic retrograde cholangiopancreatography(ERCP)pancreatitis and hyperamylasaemia in a multicentre study.METHODS:A prospective,randomised,placebocontrolled multicentre study in five endoscopic units was conducted on 686 patients randomised to receive a suppository containing 100 mg indomethacin,or an inert placebo,10-15 min before ERCP.Post-ERCP pancreatitis and hyperamylasaemia were evaluated 24 h following the procedure on the basis of clinical signs and laboratory parameters,and computed tomography/magnetic resonance imaging findings if required.RESULTS:Twenty-one patients were excluded because of incompleteness of their data or because of protocol violation.The results of 665 investigations were evaluated:347 in the indomethacin group and 318 in the placebo group.The distributions of the risk factors in the two groups did not differ significantly.Pancreatitis developed in 42 patients(6.3%):it was mild in34(5.1%)and severe in eight(1.2%)cases.Hyperamylaesemia occurred in 160 patients(24.1%).There was no significant difference between the indomethacin and placebo groups in the incidence of either postERCP pancreatitis(5.8%vs 6.9%)or hyperamylasaemia(23.3%vs 24.8%).Similarly,subgroup analysis did not reveal any significant differences between the two groups.CONCLUSION:100 mg rectal indomethacin administered before ERCP did not prove effective in preventing post-ERCP pancreatitis. | Zoltán Dbrnte Zoltán Szepes Ferenc Izbéki Judit Gervain László Lakatos Gyula Pécsi Miklós Ihász Lilla Lakner Erzsébet Toldy László Czakó | 2014 | World Journal of Gastroenterology2014，20，29： | 16 |
| 2 | Increased duodenal expression of mi R-146a and-155 in pediatric Crohn's disease显示文摘AIM: To evaluate the role of micro RNA(mi R)-146 a,-155 and-122 in the duodenal mucosa of pediatric patients with Crohn's disease(CD) and the effect of transforming growth factor-β(TGF-β) on these mi Rs in duodenal epithelial and fibroblast cells.METHODS: Formalin-fixed, paraffin-embedded biopsies derived from the macroscopically inflamed(CD inflamed: n = 10) and intact(CD intact: n = 10) duodenal mucosa of pediatric CD patients and control children(C: n = 10) were examined. Expression of mi R-146 a,-155 and-122 was determined by realtime polymerase-chain reaction(PCR). The expression of the above mi Rs was investigated in recombinant human TGF-β(1 nmol/L, 24 h) or vehicle treated small intestinal epithelial cells(CCL-241) and primary duodenal fibroblast cells derived from healthy children as well.RESULTS: Expression of mi R-146 a was significantly higher in the inflamed duodenal mucosa compared to the intact duodenal mucosa of children with CD(CD inflamed: 3.21 ± 0.50 vs CD intact: 0.62 ± 0.26, p ≤ 0.01) and to the control group(CD inflamed: 3.21 ± 0.50 vs C: 1.00 ± 0.33, p ≤ 0.05). The expression of mi R-155 was significantly increased in the inflamed region of the duodenum compared to the control group(CD inflamed: 4.87 ± 1.02 vs Control: 1.00 ± 0.40, p ≤ 0.001). The expression of mi R-122 was unchanged in the inflamed or intact mucosa of CD patients compared to controls. TGF-β treatment significantly decreased the expression of mi R-155 in small intestinal epithelial cells(TGF-β: 0.7 ± 0.083 vs Control: 1 ± 0.09, p ≤ 0.05) and also the expression of mi R-146a(TGF-β: 0.67 ± 0.04 vs Control: 1 ± 0.15, p ≤ 0.01) and mi R-155(TGF-β: 0.72 ± 0.09 vs Control: 1 ± 0.06, p ≤ 0.05) in primary duodenal fibroblasts compared to corresponding vehicle treated controls. TGF-β treatment did not influence the expression of mi R-122.CONCLUSION: The elevated expression of mi R-146 a and-155 in the inflamed duodenal mucosa of CD patients suggests the role of these mi Rs in the pathomechanism of inflammatory bowel disease. Antiinflammatory TGF-β plays an important role in the regulation of the expression of these mi Rs. | Dániel Szucs Nóra Judit Béres Réka Rokonay Kriszta Boros Katalin Borka Zoltán Kiss András Arató Attila J Szabó ádám Vannay Erna Sziksz Csaba Bereczki Gábor Veres | 2016 | World Journal of Gastroenterology2016，22，26： | 2 |
| 3 | Phytoplankton functional groups as indicators of human impacts along the River Loire (France)显示文摘 | András Abonyi Maria Leit?o Anne Marie Lan?on Judit Padisák | 2012 | Hydrobiologia2012，，1： | 2 |
| 4 | Interaction of the major inflammatory bowel disease susceptibility alleles in Crohn’s disease patients显示文摘AIM:To investigate the interaction of interleukin-23 receptor(IL23R)(rs1004819 and rs2201841),autophagy-related 16-like 1(ATG16L1)(rs2241880), caspase recruitment domain-containing protein 15 (CARD15)genes,and IBD5 locus in Crohn's disease(CD) patients. METHODS:A total of 315 unrelated subjects with CD and 314 healthy controls were genotyped.Interactions and specific genotype combinations of a total of eight variants were tested.The variants of IBD5locus(IGR2198a_1 rs11739135 and IGR2096a_1 rs12521868),CARD15(R702W rs2066845 and L1007fs rs2066847),ATG16L1(rs2241880)and IL23R (rs1004819,rs2201841)genes were genotyped by PCR-RFLP,the G908R(rs2066844)in CARD15 was determined by direct sequencing. RESULTS:The association of ATG16L1 T300A with CD was confirmed[P=0.004,odds ratio(OR)=1.69, 95%CI:1.19-2.41],and both IL23R variants were found to represent significant risk for the disease(P= 0.008,OR=2.05,95%CI:1.20-3.50 for rs1004819 AA;P<0.001,OR=2.97,95%CI:1.65-5.33 for rs2201841 CC).Logistic regression analysis of pairwise interaction of the inflammatory bowel disease (IBD)loci indicated that IL23R,ATG16L1,CARD15 and IBD5(IGR2198a_1)contribute independently to disease risk.We also analysed the specific combina- tions by pair of individual ATG16L1,IL23R rs1004819, rs2201841,IGR2198a_1,IGR2096a_1 and CARD15 genotypes for disease risk influence.In almost all cases,the combined risk of susceptibility pairs was higher in patients carrying two different risk-associated gene variants together than individuals with just one polymorphism.The highest OR was found for IL23R rs2201841 homozygous genotype with combination of positive CARD15 status(P<0.001,OR=9.15,95% CI:2.05-40.74). CONCLUSION:The present study suggests a cumulative effect of individual IBD susceptibility loci. | Veronika Csngei Luca Járomi EnikSáfrány Csilla Sipeky Lili Magyari Bernadett Faragó Judit Bene Noémi Polgár Lilla Lakner Patrícia Sarlós Márta Varga Béla Melegh | 2010 | World Journal of Gastroenterology2010，16，2： | 2 |
| 5 | Does the presence of hepatitis virus B and C influence the evolution of diffuse large B-cell lymphoma?显示文摘 | Judit Rubio Fernando Franco Antonio Sá nchez Blanca Cantos Miriam Mé ndez Virginia Calvo Constanza Maximiano David Perez Isabel Millá n Margarita Sá nchez-Beato Mariano Provencio | 2015 | Leukemia & Lymphoma2015，，6： | 1 |
| 6 | Elevated Levels of Anti- Helicobacter pylori Antibodies in Henoch–Sch?nlein Purpura显示文摘 | János Novák Zoltán Szekanecz Judit Sebesi Alajos Takáts Pál Demeter László Bene Sándor Sipka Zoltán Csiki | 2003 | Autoimmunity2003，，5： | 1 |
| 7 | Review, Thermal water in resources in carbonate rock aquifers显示文摘 | NICO G JUDIT M S ANITA E | 2010 | Hydrogeolo- gy Journal2010，18，6： | 1 |
| 8 | Varma显示文摘 | Jozsef Dudas Judit Toth and Rajender S | 2001 | Tetrahedron Letter2001，42，： | 1 |
| 9 | Crystal size distributions of induced calcium carbonate crystals in polyaspartic acid and mytilus edulis acidic organic proteins aqueous solutions 显示文摘 | Josep R Q Judit M Marius V S | 2004 | J Cryst Growth2004，262，12： | 1 |
| 10 | Solvent-free reduction of aromatic nitro compounds with alumina-supported hydrazine under microwave irradiation显示文摘 | József Dudás Judit Tóth | 2001 | Tetrahedron Letters2001，42，32： | 1 |
| 11 | Calpain-1-sensitive myofibrillar proteins of the human myocardium显示文摘 | Judit Barta Attila Tóth István édes Miklós Vaszily Julius Gy. Papp András Varró Zoltán Papp | 2005 | Molecular and Cellular Biochemistry (-)2005，，1： | 1 |
| 12 | Changes of microbial population and some components in carrot juice during fermentation with selected Bifidobacterium strains显示文摘 | SZILARD K JUDIT M REZESSY S | 2008 | Process Biochemistry2008，43，： | 1 |
| 13 | A thoracalis gerinc proeessus trans- versusainak geometriai vizsgMata显示文摘 | ZoltOn C Zsoh H Judit S | 2008 | Biomech Hung2008，1，： | 1 |
| 14 | Clinical relations of methotrexate pharmacokinetics in the treatment for pediatric osteosarcoma显示文摘 | Marta Hegyi ágnes Gulácsi Edit Cságoly Katalin Csordás Olivér Eipel Dániel Erdélyi Judit Müller Karolina Nemes Orsolya Lautner-Csorba Gábor Kovács | 2012 | Journal of Cancer Research and Clinical Oncology2012，，10： | 1 |
| 15 | Intermediate disturbance in the ecology of phytoplankton and the maintenance of species diversity:a synthesis显示文摘 | REYNOLDS C S JUDIT P SOMMER U | 1993 | Hydrobiologia1993，249，1： | 1 |
| 16 | Carbon monoxide protection against endotoxic shock involves reciprocal effects on iNOS in the lung and liver 显示文摘 | Judit K Brian S Martin B | 2004 | The FASEB J2004，10，： | 1 |
| 17 | Comprehensive Functional Assessment of MLH1 Variants of Unknown Significance显示文摘 | Ester Borràs Marta Pineda Angela Brieger Inga Hinrichsen Carolina Gómez Matilde Navarro Judit Balma?a Teresa Ramón y Cajal Asunción Torres Joan Brunet Ignacio Blanco Guido Plotz Conxi Lázaro Gabriel Capellá | 2012 | Human Mutation2012，，1： | 1 |
| 18 | Mesenchymal Stem Cells Cooperate with Bone Marrow Cells in Therapy of Diabetes显示文摘 | VERONIKA S URBaNA JUDIT KISSA | 2008 | Stem Cells2008，26，： | 1 |
| 19 | Carbon monoxide protection against endotoxic shock involves reciprocal effects on iNOS in the lung and liver显示文摘 | Judit K Sarady Brian S | 2004 | FASEB J2004，18，： | 1 |
| 20 | Multicentric plasmocytic Castleman’s disease with polyneuropathy, organomegaly, endocrinopathy, M protein, skin changes syndrome and coexistent human herpes virus-6 infection – a possible relationship显示文摘 | á dá m Fazakas Má rta Csire Gy? rgy Berencsi á gota Szepesi Andrá s Matolcsy Lajos Jakab Istvá n kará di Judit Vá rkonyi | 2009 | Leukemia & Lymphoma2009，，： | 1 |
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